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1. 发明申请

US20110230700A1 EXPANDABLE BRACHYTHERAPY APPARATUS AND METHODS FOR USING THEM 有权
标题翻译：可扩展的宽带设备及其使用方法
公开(公告)号：US20110230700A1
公开(公告)日：2011-09-22
申请号：US12727209
申请日：2010-03-18
申请人： Eduardo Chi Sing , Tommy G. Nguyen , Luis R. Urquidi
发明人： Eduardo Chi Sing , Tommy G. Nguyen , Luis R. Urquidi
IPC分类号： A61M36/12
CPC分类号： A61N5/1015 , A61M25/10 , A61M29/02 , A61N2005/1004
摘要： Brachytherapy treatment apparatus are provided that include an elongate body including a core member and an outer member surrounding and movable relative to the core member. One or more helical catheters are provided on a distal portion of the elongate body, e.g., including distal ends coupled to the core member and proximal ends coupled to the outer member. The outer member is movable relative to the core member, e.g., axially and/or rotationally, to direct the helical catheters between a collapsed configuration for introduction through a tissue tract to a target location, e.g., a lumpectomy cavity, and an expanded configuration. Each helical catheter includes a lumen, and, after expansion to the expanded configuration, a source of radiation may be introduced along the helical catheters and/or a lumen of the core member for delivering radiation to the target location. Optionally, the apparatus may include a balloon surrounding or within the helical members.
摘要翻译：提供了近程放射疗法治疗装置，其包括细长体，其包括芯部件和围绕并可相对于芯部件移动的外部部件。一个或多个螺旋导管设置在细长主体的远端部分上，例如包括联接到芯部件的远端和与外部部件相连的近端。外部构件可相对于芯构件例如轴向和/或旋转地移动，以将螺旋形导管引导到折叠构型之间，用于通过组织管道引导到目标位置，例如乳房切除腔，以及扩张构型。每个螺旋导管包括内腔，并且在膨胀到扩张构型之后，可以沿着螺旋形导管和/或芯构件的内腔引入辐射源，以将辐射传送到目标位置。可选地，该装置可以包括围绕或在螺旋构件内的气球。

2. 发明授权

US08814775B2 Expandable brachytherapy apparatus and methods for using them 有权
标题翻译：可扩展近距离放射治疗仪及其使用方法
公开(公告)号：US08814775B2
公开(公告)日：2014-08-26
申请号：US12727209
申请日：2010-03-18
申请人： Eduardo Chi Sing , Tommy G. Nguyen , Luis R. Urquidi
发明人： Eduardo Chi Sing , Tommy G. Nguyen , Luis R. Urquidi
IPC分类号： A61N5/00 , A61M29/02 , A61N5/10 , A61M25/10
CPC分类号： A61N5/1015 , A61M25/10 , A61M29/02 , A61N2005/1004
摘要： Brachytherapy treatment apparatus are provided that include an elongate body including a core member and an outer member surrounding and movable relative to the core member. One or more helical catheters are provided on a distal portion of the elongate body, e.g., including distal ends coupled to the core member and proximal ends coupled to the outer member. The outer member is movable relative to the core member, e.g., axially and/or rotationally, to direct the helical catheters between a collapsed configuration for introduction through a tissue tract to a target location, e.g., a lumpectomy cavity, and an expanded configuration. Each helical catheter includes a lumen, and, after expansion to the expanded configuration, a source of radiation may be introduced along the helical catheters and/or a lumen of the core member for delivering radiation to the target location. Optionally, the apparatus may include a balloon surrounding or within the helical members.
摘要翻译：提供了近程放射疗法治疗装置，其包括细长体，其包括芯部件和围绕并可相对于芯部件移动的外部部件。一个或多个螺旋导管设置在细长主体的远端部分上，例如包括联接到芯部件的远端和与外部部件相连的近端。外部构件可相对于芯构件例如轴向和/或旋转地移动，以将螺旋形导管引导到折叠构型之间，用于通过组织管道引导到目标位置，例如乳房切除腔，以及扩张构型。每个螺旋导管包括内腔，并且在膨胀到扩张构型之后，可以沿着螺旋形导管和/或芯构件的内腔引入辐射源，以将辐射传送到目标位置。可选地，该装置可以包括围绕或在螺旋构件内的气球。

