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1. 发明授权

US08887713B2 Vaccine nebulisers 有权
标题翻译：疫苗雾化器
公开(公告)号：US08887713B2
公开(公告)日：2014-11-18
申请号：US13650535
申请日：2012-10-12
申请人： Felicity Cutts , Jorge Fernandez De Castro , John V. Bennett , Beth Laube , Clyde Witham , Ana Maria Henao-Restrepo , Bernard Cohen , David Brown , John Dennis
发明人： Felicity Cutts , Jorge Fernandez De Castro , John V. Bennett , Beth Laube , Clyde Witham , Ana Maria Henao-Restrepo , Bernard Cohen , David Brown , John Dennis
IPC分类号： A61M11/00 , A61M16/10 , A61M11/02 , A61M16/00 , A61M15/00 , A61M16/06
CPC分类号： A61M11/02 , A61M11/005 , A61M15/0086 , A61M16/0045 , A61M16/0666 , A61M16/1055 , A61M16/107 , A61M2202/30
摘要： The invention provides a method of selecting a nebulizer device to be used to deliver a vaccine comprising selecting a nebulizer capable of producing a plurality of vaccine particles having the following particle droplet size distribution: (i) Dv10: 2.0+/−0.2 μm (ii) Dv50: 5.0+/−0.5 μm (iii) Dv90: 10.0+/−1.0 μm (iv) a mean mass aerodynamic diameter (MMAD) of 4.5 to 8.0 μm This allows the selection of, for example, commercially available nebulizers, previously used for drug delivery, for vaccine delivery. This considerably reduces the work required to identify suitable nebulizers. Nebulizers identified by the methods of the invention are also claimed.
摘要翻译：本发明提供了一种选择用于递送疫苗的喷雾器装置的方法，包括选择能够产生具有以下粒子液滴尺寸分布的多个疫苗颗粒的雾化器：（i）Dv10：2.0 +/-0.2μm（ii ）Dv50：5.0 +/-0.5μm（iii）Dv90：10.0 +/-1.0μm（iv）4.5-8.0μm的平均质量空气动力学直径（MMAD）这允许例如以前可商购的喷雾器用于药物输送，用于疫苗递送。这大大降低了识别合适的喷雾器所需的工作。通过本发明的方法识别的喷雾器也被要求保护。

2. 发明申请

US20100074911A1 VACCINE NEBULIZERS 审中-公开
标题翻译：疫苗接种者
公开(公告)号：US20100074911A1
公开(公告)日：2010-03-25
申请号：US11993520
申请日：2006-06-27
申请人： Felicity Cutts , Jorge Fernandez De Castro , John V. Bennett , Beth Laube , Clyde Witham , Ana Maria Henao-Restrepo , Bernard Cohen , David Brown , John Dennis
发明人： Felicity Cutts , Jorge Fernandez De Castro , John V. Bennett , Beth Laube , Clyde Witham , Ana Maria Henao-Restrepo , Bernard Cohen , David Brown , John Dennis
IPC分类号： A61K39/00 , A61M11/00
CPC分类号： A61M11/02 , A61M11/005 , A61M15/0086 , A61M16/0045 , A61M16/0666 , A61M16/1055 , A61M16/107 , A61M2202/30
摘要： The invention provides a method of selecting or optimising a nebuliser device to be used to deliver a vaccine comprising selecting a nebuliser capable of producing a plurality of vaccine particles having the following particle droplet size distribution: (i) Dv10: 2.0+/−0.2 μm (ii) Dv50: 5.0+/−0.5 μm (iii) Dv90: 10.0+/−1.0 μm (iv) a mean mass aerodynamic diameter (MMAD) of 4.5 to 8.0 μm This allows the selection of, for example, commercially available nebulisers, previously used for drug delivery, for vaccine delivery. This considerably reduces the work required to identify suitable nebulisers. The additional preferred features are disclosed for the selection of nebulisers for use in mass vaccination programs.Nebulisers identified by the methods of the invention are also claimed.
摘要翻译：本发明提供一种选择或优化用于递送疫苗的雾化器装置的方法，包括选择能够产生具有以下粒子液滴尺寸分布的多个疫苗颗粒的雾化器：（i）Dv10：2.0 +/-0.2μm （ii）Dv50：5.0 +/-0.5μm（iii）Dv90：10.0 +/-1.0μm（iv）4.5-8.0μm的平均质量空气动力学直径（MMAD）这允许选择例如市售的雾化器，以前用于药物递送，用于疫苗递送。这大大降低了识别合适的雾化器所需的工作。公开了额外的优选特征，用于选择用于大规模疫苗接种程序中的雾化器。通过本发明的方法识别的雾化器也被要求保护。

