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1. 发明授权

US4094980A N-[1-(3',4'-methylenedioxy-phenyl)-propyl-(2)]-N'-phenyl-piperazines and salts thereof 失效
标题翻译： N-（1-（3“，4” - 乙烯基 - 苯基） - 丙基 - （2）） - N“ - 苯基 - 哌嗪及其盐
公开(公告)号：US4094980A
公开(公告)日：1978-06-13
申请号：US749344
申请日：1976-12-10
申请人： Ernst-Otto Renth , Anton Mentrup , Kurt Schromm , Wilhelm Frolke
发明人： Ernst-Otto Renth , Anton Mentrup , Kurt Schromm , Wilhelm Frolke
IPC分类号： A61K31/495 , C07D295/08
摘要： Compounds of the formula ##STR1## wherein R.sub.1 and R.sub.2 are chlorine, orR.sub.1 is methyl and R.sub.2 is methoxy,And non-toxic, pharmacologically acceptable acid addition salts thereof; the compounds as well as their salts are useful as anti-hyperlipidemics and anti-hypercholesteremics with practically negligible CNS-depressing side effects.

2. 发明授权

US4581367A 1-phenyl-2-(heterocyclyl-alkyl-amino)-ethanols 失效
标题翻译： 1-苯基-2-（杂环基 - 烷基 - 氨基） - 乙醇
公开(公告)号：US4581367A
公开(公告)日：1986-04-08
申请号：US443912
申请日：1982-11-23
申请人： Kurt Schromm , Anton Mentrup , Ernst-Otto Renth , Armin Fugner , Ilse Streller
发明人： Kurt Schromm , Anton Mentrup , Ernst-Otto Renth , Armin Fugner , Ilse Streller
IPC分类号： A61K31/41 , A61K31/415 , A61K31/4166 , A61K31/4184 , A61K31/42 , A61K31/496 , A61K31/505 , A61K31/517 , A61K31/535 , A61K31/5355 , A61P1/04 , A61P1/06 , A61P9/00 , A61P9/06 , A61P9/12 , A61P11/00 , A61P11/08 , A61P13/02 , A61P15/00 , A61P25/24 , A61P25/26 , A61P27/02 , A61P27/14 , A61P37/08 , C07D233/36 , C07D233/54 , C07D233/58 , C07D233/61 , C07D235/06 , C07D235/08 , C07D235/18 , C07D239/88 , C07D239/90 , C07D239/96 , C07D249/18 , C07D413/12 , C07D521/00 , C07D235/00
CPC分类号： C07D233/64 , C07D231/12 , C07D233/36 , C07D233/56 , C07D235/06 , C07D235/08 , C07D235/18 , C07D239/88 , C07D239/96 , C07D249/08 , C07D249/18 , Y10S514/821 , Y10S514/826 , Y10S514/849 , Y10S514/906 , Y10S514/914
摘要： Compounds of the formula whereinHet is a heterocycle;n is an integer from 1 to 4, inclusive, preferably 2 or 3;R.sub.1 is H or acyl;R.sub.2 is H, R.sub.1 O, --NHSO.sub.2 R.sub.7, --NHCOR.sub.8, --NHCONHR.sub.8, --NH--CH.sub.2 --C.sub.6 H.sub.4 --R.sub.9, --CH.sub.2 OH, --CH.sub.2 SO.sub.2 R.sub.7, --CONHR.sub.8, halogen or --CN;R.sub.3 is H, halogen, R.sub.7 or --OR.sub.7 ; orR.sub.2 and R.sub.3, together with each other, are ##STR1## N.sub.4 is H, --CH.sub.3 or --C.sub.2 H.sub.5 ; R.sub.5 and R.sub.6 are each H or --CH.sub.3 ;R.sub.7 is C.sub.1 -C.sub.4 alkyl;R.sub.8 is H or C.sub.1 -C.sub.4 alkyl; andR.sub.9 is H, C.sub.1 -C.sub.4 alkyl or C.sub.1 -C.sub.4 alkoxy optionally interrupted by oxygen;and non-toxic, pharmacologically acceptable acid addition salts thereof. The compounds as well as the salts are useful as bronchospasmolytics, spasmolytics, muscle-relaxants, antiallergics and hypotensives.
摘要翻译：其中Het是杂环的式“IMAGE”的化合物; n为1〜4的整数，优选为2或3; R1是H或酰基; R2是H，R1O，-NHSO2R7，-NHCOR8，-NHCONHR8，-NH-CH2-C6H4-R9，-CH2OH，-CH2SO2R7，-CONHR8，卤素或-CN; R3是H，卤素，R7或-OR7; 或R 2和R 3彼此一起是H，-CH 3或-C 2 H 5; R5和R6各自为H或-CH3; R7是C1-C4烷基; R8是H或C1-C4烷基; 并且R 9为H，任选被氧中断的C 1 -C 4烷基或C 1 -C 4烷氧基; 和无毒的，药学上可接受的酸加成盐。化合物和盐可用作支气管解痉药，解痉药，肌肉松弛剂，抗过敏药和低血压药。

