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1. 发明授权

US06847843B1 Method and apparatus for electrophysiological testing in an implantable device 失效
标题翻译：用于在可植入装置中进行电生理测试的方法和装置
公开(公告)号：US06847843B1
公开(公告)日：2005-01-25
申请号：US09876755
申请日：2001-06-06
申请人： Elia Arambula Mouchawar , Bonian Dai , Mohssen Fard , Gregory Hauck , Corey L. Brown
发明人： Elia Arambula Mouchawar , Bonian Dai , Mohssen Fard , Gregory Hauck , Corey L. Brown
IPC分类号： A61N1/18 , A61N1/362 , A61N1/365 , A61N1/372
CPC分类号： A61N1/365 , A61N1/3625
摘要： An implantable cardiac stimulation device and associated method capable of delivering non-invasive programmed stimulation for electrophysiological testing in which the onset of the non-invasive programmed stimulation is triggered by a cardiac event, either a detected intrinsic event or a stimulated event, occurring in the heart chamber to be tested. When a non-invasive programmed stimulation command is received by the implanted device, it switches to a routine that allows transition to a non-invasive programmed stimulation from a standard operating mode, during a refractory period. The stimulation device also provides a recovery delay following the last pulse of a non-invasive programmed stimulation sequence. If no intrinsic activity is detected during the recovery delay, a refractory period is started following the expiration of the recovery delay. During this refractory period, a transition from the non-invasive programmed stimulation state machine back to the standard stimulation state machine is accomplished.
摘要翻译：可植入的心脏刺激装置和相关联的方法，其能够递送用于电生理测试的非侵入式程序刺激，其中非侵入式程序化刺激的发作由心脏事件触发，或者检测到的固有事件或刺激事件心室待测。当植入装置接收非侵入式编程刺激命令时，它切换到允许在不应期内从标准操作模式转换到无创程序刺激的程序。刺激装置还在非侵入式编程刺激序列的最后脉冲之后提供恢复延迟。如果在恢复延迟期间没有检测到内在活动，则在恢复延迟期满后开始不应期。在这个不应期内，实现了从无创程序刺激状态机转移到标准刺激状态机的过渡。

2. 发明授权

US07756572B1 System and method for efficiently distinguishing among cardiac ischemia, hypoglycemia and hyperglycemia using an implantable medical device and an external system 有权
标题翻译：使用可植入医疗器械和外部系统有效区分心脏缺血，低血糖和高血糖的系统和方法
公开(公告)号：US07756572B1
公开(公告)日：2010-07-13
申请号：US11740175
申请日：2007-04-25
申请人： Mohssen Fard , Xiaoyi Min , Peter Boileau , Jong Gill , Bing Zhu , Jay Snell , Laleh Jalali , Josh Reiss , Gene Bornzin
发明人： Mohssen Fard , Xiaoyi Min , Peter Boileau , Jong Gill , Bing Zhu , Jay Snell , Laleh Jalali , Josh Reiss , Gene Bornzin
IPC分类号： A61B5/0468
CPC分类号： A61N1/36585 , A61B5/0452 , A61B5/0468 , A61B5/14532 , A61N1/36557
摘要： Techniques are described for efficiently detecting and distinguishing among cardiac ischemia, hypoglycemia or hyperglycemia based on intracardiac electrogram (IEGM) signals. In one example, a preliminary indication of an episode of cardiac ischemia is detected based on shifts in ST segment elevation within the IEGM. In response, the implanted device then records additional IEGM data for transmission to an external system. The external system analyzes the additional IEGM data to confirm the detection of cardiac ischemia using a more sophisticated analysis procedure exploiting additional detection parameters. In particular, the external system uses detection parameters capable of distinguishing hypoglycemia, hyperglycemia and hyperkalemia from cardiac ischemia, such as QTmax and QTend intervals. Alternatively, the more sophisticated analysis procedure may be performed by the device itself, if it is so equipped. Other examples described herein pertain instead to the detection of atrial fibrillation.
摘要翻译：描述了基于心脏电图（IEGM）信号来有效检测和区分心脏缺血，低血糖或高血糖的技术。在一个实例中，基于IEGM内的ST段抬高的移动来检测心脏缺血发作的初步指示。作为响应，植入的装置然后记录附加的IEGM数据以传输到外部系统。外部系统使用更复杂的分析程序利用额外的检测参数来分析额外的IEGM数据，以确认心脏缺血的检测。特别地，外部系统使用能够区分低血糖，高血糖和高血钾从心脏缺血的检测参数，例如QTmax和QTend间期。或者，如果装置如此装备，则可以由装置本身执行更复杂的分析程序。本文描述的其它实例代替心房颤动的检测。

