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1. 发明申请

US20050143456A1 Carboxamide-substituted phenylurea derivatives, process for their preparation and their use as medicaments 审中-公开
标题翻译：羧酰胺取代的苯基脲衍生物，其制备方法及其作为药物的用途
公开(公告)号：US20050143456A1
公开(公告)日：2005-06-30
申请号：US10978674
申请日：2004-11-01
申请人： Elisabeth Defossa , Thomas Klabunde , Hans-Joerg Burger , Andreas Herling , Erich Roedern , Stefan Peukert , Alfons Enhsen , Armin Bauer , Bernd Neises , Karl Wendt
发明人： Elisabeth Defossa , Thomas Klabunde , Hans-Joerg Burger , Andreas Herling , Erich Roedern , Stefan Peukert , Alfons Enhsen , Armin Bauer , Bernd Neises , Karl Wendt
IPC分类号： C07D295/12 , A61K31/17 , A61K31/197 , A61K31/198 , A61K31/221 , A61K31/223 , A61K31/245 , A61K31/27 , A61K31/277 , A61K31/357 , A61K31/36 , A61K31/40 , A61K31/404 , A61K31/4045 , A61K31/433 , A61K31/4406 , A61K31/4409 , A61K31/445 , A61K31/4545 , A61K31/5375 , A61P3/04 , A61P3/10 , A61P7/02 , A61P9/10 , A61P11/06 , A61P13/12 , A61P17/06 , A61P19/10 , A61P25/00 , A61P25/18 , A61P25/28 , A61P27/00 , A61P29/00 , A61P31/00 , A61P31/18 , A61P35/00 , A61P37/00 , A61P37/06 , A61P43/00 , C07C275/54 , C07C313/28 , C07C323/42 , C07D209/08 , C07D209/14 , C07D211/58 , C07D213/40 , C07D285/14 , C07D295/13 , C07D295/205 , C07D317/58 , C07D319/18 , C07D401/04 , A61K31/195
CPC分类号： C07D213/40 , C07C275/54 , C07C323/42 , C07C2601/16 , C07C2602/10 , C07D209/08 , C07D211/58 , C07D285/14 , C07D295/13 , C07D295/205 , C07D317/58 , C07D319/18 , C07D401/04
摘要： The invention relates to carboxamide-substituted phenylurea derivatives and their physiologically tolerated salts and physiologically functional derivatives. Compounds of the formula I in which the radicals have the stated meanings, and the physiologically tolerated salts thereof and process for their preparation are described. The compounds are suitable, for example, for treating type II diabetes.
摘要翻译：本发明涉及羧酰胺取代的苯基脲衍生物及其生理上耐受的盐和生理功能衍生物。描述了其中基团具有所述含义的式I化合物及其生理上可耐受的盐及其制备方法。该化合物适用于例如用于治疗II型糖尿病。

2. 发明授权

US06812250B2 Carboxamide-substituted phenylurea derivatives, process for their preparation and their use as medicaments 有权
标题翻译：羧酰胺取代的苯基脲衍生物，其制备方法及其作为药物的用途
公开(公告)号：US06812250B2
公开(公告)日：2004-11-02
申请号：US10153597
申请日：2002-05-24
申请人： Elisabeth Defossa , Thomas Klabunde , Hans-Joerg Burger , Andreas Herling , Erich von Roedern , Stefan Peukert , Alfons Enhsen , Armin Bauer , Bernd Neises , Karl Ulrich Wendt
发明人： Elisabeth Defossa , Thomas Klabunde , Hans-Joerg Burger , Andreas Herling , Erich von Roedern , Stefan Peukert , Alfons Enhsen , Armin Bauer , Bernd Neises , Karl Ulrich Wendt
IPC分类号： C07C27516
CPC分类号： C07D213/40 , C07C275/54 , C07C323/42 , C07C2601/16 , C07C2602/10 , C07D209/08 , C07D211/58 , C07D285/14 , C07D295/13 , C07D295/205 , C07D317/58 , C07D319/18 , C07D401/04
摘要： The invention relates to carboxamide-substituted phenylurea derivatives and their physiologically tolerated salts and physiologically functional derivatives. Compounds of the formula I in which the radicals have the stated meanings, and the physiologically tolerated salts thereof and process for their preparation are described. The compounds are suitable, for example, for treating type II diabetes.

