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1. 发明授权

US08887713B2 Vaccine nebulisers 有权
标题翻译：疫苗雾化器
公开(公告)号：US08887713B2
公开(公告)日：2014-11-18
申请号：US13650535
申请日：2012-10-12
申请人： Felicity Cutts , Jorge Fernandez De Castro , John V. Bennett , Beth Laube , Clyde Witham , Ana Maria Henao-Restrepo , Bernard Cohen , David Brown , John Dennis
发明人： Felicity Cutts , Jorge Fernandez De Castro , John V. Bennett , Beth Laube , Clyde Witham , Ana Maria Henao-Restrepo , Bernard Cohen , David Brown , John Dennis
IPC分类号： A61M11/00 , A61M16/10 , A61M11/02 , A61M16/00 , A61M15/00 , A61M16/06
CPC分类号： A61M11/02 , A61M11/005 , A61M15/0086 , A61M16/0045 , A61M16/0666 , A61M16/1055 , A61M16/107 , A61M2202/30
摘要： The invention provides a method of selecting a nebulizer device to be used to deliver a vaccine comprising selecting a nebulizer capable of producing a plurality of vaccine particles having the following particle droplet size distribution: (i) Dv10: 2.0+/−0.2 μm (ii) Dv50: 5.0+/−0.5 μm (iii) Dv90: 10.0+/−1.0 μm (iv) a mean mass aerodynamic diameter (MMAD) of 4.5 to 8.0 μm This allows the selection of, for example, commercially available nebulizers, previously used for drug delivery, for vaccine delivery. This considerably reduces the work required to identify suitable nebulizers. Nebulizers identified by the methods of the invention are also claimed.
摘要翻译：本发明提供了一种选择用于递送疫苗的喷雾器装置的方法，包括选择能够产生具有以下粒子液滴尺寸分布的多个疫苗颗粒的雾化器：（i）Dv10：2.0 +/-0.2μm（ii ）Dv50：5.0 +/-0.5μm（iii）Dv90：10.0 +/-1.0μm（iv）4.5-8.0μm的平均质量空气动力学直径（MMAD）这允许例如以前可商购的喷雾器用于药物输送，用于疫苗递送。这大大降低了识别合适的喷雾器所需的工作。通过本发明的方法识别的喷雾器也被要求保护。

2. 发明申请

US20100074911A1 VACCINE NEBULIZERS 审中-公开
标题翻译：疫苗接种者
公开(公告)号：US20100074911A1
公开(公告)日：2010-03-25
申请号：US11993520
申请日：2006-06-27
申请人： Felicity Cutts , Jorge Fernandez De Castro , John V. Bennett , Beth Laube , Clyde Witham , Ana Maria Henao-Restrepo , Bernard Cohen , David Brown , John Dennis
发明人： Felicity Cutts , Jorge Fernandez De Castro , John V. Bennett , Beth Laube , Clyde Witham , Ana Maria Henao-Restrepo , Bernard Cohen , David Brown , John Dennis
IPC分类号： A61K39/00 , A61M11/00
CPC分类号： A61M11/02 , A61M11/005 , A61M15/0086 , A61M16/0045 , A61M16/0666 , A61M16/1055 , A61M16/107 , A61M2202/30
摘要： The invention provides a method of selecting or optimising a nebuliser device to be used to deliver a vaccine comprising selecting a nebuliser capable of producing a plurality of vaccine particles having the following particle droplet size distribution: (i) Dv10: 2.0+/−0.2 μm (ii) Dv50: 5.0+/−0.5 μm (iii) Dv90: 10.0+/−1.0 μm (iv) a mean mass aerodynamic diameter (MMAD) of 4.5 to 8.0 μm This allows the selection of, for example, commercially available nebulisers, previously used for drug delivery, for vaccine delivery. This considerably reduces the work required to identify suitable nebulisers. The additional preferred features are disclosed for the selection of nebulisers for use in mass vaccination programs.Nebulisers identified by the methods of the invention are also claimed.
摘要翻译：本发明提供一种选择或优化用于递送疫苗的雾化器装置的方法，包括选择能够产生具有以下粒子液滴尺寸分布的多个疫苗颗粒的雾化器：（i）Dv10：2.0 +/-0.2μm （ii）Dv50：5.0 +/-0.5μm（iii）Dv90：10.0 +/-1.0μm（iv）4.5-8.0μm的平均质量空气动力学直径（MMAD）这允许选择例如市售的雾化器，以前用于药物递送，用于疫苗递送。这大大降低了识别合适的雾化器所需的工作。公开了额外的优选特征，用于选择用于大规模疫苗接种程序中的雾化器。通过本发明的方法识别的雾化器也被要求保护。

3. 发明申请

US20060086537A1 Drilling with mixed tooth types 审中-公开
标题翻译：钻混合齿型
公开(公告)号：US20060086537A1
公开(公告)日：2006-04-27
申请号：US11225380
申请日：2005-09-13
申请人： John Dennis
发明人： John Dennis
IPC分类号： E21B10/00
CPC分类号： E21B10/16
摘要： A rotary-cutter Earth-penetrating bit in which a given track of bottom hole is attacked by inserts of two different types, e.g. chisel-shaped and pointed, wider and narrower, higher and shorter, and/or of different materials. The different types of inserts can both be included within a single row of a cone.
摘要翻译：一个旋转切割器地球穿透钻头，其中一个给定的井底轨道被两种不同类型的插入件所攻击。凿形和尖，宽，窄，越来越短，和/或不同的材料。不同类型的插入件都可以包含在单个圆锥体内。

