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1. 发明授权

US09670540B2 Methods and devices for DNA sequencing and molecular diagnostics 有权
公开(公告)号：US09670540B2
公开(公告)日：2017-06-06
申请号：US14234011
申请日：2012-07-23
申请人： Francis A. Barany , Steven A. Soper , George Grills , Yu-wei Cheng , Jianmin Huang , Hong Wang , Malgorzata A. Witek , Daniel Sang-won Park , Michael C. Murphy , Robin Lindsey McCarley , Mateusz L. Hupert
发明人： Francis A. Barany , Steven A. Soper , George Grills , Yu-wei Cheng , Jianmin Huang , Hong Wang , Malgorzata A. Witek , Daniel Sang-won Park , Michael C. Murphy , Robin Lindsey McCarley , Mateusz L. Hupert
IPC分类号： C12Q1/68 , G01N33/58 , C07H21/04
CPC分类号： C12Q1/6874 , C12Q1/6806 , G01N33/585 , C12Q2525/197 , C12Q2525/313 , C12Q2535/122 , C12Q2563/131 , C12Q2565/543
摘要： The present invention is directed to methods for capturing, amplifying and identifying one or more of a plurality of target nucleotide sequences in a sample. The present invention is further directed to a device comprising a solid support having a plurality of wells or pillars and a plurality of oligonucleotides attached to the wells or pillars. Other aspects of the invention are directed to methods of making such devices.

2. 发明申请

US20150099642A1 METHODS AND DEVICES FOR DNA SEQUENCING AND MOLECULAR DIAGNOSTICS 有权
标题翻译：用于DNA测序和分子诊断的方法和设备
公开(公告)号：US20150099642A1
公开(公告)日：2015-04-09
申请号：US14234011
申请日：2012-07-23
申请人： Francis A. Barany , Steven A. Soper , George Grills , Yu-wei Cheng , Jianmin Huang , Malgorzata A. Witek , Daniel San-won Park , Michael C. Murphy , Robin Lindsey McCarley , Mateusz L. Hupert
发明人： Francis A. Barany , Steven A. Soper , George Grills , Yu-wei Cheng , Jianmin Huang , Malgorzata A. Witek , Daniel San-won Park , Michael C. Murphy , Robin Lindsey McCarley , Mateusz L. Hupert
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6874 , C12Q1/6806 , G01N33/585 , C12Q2525/197 , C12Q2525/313 , C12Q2535/122 , C12Q2563/131 , C12Q2565/543
摘要： The present invention is directed to methods for capturing, amplifying and identifying one or more of a plurality of target nucleotide sequences in a sample. The present invention is further directed to a device comprising a solid support having a plurality of wells or pillars and a plurality of oligonucleotides attached to the wells or pillars. Other aspects of the invention are directed to methods of making such devices.
摘要翻译：本发明涉及用于捕获，扩增和鉴定样品中多个靶核苷酸序列中的一个或多个的方法。本发明进一步涉及包括具有多个孔或柱的固体支持物和连接到孔或支柱上的多个寡核苷酸的装置。本发明的其它方面涉及制造这种装置的方法。

3. 发明申请

US20090074637A1 Optimized Modular Microfluidic Devices 审中-公开
标题翻译：优化的模块化微流体装置
公开(公告)号：US20090074637A1
公开(公告)日：2009-03-19
申请号：US12164356
申请日：2008-06-30
申请人： Michael C. Murphy , Dimitris E. Nikitopoulos , Steven A. Soper , Pin-Chuan Chen , Daniel S.-W. Park , Mateusz L. Hupert
发明人： Michael C. Murphy , Dimitris E. Nikitopoulos , Steven A. Soper , Pin-Chuan Chen , Daniel S.-W. Park , Mateusz L. Hupert
IPC分类号： B01J19/00
CPC分类号： B01L3/502707 , B01L3/502715 , B01L3/50851 , B01L7/525 , B01L7/54 , B01L2200/025 , B01L2200/028 , B01L2300/0829 , B01L2300/0887
摘要： Passively aligned modular microfluidic devices, and a method for fabricating such passively aligned polymeric modular microfluidic devices have been reported. The modular units fabricated are plurality of integrated microdevices. Also reported are microfluidic devices wherein isolated temperature zones exist so that the temperature within each zone may be distinctly and accurately controlled, and a method for fabricating such microfluidic devices wherein there are isolated temperature zones so that the temperature within each zone may be distinctly and accurately controlled. Such devices allow one to define constant temperature zones along a microfluidic channel where different reactions or stages of reactions occur.
摘要翻译：已经报道了被动对准的模块化微流体装置，以及用于制造这种被动排列的聚合物模块化微流体装置的方法。所制造的模块化单元是多个集成的微型装置。还报道了微流体装置，其中存在隔离的温度区域，使得可以明确和精确地控制每个区域内的温度，以及制造这种微流体装置的方法，其中存在隔离的温度区域，使得每个区域内的温度可以明显且准确受控。这样的装置允许沿着微流体通道定义恒定温度区，其中发生不同的反应或反应阶段。