3. 发明授权

US07223796B2 Acyl-4-carboxyphenylurea derivatives, processes for preparing them and their use 有权
标题翻译：酰基-4-羧基苯基脲衍生物，其制备方法及其用途
公开(公告)号：US07223796B2
公开(公告)日：2007-05-29
申请号：US10410601
申请日：2003-04-10
申请人： Elisabeth Defossa , Dieter Kadereit , Karl Schoenafinger , Thomas Klabunde , Hans-Joerg Burger , Andreas Herling , Karl-Ulrich Wendt , Erich Von Roedern , Alfons Enhsen , Joerg Rieke-Zapp
发明人： Elisabeth Defossa , Dieter Kadereit , Karl Schoenafinger , Thomas Klabunde , Hans-Joerg Burger , Andreas Herling , Karl-Ulrich Wendt , Erich Von Roedern , Alfons Enhsen , Joerg Rieke-Zapp
IPC分类号： A61K31/24 , C07C265/30 , C07C275/06 , C07D207/04 , C07D263/34
CPC分类号： C07D295/155 , C07C275/54
摘要： The invention relates to acyl-4-carboxyphenylurea derivatives and to their physiologically tolerated salts and physiologically functional derivatives.The invention particularly relates to compounds of formula I, in which the radicals have the given meanings described herein, and to their physiologically tolerated salts and processes for preparing them. The compounds are, for example, suitable for use as antidiabetics.
摘要翻译：本发明涉及酰基-4-羧基苯基脲衍生物及其生理上耐受的盐和生理功能衍生物。本发明特别涉及式I化合物，其中基团具有本文所述的给定含义，以及其生理学上耐受的盐及其制备方法。化合物例如适合用作抗糖尿病药。

4. 发明授权

US07781459B2 Carboxyalkoxy-substituted acyl-carboxyphenylurea derivatives and their use as medicaments 有权
标题翻译：羧甲氧基取代的酰基 - 羧基苯基脲衍生物及其作为药物的用途
公开(公告)号：US07781459B2
公开(公告)日：2010-08-24
申请号：US11613433
申请日：2006-12-20
申请人： Elisabeth DeFossa , Dieter Kadereit , Thomas Klabunde , Hans-Joerg Burger , Andreas Herling , Karl-Ulrich Wendt , Erich Von Roedern , Karl Schoenafinger , Alfons Enhsen
发明人： Elisabeth DeFossa , Dieter Kadereit , Thomas Klabunde , Hans-Joerg Burger , Andreas Herling , Karl-Ulrich Wendt , Erich Von Roedern , Karl Schoenafinger , Alfons Enhsen
IPC分类号： A61K31/445 , C07D211/08
CPC分类号： C07C275/54
摘要： The invention relates to acyl-carboxyphenylurea derivatives and to their physiologically tolerated salts and physiologically functional derivatives.Compounds of the formula I, in which the radicals have the stated meanings, and the physiological tolerated salts thereof and processes for preparing them are described. The compounds are suitable for example for the treatment of type II diabetes.
摘要翻译：本发明涉及酰基羧基苯基脲衍生物及其生理上耐受的盐和生理功能衍生物。描述了其中基团具有所述含义的式I化合物及其生理耐受盐及其制备方法。该化合物适用于例如治疗II型糖尿病。

