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1. 发明申请

US20070100355A1 Method and device for controlling bulking agent depth in tissue 审中-公开
标题翻译：控制组织中膨化剂深度的方法和装置
公开(公告)号：US20070100355A1
公开(公告)日：2007-05-03
申请号：US11260828
申请日：2005-10-27
申请人： Eric Bonde , Carole Tronnes , Yelena Tropsha , Lisa Draper
发明人： Eric Bonde , Carole Tronnes , Yelena Tropsha , Lisa Draper
IPC分类号： A61B17/34 , A61B17/94
CPC分类号： A61B17/12022 , A61B17/12099 , A61B17/12136 , A61B17/12181 , A61B17/3468 , A61B2017/00296 , A61B2017/00827 , A61B2017/306 , A61B2090/034 , A61F2/04 , A61F2002/044
摘要： The invention includes a delivery device for introducing a prosthesis beneath a tissue surface that includes an elongate body having a proximal end and a distal end, an opening on the elongate body, which is at least partially covered by a mesh, and a deployment lumen extending through the body that has a longitudinal axis and a distal end, wherein the distal end of the deployment lumen is positioned proximal of the opening. Also included are delivery systems and kits that include delivery devices of the invention. Further, an overtube for receiving an endoscope, that includes an elongate, flexible tubular body, having a proximal end and a distal end and a longitudinal axis, at least one lumen extending therethrough for receiving an endoscope, an opening on the body, in communication with the lumen, and a tissue limiting surface within the body aligned with the opening, formed at least in part by a mesh. Methods of using the devices, and kits are also included in the invention.
摘要翻译：本发明包括用于将假体引入组织表面下方的递送装置，其包括具有近端和远端的细长主体，细长主体上的至少部分地被网状覆盖的开口，以及展开腔通过具有纵向轴线和远端的主体，其中展开腔的远端位于开口的近侧。还包括包括本发明的递送装置的递送系统和套件。此外，用于接收内窥镜的外套管，其包括细长的柔性管状体，其具有近端和远端和纵向轴线，延伸穿过其中的至少一个内腔，用于接纳内窥镜，在身体上的开口与内腔对齐，以及与开口对齐的体内的组织限制表面，至少部分地由网状物形成。使用装置和试剂盒的方法也包括在本发明中。

2. 发明申请

US20060088568A1 Implantation of tissue bulking devices 有权
标题翻译：植入组织膨胀装置
公开(公告)号：US20060088568A1
公开(公告)日：2006-04-27
申请号：US10974001
申请日：2004-10-26
申请人： Yelena Tropsha , Chris Deegan , Carole Tronnes
发明人： Yelena Tropsha , Chris Deegan , Carole Tronnes
IPC分类号： A61M31/00 , A61B1/00 , A61F13/00
CPC分类号： A61B17/3468 , A61B2017/00292 , A61B2017/306
摘要： One or more tissue bulking devices are implanted to bulk a structure within a patient. The tissue bulking devices may be implanted between the structure and an adventitial layer that at least partially covers the structure, or within the adventitial layer. In some embodiments, the structure is a luminal wall that defines an inner lumen, and the bulking devices are implanted endoscopically via the lumen. In such embodiments, the tissue bulking devices may be implanted between a muscular layer of the luminal wall and an adventitial layer that at least partially covers the luminal wall, or within the adventitial layer. In exemplary embodiments, the luminal wall is the wall of the esophagus of the patient, and the tissue bulking devices are implanted proximate to the lower esophageal sphincter (LES) of the patient to treat gastroesophageal reflux disease (GERD).
摘要翻译：植入一个或多个组织填充装置来批量在患者体内的结构。组织填充装置可以植入结构和至少部分地覆盖结构的外膜之间，或在外膜内。在一些实施例中，该结构是限定内腔的腔壁，并且通过管腔内窥镜注射膨胀装置。在这样的实施方案中，组织膨胀装置可以植入在管腔壁的肌层与至少部分地覆盖腔壁之间或外膜内层的外膜层之间。在示例性实施例中，腔壁是患者的食道的壁，并且组织膨胀装置被植入患者的食管下端括约肌（LES）附近以治疗胃食管反流病（GERD）。

