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1. 发明授权

US5499967A Transdermal drug delivery device with waveshape generator 失效
标题翻译：具有波形发生器的透皮药物输送装置
公开(公告)号：US5499967A
公开(公告)日：1996-03-19
申请号：US181078
申请日：1994-01-13
申请人： Eric Teillaud , Bruno Bevan , Claude Mikler , Paul Reilly , Philippe Millot
发明人： Eric Teillaud , Bruno Bevan , Claude Mikler , Paul Reilly , Philippe Millot
IPC分类号： A61N1/32 , A61N1/37 , G05F1/46 , H02M3/157 , A61N1/30
CPC分类号： G05F1/468 , A61N1/325 , A61N1/37 , H02M3/157
摘要： The device comprises a switched-mode power supply (1) equipped with an electronic switching member (T.sub.1), the closing of which controls the power supply to an inductor (L.sub.1) which discharges, when the member reopens, into a capacitor (C.sub.1) at the terminals of which the output voltage of the device appears, characterized in that it comprises (a) storage means for recording a sequence of image numbers of successive segments of the predetermined waveform, (b) a clocked digital counter (2) and (c) means (3) for successively loading this counter (2) with each of the numbers of this sequence considered as a bound of the count performed by the counter (2), the latter cyclically controlling the closing of the switching member (T.sub.1) for a predetermined time interval, each time the count performed reaches the limit thus fixed.
摘要翻译：该装置包括配备有电子开关元件（T1）的开关电源（1），其关闭控制向电感器（L1）的电源，当电容器重新开启时，电感器（L1）放电到电容器（C1）中，在其端子处出现输出电压，其特征在于它包括：（a）用于记录预定波形的连续段的图像序列序列的存储装置，（b）时钟数字计数器（2）和（ c）用于连续加载该计数器（2）的装置（3），其中该序列的每个编号被认为是由计数器（2）执行的计数的边界，后者循环地控制切换构件（T1）的关闭，每次执行的计数达到如此固定的极限时，预定的时间间隔。

2. 发明授权

US5426387A Device for generating an electrical voltage of predetermined waveform, iontophoresis apparatus for transdermally administering medicinal products and electrical stimulation apparatus, which apparatuses are equipped with such a device 失效
标题翻译：用于产生预定波形的电压的装置，用于经皮给药药物的离子电渗疗法和电刺激装置，所述装置装备有这种装置
公开(公告)号：US5426387A
公开(公告)日：1995-06-20
申请号：US16269
申请日：1993-02-11
申请人： Eric Teillaud , Bruno Bevan , Claude Mikler , Paul Reilly
发明人： Eric Teillaud , Bruno Bevan , Claude Mikler , Paul Reilly
IPC分类号： A61N1/30 , A61N1/32 , A61N1/37 , G05F1/46 , H02M3/155 , H02M3/157 , H03K4/92 , H03K4/02
CPC分类号： G05F1/468 , A61N1/325 , A61N1/37 , H02M3/157
摘要： The device comprises a switched-mode power supply (1) equipped with an electronic switching member (T.sub.1), the closing of which controls the power supply to an inductor (L.sub.1) which discharges, when the member reopens, into a capacitor (C.sub.1) at the terminals of which the output voltage of the device appears, characterized in that it comprises (a) storage means for recording a sequence of image numbers of successive segments of the predetermined waveform, (b) a clocked digital counter (2) and (c) means (3) for successively loading this counter (2) with each of the numbers of this sequence considered as a bound of the count performed by the counter (2), the latter cyclically controlling the closing of the switching member (T.sub.1) for a predetermined time interval, each time the count performed reaches the limit thus fixed.
摘要翻译：该装置包括配备有电子开关元件（T1）的开关电源（1），其关闭控制向电感器（L1）的电源，当电容器重新开启时，电感器（L1）放电到电容器（C1）中，在其端子处出现输出电压，其特征在于它包括：（a）用于记录预定波形的连续段的图像序列序列的存储装置，（b）时钟数字计数器（2）和（ c）用于连续加载该计数器（2）的装置（3），其中该序列的每个编号被认为是由计数器（2）执行的计数的边界，后者循环地控制切换构件（T1）的关闭，每次执行的计数达到如此固定的极限时，预定的时间间隔。

