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1. 发明授权

US08187302B2 Osteointegration apparatus 有权
标题翻译：骨整合装置
公开(公告)号：US08187302B2
公开(公告)日：2012-05-29
申请号：US12350936
申请日：2009-01-08
申请人： Fraser Cummins Henderson, Sr. , Rebecca M. S. Henderson , John W. Newman
发明人： Fraser Cummins Henderson, Sr. , Rebecca M. S. Henderson , John W. Newman
IPC分类号： A61B17/70
CPC分类号： A61B17/7055 , A61B17/7011 , A61B17/7043 , A61B17/7044 , A61B17/7049 , A61B17/7052 , A61B17/8061
摘要： A method for effecting reduction, stabilization and enhancement of fusion of the human cranio-cervical junction, which may be performed in order to relieve mechanical stresses imparted to the spinal cord and brainstem as a result of an abnormal clivo-axial angle, includes steps of achieving the correct craniocervical relationship, of effecting a fusion of a first portion of a bone forming material based structural member to a human cranium, and effecting fusion of a second portion of the bone forming material based structural member to a least one portion of a human cervical spine. Fusion of the bone forming material based structural member to the human cranium may be promoted through the use an osteointegration apparatus that includes a porous ossomeric mesh and a frame member.
摘要翻译：包括以下步骤：用于减轻，稳定和增强人类颅颈交界处融合的方法，所述方法可以执行以减轻由于异常的轴向角度而施加给脊髓和脑干的机械应力实现正确的颅颈关系，实现基于骨形成材料的结构构件的第一部分与人颅骨的融合，并且将骨形成材料基结构构件的第二部分熔化到人的至少一部分颈椎。可以通过使用包括多孔骨架网和框架构件的骨整合装置来促进基于骨形成材料的结构构件与人颅骨的融合。

2. 发明授权

US09107717B2 Craniospinal fusion method and apparatus 有权
标题翻译：颅内融合方法及装置
公开(公告)号：US09107717B2
公开(公告)日：2015-08-18
申请号：US13335248
申请日：2011-12-22
申请人： Fraser Cummins Henderson, Sr. , John W. Newman
发明人： Fraser Cummins Henderson, Sr. , John W. Newman
IPC分类号： A61B17/80 , A61B17/70 , A61B17/88 , A61B17/00
CPC分类号： A61B17/8071 , A61B17/7055 , A61B17/80 , A61B17/8085 , A61B17/8891 , A61B2017/00004 , Y10S606/902 , Y10S606/903
摘要： A method for effecting reduction, stabilization and enhancement of fusion of the human cranio-cervical junction, which may be performed in order to relieve mechanical stresses imparted to the spinal cord and brainstem as a result of an abnormal clivo-axial angle, includes steps of achieving the correct craniocervical relationship, of effecting a fusion of a first portion of a bone forming material based structural member to a human cranium, and effecting fusion of a second portion of the bone forming material based structural member to a least one portion of a human cervical spine. Fusion of the bone forming material based structural member to the human cranium may be promoted through the use of plate member that is shaped to define a graft accommodation space between the plate member and the cranium.
摘要翻译：包括以下步骤：用于减轻，稳定和增强人类颅颈交界处融合的方法，所述方法可以执行以减轻由于异常的轴向角度而施加给脊髓和脑干的机械应力实现正确的颅颈关系，实现基于骨形成材料的结构构件的第一部分与人颅骨的融合，并且将骨形成材料基结构构件的第二部分熔化到人的至少一部分颈椎。可以通过使用成形为在板构件和颅骨之间限定移植物容纳空间的板构件来促进基于骨形成材料的结构构件与人颅骨的融合。

