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1. 发明授权

US06812250B2 Carboxamide-substituted phenylurea derivatives, process for their preparation and their use as medicaments 有权
标题翻译：羧酰胺取代的苯基脲衍生物，其制备方法及其作为药物的用途
公开(公告)号：US06812250B2
公开(公告)日：2004-11-02
申请号：US10153597
申请日：2002-05-24
申请人： Elisabeth Defossa , Thomas Klabunde , Hans-Joerg Burger , Andreas Herling , Erich von Roedern , Stefan Peukert , Alfons Enhsen , Armin Bauer , Bernd Neises , Karl Ulrich Wendt
发明人： Elisabeth Defossa , Thomas Klabunde , Hans-Joerg Burger , Andreas Herling , Erich von Roedern , Stefan Peukert , Alfons Enhsen , Armin Bauer , Bernd Neises , Karl Ulrich Wendt
IPC分类号： C07C27516
CPC分类号： C07D213/40 , C07C275/54 , C07C323/42 , C07C2601/16 , C07C2602/10 , C07D209/08 , C07D211/58 , C07D285/14 , C07D295/13 , C07D295/205 , C07D317/58 , C07D319/18 , C07D401/04
摘要： The invention relates to carboxamide-substituted phenylurea derivatives and their physiologically tolerated salts and physiologically functional derivatives. Compounds of the formula I in which the radicals have the stated meanings, and the physiologically tolerated salts thereof and process for their preparation are described. The compounds are suitable, for example, for treating type II diabetes.

2. 发明申请

US20050143456A1 Carboxamide-substituted phenylurea derivatives, process for their preparation and their use as medicaments 审中-公开
标题翻译：羧酰胺取代的苯基脲衍生物，其制备方法及其作为药物的用途
公开(公告)号：US20050143456A1
公开(公告)日：2005-06-30
申请号：US10978674
申请日：2004-11-01
申请人： Elisabeth Defossa , Thomas Klabunde , Hans-Joerg Burger , Andreas Herling , Erich Roedern , Stefan Peukert , Alfons Enhsen , Armin Bauer , Bernd Neises , Karl Wendt
发明人： Elisabeth Defossa , Thomas Klabunde , Hans-Joerg Burger , Andreas Herling , Erich Roedern , Stefan Peukert , Alfons Enhsen , Armin Bauer , Bernd Neises , Karl Wendt
IPC分类号： C07D295/12 , A61K31/17 , A61K31/197 , A61K31/198 , A61K31/221 , A61K31/223 , A61K31/245 , A61K31/27 , A61K31/277 , A61K31/357 , A61K31/36 , A61K31/40 , A61K31/404 , A61K31/4045 , A61K31/433 , A61K31/4406 , A61K31/4409 , A61K31/445 , A61K31/4545 , A61K31/5375 , A61P3/04 , A61P3/10 , A61P7/02 , A61P9/10 , A61P11/06 , A61P13/12 , A61P17/06 , A61P19/10 , A61P25/00 , A61P25/18 , A61P25/28 , A61P27/00 , A61P29/00 , A61P31/00 , A61P31/18 , A61P35/00 , A61P37/00 , A61P37/06 , A61P43/00 , C07C275/54 , C07C313/28 , C07C323/42 , C07D209/08 , C07D209/14 , C07D211/58 , C07D213/40 , C07D285/14 , C07D295/13 , C07D295/205 , C07D317/58 , C07D319/18 , C07D401/04 , A61K31/195
CPC分类号： C07D213/40 , C07C275/54 , C07C323/42 , C07C2601/16 , C07C2602/10 , C07D209/08 , C07D211/58 , C07D285/14 , C07D295/13 , C07D295/205 , C07D317/58 , C07D319/18 , C07D401/04
摘要： The invention relates to carboxamide-substituted phenylurea derivatives and their physiologically tolerated salts and physiologically functional derivatives. Compounds of the formula I in which the radicals have the stated meanings, and the physiologically tolerated salts thereof and process for their preparation are described. The compounds are suitable, for example, for treating type II diabetes.
摘要翻译：本发明涉及羧酰胺取代的苯基脲衍生物及其生理上耐受的盐和生理功能衍生物。描述了其中基团具有所述含义的式I化合物及其生理上可耐受的盐及其制备方法。该化合物适用于例如用于治疗II型糖尿病。

