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1. 发明授权

US4100282A N-Aryl-N'-(phenyl- or phenoxy-alkyl)-piperazines and salts thereof 失效
标题翻译： N-芳基-N {40-（苯基 - 或苯氧基 - 烷基） - 哌嗪及其盐
公开(公告)号：US4100282A
公开(公告)日：1978-07-11
申请号：US793736
申请日：1977-05-04
申请人： Ernst-Otto Renth , Anton Mentrup , Kurt Schromm , Peter Danneberg
发明人： Ernst-Otto Renth , Anton Mentrup , Kurt Schromm , Peter Danneberg
IPC分类号： A61K31/495 , C07D207/26 , C07D207/27 , C07D279/02
CPC分类号： C07D207/27 , A61K31/495
摘要： Compounds of the formula ##STR1## wherein R is phenyl; phenyl having one or two substituents attached thereto, said substituents being selected from the group consisting of alkyl of 1 to 4 carbon atoms, alkoxy of 1 to 4 carbon atoms, alkylthio of 1 to 4 carbon atoms, chlorine and trifluoromethyl; naphthyl; tetrahydronaphthyl; indanyl; pyridyl; isoquinolyl; or thiazolyl;R.sub.1 is ##STR2## where R.sub.3 is hydrogen, alkyl of 1 to 4 carbon atoms,R.sub.4 and R.sub.5 are each hydrogen or alkyl of 1 to 4 carbon atoms, andQ is oxygen or two hydrogens,R.sub.2 is hydrogen, alkyl of 1 to 4 carbon atoms, alkoxy of 1 to 4 carbon atoms or halogen,A is a single carbon-to-carbon bond or --OCH.sub.2 --,R.sub.6 is hydrogen, hydroxyl, alkoxy of 1 to 4 carbon atoms or alkanoyloxy of 1 to 4 carbon atoms, andm is 0, 1, 2, 3, 4 or 5, but other than 0 when R.sub.6 is hydroxyl,And non-toxic, pharmacologically acceptable acid addition salts thereof; the compounds as well as their salts are useful as CNS-depressants, adrenolytics, antiphlogistics, analgesics, antihistaminics and anticholesteremics.
摘要翻译：其中R是苯基的式“IMAGE”的化合物; 所述取代基选自1至4个碳原子的烷基，1至4个碳原子的烷氧基，1至4个碳原子的烷硫基，氯和三氟甲基; 萘基; 四氢萘基; 茚满基吡啶基异喹啉基或噻唑基; R1是，其中R3是氢，1-4个碳原子的烷基，R4和R5分别是氢或1-4个碳原子的烷基，Q是氧或两个氢，R2是氢，1-4个碳原子数为1〜4的烷氧基或卤素，A为单碳 - 碳键或-OCH2-，R6为氢，羟基，1〜4个碳原子的烷氧基或1〜4个碳原子的烷酰氧基，并且M IS为0,1,2,3,4或5，但当R6为羟基时为0以及非毒性，药理学上可接受的酸添加量; 化合物作为它们的有效作为CNS抑制剂，肾上腺素，消炎药，镇痛药，抗组胺药和抗胆碱血症有用。