3. 发明申请

US20120116455A1 CRANIOSPINAL FUSION METHOD AND APPARATUS 有权
标题翻译： CRANIOSPINAL FUSION方法和装置
公开(公告)号：US20120116455A1
公开(公告)日：2012-05-10
申请号：US13335248
申请日：2011-12-22
申请人： Fraser Cummins Henderson, Sr. , John W. Newman
发明人： Fraser Cummins Henderson, Sr. , John W. Newman
IPC分类号： A61B17/70 , A61B17/88
CPC分类号： A61B17/8071 , A61B17/7055 , A61B17/80 , A61B17/8085 , A61B17/8891 , A61B2017/00004 , Y10S606/902 , Y10S606/903
摘要： A method for effecting reduction, stabilization and enhancement of fusion of the human cranio-cervical junction, which may be performed in order to relieve mechanical stresses imparted to the spinal cord and brainstem as a result of an abnormal clivo-axial angle, includes steps of achieving the correct craniocervical relationship, of effecting a fusion of a first portion of a bone forming material based structural member to a human cranium, and effecting fusion of a second portion of the bone forming material based structural member to a least one portion of a human cervical spine. Fusion of the bone forming material based structural member to the human cranium may be promoted through the use of plate member that is shaped to define a graft accommodation space between the plate member and the cranium.
摘要翻译：包括以下步骤：用于减轻，稳定和增强人类颅颈交界处融合的方法，所述方法可以执行以减轻由于异常的轴向角度而施加给脊髓和脑干的机械应力实现正确的颅颈关系，实现基于骨形成材料的结构构件的第一部分与人颅骨的融合，并且将骨形成材料基结构构件的第二部分熔化到人的至少一部分颈椎。可以通过使用成形为在板构件和颅骨之间限定移植物容纳空间的板构件来促进基于骨形成材料的结构构件与人颅骨的融合。

4. 发明授权

US08043342B2 Craniospinal fusion method and apparatus 有权
标题翻译：颅内融合方法及装置
公开(公告)号：US08043342B2
公开(公告)日：2011-10-25
申请号：US11832643
申请日：2007-08-01
申请人： Fraser Cummins Henderson, Sr. , John W. Newman
发明人： Fraser Cummins Henderson, Sr. , John W. Newman
IPC分类号： A61B17/70
CPC分类号： A61B17/8071 , A61B17/7055 , A61B17/80 , A61B17/8085 , A61B17/8891 , A61B2017/00004 , Y10S606/902 , Y10S606/903
摘要： A method for effecting reduction, stabilization and enhancement of fusion of the human cranio-cervical junction, which may be performed in order to relieve mechanical stresses imparted to the spinal cord and brainstem as a result of an abnormal clivo-axial angle, includes steps of achieving the correct craniocervical relationship, of effecting a fusion of a first portion of a bone forming material based structural member to a human cranium, and effecting fusion of a second portion of the bone forming material based structural member to a least one portion of a human cervical spine. Fusion of the bone forming material based structural member to the human cranium may be promoted through the use of plate member that is shaped to define a graft accommodation space between the plate member and the cranium.
摘要翻译：包括以下步骤：用于减轻，稳定和增强人类颅颈交界处融合的方法，所述方法可以执行以减轻由于异常的轴向角度而施加给脊髓和脑干的机械应力实现正确的颅颈关系，实现基于骨形成材料的结构构件的第一部分与人颅骨的融合，并且将骨形成材料基结构构件的第二部分熔化到人的至少一部分颈椎。可以通过使用成形为在板构件和颅骨之间限定移植物容纳空间的板构件来促进基于骨形成材料的结构构件与人颅骨的融合。

