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1. 发明授权

US4546102A 1-(6,7-Dimethoxyquinazol-4-yl)semicarbazides 失效
标题翻译： 1-（6,7-二甲氧基喹唑啉-4-基）氨基脲
公开(公告)号：US4546102A
公开(公告)日：1985-10-08
申请号：US546864
申请日：1983-10-31
申请人： Ernst-Otto Renth , Anton Mentrup , Kurt Schromm , Werner Traunecker , Richard Reichl
发明人： Ernst-Otto Renth , Anton Mentrup , Kurt Schromm , Werner Traunecker , Richard Reichl
IPC分类号： A61K31/505 , A61K31/517 , A61P9/00 , A61P9/04 , A61P9/08 , A61P9/12 , A61P43/00 , C07D239/94
CPC分类号： C07D239/94
摘要： Compounds of the formula ##STR1## wherein R.sub.1 is hydrogen, alkyl of 1 to 4 carbon atoms or trifluoromethyl;R.sub.2, R.sub.3 and R.sub.4 are each independently hydrogen, methyl or ethyl;R.sub.5 is hydrogen, alkyl of 1 to 8 carbon atoms, phenyl-(alkyl of 1 to 8 carbon atoms), cycloalkyl of 3 to 7 carbon atoms, (alkoxy of 1 to 4 carbon atoms) carbonyl-methyl, phenyl, substituted phenyl, naphthyl or substituted naphthyl; orR.sub.4 and R.sub.5, together with each other, are alkylene of 4 to 5 carbon atoms, optionally interrupted by --O-- or --NR.sub.6 --, where R.sub.6 is alkyl of 1 to 4 carbon atoms;and non-toxic, pharmacologically acceptable acid addition salts thereof. The compounds as well as their salts are useful as cardiotonics.
摘要翻译：其中R 1为氢，1至4个碳原子的烷基或三氟甲基的化合物＆lt; IMAGE＆gt; R2，R3和R4各自独立地为氢，甲基或乙基; R5是氢，1至8个碳原子的烷基，苯基（1至8个碳原子的烷基），3至7个碳原子的环烷基，（1至4个碳原子的烷氧基）羰基 - 甲基，苯基，取代的苯基，萘基或取代的萘基; 或R 4和R 5彼此一起是4至5个碳原子的亚烷基，任选被-O-或-NR 6 - 间隔，其中R 6是具有1至4个碳原子的烷基; 和无毒的，药学上可接受的酸加成盐。化合物及其盐可用作强心剂。

2. 发明授权

US4363814A Aminoalkyl-substituted heterocycles 失效
标题翻译：氨基烷基取代的杂环
公开(公告)号：US4363814A
公开(公告)日：1982-12-14
申请号：US218786
申请日：1980-12-22
申请人： Anton Mentrup , Kurt Schromm , Ernst-Otto Renth , Richard Reichl , Werner Traunecker
发明人： Anton Mentrup , Kurt Schromm , Ernst-Otto Renth , Richard Reichl , Werner Traunecker
IPC分类号： C07D215/02 , A61K31/404 , A61K31/415 , A61K31/4166 , A61K31/4184 , A61K31/42 , A61K31/423 , A61K31/4245 , A61K31/536 , A61P9/08 , A61P9/12 , A61P11/00 , A61P25/24 , A61P25/26 , C07D215/22 , C07D215/227 , C07D223/04 , C07D233/32 , C07D233/36 , C07D235/04 , C07D235/22 , C07D235/26 , C07D263/54 , C07D263/58 , C07D265/22 , C07D265/36 , C07D405/04 , C07D405/12 , C07D413/12
CPC分类号： C07D215/227 , C07D233/36 , C07D235/26 , C07D263/58 , C07D265/36 , Y10S514/929
摘要： Racemic or optically active compounds of the formulaQ--C.sub.n H.sub.2n --NH--Rwherein Q is ##STR1## where R.sub.1 is hydrogen, halogen, alkyl of 1 to 4 carbon atoms, alkoxy of 1 to 4 carbon atoms, trifluoromethyl or amino,R.sub.2 is hydrogen, halogen, alkyl of 1 to 4 carbon atoms, alkoxy of 1 to 4 carbon atoms or trifluoromethyl, orR.sub.1 and R.sub.2, together with each other, are methylenedioxy or ethylenedioxy;n is an integer from 2 to 6, inclusive; andR is hydrogen, benzyl or ##STR2## and non-toxic, pharmacologically acceptable acid addition salts thereof. The compounds as well as their salts are useful as vasodilators and CNS-stimulators.
摘要翻译：其中Q为氢，卤素，1至4个碳原子的烷基，1至4个碳原子的烷氧基，三氟甲基或氨基，R 2为式Q-C n H 2n-NH-R的外消旋或旋光活性化合物氢，卤素，1至4个碳原子的烷基，1至4个碳原子的烷氧基或三氟甲基，或R 1和R 2彼此一起是亚甲二氧基或亚乙二氧基; n为2〜6的整数，包括0〜6; 并且R是氢，苄基或者它们的无毒的药学上可接受的酸加成盐。化合物及其盐可用作血管扩张剂和CNS刺激剂。