4. 发明申请

US20160193606A1 METHODS OF AND DEVICES FOR CAPTURING CIRCULATING TUMOR CELLS 审中-公开
公开(公告)号：US20160193606A1
公开(公告)日：2016-07-07
申请号：US15066426
申请日：2016-03-10
申请人： Taehyun Park , Daniel Sang-Won Park , Sudheer D. Rani , Michael C. Murphy , Dimitris E. Nikitopoulos
发明人： Taehyun Park , Daniel Sang-Won Park , Sudheer D. Rani , Michael C. Murphy , Dimitris E. Nikitopoulos
IPC分类号： B01L3/00 , G01N33/569 , G01N33/574 , C12Q1/24
CPC分类号： B01L3/502761 , B01L3/502753 , B01L2200/0668 , B01L2300/0816 , B01L2300/0858 , B01L2400/0487 , C12M47/04 , C12Q1/24 , G01N33/56966 , G01N33/574
摘要： A device and methods are provided for efficient and quick capture of target cells through a main microchannel having capture elements immobilized thereon and manipulating a velocity profile of a sample as it passes through the main microchannel. The cell capture device may have a main microchannel with a depth slightly larger than the diameter of the target cells and a plurality of side microchannels. The side microchannels may have a depth smaller than the diameter of the target cells. The device and methods may be used for early cancer detection.

5. 发明授权

US10429376B2 Microfluidic isolation of tumor cells or other rare cells from whole blood or other liquids 有权
公开(公告)号：US10429376B2
公开(公告)日：2019-10-01
申请号：US12992225
申请日：2009-05-13
申请人： Steven A. Soper , Michael C. Murphy , June Feng , Robin L. McCarley , André A. Adams
发明人： Steven A. Soper , Michael C. Murphy , June Feng , Robin L. McCarley , André A. Adams
IPC分类号： B01L3/00 , G01N33/49 , G01N15/14 , G01N15/10
摘要： Microdevices are disclosed to efficiently, accurately, and rapidly isolate and enumerate rare cells, such as circulating tumor cells, from liquids such as whole blood. The system employs multiple parallel meandering channels having a width on the order of 1-2 cell diameters. The microdevices can be produced at low-cost, may readily be automated, and in many instances may be used without pre-processing of the sample. They may be used to isolate and enumerate rare cells, including for example the detection and diagnosis of cancers, cancer staging, or evaluating the effectiveness of a therapeutic intervention, or detecting pathogenic bacteria. The device may optionally be used to nondestructively capture and later to release target cells.

6. 发明申请

US20120100521A1 Microfluidic Isolation of Tumor Cells or Other Rare Cells from Whole Blood or Other Liquids 审中-公开
标题翻译：来自全血或其他液体的肿瘤细胞或其他罕见细胞的微流控分离
公开(公告)号：US20120100521A1
公开(公告)日：2012-04-26
申请号：US12992225
申请日：2009-05-13
申请人： Steven A. Soper , Michael C. Murphy , June Feng , Robin L. McCarley , André A. Adams
发明人： Steven A. Soper , Michael C. Murphy , June Feng , Robin L. McCarley , André A. Adams
IPC分类号： C12N5/078 , B01L99/00 , C12Q1/06 , C12M1/34 , C12N5/09
CPC分类号： G01N33/49 , B01L3/5027 , B01L2300/0645 , B01L2300/0816 , B01L2300/0864 , B01L2300/0883 , G01N15/1459 , G01N15/1484 , G01N33/4915 , G01N2015/1006
摘要： Microdevices are disclosed to efficiently, accurately, and rapidly isolate and enumerate rare cells, such as circulating tumor cells, from liquids such as whole blood. The system employs multiple parallel meandering channels having a width on the order of 1-2 cell diameters. The microdevices can be produced at low-cost, may readily be automated, and in many instances may be used without pre-processing of the sample. They may be used to isolate and enumerate rare cells, including for example the detection and diagnosis of cancers, cancer staging, or evaluating the effectiveness of a therapeutic intervention, or detecting pathogenic bacteria. The device may optionally be used to nondestructively capture and later to release target cells.
摘要翻译：公开了微装置，以从诸如全血的液体中有效地，准确地并快速地分离和枚举诸如循环肿瘤细胞的稀有细胞。该系统采用多个平行的曲折通道，其宽度为1-2个单元直径。微型器件可以以低成本生产，可以容易地自动化，并且在许多情况下可以使用，而不需要对样品进行预处理。它们可用于分离和枚举稀有细胞，包括例如癌症的检测和诊断，癌症分期或评估治疗干预的有效性或检测病原菌。该装置可以可选地用于非破坏性地捕获和稍后释放靶细胞。