2. 发明授权

US3992537A Pharmaceutical compositions containing an N-phenyl-imidazolidine-2-one and method of use 失效
标题翻译：含有N-苯基 - 咪唑烷-2-酮的药物组合物及其使用方法
公开(公告)号：US3992537A
公开(公告)日：1976-11-16
申请号：US636738
申请日：1975-12-01
申请人： Anton Mentrup , Ernst-Otto Renth , Kurt Schromm , Peter Danneberg
发明人： Anton Mentrup , Ernst-Otto Renth , Kurt Schromm , Peter Danneberg
IPC分类号： A61K31/495 , C07D401/14 , C07D403/10
CPC分类号： C07D401/14 , A61K31/495 , C07D403/10
摘要： Pharmaceutical compositions containing as an active ingredient a compound of the formula ##SPC1##Wherein R' is in the m- or p-position and is selected from the group consisting of--CH.sub.2 --A, --CHR.sub.1 --CH.sub.2 --Aand ##EQU1## where R.sub.1 is hydrogen or hydroxyl, andA is ##SPC2##WhereR.sub.3 is hydrogen, chlorine, methyl, ethyl, trifluoromethyl or lower alkoxy, andR.sub.4 is hydrogen or methyl, orR.sub.3 and R.sub.4, together with each other and neighboring carbon atoms of the phenyl ring to which they are attached, are naphthyl,Or a non-toxic, pharmacologically acceptable acid addition salt thereof; and a method of using the same as CNS-depressants, neuroleptics and anticholesteremics.
摘要翻译：含有式+ q，10的化合物作为活性成分的药物组合物在m-或p-位，并且选自-CH2-A，-CHR1-CH2-A和-CHR1 -CH-A，| CH3，其中R1是氢或羟基，A是+ q，12，其中R3是氢，氯，甲基，乙基，三氟甲基或低级烷氧基，R4是氢或甲基，或R3和R4一起与它们所连接的苯环的彼此和相邻的碳原子是萘基，或非毒性，药理学上可接受的酸加成盐; 和使用它们作为CNS抑制剂，精神安定药和抗胆固醇药的方法。

3. 发明授权

US4136185A N-Aryl-N'-(phenyl-or phenoxy-alkyl)-piperazines and salts thereof 失效
标题翻译： N-ARYL-N“ - （苯基或苯甲基） - 哌嗪及其盐
公开(公告)号：US4136185A
公开(公告)日：1979-01-23
申请号：US886634
申请日：1978-03-15
申请人： Ernst-Otto Renth , Anton Mentrup , Kurt Schromm , Peter Danneberg
发明人： Ernst-Otto Renth , Anton Mentrup , Kurt Schromm , Peter Danneberg
IPC分类号： A61K31/495 , C07D207/26 , C07D207/27 , A61K31/505 , C07D403/10
CPC分类号： C07D207/27 , A61K31/495
摘要： Compounds of the formula ##STR1## wherein R is phenyl; phenyl having one or two substituents attached thereto, said substituents being selected from the group consisting of alkyl of 1 to 4 carbon atoms, alkoxy of 1 to 4 carbon atoms, alkylthio of 1 to 4 carbon atoms, chlorine and trifluoromethyl; naphthyl; tetrahydronaphthyl; indanyl; pyridyl; isoquinolyl; or thiazolyl;R.sub.3 is hydrogen, alkyl of 1 to 4 carbon atoms;R.sub.4 and R.sub.5 are each hydrogen or alkyl of 1 to 4 carbon atoms;Q is oxygen or two hydrogens;R.sub.2 is hydrogen, alkyl of 1 to 4 carbon atoms; alkoxy of 1 to 4 carbon atoms or halogen;A is a single carbon-to-carbon bond or --OCH.sub.2 --;R.sub.6 is hydrogen, hydroxyl, alkoxy of 1 to 4 carbon atoms or alkanolyloxy of 1 to 4 carbon atoms, andM is 0, 1, 2, 3, 4 or 5, but other than O when R.sub.6 is hydroxyl,And non-toxic, pharmacologically acceptable acid addition salts thereof; the compounds as well as their salts are useful as CNS-depressants, adrenolytics, antiphlogistics, analgesics, antihistaminics and antihypercholesteremics.

