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1. 发明授权

US09718676B2 Polymeric nanopillars and nanotubes, their manufacture and uses 有权
公开(公告)号：US09718676B2
公开(公告)日：2017-08-01
申请号：US12440546
申请日：2007-09-12
申请人： Steven A. Soper , Robin L. McCarley , Guofang Chen , Hamed Shadpour
发明人： Steven A. Soper , Robin L. McCarley , Guofang Chen , Hamed Shadpour
IPC分类号： B82B3/00 , G01N27/26 , G01N33/561 , B81C1/00 , G01N27/447
CPC分类号： B81C1/00111 , B81C2201/034 , G01N27/44773 , Y10T428/2982
摘要： A method is disclosed for fabricating free-standing polymeric nanopillars or nanotubes with remarkably high aspect ratios. The nanopillars and nanotubes may be used, for example, in integrated microfluidic systems for rapid, automated, high-capacity analysis or separation of complex protein mixtures or their enzyme digest products. One embodiment, preferably fabricated entirely from polymer substrates, comprises a cell lysis unit; a solid-phase extraction unit with free-standing, polymeric nanostructures; a multi-dimensional electrophoretic separation unit with high peak capacity; a solid-phase nanoreactor for the proteolytic digestion of isolated proteins; and a chromatographic unit for the separation of peptide fragments from the digestion of proteins. The nanopillars and nanotubes may also be used to increase surface area for reaction with a solid phase, for example, with immobilized enzymes or other catalysts within a microchannel, or as a solid support for capillary electrochromatography-based separations of proteins or peptides.

2. 发明授权

US08758974B2 Photoresist-free micropatterning on polymer surfaces 有权
标题翻译：聚合物表面上无光阻的微图案
公开(公告)号：US08758974B2
公开(公告)日：2014-06-24
申请号：US10734816
申请日：2003-12-12
申请人： Steven A. Soper , Robin L. McCarley , Bikas Vaidya
发明人： Steven A. Soper , Robin L. McCarley , Bikas Vaidya
IPC分类号： G03F7/004 , G03F7/038 , G03F7/20
CPC分类号： G03F7/40 , B01L3/502707 , G01N21/7703 , G03F7/039 , G03F7/165 , G03F7/26
摘要： A method is described for the direct photochemical modification and micro-patterning of polymer surfaces, without the need to use a photoresist. For example, micropatterns of various functional chemical groups, biomolecules, and metal films have been deposited on poly(carbonate) and poly(methyl methacrylate) surfaces. These patterns may be used, for example, in integrated electronics, capture elements, or sensing elements in micro-fluidic channels.
摘要翻译：描述了用于聚合物表面的直接光化学修饰和微图案化的方法，而不需要使用光致抗蚀剂。例如，各种功能化学基团的微图案，生物分子和金属膜已沉积在聚（碳酸酯）和聚（甲基丙烯酸甲酯）表面上。这些图案可以用于例如微流体通道中的集成电路，捕获元件或感测元件。

3. 发明授权

US10429376B2 Microfluidic isolation of tumor cells or other rare cells from whole blood or other liquids 有权
公开(公告)号：US10429376B2
公开(公告)日：2019-10-01
申请号：US12992225
申请日：2009-05-13
申请人： Steven A. Soper , Michael C. Murphy , June Feng , Robin L. McCarley , André A. Adams
发明人： Steven A. Soper , Michael C. Murphy , June Feng , Robin L. McCarley , André A. Adams
IPC分类号： B01L3/00 , G01N33/49 , G01N15/14 , G01N15/10
摘要： Microdevices are disclosed to efficiently, accurately, and rapidly isolate and enumerate rare cells, such as circulating tumor cells, from liquids such as whole blood. The system employs multiple parallel meandering channels having a width on the order of 1-2 cell diameters. The microdevices can be produced at low-cost, may readily be automated, and in many instances may be used without pre-processing of the sample. They may be used to isolate and enumerate rare cells, including for example the detection and diagnosis of cancers, cancer staging, or evaluating the effectiveness of a therapeutic intervention, or detecting pathogenic bacteria. The device may optionally be used to nondestructively capture and later to release target cells.

4. 发明申请

US20120100521A1 Microfluidic Isolation of Tumor Cells or Other Rare Cells from Whole Blood or Other Liquids 审中-公开
标题翻译：来自全血或其他液体的肿瘤细胞或其他罕见细胞的微流控分离
公开(公告)号：US20120100521A1
公开(公告)日：2012-04-26
申请号：US12992225
申请日：2009-05-13
申请人： Steven A. Soper , Michael C. Murphy , June Feng , Robin L. McCarley , André A. Adams
发明人： Steven A. Soper , Michael C. Murphy , June Feng , Robin L. McCarley , André A. Adams
IPC分类号： C12N5/078 , B01L99/00 , C12Q1/06 , C12M1/34 , C12N5/09
CPC分类号： G01N33/49 , B01L3/5027 , B01L2300/0645 , B01L2300/0816 , B01L2300/0864 , B01L2300/0883 , G01N15/1459 , G01N15/1484 , G01N33/4915 , G01N2015/1006
摘要： Microdevices are disclosed to efficiently, accurately, and rapidly isolate and enumerate rare cells, such as circulating tumor cells, from liquids such as whole blood. The system employs multiple parallel meandering channels having a width on the order of 1-2 cell diameters. The microdevices can be produced at low-cost, may readily be automated, and in many instances may be used without pre-processing of the sample. They may be used to isolate and enumerate rare cells, including for example the detection and diagnosis of cancers, cancer staging, or evaluating the effectiveness of a therapeutic intervention, or detecting pathogenic bacteria. The device may optionally be used to nondestructively capture and later to release target cells.
摘要翻译：公开了微装置，以从诸如全血的液体中有效地，准确地并快速地分离和枚举诸如循环肿瘤细胞的稀有细胞。该系统采用多个平行的曲折通道，其宽度为1-2个单元直径。微型器件可以以低成本生产，可以容易地自动化，并且在许多情况下可以使用，而不需要对样品进行预处理。它们可用于分离和枚举稀有细胞，包括例如癌症的检测和诊断，癌症分期或评估治疗干预的有效性或检测病原菌。该装置可以可选地用于非破坏性地捕获和稍后释放靶细胞。