3. 发明授权

US4215119A Aminoalkyl-substituted benzimidazolidin-2-ones 失效
标题翻译：氨基烷基取代的苯并咪唑烷-2-酮
公开(公告)号：US4215119A
公开(公告)日：1980-07-29
申请号：US26608
申请日：1979-04-03
申请人： Anton Mentrup , Kurt Schromm , Ernst-Otto Renth , Richard Reichl , Werner Traunecker , Wolfgang Hoefke
发明人： Anton Mentrup , Kurt Schromm , Ernst-Otto Renth , Richard Reichl , Werner Traunecker , Wolfgang Hoefke
IPC分类号： C07D215/02 , A61K31/404 , A61K31/415 , A61K31/4166 , A61K31/4184 , A61K31/42 , A61K31/423 , A61K31/4245 , A61K31/536 , A61P9/08 , A61P9/12 , A61P11/00 , A61P25/24 , A61P25/26 , C07D215/22 , C07D215/227 , C07D223/04 , C07D233/32 , C07D233/36 , C07D235/04 , C07D235/22 , C07D235/26 , C07D263/54 , C07D263/58 , C07D265/22 , C07D265/36 , C07D405/04 , C07D405/12 , C07D413/12 , A61K31/535
CPC分类号： C07D215/227 , C07D233/36 , C07D235/26 , C07D263/58 , C07D265/36 , Y10S514/929
摘要： Racemic and optically active compounds of the formulaQ-C.sub.n H.sub.2n -NH-Rwherein Q is ##STR1## where R.sub.1 is hydrogen, halogen, alkyl of 1 to 4 carbon atoms, alkoxy of 1 to 4 carbon atoms, trifluoromethyl or amino,R.sub.2 is hydrogen, halogen, alkyl of 1 to 4 carbon atoms, alkoxy of 1 to 4 carbon atoms or trifluoromethyl,R.sub.1 and R.sub.2, together with each other, are methylenedioxy or ethylenedioxy, andA is --O--, --CH.sub.2 --CH.sub.2 --, or --NR.sub.3 -- where R.sub.3 is hydrogen or alkyl or 1 to 4 carbon atoms,n is an integer from 2 to 6, inclusive, andR is hydrogen, benzyl or ##STR2## where R.sub.4 is hydrogen, methyl or ethyl,R.sub.5, R.sub.6 and R.sub.7, which may be identical to or different from each other, are each hydrogen, halogen, hydroxymethyl, trifluoromethyl, alkyl of 1 to 4 carbon atoms, alkoxy of 1 to 4 carbon atoms, nitro, cyano, --CONHR.sub.3, --CONHOH, --COOR.sub.3, R.sub.8 O--, methylsulfonylmethyl or, when one or two of R.sub.5 through R.sub.7 are other than halogen or trifluoromethyl, also --NR.sub.3 R.sub.9,whereR.sub.3 has the meanings defined above,R.sub.8 is hydrogen, alkanoyl of 1 to 20 carbon atoms, alkyl of 1 to 4 carbon atoms, or aralkyl, andR.sub.9 is hydrogen, lower alkanoyl, methanesulfonyl, carbamoyl, dimethylsulfamoyl, or alkoxycarbonyl of 2 to 5 carbon atoms, andR.sub.5 and R.sub.6, together with each other, are --O--CH.sub.2 --O, --O--CH.sub.2 --CH.sub.2 --O--, --CH.dbd.CH--CH.dbd.CH--, --O--CH.sub.2 --CONH--, --CH.sub.2 --CH.sub.2 --COHN-- or --O--CO--NH--,and non-toxic, pharmacologically acceptable acid addition salts thereof. The compounds as well as their salts are useful as vasodilators and CNS-stimulators.
摘要翻译：其中Q为氢，卤素，1至4个碳原子的烷基，1至4个碳原子的烷氧基，三氟甲基或氨基，R 2为式Q-C n H 2n-NH-R的外消旋和旋光活性化合物氢，卤素，1至4个碳原子的烷基，1至4个碳原子的烷氧基或三氟甲基，R 1和R 2彼此一起是亚甲二氧基或亚乙二氧基，A是-O-，-CH 2 -CH 2 - 或 -NR 3 - ，其中R 3是氢或烷基或1至4个碳原子，n是2-6的整数，包括2和6，R是氢，苄基或者其中R 4是氢，甲基或乙基，R 5，R 6和 R 7可以相同或不同，分别为氢，卤素，羟甲基，三氟甲基，1至4个碳原子的烷基，1至4个碳原子的烷氧基，硝基，氰基，-CONHR 3，-CONHOH， - COOR 3，R8O-，甲基磺酰基甲基，或当R 5至R 7中的一个或两个不同于卤素或三氟甲基时，也可以是-NR 3 R 9，其中R 3具有上述定义，R 8是氢， 1至20个碳原子的烷酰基，1至4个碳原子的烷酰基或芳烷基，R 9是氢，低级烷酰基，甲磺酰基，氨基甲酰基，二甲基氨磺酰基或2至5个碳原子的烷氧基羰基，以及R5和R6，另一个是-O-CH 2 -O，-O-CH 2 -CH 2 -O - ， - CH = CH-CH = CH-，-O-CH 2 -CONH-，-CH 2 -CH 2 -COOH-或-O-CO -NH-和无毒的药学上可接受的酸加成盐。化合物及其盐可用作血管扩张剂和CNS刺激剂。