3. 发明授权

US09713437B2 Microwave antenna apparatus, systems, and methods for localizing markers or tissue structures within a body 有权
公开(公告)号：US09713437B2
公开(公告)日：2017-07-25
申请号：US14165253
申请日：2014-01-27
申请人： Larry W. Fullerton , John E. Greene , Tommy G. Nguyen , Eduardo Chi Sing
发明人： Larry W. Fullerton , John E. Greene , Tommy G. Nguyen , Eduardo Chi Sing
IPC分类号： A61B5/06 , A61B90/98 , A61B5/00 , A61B5/05 , A61B34/20 , A61B90/00
CPC分类号： A61B5/064 , A61B5/0507 , A61B5/4312 , A61B5/6847 , A61B90/39 , A61B2034/2048 , A61B2090/3908 , A61B2090/3925 , A61B2090/3966 , A61B2090/3975 , A61B2090/3987 , A61B2090/3991
摘要： Apparatus, systems, and methods are provided for localizing lesions within a patient's body, e.g., within a breast. The system includes a microwave antenna probe for transmitting and receiving electromagnetic signals to detect one or more markers that are implanted within or around the target tissue region. During use, the marker(s) are implanted into a target tissue region, and the microwave antenna probe is placed against the patient's skin to transmit a signal to the marker(s) and to receive the reflected signal from the marker(s) in order to determine the location of the marker(s). A tissue specimen, including the lesion and the marker(s), is then removed from the target tissue region based at least in part on the location information from the microwave antenna probe.

4. 发明授权

US09386942B2 Apparatus, systems, and methods for localizing markers or tissue structures within a body 有权
标题翻译：用于在身体内定位标记物或组织结构的装置，系统和方法
公开(公告)号：US09386942B2
公开(公告)日：2016-07-12
申请号：US13053197
申请日：2011-03-21
申请人： Eduardo Chi Sing , Tommy G. Nguyen , Luis Urquidi
发明人： Eduardo Chi Sing , Tommy G. Nguyen , Luis Urquidi
IPC分类号： A61B6/12 , A61B5/06 , A61B5/05 , A61B5/00 , A61B8/08 , A61B19/00 , A61B17/00
CPC分类号： A61B90/39 , A61B5/0507 , A61B5/06 , A61B5/064 , A61B5/4312 , A61B8/0825 , A61B8/0841 , A61B8/481 , A61B10/0041 , A61B17/3468 , A61B90/37 , A61B2017/00438 , A61B2017/00442 , A61B2034/2051 , A61B2034/2072 , A61B2090/3908 , A61B2090/3925 , A61B2090/397 , A61B2090/3975 , A61B2090/3983 , A61B2090/3987
摘要： Apparatus, systems, and methods are provided for localizing lesions within a patient's body, e.g., within a breast. The system may include one or more markers implantable within or around the target tissue region, and a probe for transmitting and receiving electromagnetic signals to detect the one or more markers. During use, the marker(s) are into a target tissue region, and the probe is placed against the patient's skin to detect and localize the marker(s). A tissue specimen, including the lesion and the marker(s), is then removed from the target tissue region based at least in part on the localization information from the probe.
摘要翻译：提供了设备，系统和方法，用于定位患者身体内的损伤，例如在乳房内。系统可以包括可植入在目标组织区域内或周围的一个或多个标记，以及用于发送和接收电磁信号以检测一个或多个标记的探针。在使用期间，标记物进入目标组织区域，并将探针放置在患者皮肤上以检测和定位标记物。然后至少部分地基于来自探针的定位信息从靶组织区域中移除包括病变和标记物的组织标本。