5. 发明申请

US20050014822A1 Carbonylamino-substituted acyl phenyl urea derivatives, process for their preparation and their use 有权
标题翻译：羰基氨基取代的酰基苯基脲衍生物，其制备方法及其应用
公开(公告)号：US20050014822A1
公开(公告)日：2005-01-20
申请号：US10763877
申请日：2004-01-23
申请人： Elisabeth Defossa , Dieter Kadereit , Thomas Klabunde , Hans-Joerg Burger , Andreas Herling , Karl-Ulrich Wendt , Erich Von Roedern , Karl Schoenafinger , Alfons Enhsen
发明人： Elisabeth Defossa , Dieter Kadereit , Thomas Klabunde , Hans-Joerg Burger , Andreas Herling , Karl-Ulrich Wendt , Erich Von Roedern , Karl Schoenafinger , Alfons Enhsen
IPC分类号： C07C275/54 , C07D209/12 , C07D213/82 , C07D295/02 , C07D295/033 , C07D307/68 , C07D307/85 , C07D333/38 , A61K31/325 , A61K31/17 , A61K31/195 , C07C275/52
CPC分类号： C07D213/82 , C07C275/54 , C07C2601/04 , C07D209/12 , C07D295/033 , C07D307/68 , C07D307/85 , C07D333/38
摘要： The invention relates to compounds of the formula I in which the radicals are defined as specified, and also to their physiologically tolerated salts. The compounds are suitable, for example, as medicaments for preventing and treating type 2 diabetes.
摘要翻译：本发明涉及式Ⅰ化合物，其中基团按照规定定义，也涉及其生理上耐受的盐。该化合物例如可用作预防和治疗2型糖尿病的药物。

6. 发明申请

US20070088083A1 CARBOXYALKOXY-SUBSTITUTED ACYL-CARBOXYPHENYLUREA DERIVATIVES AND THEIR USE AS MEDICAMENTS 有权
标题翻译：羧氧基取代的乙酰氧基苯甲醛衍生物及其作为药物的用途
公开(公告)号：US20070088083A1
公开(公告)日：2007-04-19
申请号：US11613433
申请日：2006-12-20
申请人： Elisabeth DeFossa , Dieter Kadereit , Thomas Klabunde , Hans-Joerg Burger , Andreas Herling , Karl-Ulrich Wendt , Erich Von Roedern , Karl Schoenafinger , Alfons Enhsen
发明人： Elisabeth DeFossa , Dieter Kadereit , Thomas Klabunde , Hans-Joerg Burger , Andreas Herling , Karl-Ulrich Wendt , Erich Von Roedern , Karl Schoenafinger , Alfons Enhsen
IPC分类号： A61K31/277 , A61K31/24 , A61K31/195 , C07C275/46
CPC分类号： C07C275/54
摘要： The invention relates to acyl-carboxyphenylurea derivatives and to their physiologically tolerated salts and physiologically functional derivatives. Compounds of the formula I, in which the radicals have the stated meanings, and the physiological tolerated salts thereof and processes for preparing them are described. The compounds are suitable for example for the treatment of type II diabetes.
摘要翻译：本发明涉及酰基羧基苯基脲衍生物及其生理上耐受的盐和生理功能衍生物。描述了其中基团具有所述含义的式I化合物及其生理耐受盐及其制备方法。该化合物适用于例如治疗II型糖尿病。

7. 发明授权

US07179941B2 Carbonylamino-substituted acyl phenyl urea derivatives, process for their preparation and their use 有权
标题翻译：羰基氨基取代的酰基苯基脲衍生物，其制备方法及其应用
公开(公告)号：US07179941B2
公开(公告)日：2007-02-20
申请号：US10763877
申请日：2004-01-23
申请人： Elisabeth Defossa , Dieter Kadereit , Thomas Klabunde , Hans-Joerg Burger , Andreas Herling , Karl-Ulrich Wendt , Erich Von Roedern , Karl Schoenafinger , Alfons Enhsen
发明人： Elisabeth Defossa , Dieter Kadereit , Thomas Klabunde , Hans-Joerg Burger , Andreas Herling , Karl-Ulrich Wendt , Erich Von Roedern , Karl Schoenafinger , Alfons Enhsen
IPC分类号： C07C273/00 , C07C53/00 , C07C59/00 , C07C229/00 , A61K31/00
CPC分类号： C07D213/82 , C07C275/54 , C07C2601/04 , C07D209/12 , C07D295/033 , C07D307/68 , C07D307/85 , C07D333/38
摘要： The invention relates to compounds of the formula I in which the radicals are defined as specified, and also to their physiologically tolerated salts. The compounds are suitable, for example, as medicaments for preventing and treating type 2 diabetes.
摘要翻译：本发明涉及式Ⅰ化合物，其中基团按照规定定义，也涉及其生理上耐受的盐。该化合物例如可用作预防和治疗2型糖尿病的药物。

