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1. 发明申请

US20080039866A1 LOCATING GUIDE 失效
标题翻译：定位指南
公开(公告)号：US20080039866A1
公开(公告)日：2008-02-14
申请号：US11835296
申请日：2007-08-07
申请人： Eric Stetz , Eric Bonde , Yelena Tropsha , Thomas Chun
发明人： Eric Stetz , Eric Bonde , Yelena Tropsha , Thomas Chun
IPC分类号： A61B19/00
CPC分类号： A61B90/39 , A61B90/11 , A61B2090/376 , A61B2090/3916 , A61B2090/3983 , A61N1/0551 , A61N1/08
摘要： A locating guide for locating a target tissue site within a patient includes a body, a first substantially radiopaque reference marker on the body, and a second substantially radiopaque reference marker extending from a major surface of the body. The reference markers provide reference points that extend in at least two dimensions, and may be useful for registering a medical image of tissue with an actual location on or within the patient in order to more accurately and precisely locate a target tissue site within the patient. In some embodiments, the second reference marker is oriented at a predetermined angle relative to the major surface of the body, and provides a guide that a clinician may reference in order to orient a medical element introducer when introducing the introducer into the patient to access a particular target tissue site.
摘要翻译：用于定位患者内的目标组织部位的定位引导件包括主体，身体上的第一基本上不透射线的参考标记以及从主体的主表面延伸的第二基本不透射线的参考标记。参考标记提供在至少两个维度上延伸的参考点，并且可用于将具有实际位置的组织的医学图像登记在患者身上或内部，以便更精确地和精确地定位患者内的目标组织部位。在一些实施例中，第二参考标记物相对于主体的主表面以预定角度定向，并且提供临床医生可引用的引导件，以便在将导引器引入患者时进行定位以导向医疗元件导入器特定目标组织部位。

2. 发明申请

US20070100355A1 Method and device for controlling bulking agent depth in tissue 审中-公开
标题翻译：控制组织中膨化剂深度的方法和装置
公开(公告)号：US20070100355A1
公开(公告)日：2007-05-03
申请号：US11260828
申请日：2005-10-27
申请人： Eric Bonde , Carole Tronnes , Yelena Tropsha , Lisa Draper
发明人： Eric Bonde , Carole Tronnes , Yelena Tropsha , Lisa Draper
IPC分类号： A61B17/34 , A61B17/94
CPC分类号： A61B17/12022 , A61B17/12099 , A61B17/12136 , A61B17/12181 , A61B17/3468 , A61B2017/00296 , A61B2017/00827 , A61B2017/306 , A61B2090/034 , A61F2/04 , A61F2002/044
摘要： The invention includes a delivery device for introducing a prosthesis beneath a tissue surface that includes an elongate body having a proximal end and a distal end, an opening on the elongate body, which is at least partially covered by a mesh, and a deployment lumen extending through the body that has a longitudinal axis and a distal end, wherein the distal end of the deployment lumen is positioned proximal of the opening. Also included are delivery systems and kits that include delivery devices of the invention. Further, an overtube for receiving an endoscope, that includes an elongate, flexible tubular body, having a proximal end and a distal end and a longitudinal axis, at least one lumen extending therethrough for receiving an endoscope, an opening on the body, in communication with the lumen, and a tissue limiting surface within the body aligned with the opening, formed at least in part by a mesh. Methods of using the devices, and kits are also included in the invention.
摘要翻译：本发明包括用于将假体引入组织表面下方的递送装置，其包括具有近端和远端的细长主体，细长主体上的至少部分地被网状覆盖的开口，以及展开腔通过具有纵向轴线和远端的主体，其中展开腔的远端位于开口的近侧。还包括包括本发明的递送装置的递送系统和套件。此外，用于接收内窥镜的外套管，其包括细长的柔性管状体，其具有近端和远端和纵向轴线，延伸穿过其中的至少一个内腔，用于接纳内窥镜，在身体上的开口与内腔对齐，以及与开口对齐的体内的组织限制表面，至少部分地由网状物形成。使用装置和试剂盒的方法也包括在本发明中。

