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1. 发明申请

US20130110137A1 Surface Treated Polymeric Synthetic Hernia Mesh Prosthesis, Surface Treated Sutures and Staples and Methods of Manufacturing the Same 审中-公开
标题翻译：表面处理聚合物合成疝网假体，表面处理缝线和钉子及其制造方法
公开(公告)号：US20130110137A1
公开(公告)日：2013-05-02
申请号：US13632197
申请日：2012-10-01
申请人： Enrico Nicolo , Linda Cahalan , Greg Johnson , Mark Gartner , Patrick Cahalan , Brian J Fill , Ali HUSSAIN , Jeffrey W. Speakman
发明人： Enrico Nicolo , Linda Cahalan , Greg Johnson , Mark Gartner , Patrick Cahalan , Brian J Fill , Ali HUSSAIN , Jeffrey W. Speakman
IPC分类号： A61L27/24 , A61L27/22
CPC分类号： A61L27/24 , A61L27/227 , A61L31/048 , A61L31/10 , A61L33/0029 , A61L2400/18 , A61M1/1698 , C08L83/04 , C08L23/12
摘要： A variety of polymeric synthetic hernia mesh prosthesis with surface treatment on at least one tissue-facing surface to control tissue adhesion are disclosed including heparin surface treatment which provides heparin present in an amount to yield heparin bioactivity of at least one of i) an ATIII binding of at least 2 pmol/cm2, and ii) a thrombin deactivation of at least 0.2 IU/cm2; an acrylic surface treatment for coupling thereto of a heparin surface treatment, a collagen surface treatment or both; and an amino-functional polysiloxane surface treatment for coupling thereto of a heparin surface treatment. The synthetic hernia mesh may be formed of monofilament or multifilament polypropylene or polyester, and may be formed as a multi-layer prosthesis with an outer layer formed of a polymeric synthetic hernia mesh with surface treatment to control tissue adhesion coupled to one or more polymeric synthetic hernia meshes without such surface treatments.
摘要翻译：公开了在至少一个面向组织的表面上进行表面处理以控制组织粘附的各种聚合合成疝网假体，其包括肝素表面处理，其提供一定量的肝素以产生以下至少一种的肝素生物活性：i）ATIII结合至少2pmol / cm 2，和ii）至少0.2IU / cm 2的凝血酶失活; 用于与肝素表面处理，胶原表面处理或两者结合的丙烯酸表面处理; 和用于与肝素表面处理偶联的氨基官能聚硅氧烷表面处理。合成疝网可以由单丝或多丝聚丙烯或聚酯形成，并且可以形成为具有由聚合物合成疝网形成的外层的多层假体，其具有表面处理以控制与一种或多种聚合物合成没有这种表面处理的疝气网眼。

2. 发明授权

US09693841B2 Surface treated staples, sutures and dental floss and methods of manufacturing the same 有权
公开(公告)号：US09693841B2
公开(公告)日：2017-07-04
申请号：US14214248
申请日：2014-03-14
申请人： Ali Hussain , Linda Cahalan , Greg Johnson , Mark Gartner , Patrick Cahalan , Brian J Fill , Jeffrey W. Speakman
发明人： Ali Hussain , Linda Cahalan , Greg Johnson , Mark Gartner , Patrick Cahalan , Brian J Fill , Jeffrey W. Speakman
IPC分类号： A61C15/04 , A61B17/06 , A61B17/064 , A61L31/04 , A61L31/10 , A61L33/00 , B05D3/06 , A61M1/16 , B05D7/02 , B05D1/36 , B05D1/00
CPC分类号： A61C15/041 , A61B17/06 , A61B17/06166 , A61B17/064 , A61L31/048 , A61L31/10 , A61L33/0029 , A61L2400/18 , A61M1/1698 , B05D1/36 , B05D1/62 , B05D3/06 , B05D7/02 , B05D2256/00 , B05D2258/00 , C08L83/04 , C08L23/12
摘要： A variety of medical devices including staples sutures and dental floss with surface treatment on at least one tissue-facing surface to improve biologic function such as to control tissue adhesion are disclosed including heparin surface treatment which provides heparin present in an amount to yield heparin bioactivity of at least one of i) an ATIII binding of at least 2 pmol/cm2, and ii) a thrombin deactivation of at least 0.2 IU/cm2; an acrylic surface treatment for coupling thereto of a heparin surface treatment, a collagen surface treatment or both; and an amino-functional polysiloxane surface treatment for coupling thereto of a heparin surface treatment.