3. 发明申请

US20050136766A1 Wet-or dry-use biodegradable collecting sheet 审中-公开
标题翻译：湿式或干式可生物降解的收集片
公开(公告)号：US20050136766A1
公开(公告)日：2005-06-23
申请号：US10738959
申请日：2003-12-17
申请人： James Tanner , Jason Lye , Bernard Cohen
发明人： James Tanner , Jason Lye , Bernard Cohen
IPC分类号： D21H23/22 , D21H25/04 , D03D15/00 , B05D3/00 , B05D3/12 , B32B5/08 , D03D11/00 , D03D25/00
CPC分类号： D21H23/22 , D21H25/04 , Y10T442/30 , Y10T442/3057 , Y10T442/3195 , Y10T442/322 , Y10T442/3228 , Y10T442/3301 , Y10T442/3317
摘要： A biodegradable, cellulose-based collecting sheet that can be used in either a wet state or a dry state. The collecting sheet may be a double recreped cellulose substrate reinforced with a binder, such as a latex binder. Alternatively, or in addition to the binder, the collecting sheet may be coated with a dielectric material and electret treated to establish a charge on the dielectric material. Additionally, the collecting sheet may be embossed to provide more interstices and greater surface area to enhance the pick-up ability of the collecting sheet. The invention further includes a method of forming such a collecting sheet.
摘要翻译：可以在湿态或干态下使用的可生物降解的纤维素基收集片。收集片材可以是用粘合剂如胶乳粘合剂增强的双重再生纤维素基质。或者，除了粘合剂之外，收集片可以涂覆有电介质材料，并经驻极体处理以在电介质材料上建立电荷。此外，收集片材可以被压花以提供更多的间隙和更大的表面积，以增强收集片材的拾取能力。本发明还包括形成这种收集片的方法。

4. 发明授权

US06880770B2 Method of retrofitting an unitized injector for ultrasonically stimulated operation 有权
标题翻译：用于超声波刺激操作的整流式注射器的改装方法
公开(公告)号：US06880770B2
公开(公告)日：2005-04-19
申请号：US10617649
申请日：2003-07-11
申请人： Lee Kirby Jameson , Bernard Cohen , Lamar Heath Gipson
发明人： Lee Kirby Jameson , Bernard Cohen , Lamar Heath Gipson
IPC分类号： F02M51/06 , F02M57/02 , F02M61/16 , F02M61/18 , F02M63/00 , F02M69/04 , F02M59/00 , B05B1/30 , F02M39/00
CPC分类号： F02M57/023 , F02M61/16 , F02M61/166 , F02M61/168 , F02M61/18 , F02M69/041 , F02M2200/24 , F02M2200/9007
摘要： A method involves retrofitting conventional injectors with needles having magnetostrictive portions and wound coils configured and disposed so as to subject the magnetostrictive portions of the needles to ultrasonically oscillating magnetic fields.
摘要翻译：一种方法包括用具有磁致伸缩部分的针和传统的注射器来构造和设置缠绕线圈，以使针的磁致伸缩部分经受超声振荡的磁场。