3. 发明申请

US20060088568A1 Implantation of tissue bulking devices 有权
标题翻译：植入组织膨胀装置
公开(公告)号：US20060088568A1
公开(公告)日：2006-04-27
申请号：US10974001
申请日：2004-10-26
申请人： Yelena Tropsha , Chris Deegan , Carole Tronnes
发明人： Yelena Tropsha , Chris Deegan , Carole Tronnes
IPC分类号： A61M31/00 , A61B1/00 , A61F13/00
CPC分类号： A61B17/3468 , A61B2017/00292 , A61B2017/306
摘要： One or more tissue bulking devices are implanted to bulk a structure within a patient. The tissue bulking devices may be implanted between the structure and an adventitial layer that at least partially covers the structure, or within the adventitial layer. In some embodiments, the structure is a luminal wall that defines an inner lumen, and the bulking devices are implanted endoscopically via the lumen. In such embodiments, the tissue bulking devices may be implanted between a muscular layer of the luminal wall and an adventitial layer that at least partially covers the luminal wall, or within the adventitial layer. In exemplary embodiments, the luminal wall is the wall of the esophagus of the patient, and the tissue bulking devices are implanted proximate to the lower esophageal sphincter (LES) of the patient to treat gastroesophageal reflux disease (GERD).
摘要翻译：植入一个或多个组织填充装置来批量在患者体内的结构。组织填充装置可以植入结构和至少部分地覆盖结构的外膜之间，或在外膜内。在一些实施例中，该结构是限定内腔的腔壁，并且通过管腔内窥镜注射膨胀装置。在这样的实施方案中，组织膨胀装置可以植入在管腔壁的肌层与至少部分地覆盖腔壁之间或外膜内层的外膜层之间。在示例性实施例中，腔壁是患者的食道的壁，并且组织膨胀装置被植入患者的食管下端括约肌（LES）附近以治疗胃食管反流病（GERD）。

4. 发明申请

US20050245924A1 Ion eluting tuna device 有权
标题翻译：离子洗脱金枪鱼装置
公开(公告)号：US20050245924A1
公开(公告)日：2005-11-03
申请号：US10836467
申请日：2004-04-30
申请人： John Swoyer , Yelena Tropsha , Julie Woessner , Mark Christopherson
发明人： John Swoyer , Yelena Tropsha , Julie Woessner , Mark Christopherson
IPC分类号： A61B18/14
CPC分类号： A61B18/14 , A61B2018/00077 , A61B2018/00148 , A61B2018/1472
摘要： Delivery elements, including needle electrodes and sheaths of tissue ablation devices, containing a conductivity-enhancing agent are discussed. The delivery elements contain a body member and optionally one or more coating layers. The conductivity-enhancing agent is disposed on or in the body member and/or at least one of the one or more coating layers. The conductivity-enhancing agent is capable of eluting from the delivery element when the delivery element is contacted with bodily tissue or fluid and increases conductivity of the tissue, making tissue ablation more efficient.
摘要翻译：讨论了包含导电性增强剂的递送元件，包括组织消融装置的针电极和护套。递送元件包含主体部件和可选的一个或多个涂层。导电性增强剂设置在主体部件中和/或主体部件和/或一个或多个涂层中的至少一个上。当递送元件与身体组织或流体接触并且增加组织的电导率时，导电性增强剂能够从递送元件洗脱，从而使组织消融更有效率。

5. 发明申请

US20070098798A1 Method and article to restore function to a flow control location in a patient 审中-公开
标题翻译：将功能恢复到患者流量控制位置的方法和物品
公开(公告)号：US20070098798A1
公开(公告)日：2007-05-03
申请号：US11262486
申请日：2005-10-28
申请人： Yelena Tropsha , Warren Starkebaum
发明人： Yelena Tropsha , Warren Starkebaum
IPC分类号： A61K35/12 , A61K9/14
CPC分类号： A61K9/0024 , A61K35/33 , A61K35/34 , A61K35/44 , A61K35/545 , A61K38/18
摘要： Article and method of restoring function to a flow control location in a patient. A biological agent is inserted into a region near the flow control location. The biological agent is stabilized in the region. The biological agent is a biological agent selected from a group consisting of growth factors, fibroblast cells, smooth muscle cells, endothelial cells, stem cells and combinations thereof.
摘要翻译：将功能恢复到患者流量控制位置的文章和方法。将生物剂插入流动控制位置附近的区域。生物制剂在该地区稳定。生物制剂是选自生长因子，成纤维细胞，平滑肌细胞，内皮细胞，干细胞及其组合的生物剂。

6. 发明申请

US20060257445A1 Devices for augmentation of lumen walls 审中-公开
公开(公告)号：US20060257445A1
公开(公告)日：2006-11-16
申请号：US11118620
申请日：2005-04-29
申请人： Yelena Tropsha , Warren Starkebaum
发明人： Yelena Tropsha , Warren Starkebaum
IPC分类号： A61F2/00
CPC分类号： A61F2/0036 , A61B17/12 , A61F5/0079
摘要： A bulking device for implantation into a lumen wall that includes a bulking material that is configured to alter the portion of the lumen into which it is implanted and one or more therapeutic substances in association with the bulking material, wherein the device is configured to alter the portion of the lumen wall into which it is implanted. A method for inserting devices of the invention are also included.