3. 发明申请

US20070255368A1 Implantable medical electrical stimulation lead with distal fixation and method 审中-公开
标题翻译：植入式医疗电刺激引导与远端固定和方法
公开(公告)号：US20070255368A1
公开(公告)日：2007-11-01
申请号：US11413354
申请日：2006-04-28
申请人： Eric Bonde , Eric Stetz , Carole Tronnes , James Henry
发明人： Eric Bonde , Eric Stetz , Carole Tronnes , James Henry
IPC分类号： A61N1/00
CPC分类号： A61N1/0558
摘要： An implantable medical electrical lead for applying electrical stimulation energy from an external power source and adapted to be introduced through a small diameter needle. The lead includes a lead body and a fixation assembly. The lead body includes a wire and an electrically non-conductive material. The wire forms a wound coil along a distal portion thereof. The non-conductive material covers some of the wire coil, with an uncovered distal region of the wire serving as an electrode. The fixation assembly is coupled to the uncovered distal region and includes at least one fixation member. The fixation assembly is transitionable between a contracted state and an expanded state, with the fixation member extending outwardly relative to the coil to a greater extent in the expanded state. In the expanded state, the fixation assembly serves to inhibit axial migration of the lead body.
摘要翻译：一种用于从外部电源施加电刺激能量并且适于通过小直径针引入的可植入医用电线。引线包括引线体和固定组件。引线体包括导线和非导电材料。线沿其远端部分形成缠绕线圈。非导电材料覆盖一些线圈，其中未覆盖的导线远端区域用作电极。固定组件联接到未覆盖的远侧区域并且包括至少一个固定构件。固定组件在收缩状态和展开状态之间是可转换的，其中固定构件在膨胀状态下相对于线圈向外延伸到更大的程度。在膨胀状态下，固定组件用于抑制引线体的轴向迁移。

4. 发明申请

US20070255370A1 Implantable medical electrical stimulation lead, such as a PNE lead, and method of use 有权
标题翻译：植入式医疗电刺激引线，如PNE引线，以及使用方法
公开(公告)号：US20070255370A1
公开(公告)日：2007-11-01
申请号：US11413301
申请日：2006-04-28
申请人： Eric Bonde , Eric Stetz , Carole Tronnes
发明人： Eric Bonde , Eric Stetz , Carole Tronnes
IPC分类号： A61N1/00
CPC分类号： A61N1/0558
摘要： An implantable medical electrode lead for stimulation of bodily tissue. The lead is adapted for use with a needle lumen diameter of not greater than 0.05 inch, and includes a lead body and a tine assembly. The lead body has a distal section forming at least one exposed electrode surface. The tine assembly includes a plurality of tines each having a base end coupled to an exterior of the lead body immediately adjacent the exposed electrode surface and a free end that is movable relative to the lead body to inhibit axial migration of the lead body upon implantation into a patient. In one embodiment, the lead body is a PNE lead and provides two electrode surfaces for bipolar operation.
摘要翻译：用于刺激身体组织的可植入医用电极引线。引线适用于针腔直径不大于0.05英寸，并且包括引线体和齿组件。引线体具有形成至少一个暴露的电极表面的远端部分。齿组件包括多个尖齿，每个尖头具有紧邻暴露的电极表面的引线体的外部的基端，以及相对于引线本体可移动的自由端，以阻止引线体在植入时的轴向迁移病人。在一个实施例中，引线体是PNE引线，并提供用于双极性操作的两个电极表面。

5. 发明申请

US20070255371A1 System and method for electrically probing and providing medical electrical stimulation 有权
标题翻译：电探测和提供医疗电刺激的系统和方法
公开(公告)号：US20070255371A1
公开(公告)日：2007-11-01
申请号：US11413310
申请日：2006-04-28
申请人： Eric Bonde , Eric Stetz , Carole Tronnes
发明人： Eric Bonde , Eric Stetz , Carole Tronnes
IPC分类号： A61N1/00
CPC分类号： A61N1/0551
摘要： A system for providing medical electrical stimulation including a lead assembly and a cannula. The lead assembly includes a lead body and a needle tip. The lead body has a distal section and a proximal section. The needle tip is formed of an electrically conductive material and is connected to the distal section of the lead body. The lead body is slidably disposed within a cannula lumen, with a distal end of the cannula being selectively connected to an abutment surface of the needle tip such that the needle tip extends distal the cannula to define a needle probe. With this construction, the lead assembly can be delivered to a desired implantation site via manipulation of the cannula and/or energization of the needle tip, and the cannula can be removed from the lead body without requiring movement of the needle tip.
摘要翻译：一种用于提供医疗电刺激的系统，包括引线组件和套管。引线组件包括引线体和针尖。引线体具有远侧部分和近端部分。针尖由导电材料形成并且连接到引线主体的远端部分。引导体可滑动地设置在套管腔内，套管的远端选择性地连接到针尖的邻接表面，使得针尖延伸到套管的远端以限定针头探针。利用这种结构，引导组件可以通过插管的操作和/或针尖的通电而被输送到期望的植入位置，并且可以不用移动针尖从导线主体移除套管。