3. 发明申请

US20140288592A1 SURFACE TREATED STAPLES, SUTURES AND DENTAL FLOSS AND METHODS OF MANUFACTURING THE SAME 有权
标题翻译：表面处理的绷带，URES URES和牙龈及其制造方法
公开(公告)号：US20140288592A1
公开(公告)日：2014-09-25
申请号：US14214248
申请日：2014-03-14
申请人： Ali HUSSAIN , Linda Cahalan , Greg Johnson , Mark Gartner , Patrick Cahalan , Brian J. Fill , Jeffrey W. Speakman
发明人： Ali HUSSAIN , Linda Cahalan , Greg Johnson , Mark Gartner , Patrick Cahalan , Brian J. Fill , Jeffrey W. Speakman
IPC分类号： A61L31/04 , A61C15/04 , A61L17/00 , A61B17/06 , A61B17/064
CPC分类号： A61C15/041 , A61B17/06 , A61B17/06166 , A61B17/064 , A61L31/048 , A61L31/10 , A61L33/0029 , A61L2400/18 , A61M1/1698 , B05D1/36 , B05D1/62 , B05D3/06 , B05D7/02 , B05D2256/00 , B05D2258/00 , C08L83/04 , C08L23/12
摘要： A variety of medical devices including staples sutures and dental floss with surface treatment on at least one tissue-facing surface to improve biologic function such as to control tissue adhesion are disclosed including heparin surface treatment which provides heparin present in an amount to yield heparin bioactivity of at least one of i) an ATIII binding of at least 2 pmol/cm2, and ii) a thrombin deactivation of at least 0.2 IU/cm2; an acrylic surface treatment for coupling thereto of a heparin surface treatment, a collagen surface treatment or both; and an amino-functional polysiloxane surface treatment for coupling thereto of a heparin surface treatment.
摘要翻译：公开了包括缝合缝合线和在至少一个面向组织表面上进行表面处理以改善生物学功能以控制组织粘附的各种医疗装置，包括肝素表面处理，其提供以产生肝素生物活性的量存在的肝素 i）至少2pmol / cm 2的ATIII结合中的至少一种，和ii）至少0.2IU / cm 2的凝血酶失活; 用于与肝素表面处理，胶原表面处理或两者结合的丙烯酸表面处理; 和用于与肝素表面处理偶联的氨基官能聚硅氧烷表面处理。

4. 发明授权

US08114465B2 Process for preparing a substrate coated with a biomolecule 有权
标题翻译：制备涂有生物分子的基材的方法
公开(公告)号：US08114465B2
公开(公告)日：2012-02-14
申请号：US12061212
申请日：2008-04-02
申请人： Patrick Cahalan , Linda Cahalan , Greg Johnson , Mark Gartner
发明人： Patrick Cahalan , Linda Cahalan , Greg Johnson , Mark Gartner
IPC分类号： B05D3/04
CPC分类号： A61L31/10 , A61M1/1698 , C08L83/04
摘要： Processes are provided for preparing a substrate coated with a biomolecule, comprising: a) providing a substrate; b) coating the substrate with a polysiloxane, typically by exposing the substrate to a reactive gas containing siloxane functional groups and to plasma energy to yield a plasma-deposited polysiloxane surface on the substrate; c) rendering the polysiloxane surface amino functional; and d) contacting the amino-functional polysiloxane surface with a biomolecule under conditions effective to attach the biomolecule to the substrate. The coated substrate may be a medical device that demonstrates an ability to maintain gas permeability when in contact with blood or blood components, compared to a substantially identical medical device that has not been coated with a biomolecule using this process.
摘要翻译：提供了制备涂覆有生物分子的底物的方法，包括：a）提供底物; b）用聚硅氧烷涂覆基材，通常通过将基材暴露于含有硅氧烷官能团的反应性气体和等离子体能量，以在基材上产生等离子体沉积的聚硅氧烷表面; c）使聚硅氧烷表面具有氨基功能; 和d）在有效地将生物分子附着到底物的条件下，使氨基官能聚硅氧烷表面与生物分子接触。涂覆的基底可以是与使用该方法未用生物分子涂覆的基本相同的医疗装置相比，其表现出与血液或血液成分接触时保持透气性的能力的医疗装置。