4. 发明授权

US4038279A N-aryl-N'-(phenyl-or phenoxy-alkyl)-piperazines and salts thereof 失效
标题翻译： N-芳基-N' - （苯基或苯氧基） - 哌嗪及其盐
公开(公告)号：US4038279A
公开(公告)日：1977-07-26
申请号：US636734
申请日：1975-12-01
申请人： Ernst-Otto Renth , Anton Mentrup , Kurt Schromm , Peter Danneberg
发明人： Ernst-Otto Renth , Anton Mentrup , Kurt Schromm , Peter Danneberg
IPC分类号： A61K31/495 , C07D207/26 , C07D207/27 , C07D401/14
CPC分类号： C07D207/27 , A61K31/495
摘要： Compounds of the formula ##STR1## wherein R is phenyl; phenyl having one or two substituents attached thereto, said substituents being selected from the group consisting of alkyl of 1 to 4 carbon atoms, alkoxy of 1 to 4 carbon atoms, alkylthio of 1 to 4 carbon atoms, chlorine and trifluoromethyl; naphthyl; tetrahydronaphthyl; indanyl; pyridyl; isoquinolyl; or thiazolyl;R.sub.1 is ##STR2## where B is ##STR3## or ##STR4## R.sub.3 is hydrogen, alkyl of 1 to 4 carbon atoms, R.sub.4 and R.sub.5 are each hydrogen or alkyl of 1 to 4 carbon atoms, andQ is oxygen or two hydrogens,R.sub.2 is hydrogen, alkyl of 1 to 4 carbon atoms, alkoxy of 1 to 4 carbon atoms or halogen,A is a single carbon-to-carbon bond or --OCH.sub.2 --,R.sub.6 is hydrogen, hydroxyl, alkoxy of 1 to 4 carbon atoms or alkanoyloxy of 1 to 4 carbon atoms, andm is 0, 1, 2, 3, 4 or 5, but other than 0 when R.sub.6 is hydroxyl,And non-toxic, pharmacologically acceptable acid addition salts thereof; the compounds as well as their salts are useful as CNS-depressants, adrenolytics, antiphologistics, analgesics, antihistaminic and anticholesteremics.

5. 发明授权

US3941789A N-Aryl-N'-(phenyl-or phenoxy-alkyl)-piperazines and salts thereof 失效
标题翻译： N-芳基-N {40-（苯基 - 或苯氧基 - 烷基） - 哌嗪及其盐
公开(公告)号：US3941789A
公开(公告)日：1976-03-02
申请号：US427367
申请日：1973-12-21
申请人： Ernst-Otto Renth , Anton Mentrup , Kurt Schromm , Peter Danneberg
发明人： Ernst-Otto Renth , Anton Mentrup , Kurt Schromm , Peter Danneberg
IPC分类号： C07D233/72 , A61K31/415 , A61K31/4166 , A61K31/495 , A61K31/505 , A61K33/44 , A61P3/06 , A61P9/02 , A61P9/12 , A61P11/00 , A61P11/08 , A61P25/00 , A61P25/02 , A61P25/04 , A61P25/20 , A61P29/00 , A61P43/00 , C07D207/26 , C07D207/27 , C07D211/76 , C07D239/10 , C07D275/02 , C07D279/02 , C07D295/092 , C07D295/135 , C07D401/12 , C07D403/12 , C07D417/12 , C07D241/02
CPC分类号： C07D207/27 , A61K31/495 , C07D295/088 , C07D295/135
摘要： Compounds of the formula ##EQU1## wherein R is phenyl; phenyl having one or more substituents attached thereto, said substituents being selected from the group consisting of alkyl of 1 to 4 carbon atoms, alkoxy of 1 to 4 carbon atoms, alkylthio of 1 to 4 carbon atoms, halogen and trifluoromethyl; a bicyclic aromatic or cycloaliphatic-aromatic ring, especially naphthyl, tetrahydronaphthyl or indanyl; or a mono- or bicyclic heterocyclic ring, especially pyridyl, pyrimidyl, isoquinolyl or thiazolyl;R.sub.1 is ##EQU2## where B is ##EQU3## n is 2, 3 or 4, R.sub.3 is hydrogen, alkyl of 1 to 4 carbon atoms or alkanoyl of 1 to 4 carbon atoms,R.sub.4 and R.sub.5, which may be identical to or different from each other, are each hydrogen or alkyl of 1 to 4 carbon atoms,p is 0 or 1, andQ is oxygen or two hydrogens,R.sub.2 is hydrogen, alkyl of 1 to 4 carbon atoms, alkoxy of 1 to 4 carbon atoms or halogen,A is a single carbon-to-carbon bond or --OCH.sub.2 --,R.sub.6 is hydrogen, hydroxyl, alkoxy of 1 to 4 carbon atoms or alkanoyloxy of 1 to 4 carbon atoms, andm is 0, 1, 2, 3, 4 or 5, but other than 0 when R.sub.6 is hydroxyl,And non-toxic, pharmacologically acceptable acid addition salts thereof; the compounds as well as their salts are useful as CNS-depressants, adrenolytics, antiphologistics, analgesics, antihistamines and anticholesterols.
摘要翻译：式A-CH-CmH2m-NN-R | R6的化合物，其中R是苯基; 具有一个或多个取代基的苯基，所述取代基选自1至4个碳原子的烷基，1至4个碳原子的烷氧基，1至4个碳原子的烷硫基，卤素和三氟甲基; 双环芳族或脂环族芳族环，特别是萘基，四氢萘基或茚满基; 或单环或双环杂环，特别是吡啶基，嘧啶基，异喹啉基或噻唑基; R 1（CH 2）p R 4角度-N（CH 2）n或Q = CR 5 ANGLE || B -NN-R3角度C平行O其中B为O O平行角-C-或-S-，n为2,3或 4，R3为氢，1〜4个碳原子的烷基或1〜4个碳原子的烷酰基，R4和R5可以相同或不同，分别为氢或1-4个碳原子的烷基，P IS 0 OR 1，Q为氧或两个氢，R 2为氢，1至4个碳原子的烷基，1至4个碳原子的烷氧基或卤素，A为单个碳 - 碳键或-OCH 2 - R6为氢，羟基，1〜4个碳原子的烷氧基或1〜4个碳原子的烷酰氧基，M为0,1,2,3,4或5，但当R6为羟基时，为0以及非毒性其药理学可接受的酸添加剂; 化合物作为它们的有效成分可用作CNS抑制剂，肾上腺素，抗病毒药物，镇痛药，抗组胺药和抗胆固醇。