7. 发明申请

US20090155894A1 Electrokinetic Thermal Cycler and Reactor 审中-公开
标题翻译：电动热循环器和反应器
公开(公告)号：US20090155894A1
公开(公告)日：2009-06-18
申请号：US12090396
申请日：2006-10-17
申请人： Steven A. Soper , Dimitris E. Nikitopoulos , Michael C. Murphy
发明人： Steven A. Soper , Dimitris E. Nikitopoulos , Michael C. Murphy
IPC分类号： C12M1/02 , B01J19/00 , G01N21/00
CPC分类号： B01L3/5027 , B01L7/525 , B01L2300/0816 , B01L2300/0861 , B01L2300/1827 , B01L2300/1883 , B01L2400/0418
摘要： Microfluidic devices are disclosed for carrying out cyclic or iterated reactions such as PCR, LDR, and other cyclic or iterated reactions. A microchannel forms a closed loop, through which a reaction mixture may be thermally cycled an arbitrary number of times. Flow is preferably mediated primarily by electrokinetics. Multiple temperature zones may be employed along the course of a single microchannel loop, for example for PCR. Embodiments may be compact, automated, fast, and operable in continuous-flow mode. Real-time reaction monitoring may optionally be used.
摘要翻译：公开了用于进行循环或重复反应的微流体装置，例如PCR，LDR和其它循环或重复反应。微通道形成闭环，通过该闭环，反应混合物可以热循环任意次数。流动优选主要由电动力介导。可以沿着单个微通道环路的过程使用多个温度区域，例如用于PCR。实施例可以是紧凑的，自动化的，快速的和可操作的连续流模式。可以可选地使用实时反应监测。

8. 发明授权

US07296358B1 Digital vertical level indicator for improving the aim of projectile launching devices 有权
标题翻译：数字垂直液位指示器，用于改善射弹发射装置的目标
公开(公告)号：US07296358B1
公开(公告)日：2007-11-20
申请号：US11040067
申请日：2005-01-21
申请人： Patrick J. Murphy , Matthew A. Johnson , Michael C. Murphy
发明人： Patrick J. Murphy , Matthew A. Johnson , Michael C. Murphy
IPC分类号： F41G1/467
CPC分类号： F41G1/44 , F41G1/467 , F41G1/48
摘要： An electronic vertical angle sensing and indicating device for use on aiming systems is provided for bow sights and for other aiming sights for projectile launchers. Improved vertical level measurement and display minimizes the left-right drift of a projectile by sensing and indicating to the user when the projectile launcher is tilted slightly prior to release of the projectile. The vertical level indicator is easily viewed within the field of direct or near direct vision and focus of the eye in a reduced profile that does not distract the operator from the task of accurately aiming the projectile is provided. One embodiment of the present invention positions the signal indicators in the far-field of view of the eye, so that all of the signal indicators, the sighting means and the distant target being viewed are simultaneously in focus or near-focus.
摘要翻译：提供了一种用于瞄准系统的电子垂直角度感测和指示装置，用于弓形瞄准镜和其他瞄准瞄准镜的射弹发射器。改进的垂直液位测量和显示可以通过感测并向用户指示抛射体发射器在弹丸释放之前稍稍倾斜的情况下，最大限度地减少弹丸的左右漂移。垂直水平指示器可以在直接或近距离直视和眼睛的焦点范围内以缩小的轮廓容易地观看，这不会使操作者分散注意力来准确地瞄准射弹的任务。本发明的一个实施例将信号指示器定位在眼睛的远场中，使得所有信号指示器，瞄准装置和被观察的远距离目标同时处于聚焦或近焦点。

9. 发明授权

US07042952B1 Methods and apparatuses for receiving and transmitting signals 失效
标题翻译：用于接收和发送信号的方法和装置
公开(公告)号：US07042952B1
公开(公告)日：2006-05-09
申请号：US09781459
申请日：2001-02-12
申请人： Michael C. Murphy
发明人： Michael C. Murphy
IPC分类号： H04B15/00
CPC分类号： H04B1/581
摘要： Circuitry for transmitting signals through a transformer has an output transistor and circuitry which provides a controlled current to and from the output transistor's gate, so as to charge and discharge the gate's parasitic capacitance and increase and decrease the transistor's output current in a controlled manner. Feedback can be used to sense an output signal created by the transistor and turn off current to or from the transistor's gate when the output signal has reached a desired level. The output signal can be the voltage differential produced across an output transformer, and, where the output transformer is center-tapped, it can be the voltage differential across both halves of the center tapped winding.
摘要翻译：用于通过变压器发送信号的电路具有输出晶体管和电路，其向输出晶体管的栅极提供受控电流，并且从输出晶体管的栅极提供受控电流，以便以受控的方式对栅极的寄生电容进行充电和放电，并增加和减少晶体管的输出电流。当输出信号达到所要求的电平时，可以使用反馈来感测由晶体管产生的输出信号，并关断来自晶体管栅极的电流。输出信号可以是输出变压器两端产生的电压差，而在输出变压器进行中心抽头的情况下，它可以是中心抽头绕组的两半的电压差。

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