会员体验
专利管家(专利管理)
工作空间(专利管理)
风险监控(情报监控)
数据分析(专利分析)
侵权分析(诉讼无效)
联系我们
交流群
官方交流:
QQ群: 891211   
微信请扫码    >>>
现在联系顾问~
热词
    • 3. 发明申请
    • Potent LNA oligonucleotides for the inhibition of HIF-1a expression
    • 用于抑制HIF-1a表达的强大的LNA寡核苷酸
    • US20060252721A1
    • 2006-11-09
    • US11271686
    • 2005-11-09
    • Majken WestergaardCharlotte ThrueFrank RasmussenHenrik Hansen
    • Majken WestergaardCharlotte ThrueFrank RasmussenHenrik Hansen
    • A61K48/00C07H21/02
    • C12N15/113C12N2310/11C12N2310/315C12N2310/3231C12N2310/3341C12N2310/341C12N2310/345C12N2310/346
    • The present disclosure relates to an LNA oligonucleotide consisting of a sequence selected from the group consisting of 5′-(Tx)GxGxcsasasgscsastscscsTxGxT-3′ and 5′-(Gx)TxTxascstsgscscststscsTxTxA-3′, wherein capital letters designate a beta-D-oxy-LNA nucleotide analogue, small letters designate a 2-deoxynucleotide, underline designates either a beta-D-oxy-LNA nucleotide analogue or a 2-deoxynucleotide, subscript “s” designates a phosphorothioate link between neighbouring nucleotides/LNA nucleotide analogues, and subscript “x” designates either a phosphorothioate link or a phosphorodiester link between neighbouring nucleotides/LNA nucleotide analogues, and wherein the sequence is optionally extended by up to five 2-deoxynucleotide units. The LNA oligonucleotides are useful for modulating the expression of hypoxia-inducible factor-1a (HIF-1a), e.g. in the treatment of cancer diseases, inhibiting angiogenesis, inducing apoptosis, preventing cellular proliferation, or treating an angiogenic disease, e.g. diabetic retinopathy, macular degeneration (ARMD), psoriasis, rheumatoid arthritis and other inflammatory diseases.
    • 本公开内容涉及由选自下组的序列组成的LNA寡核苷酸:5' - (T x)X G x 例如,本发明的一个或多个实施方案,其中, x> T T T T T T T T T T T T T T T T T T T T T T T T T T T T T T T T T T T T T T T T T T T T T T T T T T T T T T T T T T T T -3'和5' - (G x x)T x x T x 其中一个或多个第一个或更多个> 其中大写字母表示β-D-氧基,其中大写字母表示β-D-氧基, -LNA核苷酸类似物,小写字母表示2-脱氧核苷酸,下划线表示β-D-氧-LNA核苷酸类似物或2-脱氧核苷酸,下标“s”表示相邻核苷酸/ LNA核苷酸类似物之间的硫代磷酸酯连接,下标 “x”表示相邻核苷酸/ LNA核苷酸类似物之间的硫代磷酸酯连接或磷酸二酯连接,并且其中该序列是选择性的 最多延伸5个2-脱氧核苷酸单位。 LNA寡核苷酸可用于调节缺氧诱导因子-1a(HIF-1a)的表达,例如, 在治疗癌症疾病,抑制血管发生,诱导细胞凋亡,预防细胞增殖或治疗血管生成疾病,例如, 糖尿病性视网膜病变,黄斑变性(ARMD),牛皮癣,类风湿性关节炎等炎症性疾病。
    • 9. 发明申请
    • Wind noise insensitive hearing aid
    • 风噪声不敏感助听器
    • US20050041825A1
    • 2005-02-24
    • US10501231
    • 2003-01-07
    • Karsten RasmussenPeter FrederiksenFrank RasmussenKim Petersen
    • Karsten RasmussenPeter FrederiksenFrank RasmussenKim Petersen
    • H04R25/00
    • H04R25/402H04R25/407H04R2410/07
    • The invention concerns a hearing aid with at least one primary sound to electric converting transducer converting sounds in the environment into electrical signals and a signal processing unit for amplifying the electrical signal according to the needs of the user and an electrical to sound transducer for receiving the amplified electrical signal and delivering a sound signal to the ear wherein at least one further sound to electrical transducer is provided. The said further transducer has a sensitivity to wind noise which is smaller than the sensitivity to wind noise of the primary transducer and further the signal processing unit has means for detecting the level of wind noise in the signal from the primary sound to electric converting transducer. According to the invention also selecting means are provided for selecting the signal to be amplified from either the primary—or the at least one further sound to electrical transducer.
    • 本发明涉及一种助听器,其具有至少一个主要声音以电转换换能器将环境中的声音转换为电信号;以及信号处理单元,用于根据用户的需要放大电信号,以及电 - 声换能器,用于接收 放大的电信号并将声音信号传送到耳朵,其中提供至少一个另外的声音至电变换器。 所述另外的传感器对风噪声的灵敏度小于主要传感器的风噪声的灵敏度,此外,信号处理单元具有用于检测从主声音到电转换换能器的信号中的风噪声水平的装置。 根据本发明,还提供了选择装置,用于从主要或至少一个另外的声音到电变换器中选择要被放大的信号。