4. 发明授权

US4154829A Aminoalkyl-substituted benzoxazine derivatives 失效
标题翻译：氨基烷基取代的苯并恶嗪衍生物
公开(公告)号：US4154829A
公开(公告)日：1979-05-15
申请号：US773394
申请日：1977-03-02
申请人： Anton Mentrup , Kurt Schromm , Ernst-Otto Renth , Richard Reichl , Werner Traunecker , Wolfgang Hoefke
发明人： Anton Mentrup , Kurt Schromm , Ernst-Otto Renth , Richard Reichl , Werner Traunecker , Wolfgang Hoefke
IPC分类号： C07D215/02 , A61K31/404 , A61K31/415 , A61K31/4166 , A61K31/4184 , A61K31/42 , A61K31/423 , A61K31/4245 , A61K31/536 , A61P9/08 , A61P9/12 , A61P11/00 , A61P25/24 , A61P25/26 , C07D215/22 , C07D215/227 , C07D223/04 , C07D233/32 , C07D233/36 , C07D235/04 , C07D235/22 , C07D235/26 , C07D263/54 , C07D263/58 , C07D265/22 , C07D265/36 , C07D405/04 , C07D405/12 , C07D413/12 , C07D265/30 , A61K31/535
CPC分类号： C07D215/227 , C07D233/36 , C07D235/26 , C07D263/58 , C07D265/36 , Y10S514/929
摘要： Racemic and optically active compounds of the formulaQ--C.sub.n H.sub.2n --NH--Rwherein Q is ##STR1## where R.sub.1 is hydrogen, halogen, alkyl of 1 to 4 carbon atoms, alkoxy of 1 to 4 carbon atoms, trifluoromethyl or amino,R.sub.2 is hydrogen, halogen, alkyl of 1 to 4 carbon atoms, alkoxy of 1 to 4 carbon atoms or trifluoromethyl,R.sub.1 and R.sub.2, together with each other, are methylenedioxy or ethylenedioxy, andA is --O--, --CH.sub.2 --CH.sub.2 --, --O--CH.sub.2 -- where the oxygen is bonded to the benzene ring, or --NR.sub.3 -- where R.sub.3 is hydrogen or alkyl of 1 to 4 carbon atoms,N is an integer from 2 to 6, inclusive, andR is hydrogen, benzyl or ##STR2## where R.sub.4 is hydrogen, methyl or ethyl,R.sub.5, r.sub.6 and R.sub.7, which may