5. 发明申请

US20090177230A1 OSTEOINTEGRATION APPARATUS 有权
标题翻译： OSTEOINTEGRATION装置
公开(公告)号：US20090177230A1
公开(公告)日：2009-07-09
申请号：US12350936
申请日：2009-01-08
申请人： Fraser Cummins Henderson, SR. , Rebecca M.S. Henderson , John W. Newman
发明人： Fraser Cummins Henderson, SR. , Rebecca M.S. Henderson , John W. Newman
IPC分类号： A61B17/70 , A61B17/88
CPC分类号： A61B17/7055 , A61B17/7011 , A61B17/7043 , A61B17/7044 , A61B17/7049 , A61B17/7052 , A61B17/8061
摘要： A method for effecting reduction, stabilization and enhancement of fusion of the human cranio-cervical junction, which may be performed in order to relieve mechanical stresses imparted to the spinal cord and brainstem as a result of an abnormal clivo-axial angle, includes steps of achieving the correct craniocervical relationship, of effecting a fusion of a first portion of a bone forming material based structural member to a human cranium, and effecting fusion of a second portion of the bone forming material based structural member to a least one portion of a human cervical spine. Fusion of the bone forming material based structural member to the human cranium may be promoted through the use an osteointegration apparatus that includes a porous ossomeric mesh and a frame member.
摘要翻译：包括以下步骤：用于减轻，稳定和增强人类颅颈交界处融合的方法，所述方法可以执行以减轻由于异常的轴向角度而施加给脊髓和脑干的机械应力实现正确的颅颈关系，实现基于骨形成材料的结构构件的第一部分与人颅骨的融合，并且将骨形成材料基结构构件的第二部分熔化到人的至少一部分颈椎。可以通过使用包括多孔骨架网和框架构件的骨整合装置来促进基于骨形成材料的结构构件与人颅骨的融合。

6. 发明授权

US08083743B2 Craniospinal fusion method and apparatus 有权
公开(公告)号：US08083743B2
公开(公告)日：2011-12-27
申请号：US11832646
申请日：2007-08-01
申请人： Fraser Cummins Henderson, Sr. , John W. Newman
发明人： Fraser Cummins Henderson, Sr. , John W. Newman
IPC分类号： A61B17/80
CPC分类号： A61B17/8071 , A61B17/7055 , A61B17/80 , A61B17/8085 , A61B17/8891 , A61B2017/00004 , Y10S606/902 , Y10S606/903
摘要： A method for effecting reduction, stabilization and enhancement of fusion of the human cranio-cervical junction, which may be performed in order to relieve mechanical stresses imparted to the spinal cord and brainstem as a result of an abnormal clivo-axial angle, includes steps of achieving the correct craniocervical relationship, of effecting a fusion of a first portion of a bone forming material based structural member to a human cranium, and effecting fusion of a second portion of the bone forming material based structural member to a least one portion of a human cervical spine. Fusion of the bone forming material based structural member to the human cranium may be promoted through the use of plate member that is shaped to define a graft accommodation space between the plate member and the cranium.

7. 发明申请

US20100076366A1 MODULAR SPINAL FLUID FLOW REGULATION DEVICE AND METHOD 审中-公开
标题翻译：模块化脊柱液体流量调节装置及方法
公开(公告)号：US20100076366A1
公开(公告)日：2010-03-25
申请号：US12562926
申请日：2009-09-18
申请人： Fraser Cummins Henderson, SR. , John W. Newman
发明人： Fraser Cummins Henderson, SR. , John W. Newman
IPC分类号： A61M1/00
CPC分类号： A61B5/031 , A61B5/076 , A61M27/006
摘要： A shunt system for telemetrically measuring, regulating and/or adjusting cerebrospinal fluid flow rate, intercranial pressure, intraspinal pressure and/or intraventricular pressure and a method for use. The shunt system includes a shunt assembly, a first catheter and a second catheter that may be implanted using a novel introducer assembly. In addition to regulating fluid pressure and flow rate, the shunt system may also be used to deliver therapeutic compositions.
摘要翻译：用于遥测测量，调节和/或调节脑脊液流速，颅内压，脊柱内压力和/或心室内压力的分流系统及其使用方法。分流系统包括可以使用新颖的导引器组件植入的分流组件，第一导管和第二导管。除了调节流体压力和流速之外，分流系统还可用于递送治疗组合物。

