专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US5358732A Method and system for removing impurities from aliments 失效
标题翻译：从营养中去除杂质的方法和系统
公开(公告)号：US5358732A
公开(公告)日：1994-10-25
申请号：US105024
申请日：1993-08-10
申请人： Eli Seifter , Jacques Padawer , Iraj Lalezari
发明人： Eli Seifter , Jacques Padawer , Iraj Lalezari
IPC分类号： A23L5/20 , C12H1/07 , C12M1/12 , A23L1/015 , C12G3/08
CPC分类号： C12M37/02 , A23L5/25 , A23L5/27 , C12H1/063
摘要： A method for improving the quality of an aliment, such as an alcoholic liquor, by removing impurities such as carbamates, sulfites and bioamines, includes contacting an aliment containing the impurity with a container formed of a membrane permeable to the impurity. The container encloses a non-diffusible reactant such as binding agents, neutralizing agents, oxidizing agents, transesterifying agents and hydrolyzing agents. The container and the contents are separated from the aliment after a period of time sufficient for the reactants to react with the impurity.
摘要翻译：通过除去诸如氨基甲酸酯，亚硫酸盐和生物胺等杂质的方法来提高诸如酒精等营养物质的方法，包括使含有杂质的营养物与由可渗透的杂质形成的容器接触。该容器包含非扩散性反应物，例如粘合剂，中和剂，氧化剂，酯交换剂和水解剂。在足以使反应物与杂质反应的一段时间后，将容器和内容物与营养物分离。

2. 发明授权

US6072072A Compounds for preparing modified hemoglobin 有权
标题翻译：用于制备改性血红蛋白的化合物
公开(公告)号：US6072072A
公开(公告)日：2000-06-06
申请号：US274072
申请日：1999-03-22
申请人： Iraj Lalezari , Parviz Lalezari
发明人： Iraj Lalezari , Parviz Lalezari
IPC分类号： A61K38/00 , C07K14/805 , C07C69/76 , A61K35/14 , A61K38/16
CPC分类号： C07K14/805 , A61K38/00 , Y10S530/829
摘要： The present invention provides a chemically modified form of hemoglobin that is stabilized and can efficiently bind and release oxygen. In addition the chemically modified hemoglobin may be polymerized to increase its molecular weight and increase its stability so that it will have a longer half life in the circulatory system and may be used as a stable oxygen transport mediator which is useful as the basis of a blood substitute.
摘要翻译：本发明提供稳定化并可有效结合和释放氧的血红蛋白的化学修饰形式。此外，化学修饰的血红蛋白可以聚合以增加其分子量并增加其稳定性，使得其在循环系统中具有更长的半衰期，并且可以用作稳定的氧输送介质，其可用作血液的基础替代。

3. 发明授权

US5472981A Method of synthesis and novel compounds for pharmaceutical uses 失效
标题翻译：合成方法和药物用途的新型化合物
公开(公告)号：US5472981A
公开(公告)日：1995-12-05
申请号：US158702
申请日：1993-11-29
申请人： Iraj Lalezari , Parviz Lalezari
发明人： Iraj Lalezari , Parviz Lalezari
IPC分类号： C07C233/75 , C07C273/18 , C07C275/34 , A61K31/195 , A61K31/24
CPC分类号： C07C273/1827 , C07C233/75 , C07C275/34
摘要： The present invention is concerned with a method for treating hemoglobin or blood in vivo or in vitro to modify the affinity of hemoglobin for oxygen, said method comprising causing an effective amount of a substituted arylureidophenoxymethyl propionic acid to come in contact with hemoglobin.
摘要翻译：本发明涉及一种用于在体内或体外处理血红蛋白或血液以改变血红蛋白对氧的亲和力的方法，所述方法包括使有效量的取代的芳基脲基苯氧基甲基丙酸与血红蛋白接触。

4. 发明申请

US20140371316A1 DERIVATIVES OF PHENOXYISOBUTYRIC ACID 审中-公开
标题翻译：苯甲酸的衍生物
公开(公告)号：US20140371316A1
公开(公告)日：2014-12-18
申请号：US14360252
申请日：2012-11-23
申请人： Jill S. FABRICANT , Iraj LALEZARI
发明人： Iraj Lalezari , Jill S. Fabricant
IPC分类号： C07D265/30 , C07D213/55 , C07D235/18 , A61Q19/08 , C07C217/92 , A61K8/41 , A61K8/49 , C07D211/08 , C07C237/40
CPC分类号： C07D265/30 , A61K8/411 , A61K8/42 , A61K8/49 , A61K8/4926 , A61K8/4946 , A61Q19/08 , C07C217/84 , C07C217/92 , C07C233/25 , C07C233/75 , C07C235/74 , C07C237/40 , C07C2601/14 , C07D209/48 , C07D211/08 , C07D213/36 , C07D213/55 , C07D235/14 , C07D235/18 , C07D295/096 , C07D295/125
摘要： The present invention provides a process for the synthesis of substituted phenoxymethylpropiomc acid and related compounds. The compounds are useful for inhibiting the formation of AGEs (Advanced Glycation End Products).
摘要翻译：本发明提供了一种合成取代的苯氧基甲基丙酸及其相关化合物的方法。该化合物可用于抑制AGEs（高级糖化终产物）的形成。

