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1. 发明授权

US06653071B1 Dissecting the regulatory circuitry of a eukaryotic genomei 失效
标题翻译：解剖真核基因组的调控电路
公开(公告)号：US06653071B1
公开(公告)日：2003-11-25
申请号：US09326137
申请日：1999-06-04
申请人： Frank C. P. Holstege , Richard A. Young
发明人： Frank C. P. Holstege , Richard A. Young
IPC分类号： C12Q168
CPC分类号： G01N33/5023 , C07K14/4702 , G01N33/5008 , G01N33/5041
摘要： A method of identifying cellular regulatory circuits which employ at least one component of a subcomplex of regulatory proteins within the RNA II polymerase holoenzyme which behaves as a signal processor for gene-specific regulators (at least one component of a eukaryotic transcription initiation apparatus) and of determining the set of components of the apparatus which are responsible for regulation of each gene and the set of genes which are coordinately controlled by each transcription factor.
摘要翻译：鉴定在RNAII聚合酶全酶中使用调节蛋白亚复合物的至少一种组分的细胞调节电路的方法，其作为基因特异性调节剂（真核转录起始装置的至少一种成分）的信号处理器和确定负责每个基因的调节的装置的组成和由每个转录因子协调控制的一组基因。

2. 发明申请

US20090221428A1 Methods of Genome-Wide Location Analysis in Stem Cells 审中-公开
标题翻译：干细胞基因组位置分析方法
公开(公告)号：US20090221428A1
公开(公告)日：2009-09-03
申请号：US12065076
申请日：2006-09-07
申请人： Richard A. Young , Tong Ihn Lee , Matthew Guenther , Laurie A. Boyer
发明人： Richard A. Young , Tong Ihn Lee , Matthew Guenther , Laurie A. Boyer
IPC分类号： C40B20/04 , C12Q1/68 , C07H1/00 , C40B50/14
CPC分类号： C12Q1/6809 , C12Q1/6837 , C12Q2565/501 , C12Q2523/101 , C12Q2522/101
摘要： The invention relates to improved methods of identifying the genomic regions to which a protein of interest binds, and in particular, to methods that apply to stem cells such as but not limited to; embryonic stem cells and adult stem cells. The invention also provides methods of identifying agents which modulate differentiation of stem cells. The invention also provides methods of defining the differentiation potential of a cell and of designing array oligonucleotides.
摘要翻译：本发明涉及鉴定目标蛋白质结合的基因组区域的改进方法，特别涉及适用于干细胞的方法，例如但不限于：胚胎干细胞和成体干细胞。本发明还提供鉴定调节干细胞分化的药剂的方法。本发明还提供了定义细胞的分化潜能和设计阵列寡核苷酸的方法。

3. 发明授权

US06482614B1 Stress proteins and uses therefor 失效
公开(公告)号：US06482614B1
公开(公告)日：2002-11-19
申请号：US09468041
申请日：1999-12-21
申请人： Richard A. Young
发明人： Richard A. Young
IPC分类号： C12P2104
CPC分类号： A61K39/21 , A61K39/00 , A61K39/0008 , A61K39/04 , A61K39/12 , A61K39/385 , A61K39/39 , A61K2039/545 , A61K2039/55516 , A61K2039/6043 , A61K2039/70 , C07K14/005 , C07K14/35 , C07K2319/03 , C07K2319/20 , C07K2319/21 , C07K2319/35 , C07K2319/40 , C07K2319/50 , C07K2319/735 , C07K2319/75 , C12N15/62 , C12N2740/16222 , C12N2740/16234
摘要： The present invention relates to stress proteins and methods of modulating an individual's immune response. In particular, it relates to the use of such stress proteins in immune therapy and prophylaxis, which results in an induction or enhancement of an individual's immune response and as an immunotherapeutic agent which results in a decrease of an individual's immune response to his or her own cells. The present invention also relates to compositions comprising a stress protein joined to another component, such as a fusion protein in which a stress protein is fused to an antigen. Further, the present invention relates to a method of generating antibodies to a substance using a conjugate comprised of a stress protein joined to the substance.