be identical to or different from each other, are each hydrogen, halogen, hydroxymethyl, trifluoromethyl, alkyl of 1 to 4 carbon atoms, alkoxy of 1 to 4 carbon atoms, nitro, cyano, --CONHR.sub.3, --CONHOH, --COOR.sub.3, R.sub.8 O--, methylsulfonylmethyl or, when one or two of R.sub.5 through R.sub.7 are other than halogen or trifluoromethyl, also --NR.sub.3 R.sub.9,whereR.sub.3 has the meanings defined above,R.sub.8 is hydrogen, alkanoyl of 1 to 20 carbon atoms, alkyl of 1 to 4 carbon atoms or aralkyl, andR.sub.9 is hydrogen, lower alkanoyl, methanesulfonyl, carbamoyl, dimethylsulfamoyl, or alkoxycarbonyl of 2 to 5 carbon atoms, andR.sub.5 and R.sub.6, together with each other, are --O--CH.sub.2 --O, --O--CH.sub.2 --CH.sub.2 --O--, --CH.dbd.CH--CH.dbd.CH--, --O--CH.sub.2 --CONH--, --CH.sub.2 --CH.sub.2 --CONH-- or --O--CO--NH--,and non-toxic, pharmacologically acceptable acid addition salts thereof; the compounds as well as their salts are useful as vasodilators and CNS-stimulators.
摘要翻译：其中Q为氢，卤素，1至4个碳原子的烷基，1至4个碳原子的烷氧基，三氟甲基或氨基，R 2为式Q-C n H 2n-NH-R的外消旋和旋光活性化合物氢，卤素，1至4个碳原子的烷基，1至4个碳原子的烷氧基或三氟甲基，R 1和R 2彼此一起是亚甲二氧基或亚乙二氧基，A是-O-，-CH 2 -CH 2 - ， - O-CH2-，其中氧与苯环结合，或-NR 3 - ，其中R 3是氢或1至4个碳原子的烷基，N是2至6，INCLUSIVE和R R的整数是氢，苄基或其中R 4是氢，甲基或乙基，R 5，R 6和R 7可以彼此相同或不同，各自为氢，卤素，羟甲基，三氟甲基，1至4个碳原子的烷基，1至 4个碳原子，硝基，氰基，-CONHR 3，-CONHOH，-COOR 3，R 8 O - ，甲基磺酰基甲基，或当R 5至R 7中的一个或两个不同于卤素或三氟甲基时，也可以是-NR 3 R 9， R 3具有上述定义，R 8为氢，1至20个碳原子的烷酰基，1至4个碳原子的烷基或芳烷基，R 9为氢，低级烷酰基，甲磺酰基，氨基甲酰基，二甲基氨磺酰基或烷氧基羰基2至5 碳原子和R 5和R 6彼此一起是-O-CH 2 -O，-O-CH 2 -CH 2 -O - ， - CH = CH-CH = CH-，-O-CH 2 -CONH-， - CH2-CH2-CONH-或-O-CO-NH-，及其无毒的药学上可接受的酸加成盐; 化合物及其盐可用作血管扩张剂和CNS刺激剂。