6. 发明授权

US4000274A Pharmaceutical compositions containing an N-aryl-N'-(phenyl-or-phenoxy-alkyl)-piperazine and method of use 失效
标题翻译：含有N-亚芳基-N' - （苯基 - 邻 - 甲基） - 哌嗪的药物组合物及其使用方法
公开(公告)号：US4000274A
公开(公告)日：1976-12-28
申请号：US636739
申请日：1975-12-01
申请人： Ernst-Otto Renth , Anton Mentrup , Kurt Schromm , Peter Danneberg
发明人： Ernst-Otto Renth , Anton Mentrup , Kurt Schromm , Peter Danneberg
IPC分类号： A61K31/495
CPC分类号： A61K31/495
摘要： Pharmaceutical compositions containing as an active ingredient a racemic or optically active compound of the formula ##STR1## wherein R is phenyl; phenyl having one or two substituents attached thereto, said substituents being selected from the group consisting of alkyl of 1 to 4 carbon atoms, alkoxy of 1 to 4 carbon atoms, alkyl-thio of 1 to four carbon atoms, chlorine and trifluoromethyl; naphthyl; tetrahydronaphthyl; indanyl; pyridyl; thiazolyl; or isoquinolyl;R.sub. 1 is ##STR2## where B is ##STR3## n is 2 or 3, R.sub.3 is hydrogen, alkyl of 1 to 4 carbon atoms,R.sub.4 and R.sub.5 are each hydrogen or alkyl of 1 to 4 carbon atoms, andQ is oxygen or two hydrogensR.sub.2 is hydrogen, alkyl of 1 to 4 carbon atoms, alkoxy of 1 to 4 carbon atoms or halogen,A is a single carbon-to-carbon bond or --OCH.sub.2 --,R.sub.6 is hydrogen, hydroxyl, alkoxy of 1 to 4 carbon atoms or alkanoyloxy of 1 to 4 carbon atoms, andm is 0, 1, 2, 3, 4 or 5, but other than 0 when R.sub.6 is hydroxyl,Or a non-toxic, pharmacologically acceptable acid addition salt thereof; and a method of using the same as CNS-depressants, adrenolytics, antiphlogistics, analgesics, antihistaminics and anticholesteremics.