6. 发明申请

US20070255369A1 Multi-electrode peripheral nerve evaluation lead and related system and method of use 有权
标题翻译：多电极周围神经评估线及相关系统及使用方法
公开(公告)号：US20070255369A1
公开(公告)日：2007-11-01
申请号：US11413432
申请日：2006-04-28
申请人： Eric Bonde , Eric Stetz , Carole Tronnes , James Henry
发明人： Eric Bonde , Eric Stetz , Carole Tronnes , James Henry
IPC分类号： A61N1/00
CPC分类号： A61B5/04001 , A61B5/6848 , A61N1/0551 , A61N1/0558
摘要： An implantable electrical lead for applying stimulation energy to bodily tissue, such as a patient's nervous system, from an external power source. The lead is defined by a distal section, an intermediate section and a proximal section, and includes a lead body, a plurality of insulated wires, and a plurality of connector elements. The lead body includes a plurality of electrodes and an anchoring device. The insulated wires are electrically coupled to the electrodes, respectively. A wire intermediate segment extends proximal the lead body and is characterized as having a non-coiled configuration, terminating at a respective connector element for coupling to an external power source. The wire intermediate segments are extendible through a patient's skin and are sealable relative to the skin. The lead is adapted for providing temporary electrical stimulation to a sacral nerve in a bipolar mode, with the anchoring device inhibiting electrode migration.
摘要翻译：用于从外部电源向身体组织（例如患者神经系统）施加刺激能量的可植入电线。引线由远端部分，中间部分和近端部分限定，并且包括引线主体，多个绝缘电线和多个连接器元件。引线体包括多个电极和锚定装置。绝缘电线分别电耦合到电极。导线中间段在引线体的近侧延伸，并且其特征在于具有非卷绕构型，终止于相应的连接器元件，用于耦合到外部电源。线中间段可通过患者的皮肤延伸并且相对于皮肤可密封。引线适于在双极模式下向骶神经提供临时电刺激，锚定装置抑制电极迁移。

7. 发明申请

US20070100386A1 Axial lead connector for implantable medical device 有权
标题翻译：用于可植入医疗器械的轴向引线连接器
公开(公告)号：US20070100386A1
公开(公告)日：2007-05-03
申请号：US11263526
申请日：2005-10-31
申请人： Carole Tronnes , Robert Munoz , Alexander Lakanu , John Swoyer , Greg Theis , Bryan Zart , David DeSmet
发明人： Carole Tronnes , Robert Munoz , Alexander Lakanu , John Swoyer , Greg Theis , Bryan Zart , David DeSmet
IPC分类号： A61N1/00
CPC分类号： A61N1/3752 , Y10T29/49208
摘要： The disclosure describes an axial lead connector assembly for an implantable medical device (IMD). The lead connector assembly facilitates electrical connection between an implantable medical lead and circuitry contained within the housing of an IMD. A connector header defines an axial stack bore to receive an axial stack of in-line connector components. The connector components define a common lead bore to receive a proximal end of an implantable lead. The in-line stack of connector components may include seals, electrical connector elements, a strain relief, and a locking device, each of which defines a passage that forms part of the lead bore.
摘要翻译：本公开描述了用于可植入医疗装置（IMD）的轴向引线连接器组件。导线连接器组件有助于可植入医疗引线和包含在IMD的壳体内的电路之间的电连接。连接器插头限定轴向堆叠孔以接收轴向堆叠的在线连接器部件。连接器部件限定了用于接收可植入引线的近端的公共引线孔。连接器部件的直列堆叠可以包括密封件，电连接器元件，应变消除件和锁定装置，每个锁定装置限定形成引导孔的一部分的通道。