8. 发明授权

US10145773B2 Method and system for measuring a property of a non-newtonian fluid 有权
公开(公告)号：US10145773B2
公开(公告)日：2018-12-04
申请号：US14413186
申请日：2013-07-08
申请人： John W. Newman
发明人： John W. Newman
IPC分类号： G01N11/06 , G01N11/00 , G01N33/42 , G01N33/26
摘要： A system and method for measuring the deformation over time of the surface of a non-Newtonian fluid in a sampling container in response to an airjet that is applied for a specified time are disclosed. The change is the sample surface displacement is measured quantitatively by means of optical triangulation or other similar optical or electronic distance measuring device. After cessation of the airjet, gravitational forces cause the sample material to flow back to its original surface profile. Both the amplitude of the deformation displacement due to the force of the airjet and the recovered displacement, within specific time periods are characteristic of asphalt binder material with varying amounts of polymer or other additives used to control the ultimate properties and performance of the material. As a result, comparison of the quantitative measurements of control samples can allow discrimination from samples with different properties and hence different formulations.

9. 发明申请

US20150204768A1 METHOD AND SYSTEM FOR MEASURING A PROPERTY OF A NON-NEWTONIAN FLUID 审中-公开
标题翻译：用于测量非牛顿流体的性质的方法和系统
公开(公告)号：US20150204768A1
公开(公告)日：2015-07-23
申请号：US14413186
申请日：2013-07-08
申请人： John W. NEWMAN
发明人： John W. Newman
IPC分类号： G01N11/00 , G01N33/26 , G01N33/42
CPC分类号： G01N11/00 , G01N11/06 , G01N33/26 , G01N33/42 , G01N2203/0044 , G01N2203/0094
摘要： A system and method for measuring the deformation over time of the surface of a non-Newtonian fluid in a sampling container in response to an airjet that is applied for a specified time are disclosed. The change is the sample surface displacement is measured quantitatively by means of optical triangulation or other similar optical or electronic distance measuring device. After cessation of the airjet, gravitational forces cause the sample material to flow back to its original surface profile. Both the amplitude of the deformation displacement due to the force of the airjet and the recovered displacement, within specific time periods are characteristic of asphalt binder material with varying amounts of polymer or other additives used to control the ultimate properties and performance of the material. As a result, comparison of the quantitative measurements of control samples can allow discrimination from samples with different properties and hence different formulations.
摘要翻译：公开了一种系统和方法，用于响应于施加了特定时间的喷气机，测量取样容器中的非牛顿流体表面随时间变化。变化是通过光学三角测量或其他类似的光学或电子距离测量装置定量测量样品表面位移。在喷气机停止后，重力会导致样品材料流回其原始的表面轮廓。在特定时间段内由于喷气的力和回收位移引起的变形位移的振幅都是具有不同量的聚合物或其他添加剂的沥青粘合剂材料的特征，所述聚合物或其它添加剂用于控制材料的最终性能和性能。因此，对照样品的定量测量的比较可以允许对具有不同性质和因此不同制剂的样品进行鉴别。

10. 发明授权

US08455652B2 Inhibitors for the soluble epoxide hydrolase 有权
公开(公告)号：US08455652B2
公开(公告)日：2013-06-04
申请号：US12396391
申请日：2009-03-02
申请人： Bruce D. Hammock , In-Hae Kim , Christophe Morisseau , Takaho Watanabe , John W. Newman
发明人： Bruce D. Hammock , In-Hae Kim , Christophe Morisseau , Takaho Watanabe , John W. Newman
IPC分类号： C07D211/68 , C07D211/80
CPC分类号： C07C275/26 , C07C275/30 , C07C275/42 , C07C311/04 , C07C311/05 , C07C311/51 , C07C323/59 , C07C2601/02 , C07C2601/14 , C07C2603/74 , C07D207/16 , C07D233/24 , C07D233/64
摘要： Inhibitors of the soluble epoxide hydrolase (sEH) are provided that incorporate multiple pharmacophores and are useful in the treatment of diseases.

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