7. 发明授权

US3975525A N-[4'-Imidazolidinon-(2)-yl-phenethyl]-N'-pyridyl-piperazines and salts thereof 失效
标题翻译： N- {8-4 {40-咪唑啉酮 - （2） - 基 - 苯乙基{9 -N {40-吡啶基 - 哌嗪及其盐
公开(公告)号：US3975525A
公开(公告)日：1976-08-17
申请号：US636740
申请日：1975-12-01
申请人： Anton Mentrup , Ernst-Otto Renth , Kurt Schromm , Peter Danneberg
发明人： Anton Mentrup , Ernst-Otto Renth , Kurt Schromm , Peter Danneberg
IPC分类号： A61K31/495 , C07D401/14 , C07D403/10
CPC分类号： C07D401/14 , A61K31/495 , C07D403/10
摘要： Compounds of the formula ##SPC1##Wherein R.sub.1 is hydrogen or hydroxyl, and Py is pyridyl,And non-toxic, pharmacologically acceptable acid addition salts thereof; the compounds as well as the salts are useful as CNS-depressants, neuroleptics and anti-cholesteremics.
摘要翻译：式WHEREIN R1的化合物是氢或羟基，Py是吡啶基，和非毒性，药理学上可接受的酸加法盐; 作为销售的化合物可用作CNS抑制剂，精神安定药和抗胆汁淤积症。

8. 发明授权

US3937708A N-phenyl-imidazolidine-1-ones 失效
标题翻译： N-苯基咪唑烷-1-酮
公开(公告)号：US3937708A
公开(公告)日：1976-02-10
申请号：US440823
申请日：1974-02-08
申请人： Anton Mentrup , Ernst-Otto Renth , Kurt Schromm , Peter Danneberg
发明人： Anton Mentrup , Ernst-Otto Renth , Kurt Schromm , Peter Danneberg
IPC分类号： A61K31/495 , C07D295/073 , C07D295/108 , C07D295/135 , C07D401/14 , C07D403/10 , C07D295/12
CPC分类号： C07D295/073 , A61K31/495 , C07D295/108 , C07D295/135 , C07D401/14 , C07D403/10
摘要： Compounds of the formula ##SPC1##WhereinR is hydrogen, halogen, lower alkyl or lower alkoxy,R' is --CHR.sub.1 --Q--A, --CHR.sub.2 --A or --O--CHR.sub.2 --CHR.sub.1 --Q--A, each in m- or p-position,WhereA is ##SPC2##Q is straight or branched alkylene of 1 to 4 carbon atoms,R.sub.1 is hydrogen, hydroxyl, lower alkoxy or --O--CO--R.sub.5,R.sub.2 is hydrogen or methyl,R.sub.3 and R.sub.4, which may be identical to or different from each other, are each hydrogen, lower alkyl, lower alkoxy, halogen, trifluoromethyl or, together with each other and neighboring carbon atoms of the phenyl ring to which they are attached, form a saturated or unsaturated carbocyclic 5- to 6-membered ring,R.sub.5 is lower alkyl, halo-lower alkyl, hydroxy-lower alkyl, lower alkoxy-lower alkyl, amino, (mono-lower alkyl)-amino or (di-lower alkyl)-amino,Z is an aromatic heterocyclic ring with one to two heteroatoms, which may optionally be condensed with a benzene ring, andR" is hydrogen, straight or branched lower alkyl, lower alkenyl, lower alkynyl, hydroxy-lower alkyl, (di-lower alkyl)-amino-lower alkyl or aralkyl,And their non-toxic, pharmacologically acceptable acid addition salts; the compounds as well as their salts are useful as CNS-depressants, neuroleptics, analgesics, antiphlogistics, spasmolytics, broncholytics, hypotensives and anti-cholesteremics.