3. 发明申请

US20110004111A1 ISCHEMIA DETECTION USING INTRA-CARDIAC SIGNALS 有权
标题翻译： ISCHEMIA检测使用内部信号
公开(公告)号：US20110004111A1
公开(公告)日：2011-01-06
申请号：US12846387
申请日：2010-07-29
申请人： Jong Gill , Peter Boileau , Gene A. Bornzin , Joseph J. Florio , Mohssen Fard
发明人： Jong Gill , Peter Boileau , Gene A. Bornzin , Joseph J. Florio , Mohssen Fard
IPC分类号： A61B5/0452
CPC分类号： A61B5/0452 , A61B5/7203 , A61B5/7264 , Y10S128/92
摘要： An implanted cardiac rhythm management device is disclosed that is operative to detect myocardial ischemia. This is done by evaluating electrogram features to detect an electrocardiographic change; specifically, changes in electrogram segment during the early part of an ST segment. The early part of the ST segment is chosen to avoid the T-wave.
摘要翻译：公开了可用于检测心肌缺血的植入式心律管理装置。这通过评估电描记图特征来检测心电图变化来完成; 具体来说，在ST段的早期部分的电描绘片段的变化。选择ST段的早期部分以避免T波。

4. 发明授权

US07274959B1 System and method for detecting cardiac ischemia using an implantable medical device 有权
标题翻译：使用可植入医疗装置检测心脏缺血的系统和方法
公开(公告)号：US07274959B1
公开(公告)日：2007-09-25
申请号：US10603429
申请日：2003-06-24
申请人： Zifei Wang , Mohssen Fard , Jeffery D. Snell
发明人： Zifei Wang , Mohssen Fard , Jeffery D. Snell
IPC分类号： A61B5/0452
CPC分类号： A61B5/0452 , A61B5/0456
摘要： A technique is provided for detecting episodes of cardiac ischemia based on an examination of post-T-wave signal segments. Since cardiac ischemia is often a precursor to acute myocardial infarction (AMI) or ventricular fibrillation (VF), the technique thereby provides a method for predicting the possible onset of AMI or VF so that a warning may be delivered to the patient. The warning preferably includes both a perceptible electrical notification signal applied directly to subcutaneous tissue and a warning signal delivered via short range telemetry to a handheld warning device external to the patient. In one example, the onset of cardiac ischemia is identified by detecting a sharp falling edge within post-T-wave signals by filtering the signals using a high-pass filter having a cutoff frequency of at least 1 Hz. The total amount of energy in the filtered signal is calculated and compared against various thresholds.
摘要翻译：提供了一种基于检查后T波信号段来检测心脏缺血发作的技术。由于心脏缺血通常是急性心肌梗死（AMI）或心室颤动（VF）的前兆，因此该技术提供了一种预测AMI或VF可能出现的方法，以便向患者传递警告。该警告优选地包括直接施加于皮下组织的可察觉的电通知信号和通过短距离遥测传送到患者外部的手持警告装置的警告信号。在一个示例中，通过使用具有至少1Hz的截止频率的高通滤波器对信号进行滤波来检测后T波信号中的尖锐下降沿来识别心脏缺血的发作。计算滤波信号中的总能量，并与各种阈值进行比较。

5. 发明授权

US08180439B2 Ischemia detection using intra-cardiac signals 有权
标题翻译：使用心脏内信号的缺血检测
公开(公告)号：US08180439B2
公开(公告)日：2012-05-15
申请号：US12846387
申请日：2010-07-29
申请人： Jong Gill , Peter Boileau , Gene A. Bornzin , Joseph J. Florio , Mohssen Fard
发明人： Jong Gill , Peter Boileau , Gene A. Bornzin , Joseph J. Florio , Mohssen Fard
IPC分类号： A61B5/0452
CPC分类号： A61B5/0452 , A61B5/7203 , A61B5/7264 , Y10S128/92
摘要： An implanted cardiac rhythm management device is disclosed that is operative to detect myocardial ischemia. This is done by evaluating electrogram features to detect an electrocardiographic change; specifically, changes in electrogram segment during the early part of an ST segment. The early part of the ST segment is chosen to avoid the T-wave.
摘要翻译：公开了可用于检测心肌缺血的植入式心律管理装置。这通过评估电描记图特征来检测心电图变化来完成; 具体来说，在ST段的早期部分，电描绘片段的变化。选择ST段的早期部分以避免T波。

6. 发明授权

US07792572B1 Ischemia detection using intra-cardiac signals 有权
标题翻译：使用心脏内信号的缺血检测
公开(公告)号：US07792572B1
公开(公告)日：2010-09-07
申请号：US11130858
申请日：2005-05-16
申请人： Jong Gill , Peter Boileau , Gene A. Bornzin , Joseph J. Florio , Mohssen Fard
发明人： Jong Gill , Peter Boileau , Gene A. Bornzin , Joseph J. Florio , Mohssen Fard
IPC分类号： A61B5/0452
CPC分类号： A61B5/0452 , A61B5/7203 , A61B5/7264 , Y10S128/92
摘要： An implanted cardiac rhythm management device is disclosed that is operative to detect myocardial ischemia. This is done by evaluating electrogram features to detect an electrocardiographic change; specifically, changes in electrogram segment during the early part of an ST segment. The early part of the ST segment is chosen to avoid the T-wave.
摘要翻译：公开了可用于检测心肌缺血的植入式心律管理装置。这通过评估电描记图特征来检测心电图变化来完成; 具体来说，在ST段的早期部分的电描绘片段的变化。选择ST段的早期部分以避免T波。

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