3. 发明授权

US4100282A N-Aryl-N'-(phenyl- or phenoxy-alkyl)-piperazines and salts thereof 失效
标题翻译： N-芳基-N {40-（苯基 - 或苯氧基 - 烷基） - 哌嗪及其盐
公开(公告)号：US4100282A
公开(公告)日：1978-07-11
申请号：US793736
申请日：1977-05-04
申请人： Ernst-Otto Renth , Anton Mentrup , Kurt Schromm , Peter Danneberg
发明人： Ernst-Otto Renth , Anton Mentrup , Kurt Schromm , Peter Danneberg
IPC分类号： A61K31/495 , C07D207/26 , C07D207/27 , C07D279/02
CPC分类号： C07D207/27 , A61K31/495
摘要： Compounds of the formula ##STR1## wherein R is phenyl; phenyl having one or two substituents attached thereto, said substituents being selected from the group consisting of alkyl of 1 to 4 carbon atoms, alkoxy of 1 to 4 carbon atoms, alkylthio of 1 to 4 carbon atoms, chlorine and trifluoromethyl; naphthyl; tetrahydronaphthyl; indanyl; pyridyl; isoquinolyl; or thiazolyl;R.sub.1 is ##STR2## where R.sub.3 is hydrogen, alkyl of 1 to 4 carbon atoms,R.sub.4 and R.sub.5 are each hydrogen or alkyl of 1 to 4 carbon atoms, andQ is oxygen or two hydrogens,R.sub.2 is hydrogen, alkyl of 1 to 4 carbon atoms, alkoxy of 1 to 4 carbon atoms or halogen,A is a single carbon-to-carbon bond or --OCH.sub.2 --,R.sub.6 is hydrogen, hydroxyl, alkoxy of 1 to 4 carbon atoms or alkanoyloxy of 1 to 4 carbon atoms, andm is 0, 1, 2, 3, 4 or 5, but other than 0 when R.sub.6 is hydroxyl,And non-toxic, pharmacologically acceptable acid addition salts thereof; the compounds as well as their salts are useful as CNS-depressants, adrenolytics, antiphlogistics, analgesics, antihistaminics and anticholesteremics.
摘要翻译：其中R是苯基的式“IMAGE”的化合物; 所述取代基选自1至4个碳原子的烷基，1至4个碳原子的烷氧基，1至4个碳原子的烷硫基，氯和三氟甲基; 萘基; 四氢萘基; 茚满基吡啶基异喹啉基或噻唑基; R1是，其中R3是氢，1-4个碳原子的烷基，R4和R5分别是氢或1-4个碳原子的烷基，Q是氧或两个氢，R2是氢，1-4个碳原子数为1〜4的烷氧基或卤素，A为单碳 - 碳键或-OCH2-，R6为氢，羟基，1〜4个碳原子的烷氧基或1〜4个碳原子的烷酰氧基，并且M IS为0,1,2,3,4或5，但当R6为羟基时为0以及非毒性，药理学上可接受的酸添加量; 化合物作为它们的有效作为CNS抑制剂，肾上腺素，消炎药，镇痛药，抗组胺药和抗胆碱血症有用。