5. 发明授权

US09072893B2 Expandable brachytherapy apparatus and methods for using them 有权
标题翻译：可扩展近距离放射治疗仪及其使用方法
公开(公告)号：US09072893B2
公开(公告)日：2015-07-07
申请号：US11757231
申请日：2007-06-01
申请人： Eduardo Chi Sing , George D. Hermann , Dong S. Sutton , Tommy G. Nguyen , Mark A. Ritchart , Steven L. Gex
发明人： Eduardo Chi Sing , George D. Hermann , Dong S. Sutton , Tommy G. Nguyen , Mark A. Ritchart , Steven L. Gex
IPC分类号： A61M36/12 , A61N5/10
CPC分类号： A61N5/1015 , A61N2005/1018
摘要： Apparatus for delivering brachytherapy to a target tissue region includes an elongate body including a proximal end, a distal end sized for introduction into a tissue tract and carrying a plurality of elongate members including pathways for receiving a source of radiation. The elongate members are movable between collapsed and expanded configurations. During use, a tract is created through tissue, and the elongate body carrying the elongate members is advanced through the tract into a target location with the elongate members in the collapsed configuration. The elongate members are directed to the expanded configuration at the target location, and radiation is delivered to treat tissue at the target location, e.g., by introducing one or more radiation sources along the pathways.
摘要翻译：用于将近距离放射治疗递送到目标组织区域的装置包括细长主体，其包括近端，远端，其尺寸适于引入到组织道中并且承载多个细长构件，包括用于接收辐射源的路径。细长构件可在折叠和膨胀构型之间移动。在使用期间，通过组织产生管道，并且携带细长构件的细长体通过管道前进到目标位置，细长构件处于收缩构型。细长构件在目标位置处被引导到扩展构型，并且例如通过沿着路径引入一个或多个辐射源，传送辐射以在目标位置处理组织。

6. 发明申请

US20140309522A1 MICROWAVE ANTENNA APPARATUS, SYSTEMS, AND METHODS FOR LOCALIZING MARKERS OR TISSUE STRUCTURES WITHIN A BODY 有权
标题翻译： MICROWAVE天线装置，系统和方法，用于在身体中标记或组织结构定位
公开(公告)号：US20140309522A1
公开(公告)日：2014-10-16
申请号：US14165253
申请日：2014-01-27
申请人： Larry W. Fullerton , John E. Greene , Tommy G. Nguyen , Eduardo Chi Sing
发明人： Larry W. Fullerton , John E. Greene , Tommy G. Nguyen , Eduardo Chi Sing
IPC分类号： A61B5/06 , A61B19/00
CPC分类号： A61B5/064 , A61B5/0507 , A61B5/4312 , A61B5/6847 , A61B90/39 , A61B2034/2048 , A61B2090/3908 , A61B2090/3925 , A61B2090/3966 , A61B2090/3975 , A61B2090/3987 , A61B2090/3991
摘要： Apparatus, systems, and methods are provided for localizing lesions within a patient's body, e.g., within a breast. The system includes a microwave antenna probe for transmitting and receiving electromagnetic signals to detect one or more markers that are implanted within or around the target tissue region. During use, the marker(s) are implanted into a target tissue region, and the microwave antenna probe is placed against the patient's skin to transmit a signal to the marker(s) and to receive the reflected signal from the marker(s) in order to determine the location of the marker(s). A tissue specimen, including the lesion and the marker(s), is then removed from the target tissue region based at least in part on the location information from the microwave antenna probe.
摘要翻译：提供了设备，系统和方法，用于定位患者身体内的损伤，例如在乳房内。该系统包括用于发送和接收电磁信号的微波天线探针，以检测植入在靶组织区域内或周围的一个或多个标记。在使用期间，将标记植入目标组织区域中，并且将微波天线探针放置在患者皮肤上以将信号传送到标记物并且从一个或多个标记物接收反射信号以确定标记的位置。至少部分地基于来自微波天线探针的位置信息，从目标组织区域中去除包括病变和标记物的组织标本。