5. 发明授权

US3966814A 1-Phenyl-2-(Naphthylalkyl-amino)-ethanols and salts thereof 失效
标题翻译： 1-苯基-2-（萘基烷基 - 氨基） - 乙醇及其盐
公开(公告)号：US3966814A
公开(公告)日：1976-06-29
申请号：US373933
申请日：1973-06-27
申请人： Kurt Schromm , Anton Mentrup , Ernst-Otto Renth , Werner Traunecker
发明人： Kurt Schromm , Anton Mentrup , Ernst-Otto Renth , Werner Traunecker
IPC分类号： A61K31/135 , A61K31/165 , A61K31/22 , A61P9/08 , A61P11/08 , A61P13/02 , A61P15/00 , A61P25/02 , A61P37/08 , C07C67/00 , C07C211/30 , C07C213/00 , C07C215/60 , C07C217/56 , C07C217/60 , C07C217/66 , C07C219/30 , C07C301/00 , C07C303/40 , C07C311/08 , C07C311/29 , C07C311/32 , C07D317/46 , C07C91/16
CPC分类号： C07D317/46 , Y10S514/929
摘要： Compounds of the formula ##SPC1##WhereinA is alkylene of 2 to 6 carbon atoms,R.sub.1 is hydrogen, lower alkyl, lower alkoxy, hydroxyl, or lower alkanoyloxy,R.sub.2 is hydrogen, lower alkyl or lower alkoxy,R.sub.3 is hydrogen, methyl or ethyl,R.sub.4 is hydrogen, lower alkyl or lower alkoxy,R.sub.5 is hydrogen, hydroxyl, lower alkanoyloxy or lower alkyl-sulfonamido, andR.sub.6 is hydrogen or lower alkanoyl,And non-toxic, pharmacologically acceptable acid addition salts thereof; the compounds as well as their salts are useful as peripheral vasodilators, antihistaminics and spasmolytics.
摘要翻译：式WHEREIN A的化合物是2至6个碳原子的亚烷基，R 1是氢，低级烷基，低级烷氧基，羟基或低级烷酰氧基，R 2是氢，低级烷基或低级烷氧基，R 3是氢，甲基或乙基，R 4 是氢，低级烷基或低级烷氧基，R5是氢，羟基，低级烷酰氧基或低级烷基 - 亚磺酰氨基，R6是氢或低级烷酰基，和非毒性，药理学上可接受的酸加法盐; 化合物作为其作为外部血管扩张剂，抗生素和弹性体的有用的化合物。

6. 发明授权

US4046913A 1-(M-alkanoyloxy-phenyl)-1-hydroxy-2-(N-lower alkyl-amino)-ethanes and salts thereof 失效
标题翻译： 1-（间 - 链烷酰氧基 - 苯基）-1-羟基-2-（N-低级烷基 - 氨基） - 乙胺及其盐
公开(公告)号：US4046913A
公开(公告)日：1977-09-06
申请号：US660401
申请日：1976-02-23
申请人： Anton Mentrup , Kurt Schromm , Ernst-Otto Renth , Werner Traunecker
发明人： Anton Mentrup , Kurt Schromm , Ernst-Otto Renth , Werner Traunecker
IPC分类号： C07C67/08 , C07C69/24 , A61K31/22
CPC分类号： C07C67/08 , C07C69/24
摘要： Compounds of the formula ##STR1## wherein R.sub.1 is alkyl of 6 to 19 carbon atoms, andR.sub.2 is methyl or ethyl,And their non-toxic, pharmacologically acceptable acid addition salts; the compounds as well as the salts are useful as pharmaceuticals for the treatment of cardiac and circulatory insufficiencies.
摘要翻译：其中R 1是6至19个碳原子的烷基，R 2是甲基或乙基，以及它们的非毒性，药理学上可接受的酸添加剂; 作为销售的化合物可用作治疗心脏病和循环障碍的药物。