4. 发明授权

US3992537A Pharmaceutical compositions containing an N-phenyl-imidazolidine-2-one and method of use 失效
标题翻译：含有N-苯基 - 咪唑烷-2-酮的药物组合物及其使用方法
公开(公告)号：US3992537A
公开(公告)日：1976-11-16
申请号：US636738
申请日：1975-12-01
申请人： Anton Mentrup , Ernst-Otto Renth , Kurt Schromm , Peter Danneberg
发明人： Anton Mentrup , Ernst-Otto Renth , Kurt Schromm , Peter Danneberg
IPC分类号： A61K31/495 , C07D401/14 , C07D403/10
CPC分类号： C07D401/14 , A61K31/495 , C07D403/10
摘要： Pharmaceutical compositions containing as an active ingredient a compound of the formula ##SPC1##Wherein R' is in the m- or p-position and is selected from the group consisting of--CH.sub.2 --A, --CHR.sub.1 --CH.sub.2 --Aand ##EQU1## where R.sub.1 is hydrogen or hydroxyl, andA is ##SPC2##WhereR.sub.3 is hydrogen, chlorine, methyl, ethyl, trifluoromethyl or lower alkoxy, andR.sub.4 is hydrogen or methyl, orR.sub.3 and R.sub.4, together with each other and neighboring carbon atoms of the phenyl ring to which they are attached, are naphthyl,Or a non-toxic, pharmacologically acceptable acid addition salt thereof; and a method of using the same as CNS-depressants, neuroleptics and anticholesteremics.
摘要翻译：含有式+ q，10的化合物作为活性成分的药物组合物在m-或p-位，并且选自-CH2-A，-CHR1-CH2-A和-CHR1 -CH-A，| CH3，其中R1是氢或羟基，A是+ q，12，其中R3是氢，氯，甲基，乙基，三氟甲基或低级烷氧基，R4是氢或甲基，或R3和R4一起与它们所连接的苯环的彼此和相邻的碳原子是萘基，或非毒性，药理学上可接受的酸加成盐; 和使用它们作为CNS抑制剂，精神安定药和抗胆固醇药的方法。

5. 发明授权

US4720496A Pyridotriazoloquinazolines and triazolopyridoquinazolines useful as antiallergics 失效
标题翻译：吡唑并三唑喹唑啉和三唑并吡啶喹唑啉可用作抗过敏药
公开(公告)号：US4720496A
公开(公告)日：1988-01-19
申请号：US870365
申请日：1986-06-04
申请人： Kurt Schromm , Anton Mentrup , Ernst-Otto Renth , Armin Fugner
发明人： Kurt Schromm , Anton Mentrup , Ernst-Otto Renth , Armin Fugner
IPC分类号： C07D487/04 , A61K31/505 , A61K31/517 , A61P9/08 , A61P11/00 , A61P11/08 , A61P37/08 , C07D471/14
CPC分类号： C07D471/14
摘要： Compounds of the formula ##STR1## wherein (a)R.sub.1 is hydrogen, lower alkyl, lower alkoxy or 8-halo;R.sub.2 is hydrogen, lower alkyl, lower alkoxy or a fused benzene ring; andR.sub.3 and R.sub.4, together with each other, are --N.dbd.N--NH--; or(b)R.sub.1 and R.sub.2, together with each other, are --N.dbd.N--NH--;R.sub.3 is hydrogen, lower alkyl, lower alkoxy, 2-halo, 3-halo or 4-halo; andR.sub.4 is hydrogen, lower alkyl, lower alkoxy or a fused benzene ring;and non-toxic, pharmacologically acceptable salts thereof formed with an inorganic or organic base. The compounds as well as their salts are useful as antiallergics.
摘要翻译：式（Ia）的化合物，其中（a）R 1是氢，低级烷基，低级烷氧基或8-卤素; R2是氢，低级烷基，低级烷氧基或稠合苯环; 并且R 3和R 4彼此一起是-N = N-NH-; 或（b）R 1和R 2彼此一起为-N = N-NH-; R3是氢，低级烷基，低级烷氧基，2-卤代，3-卤代或4-卤素; R4为氢，低级烷基，低级烷氧基或稠合苯环; 和与无机或有机碱形成的无毒的，药学上可接受的盐。化合物及其盐可用作抗过敏药。