5. 发明授权

US6053424A Apparatus and method for ultrasonically producing a spray of liquid 失效
标题翻译：用于超声波生产液体喷雾的装置和方法
公开(公告)号：US6053424A
公开(公告)日：2000-04-25
申请号：US576536
申请日：1995-12-21
申请人： Lamar Heath Gipson , Bernard Cohen , Lee Kirby Jameson
发明人： Lamar Heath Gipson , Bernard Cohen , Lee Kirby Jameson
IPC分类号： B05B17/06 , B05B1/08
CPC分类号： B05B17/0623
摘要： An apparatus and a method for ultrasonically producing a spray of liquid. The apparatus includes a die housing which defines a chamber adapted to receive a pressurized liquid and a means for applying ultrasonic energy to a portion of the pressurized liquid. The die housing further includes an inlet adapted to supply the chamber with the pressurized liquid, and an exit orifice defined by the walls of a die tip. The exit orifice is adapted to receive the pressurized liquid from the chamber and pass the liquid out of the die housing to produce a spray of liquid. When the means for applying ultrasonic energy is excited, it applies ultrasonic energy to the pressurized liquid without applying ultrasonic energy to the die tip. The method involves supplying a pressurized liquid to the foregoing apparatus, applying ultrasonic energy to the pressurized liquid but not the die tip while the exit orifice receives pressurized liquid from the chamber, and passing the pressurized liquid out of the exit orifice in the die tip to produce a spray of liquid.
摘要翻译：用于超声波生产液体喷雾的装置和方法。该装置包括限定适于接收加压液体的室的模具壳体和用于向加压液体的一部分施加超声波能量的装置。模具壳体还包括适于向腔室供应加压液体的入口和由模头尖端的壁限定的出口孔。出口孔适于从腔室接收加压液体，并将液体从模具壳体中流出以产生液体喷雾。当施加超声能量的装置被激发时，其对加压液体施加超声波能量，而不向模尖施加超声波能量。该方法包括向上述装置提供加压液体，向加压液体而不是模具顶端施加超声能量，而出口孔从腔室接收加压液体，并将加压液体从模尖中的出口孔传出到产生液体喷雾。

6. 发明授权

US6010592A Method and apparatus for increasing the flow rate of a liquid through an orifice 失效
标题翻译：通过孔口增加液体流速的方法和装置
公开(公告)号：US6010592A
公开(公告)日：2000-01-04
申请号：US477689
申请日：1995-06-07
申请人： Lee Kirby Jameson , Lamar Heath Gipson , Bernard Cohen
发明人： Lee Kirby Jameson , Lamar Heath Gipson , Bernard Cohen
IPC分类号： F02M51/06 , B01F3/08 , B05B1/30 , B05B17/06 , B29C47/00 , D01D1/04 , D01D5/08 , D01D5/247 , D01F6/04 , D04H3/16 , F02M27/08 , F02M43/04 , F02M69/00 , F02M69/04 , F23D11/34 , F23R3/28 , B27G11/02
CPC分类号： F23D11/34 , B05B1/30 , B05B17/0607 , B05B17/0623 , B29C47/0014 , B29C47/0071 , D01D1/04 , D01D5/247 , F02M27/08 , F02M43/04 , F02M69/041 , F23D11/345 , B29C47/0021
摘要： An apparatus and a method for increasing the flow rate of a pressurized liquid through an orifice by applying ultrasonic energy to a portion of the pressurized liquid. The apparatus includes a die housing which defines a chamber adapted to receive a pressurized liquid and a means for applying ultrasonic energy to a portion of the pressurized liquid. The die housing further includes an inlet adapted to supply the chamber with the pressurized liquid, and an exit orifice defined by the walls of a die tip. The exit orifice is adapted to receive the pressurized liquid from the chamber and pass the liquid out of the die housing. When the means for applying ultrasonic energy is excited, it applies ultrasonic energy to the pressurized liquid without applying ultrasonic energy to the die tip. The method involves supplying a pressurized liquid to the foregoing apparatus, applying ultrasonic energy to the pressurized liquid but not the die tip while the exit orifice receives pressurized liquid from the chamber, and passing the pressurized liquid out of the exit orifice in the die tip.
摘要翻译：一种用于通过将超声能量施加到加压液体的一部分来增加通过孔的加压液体的流速的装置和方法。该装置包括限定适于接收加压液体的室的模具壳体和用于向加压液体的一部分施加超声波能量的装置。模具壳体还包括适于向腔室供应加压液体的入口和由模头尖端的壁限定的出口孔。出口孔适于从腔室接收加压液体，并将液体从模具壳体中流出。当施加超声能量的装置被激发时，其对加压液体施加超声波能量，而不向模尖施加超声波能量。该方法包括向前述装置提供加压液体，向加压液体而不是模头提供超声波能量，而出口孔从腔室接收加压液体，并将加压液体从模尖中的出口孔传出。