4. 发明申请

US20060080385A1 System, method, and medium for configuring client computers to operate disconnected from a server computer while using a master instance of the operating system 有权
公开(公告)号：US20060080385A1
公开(公告)日：2006-04-13
申请号：US10935712
申请日：2004-09-08
申请人： Jonathan Blandford , John Dennis , Alexander Larsson , David Malcolm , Mark McLoughlin , Seth Nickell , Havoc Pennington , Brian Stevens , Owen Taylor
发明人： Jonathan Blandford , John Dennis , Alexander Larsson , David Malcolm , Mark McLoughlin , Seth Nickell , Havoc Pennington , Brian Stevens , Owen Taylor
IPC分类号： G06F15/16
CPC分类号： G06F9/4416 , G06F8/60 , G06F9/44505
摘要： A computer system comprises a server. The server, in turn, comprises one or more master instances of an operating system (OS). The OS comprises a set of computer program files to operate a computer. The server also includes a version-managing program maintaining the one or more master operating systems. The computer system also includes a number of client computers each of which is configured to operate using one of the one or more master operating systems as read-only files.

5. 发明申请

US20070173412A1 Lost circulation compositions 有权
标题翻译：迷失循环组成
公开(公告)号：US20070173412A1
公开(公告)日：2007-07-26
申请号：US11337713
申请日：2006-01-23
申请人： Melissa Allin , John Dennis , Donald Whitfill
发明人： Melissa Allin , John Dennis , Donald Whitfill
IPC分类号： C09K8/00 , E21B43/00
CPC分类号： C09K8/512 , C09K8/68
摘要： A lost circulation composition for use in a wellbore comprising a crosslinkable polymer system and a filler.
摘要翻译：一种用于井眼的易挥发组合物，其包含可交联聚合物体系和填料。

6. 发明申请

US20070169937A1 Methods of using lost circulation compositions 有权
标题翻译：使用迷失循环组合物的方法
公开(公告)号：US20070169937A1
公开(公告)日：2007-07-26
申请号：US11337707
申请日：2006-01-23
申请人： Melissa Allin , John Dennis , Donald Whitfill
发明人： Melissa Allin , John Dennis , Donald Whitfill
IPC分类号： E21B33/138
CPC分类号： C09K8/5083 , C09K8/512
摘要： A method of servicing a wellbore in contact with a subterranean formation, comprising: placing a wellbore servicing fluid comprising a crosslinkable polymer system and a filler into a lost circulation zone within the wellbore. A method of blocking the flow of fluid through a lost circulation zone in a subterranean formation comprising placing a first composition comprising a packing agent into the lost circulation zone, placing a second composition comprising a crosslinkable polymer system and a filler into the lost circulation zone, and allowing the compositions to set into place.
摘要翻译：一种维护与地下地层接触的井眼的方法，包括：将包含可交联聚合物体系和填料的井眼维修流体放置在井筒内的失水循环区域中。一种阻止流体通过地下地层中的失水循环区的流动的方法，包括将包含填料的第一组合物放入到所述失水循环区中，将包含可交联聚合物体系和填料的第二组合物放入所述流失区中，并允许组合物放置到位。

7. 发明申请

US20050215892A1 System and method for transducer array cooling through forced convection 审中-公开
标题翻译：通过强制对流传感器阵列冷却的系统和方法
公开(公告)号：US20050215892A1
公开(公告)日：2005-09-29
申请号：US10805783
申请日：2004-03-22
申请人： Charles Emery , Zoran Banjanin , Chi-Yin Lee , Alampallam Ramachandran , John Dennis
发明人： Charles Emery , Zoran Banjanin , Chi-Yin Lee , Alampallam Ramachandran , John Dennis
IPC分类号： A61B8/00 , A61B8/06 , G10K11/00
CPC分类号： A61B8/546 , A61B8/00 , A61B8/4472 , A61B2562/187 , G10K11/004
摘要： A system and method for cooling an entirely or partially immersed mechanical or other type of transducer array is disclosed. Motion/flow of the immersion fluid is induced either by motion of the mechanical transducer itself, where the transducer is of the mechanically movable type, or by a separate motion-inducing mechanism located in or coupled with the fluid-filled, or partially filled, array housing. The resultant fluid flow/motion increases, i.e. more efficiently utilizes, the thermal carrying capacity of the immersion fluid by more uniformly distributing the thermal energy convected from the transducer array throughout the fluid volume. This results in an improved ability to cool the transducer array. The disclosed cooling system and method may be used in such a way so as to not substantially inhibit operation of the transducer array.
摘要翻译：公开了一种用于冷却全部或部分浸没的机械或其他类型的换能器阵列的系统和方法。浸没流体的运动/流动是通过机械传感器本身的运动引起的，其中换能器是可机械移动的，或者通过位于流体填充或部分填充的或与部分填充的流体相连接的单独的运动诱导机构，阵列外壳。通过更均匀地将从换能器阵列对流的热能更均匀地分布在整个流体体积中，所产生的流体流动/运动增加，即更有效地利用浸入流体的热载运能力。这样可以提高冷却换能器阵列的能力。所公开的冷却系统和方法可以以这样的方式使用，以便基本上不能抑制换能器阵列的操作。

