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1. 发明授权

US06835194B2 Implantable devices and methods for treatment of pain by delivery of fentanyl and fentanyl congeners 失效
标题翻译：通过输送芬太尼和芬太尼同系物治疗疼痛的植入式装置和方法
公开(公告)号：US06835194B2
公开(公告)日：2004-12-28
申请号：US10188325
申请日：2002-06-27
申请人： Randolph Mellus Johnson , Felix Theeuwes , Edward M. Gillis , Dana Litmanovitz , Barbara Laidlaw , James Brown , John Culwell , James A. Filice , Peter Wickman , Su-Il Yum , Andrew Poutiatine , John Dinka
发明人： Randolph Mellus Johnson , Felix Theeuwes , Edward M. Gillis , Dana Litmanovitz , Barbara Laidlaw , James Brown , John Culwell , James A. Filice , Peter Wickman , Su-Il Yum , Andrew Poutiatine , John Dinka
IPC分类号： A61K922
CPC分类号： A61F2/02 , A61F2250/0067 , A61K9/0004 , A61K9/0024 , A61K31/4468 , A61K31/4535 , A61K47/10 , A61K47/14 , A61K47/26 , A61M5/141 , A61M5/14276 , A61M5/1452 , A61M5/168 , A61M5/16804 , A61M5/16881 , A61M31/002 , A61M2005/14264
摘要： The invention features devices and methods for treatment of pain. The drug delivery device is a drug delivery system adapted for whole implantation in a subject and to provide pain relief by delivery of fentanyl or a fentanyl congener (e.g., sufentanil) over a protracted period of time (e.g., at least 3 days or more than 3 days). The device comprises a housing defining a reservoir that contains a drug formulation, a pump operatively connected to the housing so as to facilitate movement of drug out of the reservoir and out of the device, and a thermal expansion element which defines a flow pathway comprising a thermal expansion channel to accommodate thermal expansion of formulation in the reservoir. The device can further comprise a valve positioned within the flow pathway so as to prevent movement of drug out of the reservoir prior to use.
摘要翻译：本发明的特征在于用于治疗疼痛的装置和方法。药物递送装置是适于整个植入受试者的药物递送系统，并通过在持续的时间段内输送芬太尼或芬太尼（例如舒芬太尼）来提供疼痛缓解（例如，至少3天或更多 3天）。该装置包括限定容纳药物制剂的储存器的壳体，可操作地连接到壳体的泵，以促进药物从储存器移出并离开装置;以及热膨胀元件，其限定流动通路，该热膨胀元件包括热膨胀通道，以适应储层中配方的热膨胀。该装置还可以包括位于流动通道内的阀，以便在使用之前防止药物从储存器中移动。

2. 发明申请

US20070014820A1 Opioid formulations 审中-公开
标题翻译：阿片制剂
公开(公告)号：US20070014820A1
公开(公告)日：2007-01-18
申请号：US11477140
申请日：2006-06-27
申请人： Dana Litmanovitz , Barbara Laidlaw
发明人： Dana Litmanovitz , Barbara Laidlaw
IPC分类号： A61K9/00 , A61K31/445
CPC分类号： A61K31/4535 , A61K31/4468
摘要： The present invention provides high-concentration formulations of opioids such as fentanyl or fentanyl congeners. The formulation of the invention comprises fentanyl or a fentanyl congener in concentrations significantly in excess of conventional formulations, e.g., on the order about 2-fold to about 10,000-fold greater than conventional formulations, e.g., currently commercially available formulations. These formulations are particularly useful for long-term delivery to a subject suffering from pain. The invention further provides drug delivery devices comprising the high-concentration opioid formulations, and further provides methods of alleviating pain in a subject, comprising administering the high-concentration formulations to a subject in need thereof.
摘要翻译：本发明提供阿片样物质如芬太尼或芬太尼同系物的高浓度制剂。本发明的制剂包括浓度显着超过常规制剂的芬太尼或芬太尼同系物，例如比常规制剂例如目前市售的制剂大约2倍至约10,000倍。这些制剂对于长期运送到患有疼痛的受试者是特别有用的。本发明进一步提供了包含高浓度阿片样物质制剂的药物递送装置，并且还提供减轻受试者疼痛的方法，包括向有需要的受试者施用高浓度制剂。

3. 发明授权

US07074803B2 Opioid formulations 失效
公开(公告)号：US07074803B2
公开(公告)日：2006-07-11
申请号：US10220525
申请日：2001-03-02
申请人： Dana Litmanovitz , Barbara J. F. Laidlaw
发明人： Dana Litmanovitz , Barbara J. F. Laidlaw
IPC分类号： A01N43/42 , C07D211/36
CPC分类号： A61K31/4535 , A61K31/4468
摘要： The present invention provides high-concentration formulations of opioids such as fentanyl or fentanyl congeners. The formulation of the invention comprises fentanyl or a fentanyl congener in concentrations significantly in excess of conventional formulations, e.g., on the order about 2-fold to about 10,000-fold greater than conventional formulations, e.g., currently commercially available formulations. These formulations are particularly useful for long-term delivery to a subject suffering from pain. The invention further provides drug delivery devices comprising the high-concentration opioid formulations, and further provides methods of alleviating pain in a subject, comprising administering the high-concentration formulations to a subject in need thereof.

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