6. 发明授权

US4558061A Bronchospasmolytic 1-(3-methanesulfonamido-4-hydroxyphenyl)-2-[(3-(4-acyl-aminophenyl)-imid azolidin-2-one-1-yl)-alkylamino]-ethanols 失效
标题翻译：支气管痉挛性1-（3-甲磺酰氨基-4-羟基苯基）-2 - [（3-（4-酰基 - 氨基苯基） - 咪唑烷-2-酮-1-基） - 烷基氨基] - 乙醇
公开(公告)号：US4558061A
公开(公告)日：1985-12-10
申请号：US628383
申请日：1984-07-06
申请人： Anton Mentrup , Kurt Schromm , Ernst-Otto Renth , Gojko Muacevic , Armin Fugner
发明人： Anton Mentrup , Kurt Schromm , Ernst-Otto Renth , Gojko Muacevic , Armin Fugner
IPC分类号： C07D233/34 , A61K31/415 , A61K31/4166 , A61P9/08 , A61P11/00 , A61P11/08 , A61P25/24 , A61P25/26 , C07D233/30 , C07D233/36
CPC分类号： C07D233/36
摘要： Compounds of the formula ##STR1## wherein n is 1 or 2, R.sub.1 is hydrogen, --CO--R.sub.2 or --SO.sub.2 R.sub.3,R.sub.2 is hydrogen, alkyl of 1 to 4 carbon atoms, alkoxy of 1 to 4 carbon atoms or (alkyl of 1 to 4 carbon atoms)amino, andR.sub.3 is alkyl of 1 to 4 carbon atoms,and non-toxic, pharmacologically acceptable acid addition salts thereof. The compounds as well as their salts are useful as bronchospasmolytics.
摘要翻译：其中n为1或2，R1为氢，-CO-R2或-SO2R3，R2为氢，1至4个碳原子的烷基，1至4个碳原子的烷氧基的化合物或（1〜4个碳原子的烷基）氨基，R3为1〜4个碳原子的烷基，以及无毒的药学上可接受的酸加成盐。化合物及其盐可用作支气管痉挛溶解剂。

7. 发明授权

US4546102A 1-(6,7-Dimethoxyquinazol-4-yl)semicarbazides 失效
标题翻译： 1-（6,7-二甲氧基喹唑啉-4-基）氨基脲
公开(公告)号：US4546102A
公开(公告)日：1985-10-08
申请号：US546864
申请日：1983-10-31
申请人： Ernst-Otto Renth , Anton Mentrup , Kurt Schromm , Werner Traunecker , Richard Reichl
发明人： Ernst-Otto Renth , Anton Mentrup , Kurt Schromm , Werner Traunecker , Richard Reichl
IPC分类号： A61K31/505 , A61K31/517 , A61P9/00 , A61P9/04 , A61P9/08 , A61P9/12 , A61P43/00 , C07D239/94
CPC分类号： C07D239/94
摘要： Compounds of the formula ##STR1## wherein R.sub.1 is hydrogen, alkyl of 1 to 4 carbon atoms or trifluoromethyl;R.sub.2, R.sub.3 and R.sub.4 are each independently hydrogen, methyl or ethyl;R.sub.5 is hydrogen, alkyl of 1 to 8 carbon atoms, phenyl-(alkyl of 1 to 8 carbon atoms), cycloalkyl of 3 to 7 carbon atoms, (alkoxy of 1 to 4 carbon atoms) carbonyl-methyl, phenyl, substituted phenyl, naphthyl or substituted naphthyl; orR.sub.4 and R.sub.5, together with each other, are alkylene of 4 to 5 carbon atoms, optionally interrupted by --O-- or --NR.sub.6 --, where R.sub.6 is alkyl of 1 to 4 carbon atoms;and non-toxic, pharmacologically acceptable acid addition salts thereof. The compounds as well as their salts are useful as cardiotonics.
摘要翻译：其中R 1为氢，1至4个碳原子的烷基或三氟甲基的化合物＆lt; IMAGE＆gt; R2，R3和R4各自独立地为氢，甲基或乙基; R5是氢，1至8个碳原子的烷基，苯基（1至8个碳原子的烷基），3至7个碳原子的环烷基，（1至4个碳原子的烷氧基）羰基 - 甲基，苯基，取代的苯基，萘基或取代的萘基; 或R 4和R 5彼此一起是4至5个碳原子的亚烷基，任选被-O-或-NR 6 - 间隔，其中R 6是具有1至4个碳原子的烷基; 和无毒的，药学上可接受的酸加成盐。化合物及其盐可用作强心剂。