7. 发明授权

US4021485A N,N'-bis-[(.beta.-hydroxy-.beta.-phenyl)-ethyl]-polymethylenediamines and salts thereof 失效
标题翻译： N，N {40-双 - {8（{62-羟基 - {62-苯基） - 乙基{9-聚亚甲基二胺及其盐
公开(公告)号：US4021485A
公开(公告)日：1977-05-03
申请号：US628819
申请日：1975-11-04
申请人： Kurt Schromm , Anton Mentrup , Ernst-Otto Renth , Werner Traunecker
发明人： Kurt Schromm , Anton Mentrup , Ernst-Otto Renth , Werner Traunecker
IPC分类号： C07C229/38 , C07C275/24 , C07D215/26 , C07D215/32 , C07C91/16
CPC分类号： C07D215/26 , C07C229/38 , C07C275/24 , C07D215/32 , Y02P20/55
摘要： Compounds of the formula ##STR1## WHEREIN R.sub.1 is hydrogen or methyl, m is 0 or an integer from 1 to 8, inclusive, andAr is ##STR2## WHERE R is hydrogen or acyl, andR.sub.2 is hydrogen or --OR, as defined above, ##STR3## WHERE R has the meanings defined above, andR.sub.3 is hydroxy-lower alkyl, --NH--CO--R.sub.4, --NH--SO.sub.2 --R.sub.5, --CH.sub.2 --NH--CO--R.sub.4, --CH.sub.2 --NH--SO.sub.2 --R.sub.5 or --CH.sub.2 --NH--CO--NH--R.sub.4, whereR.sub.4 is hydrogen or lower alkyl, andR.sub.5 is lower alkyl or di-lower alkyl-amino, ##STR4## WHERE R.sub.6 is hydrogen, amino or hydroxyl,X is chlorine or bromine, andY is hydrogen, chlorine or bromine or ##STR5## WHERE R has the meanings defined above, andA is a saturated or unsaturated 5- to 6-membered ring,And their non-toxic, pharmacologically acceptable acid addition salts; the compounds as well as their salts are useful as bronchospasmolytics, uterine spasmolytics, antipruritics and antiallergics.
摘要翻译：式（Ⅰ）化合物其中R 1为氢或甲基，M为0或整数1至8，包含和Ar为（a）R为氢或酰基，R 2为氢或-OR，如上所定义，（b）其中R具有上述定义，并且R 3是羟基 - 低级烷基，-NH-CO-R 4，-NH-SO 2 -R 5，-CH 2 -NH-CO -R4，-CH2-NH-SO2-R5或-CH2-NH-CO-NH-R4，其中R4是氢或低级烷基，R5是低级烷基或二 - 低级烷基 - 氨基，（c）其中R6是氢，氨基或羟基，X是氯或溴，Y是氢，氯或溴。（d）其中R具有上述定义，A是饱和或不饱和的5-至6- 及其非毒性，药理学上可接受的酸添加剂; 化合物作为其作为BRONCHOSPASMOLYTICS，UTERINE SPASMOLYTICS，ANTIPRITICS和ANTIALLERGICS的有用的化合物。

8. 发明授权

US5223614A New quaternary ammonium compounds, their preparation and use 失效
标题翻译：新季铵化合物，其制备和用途
公开(公告)号：US5223614A
公开(公告)日：1993-06-29
申请号：US603585
申请日：1990-10-25
申请人： Kurt Schromm , Anton Mentrup , Ernst-Otto Renth , Gojko Mualcevic , Werner Traunecker
发明人： Kurt Schromm , Anton Mentrup , Ernst-Otto Renth , Gojko Mualcevic , Werner Traunecker
IPC分类号： C07C217/60 , C07C237/10 , C07C309/14 , C07D213/20 , C07D213/38 , C07D265/36 , C07D413/12 , C07D521/00
CPC分类号： C07D213/20 , C07C217/60 , C07C237/10 , C07C309/14 , C07D213/38 , C07D231/12 , C07D233/56 , C07D249/08 , C07D265/36 , C07D413/12
摘要： Compounds of formula ##STR1## wherein the substituents are defined hereinbelow, useful in the treatment of bronchospasm are described.
摘要翻译：描述了其中下文定义的取代基用于治疗支气管痉挛的式（I）的化合物。