3. 发明授权

US4837025A Self-adhesive device for the percutaneous administration of an active ingredient 失效
标题翻译：用于经皮给药活性成分的自粘装置
公开(公告)号：US4837025A
公开(公告)日：1989-06-06
申请号：US247852
申请日：1988-09-22
申请人： Alain Guillemet , Eric Teillaud , Philippe Reginault , Bruno Bevan
发明人： Alain Guillemet , Eric Teillaud , Philippe Reginault , Bruno Bevan
IPC分类号： A61K9/00 , A61K9/70 , A61K47/00
CPC分类号： A61K9/0014 , A61K9/7053
摘要： The present invention relates to a novel self-adhesive matrix for the percutaneous administration of a pharmaceutical active ingredient. This matrix comprises a combination of the following:(a) 30 to 50 parts by weight of an ethylene/vinyl acetate copolymer material,(b) 20 to 45 parts by weight of a higher aliphatic monoalcohol compound,(c) 5 to 20 parts by weight of a cellulose derivative material,(d) 1 to 20 parts by weight of an ester compound of a polyhydric alcohol with a fatty aliphatic acid, and(e) 0.1 to 20 parts by weight of an active ingredient which can be administered percutaneously.
摘要翻译：本发明涉及用于经皮给药药用活性成分的新型自粘基质。该基质包括以下组合：（a）30至50重量份的乙烯/乙酸乙烯酯共聚物材料，（b）20至45重量份的高级脂族一元醇化合物，（c）5至20重量份的纤维素衍生物，（d）1〜20重量份的多元醇与脂肪族脂肪酸的酯化合物，和（e）0.1〜20重量份可以经皮给药的活性成分。

4. 发明授权

US6013276A Transdermal matrix system 失效
标题翻译：透皮基质系统
公开(公告)号：US6013276A
公开(公告)日：2000-01-11
申请号：US43760
申请日：1998-03-26
申请人： Marie-Christine Math , Eric Teillaud , Bruno Bevan
发明人： Marie-Christine Math , Eric Teillaud , Bruno Bevan
IPC分类号： A61K9/70 , A61K38/22 , A61F13/02
CPC分类号： A61K9/7053
摘要： A novel transdermal matrix system for the percutaneous delivery of a hormone, including a carrier and an adhesive matrix, is disclosed. The matrix includes (a) 39-61 parts by weight of an ethylene/vinyl acetate copolymer, (b) 12-17 parts by weight of 2-octyldodecyl myristate, (c) 5-17 parts by weight of diethyl phthalate, (d) 10-16 parts by weight of a compound selected from N-alkyl-2-pyrrolidones, wherein the alkyl group is a C.sub.4-15 group, and (e) 1-12 parts by weight of at least one hormone selected from the group consisting of oestrogenic and progestogenic components. A method for preparing said transdermal matrix system and the therapeutical use of said system are also disclosed.
摘要翻译： PCT No.PCT / FR96 / 01494 Sec。 371日期：1998年3月26日 102（e）1998年3月26日PCT PCT 1996年9月25日PCT公布。公开号WO97 / 11687 日本1997年4月3日公开了一种用于经皮递送激素的新型透皮基质系统，包括载体和粘合剂基质。该基质包括（a）39-61重量份的乙烯/乙酸乙烯酯共聚物，（b）12-17重量份的肉豆蔻酸2-辛基十二烷基酯，（c）5-17重量份邻苯二甲酸二乙酯，（d ）10-16重量份选自N-烷基-2-吡咯烷酮的化合物，其中烷基是C4-15基团，和（e）1-12重量份的至少一种选自以下的激素由雌激素和孕激素组成。还公开了制备所述透皮基质体系的方法和所述系统的治疗用途。

5. 发明授权

US5919477A Transdermal system for simultaneous delivery of a number of active principles 失效
标题翻译：透皮系统同时传递一些积极的原则
公开(公告)号：US5919477A
公开(公告)日：1999-07-06
申请号：US849688
申请日：1997-06-11
申请人： Bruno Bevan , Cecile Aillaud
发明人： Bruno Bevan , Cecile Aillaud
IPC分类号： A61K9/70 , A61K31/565 , A61K31/57 , A61L15/44 , A61P5/30 , A61F13/02
CPC分类号： A61K9/703 , A61K9/7053
摘要： A novel system for percutaneously delivering at least two active principles, consisting of at least two juxtaposed devices. The system includes (i) a first device containing a mixture of all the active principles in which at least one first active principle (A) is present in an amount enabling the effective therapeutic dose to be delivered, and at least one second active principle (B) is present in an amount smaller than the amount needed to deliver the effective therapeutic dose; and (ii) one or more additional devices each containing a single active principle (B) selected from those in the first device and provided in an amount smaller than the amount needed to deliver the effective therapeutic dose, said additional device(s) being designed to top up the amount of each of the active principles (B) in the system until the effective therapeutic dose is achieved.
摘要翻译： PCT No.PCT / FR95 / 01696 Sec。 371日期：1997年6月11日 102（e）日期1997年6月11日PCT 1995年12月9日PCT PCT。 WO96 / 19203 PCT出版物日期1996年6月27日一种用于经皮递送至少两个活动原理的新系统，由至少两个并置的装置组成。该系统包括（i）包含所有活性成分的混合物的第一装置，其中至少一种第一活性成分（A）以能够递送有效治疗剂量的量存在，以及至少一种第二活性成分 B）的存在量小于递送有效治疗剂量所需的量; 和（ii）一个或多个附加装置，每个装置包含选自第一装置中的单一活性成分（B）的单一活性成分（B），其量小于递送有效治疗剂量所需的量，所述附加装置被设计补充系统中每种活性成分（B）的量，直到达到有效的治疗剂量。

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