8. 发明授权

US4378361A Heterocyclic compounds 失效
标题翻译：杂环化合物
公开(公告)号：US4378361A
公开(公告)日：1983-03-29
申请号：US285713
申请日：1981-07-22
申请人： Kurt Schromm , Anton Mentrup , Ernst-Otto Renth , Armin Fugner , Ilse Streller
发明人： Kurt Schromm , Anton Mentrup , Ernst-Otto Renth , Armin Fugner , Ilse Streller
IPC分类号： A61K31/41 , A61K31/415 , A61K31/4166 , A61K31/4184 , A61K31/42 , A61K31/496 , A61K31/505 , A61K31/517 , A61K31/535 , A61K31/5355 , A61P1/04 , A61P1/06 , A61P9/00 , A61P9/06 , A61P9/12 , A61P11/00 , A61P11/08 , A61P13/02 , A61P15/00 , A61P25/24 , A61P25/26 , A61P27/02 , A61P27/14 , A61P37/08 , C07D233/36 , C07D233/54 , C07D233/58 , C07D233/61 , C07D235/06 , C07D235/08 , C07D235/18 , C07D239/88 , C07D239/90 , C07D239/96 , C07D249/18 , C07D413/12 , C07D521/00 , C07D239/72
CPC分类号： C07D233/64 , C07D231/12 , C07D233/36 , C07D233/56 , C07D235/06 , C07D235/08 , C07D235/18 , C07D239/88 , C07D239/96 , C07D249/08 , C07D249/18 , Y10S514/821 , Y10S514/826 , Y10S514/849 , Y10S514/906 , Y10S514/914
摘要： Compounds of the formula ##STR1## wherein Het is ##STR2## n is an integer from 1 to 4, inclusive, preferably 2 or 3, R.sub.1 is H or acyl,R.sub.2 is H, R.sub.1 O, --NHSO.sub.2 R.sub.7, --NHCOR.sub.8, --NHCONHR.sub.8, --NH--CH.sub.2 --C.sub.6 H.sub.4 --R.sub.9, --CH.sub.2 OH, --CH.sub.2 SO.sub.2 R.sub.7, --CONHR.sub.8, halogen or --CN,R.sub.3 is H, halogen, R.sub.7 or --OR.sub.7,R.sub.2 and R.sub.3 together with each other are ##STR3## R.sub.4 is H, --CH.sub.3 or --C.sub.2 H.sub.5, R.sub.5 and R.sub.6 are each H or --CH.sub.3,R.sub.7 is C.sub.1 -C.sub.4 alkyl,R.sub.8 is H or C.sub.1 -C.sub.4 alkyl,R.sub.9 is H, C.sub.1 -C.sub.4 alkyl or C.sub.1 -C.sub.4 alkoxy optionally interrupted by oxygen,R.sub.10 and R.sub.12 are each H, CH.sub.3, Cl or OCH.sub.3, or together methylenedioxy,X is ##STR4## or N, and Z is --CH.sub.2 or --CO;in the form of racemates, enantiomers, diastereoisomeric antipode pairs, and non-toxic, pharmacologically acceptable acid addition salts thereof. The compounds as well as the salts are useful as bronchospasmolytics, spasmolytics, muscle-relaxants, antiallergics and hypotensives.
摘要翻译：其中Het为1至4的整数，包括端值，优选2或3，R 1为H或酰基，R 2为H，R 1 O - ， - NHSO2R7，-NHCOR8，-NHCONHR8，-NH-CH2-C6H4-R9，-CH2OH，-CH2SO2R7，-CONHR8，卤素或-CN，R3是H，卤素，R7或-OR7，R2和R3彼此是 R4是H，-CH3或-C2H5，R5和R6分别是H或-CH3，R7是C1-C4烷基，R8是H或C1-C4烷基，R9是H，C1-C4烷基或C1- 任选被氧中断的C 4烷氧基，R 10和R 12各自为H，CH 3，Cl或OCH 3，或一起为亚甲二氧基，X为N或N，并且Z为-CH 2或-CO; 以外消旋物，对映异构体，非对映异构体对映体对及其无毒的药学上可接受的酸加成盐的形式存在。化合物和盐可用作支气管解痉药，解痉药，肌肉松弛剂，抗过敏药和低血压药。