7. 发明授权

US5906743A Filter with zeolitic adsorbent attached to individual exposed surfaces of an electret-treated fibrous matrix 失效
标题翻译：用连接到驻极体处理的纤维基质的各个暴露表面的沸石吸附剂过滤
公开(公告)号：US5906743A
公开(公告)日：1999-05-25
申请号：US449041
申请日：1995-05-24
申请人： Bernard Cohen , Lee Kirby Jameson
发明人： Bernard Cohen , Lee Kirby Jameson
IPC分类号： A23F5/22 , B01J20/28 , B01D39/08
CPC分类号： B01J20/28028 , A23F5/223 , B01J20/28033
摘要： An adsorbent filter for removing caffeine from liquids. The filter is composed of a liquid permeable, electret-treated matrix of fibrous material having individual exposed surfaces; and a relatively uniform distribution of adsorbent zeolite particulate material attached to individual exposed surfaces of the electret-treated fibrous material by substantially non-transient bonding, so that passage of a liquid having a caffeine concentration ranging from about 20 to about 100 mg per 100 mL of liquid through the matrix for a contact time of less than about 2 minutes results in at least a 40 percent reduction in the caffeine concentration of the liquid. The matrix of fibrous material may be selected from woven fabrics, knit fabrics and nonwoven fabrics. Generally speaking, the filter can be adapted to provide at least a 40 percent reduction in the caffeine concentration for about 1 cup to about 40 cups of a liquid.
摘要翻译：用于从液体中去除咖啡因的吸附剂过滤器。过滤器由具有单独暴露表面的可渗透的驻极体处理的纤维材料基体组成; 以及通过基本上非瞬时接合而附着到驻极体处理过的纤维材料的单个暴露表面的吸附剂沸石颗粒材料的相对均匀的分布，使得咖啡因浓度范围从约20至约100mg / 100mL的液体通过的液体通过基质接触时间小于约2分钟导致液体咖啡因浓度降低至少40％。纤维材料的基质可以选自机织织物，针织织物和非织造织物。一般来说，过滤器可以适合于提供约1杯至约40杯液体的咖啡因浓度的至少40％的降低。

8. 发明授权

US5900690A Apparatus and method for controlling an ultrasonic transducer 失效
标题翻译：用于控制超声换能器的装置和方法
公开(公告)号：US5900690A
公开(公告)日：1999-05-04
申请号：US671266
申请日：1996-06-26
申请人： Lamar Heath Gipson , Bernard Cohen , Lee Kirby Jameson
发明人： Lamar Heath Gipson , Bernard Cohen , Lee Kirby Jameson
IPC分类号： B06B1/02 , H03K3/023 , H01L41/09
CPC分类号： B06B1/0246 , B06B2201/70
摘要： An apparatus and method for controlling an ultrasonic transducer preferably including a signal generator circuit, a signal sensing circuit, a modulator circuit, and a bias circuit. The signal generator circuit provides a pulsed drive signal to the ultrasonic transducer. The signal sensing circuit senses the voltage and current of the drive signal. The modulator circuit provides a frequency control signal and an energy control signal to the signal generator circuit corresponding to a detected phase difference between the sensed voltage and the sensed current of the drive signal. The frequency control signal and energy control signal operate to adjust the frequency and energy level, respectively, of the drive signal.Within the transducer, a movable element in contact with a liquid is preferably positioned corresponding to the level of a dc bias signal provided by the bias circuit. By adjusting the level of the dc bias signal, the flow rate of the liquid is adjusted. By applying the drive signal to the transducer, the viscosity of the liquid is adjusted which establishes a second flow rate of the liquid. When the frequency and energy level of the drive signal are changed, a third flow rate of the liquid is established.
摘要翻译：一种用于控制超声换能器的装置和方法，优选地包括信号发生器电路，信号感测电路，调制器电路和偏置电路。信号发生器电路向超声换能器提供脉冲驱动信号。信号感测电路检测驱动信号的电压和电流。调制器电路向信号发生器电路提供频率控制信号和能量控制信号，该信号发生器电路对应于检测到的电压和感测到的驱动信号的电流之间的相位差。频率控制信号和能量控制信号分别用于调节驱动信号的频率和能级。在换能器内，与液体接触的可移动元件优选地对应于由偏置电路提供的直流偏置信号的电平而定位。通过调节直流偏置信号的电平，调节液体的流量。通过将驱动信号应用于换能器，调节液体的粘度，其建立液体的第二流量。当驱动信号的频率和能量水平改变时，建立液体的第三流量。