7. 发明申请

US20080077125A1 TUNA DEVICE WITH INTEGRATED SALINE RESERVOIR 有权
标题翻译： TUNA设备与集成的盐水储存
公开(公告)号：US20080077125A1
公开(公告)日：2008-03-27
申请号：US11950751
申请日：2007-12-05
申请人： John Swoyer , Yelena Tropsha , Julie Woessner , Mark Christopherson
发明人： John Swoyer , Yelena Tropsha , Julie Woessner , Mark Christopherson
IPC分类号： A61B18/18
CPC分类号： A61B18/1477 , A61B2018/1472 , A61B2018/1475
摘要： Methods and apparatus for ablating a target tissue are discussed. Such methods and apparatus include those that simplify tissue ablation. For example, a tissue ablation device having an actuator, such as a trigger mechanism, coupled to a power source and an electrode is discussed. A single step of engaging the actuator causes the electrode to be introduced into the target tissue and causes energy to be delivered from the power supply to the tissue via the electrode. By way of additional example, a tissue ablation device having an actuator coupled to a fluid source and an electrode is discussed. A single step of engaging the actuator causes conductive fluid to flow from the fluid source to the target tissue location and causes the electrode to be introduced to the target tissue location. The fluid source may be a conductive fluid, such as saline, which may increase the efficiency of ablation. Various other configurations and methods that simplify tissue ablation are also discussed.
摘要翻译：讨论了用于烧蚀靶组织的方法和装置。这些方法和装置包括简化组织消融的方法和装置。例如，讨论了具有耦合到电源和电极的诸如触发机构的致动器的组织消融装置。使执行器接合的一个步骤使得电极被引入目标组织中，并且通过电极将能量从电源传送到组织。作为另外的示例，讨论了具有耦合到流体源和电极的致动器的组织消融装置。使致动器接合的一个步骤导致导电流体从流体源流动到目标组织位置，并且使电极被引入目标组织位置。流体源可以是诸如盐水的导电流体，其可以提高消融效率。还讨论了简化组织消融的各种其它配置和方法。

8. 发明申请

US20070098754A1 Method and article to restore function to GI or urinary tract of a patient 审中-公开
标题翻译：将功能恢复到患者胃肠道或尿道的方法和文章
公开(公告)号：US20070098754A1
公开(公告)日：2007-05-03
申请号：US11261407
申请日：2005-10-28
申请人： Yelena Tropsha , Warren Starkebaum
发明人： Yelena Tropsha , Warren Starkebaum
IPC分类号： A61K38/17 , A61F2/02
CPC分类号： A61K35/38 , A61K35/30
摘要： Method and article for restoring function to a region of a body selected from the group consisting of a gastrointestinal tract and a urinary tract of a patient. A biological agent is optionally associated with a carrier and inserted into the region of the body. The biological agent is stabilized in the region of the body. The biological agent is selected from a group consisting of nerve cells, interstitial cells of Cajal, stem cells and combinations thereof.
摘要翻译：用于将功能恢复到从由胃肠道和患者的尿道组成的组中选择的身体区域的功能的方法和制品。生物制剂任选地与载体结合并插入到身体的区域中。生物制剂在身体的区域稳定。生物剂选自神经细胞，Cajal间质细胞，干细胞及其组合。

9. 发明申请

US20060257446A1 Devices for augmentation of lumen walls 失效
标题翻译：用于增加管腔壁的装置
公开(公告)号：US20060257446A1
公开(公告)日：2006-11-16
申请号：US11118628
申请日：2005-04-29
申请人： Yelena Tropsha , Warren Starkebaum
发明人： Yelena Tropsha , Warren Starkebaum
IPC分类号： A61F2/00
CPC分类号： A61F2/0036 , A61B17/12 , A61F5/0079
摘要： A bulking device for implantation into a lumen wall that includes a bulking material that is configured to alter the portion of the lumen into which it is implanted and one or more therapeutic substances in association with the bulking material, wherein the device is configured to alter the portion of the lumen wall into which it is implanted. A method for inserting devices of the invention are also included.
摘要翻译：一种用于植入到管腔壁中的填充装置，其包括填充材料，所述填充材料被配置为改变其被植入的内腔的一部分以及与所述膨胀材料相关联的一种或多种治疗物质，其中所述装置被配置为改变植入其中的管腔壁的部分。还包括用于插入本发明的装置的方法。

10. 发明申请

US20060257444A1 Devices for augmentation of lumen walls 审中-公开
公开(公告)号：US20060257444A1
公开(公告)日：2006-11-16
申请号：US11118614
申请日：2005-04-29
申请人： Yelena Tropsha , Warren Starkebaum
发明人： Yelena Tropsha , Warren Starkebaum
IPC分类号： A61F2/00
CPC分类号： A61F2/0036 , A61B17/12 , A61F5/0079
摘要： A bulking device for implantation into a lumen wall that includes a bulking material that is configured to alter the portion of the lumen into which it is implanted and one or more therapeutic substances in association with the bulking material, wherein the device is configured to alter the portion of the lumen wall into which it is implanted. A method for inserting devices of the invention are also included.

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