9. 发明授权

US4363814A Aminoalkyl-substituted heterocycles 失效
标题翻译：氨基烷基取代的杂环
公开(公告)号：US4363814A
公开(公告)日：1982-12-14
申请号：US218786
申请日：1980-12-22
申请人： Anton Mentrup , Kurt Schromm , Ernst-Otto Renth , Richard Reichl , Werner Traunecker
发明人： Anton Mentrup , Kurt Schromm , Ernst-Otto Renth , Richard Reichl , Werner Traunecker
IPC分类号： C07D215/02 , A61K31/404 , A61K31/415 , A61K31/4166 , A61K31/4184 , A61K31/42 , A61K31/423 , A61K31/4245 , A61K31/536 , A61P9/08 , A61P9/12 , A61P11/00 , A61P25/24 , A61P25/26 , C07D215/22 , C07D215/227 , C07D223/04 , C07D233/32 , C07D233/36 , C07D235/04 , C07D235/22 , C07D235/26 , C07D263/54 , C07D263/58 , C07D265/22 , C07D265/36 , C07D405/04 , C07D405/12 , C07D413/12
CPC分类号： C07D215/227 , C07D233/36 , C07D235/26 , C07D263/58 , C07D265/36 , Y10S514/929
摘要： Racemic or optically active compounds of the formulaQ--C.sub.n H.sub.2n --NH--Rwherein Q is ##STR1## where R.sub.1 is hydrogen, halogen, alkyl of 1 to 4 carbon atoms, alkoxy of 1 to 4 carbon atoms, trifluoromethyl or amino,R.sub.2 is hydrogen, halogen, alkyl of 1 to 4 carbon atoms, alkoxy of 1 to 4 carbon atoms or trifluoromethyl, orR.sub.1 and R.sub.2, together with each other, are methylenedioxy or ethylenedioxy;n is an integer from 2 to 6, inclusive; andR is hydrogen, benzyl or ##STR2## and non-toxic, pharmacologically acceptable acid addition salts thereof. The compounds as well as their salts are useful as vasodilators and CNS-stimulators.
摘要翻译：其中Q为氢，卤素，1至4个碳原子的烷基，1至4个碳原子的烷氧基，三氟甲基或氨基，R 2为式Q-C n H 2n-NH-R的外消旋或旋光活性化合物氢，卤素，1至4个碳原子的烷基，1至4个碳原子的烷氧基或三氟甲基，或R 1和R 2彼此一起是亚甲二氧基或亚乙二氧基; n为2〜6的整数，包括0〜6; 并且R是氢，苄基或者它们的无毒的药学上可接受的酸加成盐。化合物及其盐可用作血管扩张剂和CNS刺激剂。