3. 发明授权

US08039480B2 Spirocyclic nitriles as protease inhibitors 有权
标题翻译：螺环腈作为蛋白酶抑制剂
公开(公告)号：US08039480B2
公开(公告)日：2011-10-18
申请号：US12277880
申请日：2008-11-25
申请人： Manfred Schudok , Michael Wagner , Armin Bauer , Anna Kohlmann
发明人： Manfred Schudok , Michael Wagner , Armin Bauer , Anna Kohlmann
IPC分类号： A61K31/44 , C07D221/20
CPC分类号： C07D319/14 , C07C233/63 , C07C255/46 , C07C2601/02 , C07D211/66 , C07D213/26 , C07D221/20 , C07D231/54 , C07D263/52 , C07D295/215 , C07D295/26 , C07D317/72 , C07D471/10 , C07D491/10
摘要： The invention relates to substituted carbo- and heterocyclic spiro compounds of the formula Ia which inhibit thiol proteases, to processes for their preparation and to the use thereof as medicaments.
摘要翻译：本发明涉及抑制巯基蛋白酶的式Ia的取代的碳杂环和杂环螺环化合物，其制备方法及其作为药物的用途。

4. 发明申请

US20090033743A1 MONITORING DEVICE 有权
标题翻译：监控设备
公开(公告)号：US20090033743A1
公开(公告)日：2009-02-05
申请号：US12188448
申请日：2008-08-08
申请人： Thomas Gruber-Nadlinger , Armin Bauer
发明人： Thomas Gruber-Nadlinger , Armin Bauer
IPC分类号： H04N7/18
CPC分类号： G03B17/02
摘要： A device for monitoring objects, in particular for monitoring industrial environments, such as paper mills and manufacturing and/or finishing processes of a paper, board or other fibrous web being carried out therein, includes a monitoring camera, the camera with its objective being arranged in a rotationally symmetrical protective housing rotating about an axis of rotation, and a protective housing to be mounted at its one end on a rigid hollow shaft and, at its coaxially opposite other end, to have a co-rotating blower pipe or merge into the latter, and for compressed air to be applied to the protective housing, including the blower pipe.
摘要翻译：一种用于监测物体的装置，特别是用于监测工业环境，例如造纸厂以及在其中执行的纸，板或其它纤维网的制造和/或整理过程，包括监控摄像机，其目的是布置在摄像机在围绕旋转轴线旋转的旋转对称的保护壳体中，以及保护壳体，其一端安装在刚性中空轴上，并且在其同轴地相对另一端处具有同向旋转的鼓风机管道或合并到并且用于压缩空气被施加到包括鼓风机管道的保护壳体。

5. 发明授权

US07986410B2 Method for detecting a fibrous web tear in a drying section of a machine for producing the fibrous web and apparatus for performing said method 失效
标题翻译：用于检测用于生产纤维幅材的机器的干燥部分中的纤维网撕裂的方法和用于执行所述方法的装置
公开(公告)号：US07986410B2
公开(公告)日：2011-07-26
申请号：US12050621
申请日：2008-03-18
申请人： Armin Bauer , Dietmar Üblacker
发明人： Armin Bauer , Dietmar Üblacker
IPC分类号： G01N21/84
CPC分类号： G01N21/8901 , D21F7/04 , D21G9/0036
摘要： This invention relates to a method for detecting a tear in a fibrous web in a drying section of a machine for producing the fibrous web, whereby the fibrous web is passed through the drying section by way of at least one dryer fabric, whereby the tear is detected by at least one optical web tear detection device, which includes at least one luminous source and one detector, and whereby a cut-off apparatus for the fibrous web is directly or indirectly activated by the web tear detection device. The optical web tear detection device is operated over an extended wave length range in order to detect a tear in the fibrous web reliably. In addition, the invention relates to an apparatus for performing the inventive method.
摘要翻译：本发明涉及一种用于检测用于生产纤维幅材的机器的干燥部分中的纤维幅材的撕裂的方法，由此纤维幅材通过至少一个干燥织物通过干燥部分，由此撕裂是由包括至少一个发光源和一个检测器的至少一个光学纤网撕裂检测装置检测到，并且由此纤维幅材的切断装置由卷材撕裂检测装置直接或间接地启动。光纤撕裂检测装置在延长的波长范围内操作，以便可靠地检测纤维幅材中的撕裂。此外，本发明涉及一种用于执行本发明的方法的装置。