4. 发明授权

US06214588B1 Factors which modify gene transcription and methods of use therefor 失效
标题翻译：改变基因转录的因素及其使用方法
公开(公告)号：US06214588B1
公开(公告)日：2001-04-10
申请号：US08590399
申请日：1996-01-26
申请人： Richard A. Young , Anthony J. Koleske , Craig M. Thompson , David M. Chao
发明人： Richard A. Young , Anthony J. Koleske , Craig M. Thompson , David M. Chao
IPC分类号： C12P1934
CPC分类号： C12N9/1247 , C07K14/395 , C07K14/4702 , C07K16/14 , G01N33/573
摘要： Eukaryotic RNA polymerase II holoenzymes that contain RNA polymerase II and one or more regulatory proteins are described. These holoenzymes selectively initiate transcription in vitro when supplemented with general transcription factors. The regulatory proteins act positively and negatively to regulate transcription initiation, at least in part, via functional interactions with RNA polymerase II.
摘要翻译：描述了含有RNA聚合酶II和一种或多种调节蛋白的真核RNA聚合酶II全酶。当补充一般转录因子时，这些全酶在体外选择性启动转录。调节蛋白质通过与RNA聚合酶II的功能相互作用，至少部分地起到调节转录起始的作用。

5. 发明授权

US6015682A Factors which modify gene transcription and methods of use therefor 失效
标题翻译：改变基因转录的因素及其使用方法
公开(公告)号：US6015682A
公开(公告)日：2000-01-18
申请号：US521872
申请日：1995-08-31
申请人： Richard A. Young , Anthony J. Koleske , Craig M. Thompson , David M. Chao
发明人： Richard A. Young , Anthony J. Koleske , Craig M. Thompson , David M. Chao
IPC分类号： C07K14/395 , C07K14/47 , C07K16/14 , C12N9/12 , C12N15/54 , G01N33/573 , C12Q1/48 , C07K1/00
CPC分类号： C07K14/395 , C07K14/4702 , C07K16/14 , C12N9/1247 , G01N33/573
摘要： Eukaryotic RNA polymerase II holoenzymes that contain RNA polymerase II and one or more regulatory SRB proteins are described. These holoenzymes will selectively initiate transcription in vitro when supplemented with general transcription factors such as TATA-binding protein (TBP) and factor a (TFIIE). The SRB proteins act positively and negatively to regulate transcription initiation, at least in part, via functional interactions with RNA polymerase II.
摘要翻译：描述了含有RNA聚合酶II和一种或多种调节性SRB蛋白质的真核RNA聚合酶II全酶。当补充有一般转录因子如TATA结合蛋白（TBP）和因子a（TFIIE））时，这些全息酶将选择性地启动体外转录。至少部分通过与RNA聚合酶II的功能相互作用，SRB蛋白质正向和负向地起调节转录起始作用。