5. 发明申请

US20080241349A1 PROCESS FOR PREPARING A SUBSTRATE COATED WITH A BIOMOLECULE 有权
标题翻译：制备用生物分子涂覆的基材的方法
公开(公告)号：US20080241349A1
公开(公告)日：2008-10-02
申请号：US12061212
申请日：2008-04-02
申请人： Patrick Cahalan , Linda Cahalan , Greg Johnson , Mark Gartner
发明人： Patrick Cahalan , Linda Cahalan , Greg Johnson , Mark Gartner
IPC分类号： B05D3/04
CPC分类号： A61L31/10 , A61M1/1698 , C08L83/04
摘要： Processes are provided for preparing a substrate coated with a biomolecule, comprising: a) providing a substrate; b) coating the substrate with a polysiloxane, typically by exposing the substrate to a reactive gas containing siloxane functional groups and to plasma energy to yield a plasma-deposited polysiloxane surface on the substrate; c) rendering the polysiloxane surface amino functional; and d) contacting the amino-functional polysiloxane surface with a biomolecule under conditions effective to attach the biomolecule to the substrate. The coated substrate may be a medical device that demonstrates an ability to maintain gas permeability when in contact with blood or blood components, compared to a substantially identical medical device that has not been coated with a biomolecule using this process.
摘要翻译：提供了制备涂覆有生物分子的底物的方法，包括：a）提供底物; b）用聚硅氧烷涂覆基材，通常通过将基材暴露于含有硅氧烷官能团的反应性气体和等离子体能量，以在基材上产生等离子体沉积的聚硅氧烷表面; c）使聚硅氧烷表面具有氨基功能; 和d）在有效地将生物分子附着到底物的条件下，使氨基官能聚硅氧烷表面与生物分子接触。涂覆的基底可以是与使用该方法未用生物分子涂覆的基本相同的医疗装置相比，其表现出与血液或血液成分接触时保持透气性的能力的医疗装置。

6. 发明授权

US08343567B2 Method of treating the surface of a medical device with a biomolecule 有权
标题翻译：用生物分子处理医疗器械表面的方法
公开(公告)号：US08343567B2
公开(公告)日：2013-01-01
申请号：US13345813
申请日：2012-01-09
申请人： Patrick Cahalan , Linda Cahalan , Greg Johnson , Mark Gartner
发明人： Patrick Cahalan , Linda Cahalan , Greg Johnson , Mark Gartner
IPC分类号： B05D3/04
CPC分类号： A61L31/10 , A61M1/1698 , C08L83/04
摘要： A method of treating the surface of a medical device with a biomolecule comprising the steps of: providing a polyolefin substrate forming a medical device; cleaning the polyolefin substrate; exposing the polyolefin substrate to a reactive gas containing acrylic acid and to plasma energy to yield a plasma-deposited polyacrylic acid coating on the polyolefin substrate; and attaching a biomolecule, such as heparin, to the polyolefin substrate following formation of the plasma-deposited polyacrylic acid coating on the polyolefin substrate.
摘要翻译：一种用生物分子处理医疗装置的表面的方法，包括以下步骤：提供形成医疗装置的聚烯烃基材; 清洗聚烯烃基材; 将聚烯烃基材暴露于含有丙烯酸的反应性气体和等离子体能量，以在聚烯烃基材上产生等离子体沉积的聚丙烯酸涂层; 以及在聚烯烃基材上形成等离子体沉积的聚丙烯酸涂层之后，将生物分子如肝素附着到聚烯烃基材上。

7. 发明申请

US20120107901A1 METHOD OF TREATING THE SURFACE OF A MEDICAL DEVICE WITH A BIOMOLECULE 有权
标题翻译：用生物分子处理医疗器械表面的方法
公开(公告)号：US20120107901A1
公开(公告)日：2012-05-03
申请号：US13345813
申请日：2012-01-09
申请人： Patrick Cahalan , Linda Cahalan , Greg Johnson , Mark Gartner
发明人： Patrick Cahalan , Linda Cahalan , Greg Johnson , Mark Gartner
IPC分类号： B05D3/10 , C12N11/08
CPC分类号： A61L31/10 , A61M1/1698 , C08L83/04
摘要： A method of treating the surface of a medical device with a biomolecule comprising the steps of: providing a polyolefin substrate forming a medical device; cleaning the polyolefin substrate; exposing the polyolefin substrate to a reactive gas containing acrylic acid and to plasma energy to yield a plasma-deposited polyacrylic acid coating on the polyolefin substrate; and attaching a biomolecule, such as heparin, to the polyolefin substrate following formation of the plasma-deposited polyacrylic acid coating on the polyolefin substrate.
摘要翻译：一种用生物分子处理医疗装置的表面的方法，包括以下步骤：提供形成医疗装置的聚烯烃基材; 清洗聚烯烃基材; 将聚烯烃基材暴露于含有丙烯酸的反应性气体和等离子体能量，以在聚烯烃基材上产生等离子体沉积的聚丙烯酸涂层; 以及在聚烯烃基材上形成等离子体沉积的聚丙烯酸涂层之后，将生物分子如肝素附着到聚烯烃基材上。