5. 发明申请

US20120071502A1 Novel phenoxyisobutyric acid compounds and methods for synthesis 审中-公开
标题翻译：新型苯氧基异丁酸化合物及其合成方法
公开(公告)号：US20120071502A1
公开(公告)日：2012-03-22
申请号：US13199941
申请日：2011-09-13
申请人： Iraj Lalezari , Jill Fabricant
发明人： Iraj Lalezari , Jill Fabricant
IPC分类号： A61K31/196 , C07D215/14 , C07D215/52 , C07D219/04 , C07D307/87 , A61K31/47 , A61K31/473 , A61K31/343 , A61K8/49 , A61K8/44 , A61Q19/08 , A61P29/00 , A61P25/28 , A61P3/00 , A61P9/10 , A61P25/00 , A61P3/10 , C07C229/42
CPC分类号： C07D307/87 , A61K8/411 , A61K8/42 , A61K8/4926 , A61Q19/08 , C07C215/76 , C07C229/40 , C07C233/75 , C07C235/72 , C07C235/74 , C07C275/34 , C07C275/42 , C07D215/12 , C07D215/14 , C07D215/50 , C07D215/52 , C07D219/04
摘要： The present invention provides a process for the synthesis of substituted phenoxymethylpropionic acid and related compounds. The compounds are useful for inhibiting the formation of AGEs (Advanced Glycation End Products).
摘要翻译：本发明提供了一种合成取代的苯氧基甲基丙酸和相关化合物的方法。该化合物可用于抑制AGEs（高级糖化终产物）的形成。

6. 发明授权

US08034966B1 Phenoxyisobutyric acid compounds and methods for synthesis 有权
标题翻译：苯氧基异丁酸化合物及其合成方法
公开(公告)号：US08034966B1
公开(公告)日：2011-10-11
申请号：US12380020
申请日：2009-05-15
申请人： Iraj Lalezari , Jill Fabricant
发明人： Iraj Lalezari , Jill Fabricant
IPC分类号： C07C69/96 , C07C229/00
CPC分类号： C07C275/34
摘要： The present invention provides a process for the synthesis of substituted arylureidophenoxymethylpropionic acid and related compounds including bifunctional and tetrafunctional derivatives. The compounds are useful for inhibiting the formation of AGEs (Aminaglycation end products).
摘要翻译：本发明提供一种合成取代芳基脲基苯氧基甲基丙酸的方法及包括双功能和四官能衍生物的相关化合物。该化合物可用于抑制AGEs的形成（Aminaglycation最终产物）。

7. 发明授权

US5268500A Compound, composition and method for the reduction of lipids the modification of the affinity of hemoblogin for oxygen and the prevention of platelet aggregation 失效
标题翻译：用于还原脂质的化合物，组合物和方法血红蛋白对氧的亲和力的改变和预防血小板聚集
公开(公告)号：US5268500A
公开(公告)日：1993-12-07
申请号：US778706
申请日：1991-10-18
申请人： Iraj Lalezari , Samuel Rahbar , Parviz Lalezari
发明人： Iraj Lalezari , Samuel Rahbar , Parviz Lalezari
IPC分类号： C07C275/34 , A61K31/195 , C07C229/00
CPC分类号： C07C275/34
摘要： Novel compounds are disclosed which have the formula: ##STR1## wherein R.sub.1, R.sub.2, R.sub.3 and R.sub.4 may be the same or different and independently selected from the group consisting of hydrogen, halogen, straight and branched chain alkyl of from 1-6 carbon atoms, aryl, cycloalkyl of 4 to 7 carbon atoms; and alkoxy of 1 to 6 carbon atoms; R.sub.5 and R.sub.6 may be the same or different and are selected from the group consisting of hydrogen, halogen, straight and branched chain alkyl groups of from 1-6 carbon atoms, aralkyl groups wherein the alkyl portion has from 1-6 carbon atoms cycloalkyl of from 4-7 carbon atoms and aryl; R.sub.7 is hydrogen or a straight or branched chain alkyl group of 1-6 carbon atoms and the pharmaceutically acceptable salts thereof.These compounds are useful for the treatment of hyperlipidemia and for the in vivo and in vitro treatment of hemoglobin or blood to modify the affinity of hemoglobin for oxygen.
摘要翻译：公开了具有下式的新化合物：其中R 1，R 2，R 3和R 4可以相同或不同并且独立地选自氢，卤素，1-6个碳原子的直链和支链烷基芳基，4-7个碳原子的环烷基; 和1-6个碳原子的烷氧基; R5和R6可以相同或不同，并且选自氢，卤素，1-6个碳原子的直链和支链烷基，芳烷基，其中烷基部分具有1-6个碳原子的环烷基 4-7个碳原子和芳基; R7是氢或1-6个碳原子的直链或支链烷基及其药学上可接受的盐。这些化合物可用于治疗高脂血症和用于体内和体外治疗血红蛋白或血液以改变血红蛋白对氧的亲和力。