6. 发明授权

US07358268B2 Imidazole derivatives as factor Xa inhibitors 有权
标题翻译：咪唑衍生物作为因子Xa抑制剂
公开(公告)号：US07358268B2
公开(公告)日：2008-04-15
申请号：US10728339
申请日：2003-12-04
申请人： Marc Nazare , Armin Bauer , Volkmar Wehner , David W. Will , Hans Matter , Michael Wagner , Herman Schreuder
发明人： Marc Nazare , Armin Bauer , Volkmar Wehner , David W. Will , Hans Matter , Michael Wagner , Herman Schreuder
IPC分类号： A61K31/42 , C07D261/04 , C07D413/04
CPC分类号： C07D401/12 , C07D401/14 , C07D413/14 , C07D417/14
摘要： This invention is directed to the compound of formula (I) which is useful for inhibiting the activity of Factor Xa. The present invention is also directed to compositions containing said compounds, processes for their preparation, their use, such as in inhibiting the formation of thrombin or for therapeutically or prophylactically treating a patient suffering from, or subject to, or associated with a disease state associated with a cardiovascular disorder.
摘要翻译：本发明涉及可用于抑制因子Xa的活性的式（I）化合物。本发明还涉及包含所述化合物的组合物，其制备方法，其用途，例如抑制凝血酶的形成或用于治疗或预防性地治疗患有或与疾病状态有关的患者或与之相关的患者伴有心血管疾病。

7. 发明申请

US20070179122A1 Beta-Aminoacid-Derivatives As Factor Xa Inhibitors 审中-公开
标题翻译： β-氨基酸衍生物作为因子Xa抑制剂
公开(公告)号：US20070179122A1
公开(公告)日：2007-08-02
申请号：US11469513
申请日：2006-09-01
申请人： Matthias Urmann , Marc Nazare , Volkmar Wehner , Hans Matter , Armin Bauer , Michael Wagner
发明人： Matthias Urmann , Marc Nazare , Volkmar Wehner , Hans Matter , Armin Bauer , Michael Wagner
IPC分类号： A61K31/553 , A61K31/551 , A61K31/55 , A61K31/541 , A61K31/496 , A61K31/5377 , C07D417/02 , C07D413/02 , C07D403/02
CPC分类号： C07K5/0202 , C07D265/32 , C07D265/33 , C07D291/06 , C07D295/112 , C07D409/12 , C07D409/14 , C07D413/12 , C07D419/12
摘要： The present invention relates to compounds of the formula I, in which R0; R1; R2; R3; R4; R5, R, Q; V, G and M have the meanings indicated in the claims. The compounds of the formula I are valuable pharmacologically active compounds. They exhibit a strong antithrombotic effect and are suitable, for example, for the therapy and prophylaxis of cardiovascular disorders like thromboemboic diseases or restenoses. They are reversible inhibitors of the blood clotting enzymes factor Xa (FXa) and/or factor VIIa (FVIIa), and can in general be applied in conditions in which an undesired activity of factor Xa and/or factor VIIa is present or for the cure or prevention of which an inhibition of factor Xa and/or factor VIIa is intended. The invention furthermore relates to processes for the preparation of compounds of the formula I, their use, in particular as active ingredients in pharmaceuticals, and pharmaceutical preparations comprising them.
摘要翻译：本发明涉及式I化合物，其中R 0， R＆lt; 1＆gt;; R 2; 3＆lt; 3＆gt; R 4; R 5，R，Q; V，G和M具有权利要求中所示的含义。式I的化合物是有价值的药理活性化合物。它们表现出强烈的抗血栓形成作用，并且适用于例如治疗和预防心血管疾病如血栓栓塞性疾病或再狭窄。它们是血液凝固酶因子Xa（FXa）和/或因子VIIa（FVIIa）的可逆抑制剂，并且通常可用于存在因子Xa和/或因子VIIa的不期望活性或用于治愈或预防因子Xa和/或因子VIIa的抑制。本发明还涉及式I化合物的制备方法，其用途，特别是作为药物中的活性成分，以及包含它们的药物制剂。