9. 发明授权

US4146645A Hypertensive phenylalkylamines and salts thereof 失效
标题翻译：高效苯丙氨酸及其盐
公开(公告)号：US4146645A
公开(公告)日：1979-03-27
申请号：US761476
申请日：1977-01-24
申请人： Kurt Schromm , Anton Mentrup , Ernst-Otto Renth , Ludwig Pichler , Werner Traunecker
发明人： Kurt Schromm , Anton Mentrup , Ernst-Otto Renth , Ludwig Pichler , Werner Traunecker
IPC分类号： C07C275/40 , A61K31/17 , C07C127/00
CPC分类号： C07C275/40
摘要： Compounds of the formula ##STR1## wherein R.sub.1 is hydrogen, --(CH.sub.2).sub.n --R.sub.4 or --CO--R.sub.5,where n is 1 or 2,R.sub.4 is hydrogen, cyano or benzoyl, andR.sub.5 is hydrogen, lower alkoxy, benzyloxy, --CH.sub.2 --NH.sub.2, --CH(CH.sub.3)--NH.sub.2, --CH.sub.2 --NH--CH.sub.2 --C.sub.6 H.sub.5 or --CH(CH.sub.3)--NH--CH.sub.2 --C.sub.6 H.sub.5,R.sub.2 is hydrogen or methyl, andR.sub.3 is amino, nitro, --NH--CO--R.sub.6 or --NH--A--R.sub.7,where R.sub.6 is hydrogen, methyl, methoxy, ethoxy, methylthio or ethylthio,R.sub.7 is amino, methylamino or dimethylamino, andA is --CO-- or --SO.sub.2 --,provided, however, that R.sub.1 and R.sub.4 are other than hydrogen and R.sub.2 is other than hydrogen or methyl when R.sub.6 is hydrogen or methyl, and non-toxic, pharmacologically acceptable acid addition salts thereof; the compounds as well as their salts are useful as hypertensives.

10. 发明授权

US4038314A 1-Hydroxy-1-[(4'-hydroxy-3'aminosulfonamido)-phenyl]-2-amino-ethanes and salts 失效
标题翻译： 1-羟基-1 - （（4'-羟基-3'-氨基甲酰氨基） - 苯基）-2-氨基 - 乙酸和盐
公开(公告)号：US4038314A
公开(公告)日：1977-07-26
申请号：US453438
申请日：1974-03-21
申请人： Anton Mentrup , Kurt Schromm , Ernst-Otto Renth , Werner Traunecker
发明人： Anton Mentrup , Kurt Schromm , Ernst-Otto Renth , Werner Traunecker
IPC分类号： A61K31/18 , A61P9/00 , A61P9/08 , A61P11/08 , C07C67/00 , C07C301/00 , C07C303/34 , C07C307/10 , C07D207/40 , C07D295/22 , C07D295/26 , C07D473/08 , C07C143/80
CPC分类号： C07D207/40 , C07D295/26 , C07D473/08 , Y10S514/929
摘要： Compounds of the formula ##STR1## wherein R.sub.1 is hydrogen or methyl, and R.sub.2 is phenoxy-(alkyl of 2 to 3 carbon atoms), phenyl-(alkyl of 4 to 5 carbon atoms), hydroxyphenyl-(alkyl of 3 to 5 carbon atoms), or naphthyl-(alkyl of 4 to 5 carbon atoms);And their non-toxic, pharmacologically acceptable acid additions salts; the compounds as well as the salts are useful as dilators of the peripheral blood vessels, as cardiotonics and as broncholytics.

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