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1. 发明申请

US20130109737A1 MEDIATOR AND COHESIN CONNECT GENE EXPRESSION AND CHROMATIN ARCHITECTURE 审中-公开
标题翻译： MEDIATOR和COHESIN连接基因表达和染色体结构
公开(公告)号：US20130109737A1
公开(公告)日：2013-05-02
申请号：US13578114
申请日：2011-02-09
申请人： Richard A. Young , Jamie J. Newman , Michael H. Kagey , Steve Bilodeau
发明人： Richard A. Young , Jamie J. Newman , Michael H. Kagey , Steve Bilodeau
IPC分类号： C12Q1/68 , C12N9/96
CPC分类号： C12Q1/6811 , C12N9/96 , C12Q1/6804 , C12Q1/6883 , C12Q2600/136 , C12Q2600/156 , C12Q2600/178 , G01N33/574 , G01N33/6872 , G01N33/6893
摘要： In some aspects, the present invention provides compositions and methods relating at least in part to modulation of the Cohesin-Mediator interaction. The invention provides compositions and methods useful for modulating Cohesin-Mediator function. The invention further provides compositions and methods useful for identifying compounds that modulate Cohesin-Mediator function. In some aspects, the invention provides compositions and methods useful for treating a disorder involving altered Cohesin-Mediator function.
摘要翻译：在一些方面，本发明提供了至少部分地涉及Cohesin-Mediator相互作用的调制的组合物和方法。本发明提供了用于调节凝聚素介导功能的组合物和方法。本发明进一步提供可用于鉴定调节凝聚素中介功能的化合物的组合物和方法。在一些方面，本发明提供了可用于治疗涉及改变的Cohesin-Mediator功能的病症的组合物和方法。

2. 发明申请

US20120034192A1 COMPOSITIONS AND METHODS FOR ENHANCING CELL REPROGRAMMING 审中-公开
标题翻译：用于增强细胞代谢的组合物和方法
公开(公告)号：US20120034192A1
公开(公告)日：2012-02-09
申请号：US13119891
申请日：2009-09-21
申请人： Richard A. Young , Steve Bilodeau , Michael H. Kagey
发明人： Richard A. Young , Steve Bilodeau , Michael H. Kagey
IPC分类号： A61K35/12 , C40B30/06 , C12N5/10 , C12N5/071 , C12Q1/68
CPC分类号： C12N5/0696 , C12N2501/065
摘要： The invention provides compositions and methods of use to enhance reprogramming of mammalian cells. Certain compositions and methods of the invention are of use to enhance generation of induced pluripotent stem cells by reprogramming somatic cells. Certain compositions and methods of the invention are of use to enhance reprogramming of pluripotent mammalian cells to a differentiated cell type. Certain compositions and methods of the invention are of use to enhance reprogramming of differentiated mammalian cells of a first cell type to differentiated mammalian cells of a second differentiated cell type. The reprogrammed somatic cells are useful for a number of purposes, including treating or preventing a medical condition in an individual. The invention further provides methods for identifying an agent that enhances or contributes to reprogramming mammalian cells. Certain of the inventive compositions and methods relate to inhibiting histone methylation.
摘要翻译：本发明提供用于增强哺乳动物细胞重编程的组合物和方法。本发明的某些组合物和方法可用于通过重编程体细胞来增强诱导的多能干细胞的产生。本发明的某些组合物和方法可用于增强多能哺乳动物细胞对分化细胞类型的重编程。本发明的某些组合物和方法可用于增强第一细胞类型的分化哺乳动物细胞对第二分化细胞类型的分化哺乳动物细胞的重编程。重编程体细胞可用于许多目的，包括治疗或预防个体的医疗状况。本发明还提供了鉴定增强或有助于重编程哺乳动物细胞的药剂的方法。某些本发明的组合物和方法涉及抑制组蛋白甲基化。

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