9. 发明授权

US4581367A 1-phenyl-2-(heterocyclyl-alkyl-amino)-ethanols 失效
标题翻译： 1-苯基-2-（杂环基 - 烷基 - 氨基） - 乙醇
公开(公告)号：US4581367A
公开(公告)日：1986-04-08
申请号：US443912
申请日：1982-11-23
申请人： Kurt Schromm , Anton Mentrup , Ernst-Otto Renth , Armin Fugner , Ilse Streller
发明人： Kurt Schromm , Anton Mentrup , Ernst-Otto Renth , Armin Fugner , Ilse Streller
IPC分类号： A61K31/41 , A61K31/415 , A61K31/4166 , A61K31/4184 , A61K31/42 , A61K31/496 , A61K31/505 , A61K31/517 , A61K31/535 , A61K31/5355 , A61P1/04 , A61P1/06 , A61P9/00 , A61P9/06 , A61P9/12 , A61P11/00 , A61P11/08 , A61P13/02 , A61P15/00 , A61P25/24 , A61P25/26 , A61P27/02 , A61P27/14 , A61P37/08 , C07D233/36 , C07D233/54 , C07D233/58 , C07D233/61 , C07D235/06 , C07D235/08 , C07D235/18 , C07D239/88 , C07D239/90 , C07D239/96 , C07D249/18 , C07D413/12 , C07D521/00 , C07D235/00
CPC分类号： C07D233/64 , C07D231/12 , C07D233/36 , C07D233/56 , C07D235/06 , C07D235/08 , C07D235/18 , C07D239/88 , C07D239/96 , C07D249/08 , C07D249/18 , Y10S514/821 , Y10S514/826 , Y10S514/849 , Y10S514/906 , Y10S514/914
摘要： Compounds of the formula whereinHet is a heterocycle;n is an integer from 1 to 4, inclusive, preferably 2 or 3;R.sub.1 is H or acyl;R.sub.2 is H, R.sub.1 O, --NHSO.sub.2 R.sub.7, --NHCOR.sub.8, --NHCONHR.sub.8, --NH--CH.sub.2 --C.sub.6 H.sub.4 --R.sub.9, --CH.sub.2 OH, --CH.sub.2 SO.sub.2 R.sub.7, --CONHR.sub.8, halogen or --CN;R.sub.3 is H, halogen, R.sub.7 or --OR.sub.7 ; orR.sub.2 and R.sub.3, together with each other, are ##STR1## N.sub.4 is H, --CH.sub.3 or --C.sub.2 H.sub.5 ; R.sub.5 and R.sub.6 are each H or --CH.sub.3 ;R.sub.7 is C.sub.1 -C.sub.4 alkyl;R.sub.8 is H or C.sub.1 -C.sub.4 alkyl; andR.sub.9 is H, C.sub.1 -C.sub.4 alkyl or C.sub.1 -C.sub.4 alkoxy optionally interrupted by oxygen;and non-toxic, pharmacologically acceptable acid addition salts thereof. The compounds as well as the salts are useful as bronchospasmolytics, spasmolytics, muscle-relaxants, antiallergics and hypotensives.
摘要翻译：其中Het是杂环的式“IMAGE”的化合物; n为1〜4的整数，优选为2或3; R1是H或酰基; R2是H，R1O，-NHSO2R7，-NHCOR8，-NHCONHR8，-NH-CH2-C6H4-R9，-CH2OH，-CH2SO2R7，-CONHR8，卤素或-CN; R3是H，卤素，R7或-OR7; 或R 2和R 3彼此一起是H，-CH 3或-C 2 H 5; R5和R6各自为H或-CH3; R7是C1-C4烷基; R8是H或C1-C4烷基; 并且R 9为H，任选被氧中断的C 1 -C 4烷基或C 1 -C 4烷氧基; 和无毒的，药学上可接受的酸加成盐。化合物和盐可用作支气管解痉药，解痉药，肌肉松弛剂，抗过敏药和低血压药。