6. 发明授权

US5854055A Recombinant mycobacteria 失效
标题翻译：重组分枝杆菌
公开(公告)号：US5854055A
公开(公告)日：1998-12-29
申请号：US463942
申请日：1995-06-05
申请人： Barry R. Bloom , William R. Jacobs, Jr. , Ronald W. Davis , Richard A. Young , Robert N. Husson
发明人： Barry R. Bloom , William R. Jacobs, Jr. , Ronald W. Davis , Richard A. Young , Robert N. Husson
IPC分类号： G01N33/53 , A61K39/00 , A61K39/04 , A61K39/39 , A61P31/04 , A61P31/06 , A61P31/08 , A61P31/12 , A61P31/16 , A61P31/18 , A61P31/22 , A61P37/04 , A61P39/02 , C07K14/01 , C07K14/35 , C12N1/21 , C12N15/09 , C12N15/74 , C12N15/87 , C12P21/02 , C12R1/19 , C12R1/32 , C12R1/325 , C12R1/33 , C12R1/34 , G01N33/50 , C12N15/64 , C12N15/66
CPC分类号： A61K39/04 , C07K14/005 , C07K14/35 , C12N15/74 , C12N15/87 , C12R1/32 , A61K39/00 , C12N2795/10022
摘要： Recombinant mycobacterial vaccine vehicles capable of expressing DNA of interest which encodes at least one protein antigen for at least one pathogen against which an immune response is desired and which can be incorporated into the mycobacteria or stably integrated into the mycobacterial genome. The vaccine vehicles are useful for administration to mammalian hosts for purposes of immunization. A recombinant vector which replicates in E. coli but not in mycobacteria is also disclosed. The recombinant vector includes 1) a mycobacterial gene or portions thereof, necessary for recombination with homologous sequences in the genome of mycobacteria transformed with the recombinant plasmid; 2) all or a portion of a gene which encodes a polypeptide or protein whose expression is desired in mycobacteria transformed with the recombinant plasmid; 3) DNA sequences necessary for replication and selection in E. coli; and 4) DNA sequences necessary for selection in mycobacteria (e.g., drug resistance). The present invention also relates to two types of recombinant vectors useful in introducing DNA of interest into mycobacteria, where it is expressed. One type of vector is a recombinant plasmid capable of replicating as a plasmid in E. coli and of lysogenizing a mycobacterial host. The other type of vector is a recombinant plasmid which can be introduced into mycobacteria, where it is stably maintained extrachromosomally.
摘要翻译：能够表达目的的DNA的重组分枝杆菌疫苗载体，其编码针对至少一种需要免疫应答的至少一种病原体的至少一种蛋白质抗原并且可以并入分枝杆菌中或稳定整合到分枝杆菌基因组中。疫苗载体用于哺乳动物宿主用于免疫的目的。还公开了在大肠杆菌中但不在分枝杆菌中复制的重组载体。重组载体包括1）与用重组质粒转化的分枝杆菌基因组中与同源序列重组所必需的分枝杆菌基因或其部分; 2）编码在用重组质粒转化的分枝杆菌中表达所需的多肽或蛋白质的基因的全部或部分; 3）在大肠杆菌中复制和选择所需的DNA序列; 和4）在分枝杆菌中选择所需的DNA序列（例如耐药性）。本发明还涉及可用于将感兴趣的DNA引入分枝杆菌的两种类型的重组载体，其中它被表达。一种载体是能够在大肠杆菌中作为质粒复制并使分解细菌宿主溶解的重组质粒。另一种载体是可以引入分枝杆菌的重组质粒，其在染色体外稳定地保持。

7. 植物专利

USPP8530P Nandina domestica cv. "Greray" 失效
公开(公告)号：USPP8530P
公开(公告)日：1994-01-04
申请号：US893411
申请日：1992-06-02
申请人： Richard A. Young
发明人： Richard A. Young
摘要： A new variety of Nandina domestica having significant and improved characteristics not known to exist in either the variety "Harbour Dwarf" of which this new plant is a genetic mutant or the general species Nandina domestica. These characteristics include a symmetrical, densely mounding and compact form.

8. 发明授权

US09155724B2 Combination methods for treatment of disease 有权
标题翻译：治疗疾病的组合方法
公开(公告)号：US09155724B2
公开(公告)日：2015-10-13
申请号：US13577098
申请日：2011-02-04
申请人： Peter B. Rahl , Richard A. Young
发明人： Peter B. Rahl , Richard A. Young
IPC分类号： A61K31/435 , A61K31/426 , C12Q1/18 , C12N5/071 , A61K31/4025 , A61K31/445 , A61K31/453 , A61K45/06 , G01N33/50
CPC分类号： A61K31/4025 , A61K31/426 , A61K31/445 , A61K31/453 , A61K45/06 , G01N33/5011 , G01N2333/4704 , A61K2300/00
摘要： In some aspects, the invention provides compositions and methods of use for treating a variety of diseases. In some aspect, the compositions and methods involve combined modulation of transcriptional modulators.
摘要翻译：在一些方面，本发明提供用于治疗各种疾病的组合物和方法。在一些方面，组合物和方法涉及转录调节剂的组合调节。