7. 发明申请

US20120022314A1 BRACHYTHERAPY APPARATUS, SYSTEMS, AND METHODS FOR USING THEM 有权
标题翻译： BRACHYTHERAPY设备，系统和使用它们的方法
公开(公告)号：US20120022314A1
公开(公告)日：2012-01-26
申请号：US12841111
申请日：2010-07-21
申请人： Eduardo Chi Sing , Tommy G. Nguyen
发明人： Eduardo Chi Sing , Tommy G. Nguyen
IPC分类号： A61M36/04
CPC分类号： A61B90/39 , A61B2090/3925 , A61M25/0108 , A61N5/1027
摘要： A brachytherapy treatment apparatus is provided that includes a center catheter including proximal and distal ends defining a central longitudinal axis therebetween, the center catheter including a bend between the proximal and distal ends. The apparatus includes a pair of expandable catheters including pathways extending between the proximal and distal ends thereof, the expandable catheter distal ends coupled to the distal end of the core member. An actuator is coupled to the expandable catheters adjacent expandable portions that is movable relative to the center catheter for moving the expandable portions between a collapsed configuration wherein the expandable portions extend substantially parallel to the center catheter and an expanded configuration wherein the expandable portions bow away from one another substantially within a curved plane aligned generally with a bend of to the center catheter. A balloon is provided adjacent the expandable portions and surrounding a portion of the catheters.
摘要翻译：提供了一种近程放射疗法治疗装置，其包括中心导管，其包括限定其间的中心纵向轴线的近端和远端，所述中心导管包括近端和远端之间的弯曲部。该装置包括一对可扩张导管，其包括在其近端和远端之间延伸的通路，可扩张导管远端联接到芯构件的远端。致动器联接到相对于中心导管可移动的可扩张部分的可扩张导管，用于在折叠构型之间移动可膨胀部分，其中可扩张部分基本上平行于中心导管延伸，并且扩张构型，其中可扩张部分远离彼此基本上在与中心导管的弯曲部大致对齐的弯曲平面内。在可扩张部分附近提供气囊并围绕导管的一部分。

8. 发明申请

US20100048978A1 BRACHYTHERAPY APPARATUS, SYSTEMS, AND METHODS FOR USING THEM 有权
标题翻译： BRACHYTHERAPY设备，系统和使用它们的方法
公开(公告)号：US20100048978A1
公开(公告)日：2010-02-25
申请号：US12543469
申请日：2009-08-18
申请人： Eduardo Chi Sing , Tommy G. Nguyen
发明人： Eduardo Chi Sing , Tommy G. Nguyen
IPC分类号： A61M36/10 , A61M36/12
CPC分类号： A61N5/1015 , A61N5/1016
摘要： An applicator for delivering brachytherapy includes elongate members movable between collapsed and expanded configurations for delivering brachytherapy within a lumpectomy cavity, a vaginal cavity, or other target region. The elongate members may be expandable into a symmetrical or asymmetrical expanded configuration, e.g., into a generally spherical, pear-shaped, or planar configuration. A system for delivering brachytherapy includes the applicator and an access device for lining and/or dilating a body cavity and/or for receiving the applicator therein. The access device is advanced into a body cavity, an expandable member on the access device is inflated, the applicator is advanced into the access device, and the elongate members are expanded to deliver radiation to the target region. Alternatively, the access device carries an expandable device into the target region, the expandable device is removed after dilating the target region, and the applicator is introduced through the access device to deliver radiation.
摘要翻译：用于递送近距离放射治疗的施放器包括可在塌陷和膨胀构型之间移动的细长构件，用于在乳房切除腔，阴道腔或其它目标区域内输送近距离放射治疗。细长构件可以可扩展成对称或不对称的膨胀构型，例如，变成大致球形的梨形或平面构型。用于递送近距离放射治疗的系统包括施用器和用于衬里和/或扩张体腔和/或用于在其中接收施用器的进入装置。进入装置前进到体腔中，进入装置上的可膨胀构件被充气，施加器前进到进入装置中，并且细长构件被扩张以将辐射传递到目标区域。或者，接入设备将可扩展设备携带到目标区域中，在扩大目标区域之后移除可扩展设备，并且通过接入设备引入施加器以传送辐射。