10. 发明授权

US4647563A Heterocyclic compounds 失效
标题翻译：杂环化合物
公开(公告)号：US4647563A
公开(公告)日：1987-03-03
申请号：US806692
申请日：1985-12-09
申请人： Kurt Schromm , Anton Mentrup , Ernst-Otto Renth , Armin Fugner , Ilse Streller
发明人： Kurt Schromm , Anton Mentrup , Ernst-Otto Renth , Armin Fugner , Ilse Streller
IPC分类号： A61K31/41 , A61K31/415 , A61K31/4166 , A61K31/4184 , A61K31/42 , A61K31/496 , A61K31/505 , A61K31/517 , A61K31/535 , A61K31/5355 , A61P1/04 , A61P1/06 , A61P9/00 , A61P9/06 , A61P9/12 , A61P11/00 , A61P11/08 , A61P13/02 , A61P15/00 , A61P25/24 , A61P25/26 , A61P27/02 , A61P27/14 , A61P37/08 , C07D233/36 , C07D233/54 , C07D233/58 , C07D233/61 , C07D235/06 , C07D235/08 , C07D235/18 , C07D239/88 , C07D239/90 , C07D239/96 , C07D249/18 , C07D413/12 , C07D521/00
CPC分类号： C07D233/64 , C07D231/12 , C07D233/36 , C07D233/56 , C07D235/06 , C07D235/08 , C07D235/18 , C07D239/88 , C07D239/96 , C07D249/08 , C07D249/18 , Y10S514/821 , Y10S514/826 , Y10S514/849 , Y10S514/906 , Y10S514/914
摘要： Compounds of the formula ##STR1## wherein Het is ##STR2## n is an integer from 1 to 4, inclusive, preferably 2 or 3, R.sub.1 is H or acyl,R.sub.2 is H, R.sub.1 O, --NHSO.sub.2 R.sub.7, --NHCOR.sub.8, --NHCONHR.sub.8, --NH--CH.sub.2 --C.sub.6 H.sub.4 --R.sub.9, --CH.sub.2 OH, --CH.sub.2 SO.sub.2 R.sub.7, --CONHR.sub.8, halogen or --CN,R.sub.3 is H, halogen, R.sub.7 or --OR.sub.7,R.sub.2 and R.sub.3 together with each other are ##STR3## R.sub.4 is H, --CH.sub.3 or --C.sub.2 H.sub.5, R.sub.5 and R.sub.6 are each H or --CH.sub.3,R.sub.7 is C.sub.1 -C.sub.4 alkyl,R.sub.8 is H or C.sub.1 -C.sub.4 alkyl,R.sub.9 is H, C.sub.1 -C.sub.4 alkyl or C.sub.1 -C.sub.4 alkoxy optionally interrupted by oxygen,R.sub.10 and R.sub.12 are each H, CH.sub.3, Cl or OCH.sub.3, or together methylenedioxy,X is ##STR4## or N, and Z is --CH.sub.2 or --CO;in the form of racemates, enantiomers, diastereoisomeric antipode pairs, and non-toxic, pharmacologically acceptable acid addition salts thereof. The compounds as well as the salts are useful as bronchospasmolytics, spasmolytics, muscle-relaxants, antiallergics and hypotensives.
摘要翻译：其中Het为+4 的化合物，n为1〜4的整数，优选2或3，R 1为H或酰基，R 2为H，R 10，-NHSO 2 R 7， NHCOR 8，-NHCONHR 8，-NH-CH 2 -C 6 H 4 -R 9，-CH 2 OH，-CH 2 SO 2 R 7，-CONHR 8，卤素或-CN，R 3是H，卤素，R 7或-OR 7，R 2和R 3彼此是 R4是H，-CH3或-C2H5，R5和R6分别是H或-CH3，R7是C1-C4烷基，R8是H或C1-C4烷基，R9是H，C1-C4烷基或C1-C4烷氧基被氧中断，R 10和R 12各自为H，CH 3，Cl或OCH 3，或一起亚甲二氧基，X为或N，Z为-CH 2或-CO; 以外消旋物，对映异构体，非对映异构体对映体对及其无毒的药学上可接受的酸加成盐的形式存在。化合物和盐可用作支气管解痉药，解痉药，肌肉松弛剂，抗过敏药和低血压药。

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