8. 发明申请

US20060094929A1 Distal portion of an endoscopic delivery system 有权
标题翻译：内窥镜递送系统的远端部分
公开(公告)号：US20060094929A1
公开(公告)日：2006-05-04
申请号：US10977499
申请日：2004-10-29
申请人： Carole Tronnes
发明人： Carole Tronnes
IPC分类号： A61B1/00
CPC分类号： A61B17/3478 , A61B2017/00269 , A61B2017/00827 , A61B2017/306
摘要： The disclosure describes an endoscopic delivery system that includes an endoscope and a tissue-receiving member. The tissue-receiving member includes an opening to receive the distal end of the endoscope. The tissue-receiving member also defines a tissue-receiving space that receives tissue when vacuum pressure is applied to the space through the endoscope. A tool and/or material may be delivered to the tissue drawn into the tissue-receiving space. The tissue-receiving member may be cap-like, and only receive the distal end of the endoscope, or include an overtube that receives a substantial portion of the endoscope. The system may be used to, for example, deliver tissue bulking devices to a location proximate to the lower esophageal sphincter (LES) for treatment of gastroesophageal reflux disease (GERD).
摘要翻译：本公开描述了一种内窥镜递送系统，其包括内窥镜和组织接收构件。组织接收构件包括用于接收内窥镜的远端的开口。组织接收构件还限定了当通过内窥镜向空间施加真空压力时接收组织的组织接收空间。工具和/或材料可以被递送到被抽吸到组织接收空间中的组织。组织接收构件可以是帽状的，并且仅接纳内窥镜的远端，或者包括容纳内窥镜的主要部分的外套管。该系统可以用于例如将组织膨胀装置递送到靠近下食道括约肌（LES）的位置，用于治疗胃食管反流病（GERD）。

9. 发明申请

US20060095078A1 Expandable fixation mechanism 有权
公开(公告)号：US20060095078A1
公开(公告)日：2006-05-04
申请号：US10977500
申请日：2004-10-29
申请人： Carole Tronnes
发明人： Carole Tronnes
IPC分类号： A61N1/375
CPC分类号： A61N1/0558 , A61N1/3605 , A61N1/37205 , A61N1/37518
摘要： In general, the invention is directed to a medical device implantable in a body of a patient. The device includes a housing with a plurality of collapsible fixation structures coupled to the housing, and can be in a collapsed configuration or an expanded configuration. The device assumes a collapsed configuration when in the bore of an insertion device, and assumes the expanded configuration when expelled from the insertion device into the body of the patient. The extended fixation structures engage the tissues in the body and restrict migration. One exemplary application of the invention is in the context of a microstimulator, with a pulse generator housed in the housing and one or more electrodes coupled to the housing. The fixation structures help keep the electrodes proximate to the tissues that are to receive the stimulation.

10. 发明授权

US08478424B2 Medical lead having coaxial connector 有权
标题翻译：具有同轴连接器的医用引线
公开(公告)号：US08478424B2
公开(公告)日：2013-07-02
申请号：US12707311
申请日：2010-02-17
申请人： Carole Tronnes
发明人： Carole Tronnes
IPC分类号： A61N1/372
CPC分类号： A61N1/0551 , A61N1/05 , A61N1/3752 , H01R24/38 , H01R2103/00 , H01R2201/12 , Y10T29/49204
摘要： A medical lead includes a connector for operably coupling the lead to an active medical device. The connector includes a first tubular conductive contact having a length, a proximal end, a distal end and a lumen extending through the contact from the proximal end to the distal end. The connector also includes a second tubular conductive contact having a length, a proximal end, and a distal end. The length of the second contact is greater than the length of the first contact. The second contact is disposed in the lumen of the first contact such that the proximal and distal ends of the second contact extend beyond the proximal and distal ends of the first contact. The lead further includes first and second electrodes. The first electrode is operably coupled to the first contact, and the second electrode is operably coupled to the second contact.
摘要翻译：医疗引线包括用于将引线可操作地耦合到有源医疗装置的连接器。连接器包括具有长度，近端，远端和从近端到远端延伸穿过接触件的内腔的第一管状导电接触件。连接器还包括具有长度，近端和远端的第二管状导电接触件。第二接触件的长度大于第一接触件的长度。第二触点设置在第一触头的内腔中，使得第二触头的近端和远端延伸超过第一触点的近端和远端。引线还包括第一和第二电极。第一电极可操作地耦合到第一触点，并且第二电极可操作地耦合到第二触点。

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