9. 发明授权

US08517907B2 Expandable brachytherapy apparatus and methods for using them 有权
公开(公告)号：US08517907B2
公开(公告)日：2013-08-27
申请号：US12277286
申请日：2008-11-24
申请人： Eduardo Chi Sing , Tommy G. Nguyen , George D. Hermann , Than Nguyen , Doug S. Sutton
发明人： Eduardo Chi Sing , Tommy G. Nguyen , George D. Hermann , Than Nguyen , Doug S. Sutton
IPC分类号： A61M36/12
CPC分类号： A61N5/1015 , A61N2005/1018
摘要： Apparatus for delivering brachytherapy to a target tissue region includes an elongate body including a proximal end, a distal end sized for introduction into a tissue tract and carrying a plurality of elongate members including pathways for receiving a source of radiation. The elongate members are movable between collapsed and expanded configurations. During use, a tract is created through tissue, and the elongate body carrying the elongate members is advanced through the tract into a target location with the elongate members in the collapsed configuration. The elongate members are directed to the expanded configuration at the target location, and radiation is delivered to treat tissue at the target location, e.g., by introducing one or more radiation sources along the pathways.

10. 发明授权

US08475353B2 Brachytherapy apparatus, systems, and methods for using them 有权
标题翻译：近距离放射治疗仪器，系统和使用方法
公开(公告)号：US08475353B2
公开(公告)日：2013-07-02
申请号：US12543463
申请日：2009-08-18
申请人： Eduardo Chi Sing , Tommy G. Nguyen
发明人： Eduardo Chi Sing , Tommy G. Nguyen
IPC分类号： A61N5/00
CPC分类号： A61N5/1015 , A61N5/1016
摘要： An applicator for delivering brachytherapy includes elongate members movable between collapsed and expanded configurations for delivering brachytherapy within a lumpectomy cavity, a vaginal cavity, or other target region. The elongate members may be expandable into a symmetrical or asymmetrical expanded configuration, e.g., into a generally spherical, pear-shaped, or planar configuration. A system for delivering brachytherapy includes the applicator and an access device for lining and/or dilating a body cavity and/or for receiving the applicator therein. The access device is advanced into a body cavity, an expandable member on the access device is inflated, the applicator is advanced into the access device, and the elongate members are expanded to deliver radiation to the target region. Alternatively, the access device carries an expandable device into the target region, the expandable device is removed after dilating the target region, and the applicator is introduced through the access device to deliver radiation.
摘要翻译：用于递送近距离放射治疗的施放器包括可在塌陷和膨胀构型之间移动的细长构件，用于在乳房切除腔，阴道腔或其它目标区域内输送近距离放射治疗。细长构件可以可扩展成对称或不对称的膨胀构型，例如，变成大致球形的梨形或平面构型。用于递送近距离放射治疗的系统包括施用器和用于衬里和/或扩张体腔和/或用于在其中接收施用器的进入装置。进入装置前进到体腔中，进入装置上的可膨胀构件被充气，施加器前进到进入装置中，并且细长构件被扩张以将辐射传递到目标区域。或者，接入设备将可扩展设备携带到目标区域中，在扩大目标区域之后移除可扩展设备，并且通过接入设备引入施加器以传送辐射。

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