8. 发明授权

US07078404B2 Acyl-3-carboxyphenylurea derivatives, processes for preparing them and their use 有权
公开(公告)号：US07078404B2
公开(公告)日：2006-07-18
申请号：US10410892
申请日：2003-04-10
申请人： Elisabeth Defossa , Dieter Kadereit , Karl Schoenafinger , Thomas Klabunde , Hans-Joerg Burger , Andreas Herling , Karl-Ulrich Wendt , Erich Von Roedern , Alfons Enhsen
发明人： Elisabeth Defossa , Dieter Kadereit , Karl Schoenafinger , Thomas Klabunde , Hans-Joerg Burger , Andreas Herling , Karl-Ulrich Wendt , Erich Von Roedern , Alfons Enhsen
IPC分类号： A61K31/50 , C07D241/04 , C07D263/32 , C07D307/06 , C07C243/09
CPC分类号： C07C275/54
摘要： The invention relates to acyl-3-carboxyphenylurea derivatives and to their physiologically tolerated salts and physiologically functional derivatives.The invention relates to compounds of formula I, in which the radicals have the given meanings, and to their physiologically tolerated salts and processes for preparing them. The compounds are, for example, suitable for use as antidiabetics.

9. 发明授权

US07019023B2 Benzothiepine 1, 1-dioxide derivatives, a process for their preparation, pharmaceuticals comprising these compounds, and their use 有权
标题翻译：苯并噻吩1,1-二氧化物衍生物，其制备方法，包含这些化合物的药物及其用途
公开(公告)号：US07019023B2
公开(公告)日：2006-03-28
申请号：US10606771
申请日：2003-06-27
申请人： Wendelin Frick , Alfons Enhsen , Heiner Glombik , Hubert Heuer
发明人： Wendelin Frick , Alfons Enhsen , Heiner Glombik , Hubert Heuer
IPC分类号： A61K31/38
CPC分类号： C07K5/06086 , A61K38/00 , C07D337/08 , C08G65/329
摘要： Substituted benzothiepine 1,1-dioxide derivatives of formula I: in which R1, R2, R3, R4, R5 and Z have the meanings indicated, and their physiologically tolerable salts and physiologically functional derivatives and a process for their preparation are described. The compounds are suitable, for example, as hypolipidemics.
摘要翻译：取代的式I的苯并噻吩1,1-二氧化物衍生物：其中R 1，R 2，R 3，R 4， Z和Z具有所示的含义，并描述了它们的生理上可耐受的盐和生理功能衍生物及其制备方法。该化合物例如可用作降血脂药物。

10. 发明授权

US06090190A Closure systems for chromatographic columns 有权
标题翻译：色谱柱封闭系统
公开(公告)号：US06090190A
公开(公告)日：2000-07-18
申请号：US209286
申请日：1998-12-11
申请人： Alfons Enhsen , Ralf Watkowiak
发明人： Alfons Enhsen , Ralf Watkowiak
IPC分类号： B01D15/08 , G01N30/60 , F16L37/20
CPC分类号： B01D15/08 , G01N30/6004 , F16L37/20
摘要： A device for establishing a flange connection, having a bearing which can act on a first flange, a counter-bearing which can act on a second flange, and a connecting lever between the two bearings is described. The invention is distinguished by the fact that the connecting lever is a lever with a drawing element. The drawing element and the lever each have a first and second end. The drawing element's first end engages the bearing and its second end jointedly mounts in between the first and second ends of the lever. The counter-bearing has at least one contact location for the first end of the lever and a recess for the drawing element.
摘要翻译：描述了一种用于建立凸缘连接的装置，其具有能够作用在第一凸缘上的轴承，可作用在第二凸缘上的反作用轴和两个轴承之间的连接杆。本发明的特征在于连接杆是具有拉伸元件的杠杆。绘图元件和杠杆各自具有第一和第二端。拉拔元件的第一端接合轴承，并且其第二端连接地安装在杆的第一和第二端之间。反轴承具有用于杆的第一端的至少一个接触位置和用于牵引元件的凹部。

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