5. 发明申请

US20110104250A1 Redox-gated Liposomes 审中-公开
标题翻译：氧化还原门控脂质体
公开(公告)号：US20110104250A1
公开(公告)日：2011-05-05
申请号：US12676726
申请日：2008-09-08
申请人： Robin L. McCarley , Winston Z. Ong
发明人： Robin L. McCarley , Winston Z. Ong
IPC分类号： A61K9/127 , C07F9/02 , C12N5/02
CPC分类号： A61K9/1271 , A61K47/6911 , C07F9/106
摘要： The present invention provides lipid compounds for delivering therapeutic amounts of active agents in response to enzymatic activities of cancer tissues. Lipid compositions may include one or more drugs, or a biologically-active agent, encapsulated within liposomes.
摘要翻译：本发明提供了用于响应于癌组织的酶活性递送治疗量的活性剂的脂质化合物。脂质组合物可包括一种或多种包封在脂质体内的药物或生物活性剂。

6. 发明申请

US20100108519A1 Polymeric Nanopillars and Nanotubes, Their Manufacture and Uses 有权
标题翻译：聚合物纳米管和纳米管，其制造和用途
公开(公告)号：US20100108519A1
公开(公告)日：2010-05-06
申请号：US12440546
申请日：2007-09-12
申请人： Steven A. Soper , Robin L. McCarley , Guofang Chen , Hamed Shadpour
发明人： Steven A. Soper , Robin L. McCarley , Guofang Chen , Hamed Shadpour
IPC分类号： G01N27/26 , B82B3/00 , B32B5/16
CPC分类号： B81C1/00111 , B81C2201/034 , G01N27/44773 , Y10T428/2982
摘要： A method is disclosed for fabricating free-standing polymeric nanopillars or nanotubes with remarkably high aspect ratios. The nanopillars and nanotubes may be used, for example, in integrated microfluidic systems for rapid, automated, high-capacity analysis or separation of complex protein mixtures or their enzyme digest products. One embodiment, preferably fabricated entirely from polymer substrates, comprises a cell lysis unit; a solid-phase extraction unit with free-standing, polymeric nanostructures; a multi-dimensional electrophoretic separation unit with high peak capacity; a solid-phase nanoreactor for the proteolytic digestion of isolated proteins; and a chromatographic unit for the separation of peptide fragments from the digestion of proteins. The nanopillars and nanotubes may also be used to increase surface area for reaction with a solid phase, for example, with immobilized enzymes or other catalysts within a microchannel, or as a solid support for capillary electrochromatography-based separations of proteins or peptides.
摘要翻译：公开了用于制造具有非常高的纵横比的独立聚合物纳米柱或纳米管的方法。纳米管和纳米管可用于例如用于快速，自动化，高容量分析或分离复杂蛋白质混合物或其酶消化产物的集成微流体系统。一个实施方案，优选完全由聚合物底物制造，包括细胞裂解单元; 具有独立的聚合物纳米结构的固相萃取装置; 具有高峰值容量的多维电泳分离单元; 用于分离蛋白质的蛋白水解消化的固相纳米反应器; 以及用于从蛋白质消化中分离肽片段的色谱单元。纳米柱和纳米管也可用于增加与固相反应的表面积，例如固定化酶或微通道内的其它催化剂，或作为固体支持物，用于基于毛细管电色谱法的蛋白质或肽分离。

7. 发明申请

US20160025711A1 FLUORESCENT MARKERS AND METHODS FOR IMAGING DISEASES 审中-公开
标题翻译：荧光标记和成像疾病的方法
公开(公告)号：US20160025711A1
公开(公告)日：2016-01-28
申请号：US14775967
申请日：2014-03-25
申请人： Robin L. MCCARLEY , William C. SILVERS
发明人： Robin L. McCarley , William C. Silvers
IPC分类号： G01N33/52 , A61K49/00 , C07D221/14
CPC分类号： G01N33/52 , A61K49/0021 , A61K49/0052 , C07D221/14
摘要： Methods and fluorescent probes that detect the presence of diseased cells such as cancer. The fluorescent probes are cloaked, turn-on probes having the fluorescence reporter released only in the presence of enzymes typically over-expressed in diseased and cancerous tissue. Probes include a fluorescent napthalimide reporter with a quinoidal moiety cloak.
摘要翻译：检测患病细胞如癌症的方法和荧光探针。荧光探针是隐藏的，具有荧光报告基因的开启探针仅在存在通常在患病和癌性组织中过度表达的酶的存在下释放。探针包括具有喹喔啉部分斗篷的荧光萘基二酰亚胺报告物。

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