9. 发明授权

US5698294A Sterilization wrap material 失效
公开(公告)号：US5698294A
公开(公告)日：1997-12-16
申请号：US729556
申请日：1996-10-11
申请人： Leslie Hope Van Hout , Bernard Cohen , Lee Kirby Jameson
发明人： Leslie Hope Van Hout , Bernard Cohen , Lee Kirby Jameson
IPC分类号： A61L2/26 , B29C59/02 , B29C59/04 , B32B3/28 , B32B27/12 , B32B38/04 , C08J5/18 , B32B3/30
CPC分类号： B32B38/04 , A61L2/26 , B29C59/022 , B29C59/046 , B32B27/12 , B32B3/28 , C08J5/18 , B29C59/04 , B29K2023/00 , B29K2105/0854 , B29L2009/00 , B32B2305/20 , C08J2323/02 , Y10T428/24479 , Y10T428/2495 , Y10T442/674 , Y10T442/678 , Y10T442/68 , Y10T442/681
摘要： A polyolefin film for use as a sterilization wrap material which includes a film with a thickness of from about 0.005 mm to about 0.2 mm and having a plurality of discontinuous thinned regions. The thinned regions constitute at least about 25 percent of the surface area of the film. The thickness and area of the thinned regions are adapted to permit the passage of steam and water vapor through the film during steam sterilization. The film is made by a method which involves extruding a molten polyolefin film at a first temperature and passing the molten film through a nip. The nip includes an anvil roll and a pattern roll. The anvil roll has a smooth surface and the surface of the pattern roll is maintained at a temperature which is at least about 150.degree. C. lower than the first temperature and is selected to prevent sticking of the film to either roll.

10. 发明授权

US5695487A Z-directon liquid transport medium 失效
标题翻译： Z-directon液体输送介质
公开(公告)号：US5695487A
公开(公告)日：1997-12-09
申请号：US733033
申请日：1996-10-16
申请人： Bernard Cohen , Lee Kirby Jameson , Roger Bradshaw Quincy, III
发明人： Bernard Cohen , Lee Kirby Jameson , Roger Bradshaw Quincy, III
IPC分类号： A61F13/15
CPC分类号： A61F13/538 , A61F13/53713
摘要： A fibrous web having a length, a width and a thickness, with at least about 50 percent of the fibers aligned in a direction generally perpendicular to the length and width of the web. The web defines a plurality of spaced-apart gaps, each having a top and a bottom, and each of the gaps extends from one surface of the web at least about 50 percent through the thickness of the web. The density of a portion of the web defining the bottom of the gap is greater than the density of a portion of the web defining the top of the gap. The portion of the web which defines the top of the gap may be composed substantially of terminal ends of the fibers. In addition, the portion of the web which defines the bottom of the gap may be composed substantially of continuous fibers. The fibrous web may be a meltblown nonwoven web or a neck-stretched, meltblown nonwoven web. The fibrous web may be employed as a component of such absorbent products as diapers; incontinent care products; and feminine care products, such as sanitary napkins and tampons; filter elements; and the like. The web provides improved distribution of liquid in the direction of fiber alignment.
摘要翻译：具有长度，宽度和厚度的纤维幅材，其中至少约50％的纤维在大致垂直于幅材长度和宽度的方向上排列。纸幅限定了多个间隔开的间隙，每个间隙具有顶部和底部，并且每个间隙从幅材的一个表面延伸通过幅材的厚度至少约50％。限定间隙底部的幅材的一部分的密度大于限定间隙顶部的幅材的一部分的密度。限定间隙顶部的纤维网部分可以基本上由纤维的末端组成。此外，限定间隙底部的幅材部分可以基本上由连续纤维组成。纤维网可以是熔喷非织造纤维网或颈部拉伸的熔喷非织造纤维网。纤维网可以用作诸如尿布的吸收产品的组分; 失禁护理产品; 和女性护理产品，如卫生巾和卫生棉条; 滤芯; 等等。纤维网提供了在纤维排列方向上改进的液体分布。

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