10. 发明授权

US4271158A Vasodilating or antidepressant phenalkanolaminoalkyl-substituted imidazolidinones 失效
标题翻译：血管舒张或抗抑郁药苯烷醇氨基烷基取代的咪唑啉酮
公开(公告)号：US4271158A
公开(公告)日：1981-06-02
申请号：US102904
申请日：1979-12-13
申请人： Anton Mentrup , Kurt Schromm , Ernst-Otto Renth , Richard Reichl
发明人： Anton Mentrup , Kurt Schromm , Ernst-Otto Renth , Richard Reichl
IPC分类号： C07D215/02 , A61K31/404 , A61K31/415 , A61K31/4166 , A61K31/4184 , A61K31/42 , A61K31/423 , A61K31/4245 , A61K31/536 , A61P9/08 , A61P9/12 , A61P11/00 , A61P25/24 , A61P25/26 , C07D215/22 , C07D215/227 , C07D223/04 , C07D233/32 , C07D233/36 , C07D235/04 , C07D235/22 , C07D235/26 , C07D263/54 , C07D263/58 , C07D265/22 , C07D265/36 , C07D405/04 , C07D405/12 , C07D413/12 , A61K31/535
CPC分类号： C07D215/227 , C07D233/36 , C07D235/26 , C07D263/58 , C07D265/36 , Y10S514/929
摘要： Racemic and optically active compounds of the formulaQ--C.sub.n H.sub.2n --NH--RwhereinQ is ##STR1## where R.sub.1 is hydrogen, halogen, alkyl of 1 to 4 carbon atoms, alkoxy of 1 to 4 carbon atoms, trifluoromethyl or amino,R.sub.2 is hydrogen, halogen, alkyl of 1 to 4 carbon atoms, alkoxy of 1 to 4 carbon atomsor trifluoromethyl,R.sub.1 and R.sub.2, together with each other, are methylenedioxy or ethylenedioxy, andA is --O--, --CH.sub.2 --CH.sub.2 --, or --NR.sub.3 -- where R.sub.3 is hydrogen or alkyl of 1 to 4 carbon atoms,n is an integer from 2 to 6, inclusive, andR is hydrogen, benzyl or ##STR2## where R.sub.4 is hydrogen, methyl or ethyl,R.sub.5, R.sub.6 and R.sub.7, which may be identical to or different from each other, are each hydrogen, halogen, hydroxymethyl, trifluoromethyl, alkyl of 1 to 4 carbon atoms, alkoxy of 1 to 4 carbon atoms, nitro, cyano, --CONHR.sub.3, --CONHOH, --COOR.sub.3, R.sub.8 O--, methylsulfonylmethyl or, when one or two of R.sub.5 through R.sub.7 are other than halogen or trifluoromethyl, also--NR.sub.3 R.sub.9, whereR.sub.3 has the meanings defined above,R.sub.8 is hydrogen, alkanoyl of 1 to 20 carbon atoms, alkyl of 1 to 4 carbon atoms, or aralkyl, andR.sub.9 is hydrogen, lower alkanoyl, methanesulfonyl, carbamoyl, dimethylsulfamoyl, or alkoxycarbonyl of 2 or 5 carbon atoms, andR.sub.5 and R.sub.6, together with each other, are --O--CH.sub.2 --O, --O--CH.sub.2 --CH.sub.2 --O--, --CH.dbd.CH--CH.dbd.CH--, --O--CH.sub.2 --CONH--, --CH.sub.2 --CH.sub.2 --CONH-- or --O--CO--NH--, and non-toxic, pharmacologically acceptable acid addition salts thereof. The compounds as well as their salts are useful as vasodilators and CNS- stimulators.
摘要翻译：其中Q为氢，卤素，1至4个碳原子的烷基，1至4个碳原子的烷氧基，三氟甲基或氨基，R 2为式Q-C n H 2n-NH-R的外消旋和旋光活性化合物氢，卤素，1至4个碳原子的烷基，1至4个碳原子的烷氧基或三氟甲基，R 1和R 2彼此一起是亚甲二氧基或亚乙二氧基，A是-O-，-CH 2 -CH 2 - 或 - NR 3 - 其中R 3是氢或1至4个碳原子的烷基，n是2-6的整数，包括2和6，R是氢，苄基或者其中R 4是氢，甲基或乙基，R 5，R 6和R 7 可以相同或不同，分别为氢，卤素，羟甲基，三氟甲基，1至4个碳原子的烷基，1至4个碳原子的烷氧基，硝基，氰基，-CONHR 3，-CONHOH，-COOR 3 ，R8O-，甲基磺酰基甲基，或当R 5至R 7中的一个或两个不是卤素或三氟甲基时，还有-NR 3 R 9，其中R 3具有上述定义，R 8是氢， 1至20个碳原子的芳基，1至4个碳原子的烷基或芳烷基，R 9是氢，低级烷酰基，甲磺酰基，氨基甲酰基，二甲基氨磺酰基或2或5个碳原子的烷氧基羰基，以及R 5和R 6 另一个是-O-CH 2 -O，-O-CH 2 -CH 2 -O - ， - CH = CH-CH = CH-，-O-CH 2 -CONH - ， - CH 2 -CH 2 -CONH-或-O-CO -NH-和无毒的药学上可接受的酸加成盐。化合物及其盐可用作血管扩张剂和CNS刺激剂。

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