9. 发明申请

US20130109737A1 MEDIATOR AND COHESIN CONNECT GENE EXPRESSION AND CHROMATIN ARCHITECTURE 审中-公开
标题翻译： MEDIATOR和COHESIN连接基因表达和染色体结构
公开(公告)号：US20130109737A1
公开(公告)日：2013-05-02
申请号：US13578114
申请日：2011-02-09
申请人： Richard A. Young , Jamie J. Newman , Michael H. Kagey , Steve Bilodeau
发明人： Richard A. Young , Jamie J. Newman , Michael H. Kagey , Steve Bilodeau
IPC分类号： C12Q1/68 , C12N9/96
CPC分类号： C12Q1/6811 , C12N9/96 , C12Q1/6804 , C12Q1/6883 , C12Q2600/136 , C12Q2600/156 , C12Q2600/178 , G01N33/574 , G01N33/6872 , G01N33/6893
摘要： In some aspects, the present invention provides compositions and methods relating at least in part to modulation of the Cohesin-Mediator interaction. The invention provides compositions and methods useful for modulating Cohesin-Mediator function. The invention further provides compositions and methods useful for identifying compounds that modulate Cohesin-Mediator function. In some aspects, the invention provides compositions and methods useful for treating a disorder involving altered Cohesin-Mediator function.
摘要翻译：在一些方面，本发明提供了至少部分地涉及Cohesin-Mediator相互作用的调制的组合物和方法。本发明提供了用于调节凝聚素介导功能的组合物和方法。本发明进一步提供可用于鉴定调节凝聚素中介功能的化合物的组合物和方法。在一些方面，本发明提供了可用于治疗涉及改变的Cohesin-Mediator功能的病症的组合物和方法。

10. 发明申请

US20120034192A1 COMPOSITIONS AND METHODS FOR ENHANCING CELL REPROGRAMMING 审中-公开
标题翻译：用于增强细胞代谢的组合物和方法
公开(公告)号：US20120034192A1
公开(公告)日：2012-02-09
申请号：US13119891
申请日：2009-09-21
申请人： Richard A. Young , Steve Bilodeau , Michael H. Kagey
发明人： Richard A. Young , Steve Bilodeau , Michael H. Kagey
IPC分类号： A61K35/12 , C40B30/06 , C12N5/10 , C12N5/071 , C12Q1/68
CPC分类号： C12N5/0696 , C12N2501/065
摘要： The invention provides compositions and methods of use to enhance reprogramming of mammalian cells. Certain compositions and methods of the invention are of use to enhance generation of induced pluripotent stem cells by reprogramming somatic cells. Certain compositions and methods of the invention are of use to enhance reprogramming of pluripotent mammalian cells to a differentiated cell type. Certain compositions and methods of the invention are of use to enhance reprogramming of differentiated mammalian cells of a first cell type to differentiated mammalian cells of a second differentiated cell type. The reprogrammed somatic cells are useful for a number of purposes, including treating or preventing a medical condition in an individual. The invention further provides methods for identifying an agent that enhances or contributes to reprogramming mammalian cells. Certain of the inventive compositions and methods relate to inhibiting histone methylation.
摘要翻译：本发明提供用于增强哺乳动物细胞重编程的组合物和方法。本发明的某些组合物和方法可用于通过重编程体细胞来增强诱导的多能干细胞的产生。本发明的某些组合物和方法可用于增强多能哺乳动物细胞对分化细胞类型的重编程。本发明的某些组合物和方法可用于增强第一细胞类型的分化哺乳动物细胞对第二分化细胞类型的分化哺乳动物细胞的重编程。重编程体细胞可用于许多目的，包括治疗或预防个体的医疗状况。本发明还提供了鉴定增强或有助于重编程哺乳动物细胞的药剂的方法。某些本发明的组合物和方法涉及抑制组蛋白甲基化。

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