8. 发明申请

US20060030494A1 Set-on demand, ester-based wellbore fluids and methods of using the same 失效
标题翻译：基于需求的酯基井筒流体及其使用方法
公开(公告)号：US20060030494A1
公开(公告)日：2006-02-09
申请号：US10910103
申请日：2004-08-03
申请人： James Griffith , Ron Nida , John Dennis
发明人： James Griffith , Ron Nida , John Dennis
IPC分类号： C09K8/60 , E21B43/00
CPC分类号： C04B28/02 , C09K8/467 , C09K8/506 , C04B22/064 , C04B24/08 , C04B40/005 , C04B40/0075
摘要： Methods of servicing a wellbore in contact with a subterranean formation include passing an ester-based fluid into the wellbore and reducing a temperature of the ester-based fluid by an amount effective to cause the ester-based fluid to set, e.g., by from about 10° F. to about 20° F. The ester-based fluid includes a water in ester-based oil emulsion, a pH controlling additive, e.g., hydrated lime, in the water-phase, and an emulsifier to stabilize the pH controlling additive. Cooling the ester-based fluid causes the emulsion to destabilize, resulting in the release of the pH controlling additive. This release lowers the pH of the ester-based fluid by an effective amount to cause it to set. Wellbore servicing fluids comprising the foregoing ester-based fluid may be employed as environmentally friendly sealants or spotting fluids in wellbores.
摘要翻译：维护与地下地层相接触的井眼的方法包括将酯基流体通入井眼中，并且以有效地使酯基流体凝固的量使酯基流体的温度降低，例如从约 10°F至约20°F。酯基流体包括酯基油乳液中的水，水相中的pH调节添加剂，例如熟石灰，以及稳定pH控制添加剂的乳化剂。冷却酯基流体导致乳液不稳定，导致pH控制添加剂的释放。该释放将酯基流体的pH降低有效量以使其固化。包含上述酯基流体的井筒维修流体可以用作在井筒中的环境密封剂或点样液。

9. 发明申请

US20050276040A1 Candle arrangement 有权
标题翻译：蜡烛安排
公开(公告)号：US20050276040A1
公开(公告)日：2005-12-15
申请号：US10866200
申请日：2004-06-10
申请人： John Dennis , Bernard Urfig
发明人： John Dennis , Bernard Urfig
IPC分类号： F21L19/00 , F21V35/00
CPC分类号： F21V35/00
摘要： A candle arrangement having a main candle body having a relatively high melting point and the main candle body has an aperture therethrough and a plurality of burning candles having a candle wax with a lower melting point than the main candle body are slidably mounted in the aperture. The burning candle at the top of the main candle body may be burned and then discarded after it is consumed and replaced with a new burning candle.
摘要翻译：具有熔点较高的主蜡烛体和主蜡烛体的蜡烛装置具有穿过其中的孔，并且具有比主蜡烛体熔点低的烛蜡的多个燃烧蜡烛可滑动地安装在孔中。主蜡烛体顶部燃烧的蜡烛可能会被燃烧，然后在消耗之后丢弃，并用新的燃烧蜡烛代替。

10. 发明申请

US20100016719A1 ADAPTIVE REGULATION OF ACOUSTIC OUTPUT POWER IN MEDICAL ULTRASOUND IMAGING 审中-公开
标题翻译：医学超声成像中声学输出功率的自适应调节
公开(公告)号：US20100016719A1
公开(公告)日：2010-01-21
申请号：US12174514
申请日：2008-07-16
申请人： Paul Freiburger , Leixiang Fan , John Dennis
发明人： Paul Freiburger , Leixiang Fan , John Dennis
IPC分类号： A61B8/00
CPC分类号： A61B8/00 , A61B8/485 , G01S7/5202 , G01S7/52036 , G01S7/52096
摘要： Acoustic output power is adaptively regulated in medical diagnostic ultrasound imaging. Given transmit settings, the acoustic power and/or another setting may be altered to avoid violating a limit set by regulation. The limit is based, at least in part, on an assumed attenuation. By measuring the attenuation, such as by identifying a type of tissue, the power and/or limit may be altered or adapt. By accounting for the attenuation in the region to be scanned, a greater output power may be possible while still providing the same level of safety.
摘要翻译：声学输出功率在医学诊断超声成像中自适应调节。给定发送设置，可以改变声功率和/或另一设置以避免违反通过调节设置的限制。该限制至少部分地基于假定的衰减。通过测量衰减，例如通过识别组织的类型，可以改变或适应功率和/或限制。通过考虑要扫描的区域中的衰减，在仍然提供相同的安全级别的情况下，可以实现更大的输出功率。

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