8. 发明授权

US5350800A Method for improving the biocompatibility of solid surfaces 失效
标题翻译：提高固体表面生物相容性的方法
公开(公告)号：US5350800A
公开(公告)日：1994-09-27
申请号：US5711
申请日：1993-01-19
申请人： Michel Verhoeven , Patrick Cahalan , Linda Cahalan , Marc Hendriks , Benedicte Foache
发明人： Michel Verhoeven , Patrick Cahalan , Linda Cahalan , Marc Hendriks , Benedicte Foache
IPC分类号： A61L27/00 , A61L29/00 , A61L33/00 , A61L33/10 , A61F2/54 , A61F2/02 , A61K9/22
CPC分类号： A61L33/0029 , A61L33/0041 , A61L33/0047 , A61L33/0088
摘要： A method for attaching a biomolecule having a plurality of carboxyl groups to an aminated solid surface by reacting the biomolecule with a carbodiimide to effect an activation of the carboxyl groups of the biomolecule, reacting the carbodiimide activated biomolecule with the solid surface to covalently bind the biomolecule to the aminated solid surface, and then selectively restoring carboxyl groups to the biomolecule. The selective restoration of carboxyl groups can be carried out by mild hydrolysis and restores the functionality of the biomolecule. The method is "selective" since the bonds between the biomolecule and the aminated solid surface remain intact.
摘要翻译：通过使生物分子与碳二亚胺反应以使生物分子的羧基活化，使碳二亚胺活化的生物分子与固体表面反应，使生物分子共价结合，将具有多个羧基的生物分子连接到胺化的固体表面上的方法到胺化的固体表面，然后选择性地将羧基还原成生物分子。羧基的选择性还原可以通过温和的水解进行，并恢复生物分子的功能。该方法是“选择性的”，因为生物分子和胺化的固体表面之间的键保持完整。

9. 发明授权

US06303179B1 Method for attachment of biomolecules to surfaces through amine-functional groups 失效
标题翻译：通过胺官能团将生物分子附着到表面的方法
公开(公告)号：US06303179B1
公开(公告)日：2001-10-16
申请号：US09245834
申请日：1999-02-08
申请人： Edouard Koulik , Michel Verhoeven , Patrick Cahalan , Linda Cahalan , Judith Vincent
发明人： Edouard Koulik , Michel Verhoeven , Patrick Cahalan , Linda Cahalan , Judith Vincent
IPC分类号： A61L5103
CPC分类号： A61L33/0029
摘要： A method of modifying the surface characteristics of a substrate having a surface with an amide-functional polymer thereon. The method involves contacting the amide-functional polymer with a source of hydroxide ions and a source of hypohalite ions at a temperature of at least about 20° C. for a time effective to convert at least a portion of the amide-functional groups to amine-functional groups to form a substrate surface comprising an amine-functional polymer, wherein the hydroxide ions are present in a molar excess relative to the hypohalite ions and at a concentration of no more than about 0.1 M, based on the total volume of the reaction mixture. A biomolecule is attached to the resultant amine-functional polymer.
摘要翻译：一种改变其上具有酰胺官能聚合物的表面的基材的表面特性的方法。该方法包括在至少约20℃的温度下将酰胺官能聚合物与氢氧根离子源和次卤酸盐离子源接触，将有效的至少一部分酰胺官能团转化成胺功能基团以形成包含胺官能聚合物的底物表面，其中氢氧根离子相对于次卤酸盐离子以摩尔过量存在，并且以不超过约0.1M的浓度，基于反应的总体积混合物。将生物分子连接到所得的胺官能聚合物上。

10. 发明授权

US6166184A Process for making a bioprosthetic device 失效
标题翻译：制作生物假体装置的过程
公开(公告)号：US6166184A
公开(公告)日：2000-12-26
申请号：US912778
申请日：1997-08-18
申请人： Marc Hendriks , Verhoeven Michel , Patrick Cahalan , Mark W. Torrianni , Linda Cahalan , Benedicte Fouache
发明人： Marc Hendriks , Verhoeven Michel , Patrick Cahalan , Mark W. Torrianni , Linda Cahalan , Benedicte Fouache
IPC分类号： A61L27/36 , C08H1/06 , C07K13/00 , C07K15/00
CPC分类号： A61L27/3687 , C08H1/06
摘要： Methods for making bioprosthetic devices made of collagen-based material having collagen amine groups and collagen carboxyl groups are provided. The methods include blocking at least a portion of the collagen amine groups with a blocking agent, activating at least a portion of the collagen carboxyl groups after blocking at least a portion of the collagen amine groups to form activated carboxyl groups, and contacting the activated collagen carboxyl groups with a polyfunctional spacer to crosslink the collagen-based material.
摘要翻译：提供用于制造具有胶原胺基和胶原羧基的胶原基材料制成生物假体装置的方法。所述方法包括用封闭剂封闭至少一部分胶原胺基团，在封闭至少一部分胶原胺基团以形成活化的羧基之后激活至少一部分胶原羧基，并使活化的胶原羧基与多官能间隔基交联胶原基材料。

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