8. 发明授权

US4780542A Process for the synthesis of esters and amides of carboxylic acids 失效
标题翻译：合成羧酸酯和酰胺的方法
公开(公告)号：US4780542A
公开(公告)日：1988-10-25
申请号：US535573
申请日：1983-09-26
申请人： Iraj Lalezari
发明人： Iraj Lalezari
IPC分类号： C07D277/82 , C07D249/18 , C07C67/08 , C07C102/00 , C11C1/00
CPC分类号： C07D277/82
摘要： The invention relates to the preparation of an ester or an amide from an anhydride with an alcohol or an amine, wherein the anhydride is first prepared by reacting an acid and an alkyl chloroformate in a 100% aqueous medium, that is, 100% water.
摘要翻译：本发明涉及由酸酐与醇或胺制备酯或酰胺，其中酸酐首先通过酸和氯甲酸烷基酯在100％水性介质，即100％水中反应来制备。

9. 发明授权

US5962651A Modified hemoglobin and its use as a component of an artificial blood substitute 失效
标题翻译：改性血红蛋白及其作为人造血液替代品成分的用途
公开(公告)号：US5962651A
公开(公告)日：1999-10-05
申请号：US903930
申请日：1997-07-31
申请人： Iraj Lalezari , Parviz Lalezari
发明人： Iraj Lalezari , Parviz Lalezari
IPC分类号： A61K38/00 , C07K14/805 , A61K35/14 , A61K38/16 , C07C69/76
CPC分类号： C07K14/805 , A61K38/00 , Y10S530/829
摘要： The present invention provides a chemically modified form of hemoglobin that is stabilized and can efficiently bind and release oxygen. In addition the chemically modified hemoglobin may be polymerized to increase its molecular weight and increase its stability so that it will have a longer half life in the circulatory system and may be used as a stable oxygen transport mediator which is useful as the basis of a blood substitute.
摘要翻译：本发明提供稳定化并可有效结合和释放氧的血红蛋白的化学修饰形式。此外，化学修饰的血红蛋白可以聚合以增加其分子量并增加其稳定性，使得其在循环系统中具有更长的半衰期，并且可以用作稳定的氧输送介质，其可用作血液的基础替代。

10. 发明授权

US4734275A Anti-curare agents 失效
标题翻译：防腐剂
公开(公告)号：US4734275A
公开(公告)日：1988-03-29
申请号：US855053
申请日：1986-04-22
申请人： Iraj Lalezari , Francis F. Foldes
发明人： Iraj Lalezari , Francis F. Foldes
IPC分类号： A61K31/44 , C07D213/75
CPC分类号： C07D213/75 , A61K31/44 , Y10S514/823
摘要： This invention relates to a method for antagonizing induced the neuromuscular blocking effects of certain therapeutic agents and pathological disorders in mammals, which comprises administering to said mammal an antagonizing-effective amount of a compound of the formula: ##STR1## wherein R.sub.1 and R.sub.2 are each hydrogen, alkyl, alkenyl, alkynyl, aryl, aralkyl, cycloalkyl, cycloalkyl-lower alkyl or hydroxyalkyl, or, when taken together, form a heterocyclic ring with the nitrogen to which they are attached, with the proviso that both are not hydrogen;R.sub.3 is hydrogen or alkyl; andR.sub.4 is hydrogen, alkyl, alkenyl, alkynyl, halogen or acyl; or a salt thereof with acids.
摘要翻译：本发明涉及一种拮抗诱导哺乳动物某些治疗剂和病理学障碍的神经肌肉阻滞作用的方法，其包括向所述哺乳动物施用拮抗有效量的下式化合物：其中R1和R2各自为氢，烷基，烯基，炔基，芳基，芳烷基，环烷基，环烷基 - 低级烷基或羟基烷基，或者当与它们所连接的氮形成杂环时，条件是两者都不是氢; R3是氢或烷基; R4是氢，烷基，烯基，炔基，卤素或酰基; 或其与酸的盐。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式