8. 发明申请

US20090275523A1 Spirocyclic nitriles as protease inhibitors 有权
标题翻译：螺环腈作为蛋白酶抑制剂
公开(公告)号：US20090275523A1
公开(公告)日：2009-11-05
申请号：US12277880
申请日：2008-11-25
申请人： Manfred Schudok , Michael Wagner , Armin Bauer , Anna Kohlmann
发明人： Manfred Schudok , Michael Wagner , Armin Bauer , Anna Kohlmann
IPC分类号： A61K38/05 , C07D221/20 , C07D471/10 , C07C255/29 , C07D498/10 , A61P35/00
CPC分类号： C07D319/14 , C07C233/63 , C07C255/46 , C07C2601/02 , C07D211/66 , C07D213/26 , C07D221/20 , C07D231/54 , C07D263/52 , C07D295/215 , C07D295/26 , C07D317/72 , C07D471/10 , C07D491/10
摘要： The invention relates to substituted carbo- and heterocyclic spiro compounds of the formula Ia which inhibit thiol proteases, to processes for their preparation and to the use thereof as medicaments.
摘要翻译：本发明涉及抑制巯基蛋白酶的式Ia的取代的碳杂环和杂环螺环化合物，其制备方法及其作为药物的用途。

9. 发明授权

US07465806B2 Pyrrole-derivatives as factor Xa inhibitors 有权
标题翻译：吡咯衍生物作为因子Xa抑制剂
公开(公告)号：US07465806B2
公开(公告)日：2008-12-16
申请号：US11467277
申请日：2006-08-25
申请人： Armin Bauer , Michael Wagner , Marc Nazare , Volkmar Wehner , Matthias Urmann , Hans Matter
发明人： Armin Bauer , Michael Wagner , Marc Nazare , Volkmar Wehner , Matthias Urmann , Hans Matter
IPC分类号： C07D261/06 , C07D207/32
CPC分类号： C07D401/12 , C07D401/14 , C07D413/14
摘要： The present invention relates to compounds of the formulae I and Ia, wherein R0; R1; R3; R4; R22, Q; V, G and M have the meanings indicated in the claims. The compounds of the formulae I and Ia are valuable pharmacologically active compounds. They exhibit a strong antithrombotic effect and are suitable for the therapy and prophylaxis of cardiovascular disorders like thromboembolic diseases or restenoses. They are reversible inhibitors of the blood clotting enzymes factor Xa (FXa) and/or factor VIIa (FVIIa), and can in general be applied in conditions in which an undesired activity of factor Xa and/or factor VIIa is present or for the cure or prevention of which an inhibition of factor Xa and/or factor VIIa is intended. The invention furthermore relates to processes for the preparation of compounds of the formulae I and Ia, their use, in particular as active ingredients in pharmaceuticals, and pharmaceutical preparations comprising them.
摘要翻译：本发明涉及式I和Ia的化合物，其中R 0; R1; R3; R4; R22，Q; V，G和M具有权利要求中所示的含义。式I和Ia的化合物是有价值的药理活性化合物。它们具有强烈的抗血栓形成作用，适用于治疗和预防心血管疾病如血栓栓塞性疾病或再狭窄。它们是血液凝固酶因子Xa（FXa）和/或因子VIIa（FVIIa）的可逆抑制剂，并且通常可用于存在因子Xa和/或因子VIIa的不期望活性或用于治愈或预防因子Xa和/或因子VIIa的抑制。本发明还涉及制备式I和Ia化合物的方法，其用途，特别是作为药物中的活性成分，以及包含它们的药物制剂。

10. 发明授权

US06900233B2 Substituted 3-phenyl-5-alkoxy-3H-(1,3,4)-oxadiazol-2-ones, pharmaceutical composition and method for treating obesity thereof 有权
标题翻译：取代的3-苯基-5-烷氧基-3H-（1,3,4） - 恶二唑-2-酮药物组合物及其肥胖症的治疗方法
公开(公告)号：US06900233B2
公开(公告)日：2005-05-31
申请号：US10375247
申请日：2003-02-27
申请人： Karl Schoenafinger , Stefan Petry , Günter Müller , Armin Bauer , Hubert Otto Heuer
发明人： Karl Schoenafinger , Stefan Petry , Günter Müller , Armin Bauer , Hubert Otto Heuer
IPC分类号： C07D271/10 , C07D271/113 , A61K31/4245 , A61P3/00
CPC分类号： C07D271/113
摘要： A substituted 3-phenyl-5-alkoxy-3H-(1,3,4)-oxadiazol-2-one, compound of formula 1, wherein R1, R2, R3, R4 and R5 are as defined herein, pharmaceutical composition comprising the compound and use of the compound for inhibiting pancreatic lipase, or the prophylaxis or treatment of obesity are described.
摘要翻译：取代的3-苯基-5-烷氧基-3H-（1,3,4） - 恶二唑-2-酮，式1的化合物，其中R 1，R 2， >，R 3，R 4和R 5如本文所定义，包含该化合物的药物组合物和用于抑制胰脂肪酶的化合物，或预防或治疗肥胖症。

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