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1. 发明申请

US20100159507A1 SHREDDER FOR MECHANICAL DISRUPTION BY GENTLE CONTROLLED COMPRESSIVE ROTATION 审中-公开
标题翻译：用于机械控制压缩旋转的机械式破坏机
公开(公告)号：US20100159507A1
公开(公告)日：2010-06-24
申请号：US12562098
申请日：2009-09-17
申请人： Edmund Y. Ting , Alexander Lazarev , Vera Gross , Charles Dussault , Chunqin Li , Nathan Lawrence , Richard Schumacher
发明人： Edmund Y. Ting , Alexander Lazarev , Vera Gross , Charles Dussault , Chunqin Li , Nathan Lawrence , Richard Schumacher
IPC分类号： G01N1/28 , C12M1/00 , C12M1/33
CPC分类号： G01N1/286 , C12M35/04 , G01N2001/2866
摘要： The systems and techniques of the present invention can also synergistically utilize mechanical disruption processes with the use of high hydrostatic pressure extraction, such as pressure cycling extraction techniques to achieve high yield of difficult to extract sample constituents without generating high shear stress or high temperatures.
摘要翻译：本发明的系统和技术还可以协同地利用机械破碎过程，使用高静态压力提取，例如压力循环提取技术，以实现高产率的难以提取样品组分而不产生高剪切应力或高温。

2. 发明申请

US20100281955A1 MICROTUBE AND RELATED METHODS THEREFOR 审中-公开
标题翻译： MICROTUBE及其相关方法
公开(公告)号：US20100281955A1
公开(公告)日：2010-11-11
申请号：US12774577
申请日：2010-05-05
申请人： Edmund Y. Ting , Alexander Lazarev , Richard Schumacher , Charles Dussault , Wayne Fritzche
发明人： Edmund Y. Ting , Alexander Lazarev , Richard Schumacher , Charles Dussault , Wayne Fritzche
IPC分类号： G01M3/00
CPC分类号： G01N1/286 , B01L3/505 , B01L3/5082 , B01L9/06 , B01L2300/14
摘要： Sample processing devices having collapsible, flexible bodies are disclosed. The flexible microtube sampling devices are utilizable in pressure mediated, pressure cycling procedures. Externally applied pressure on the flexible microtube sample processing devices allow buckling thereof and transfer of the applied pressure to the sample contained therein.
摘要翻译：公开了具有可折叠，柔性体的样品处理装置。柔性微管采样装置可用于压力介导的压力循环程序。柔性微管样品处理装置上的外部施加的压力允许其弯曲并将施加的压力转移到其中所含的样品。

3. 发明申请

US20090286301A1 EXTRACTION OF BIOMOLECULAR COMPLEXES ASSISTED BY ALTERNATING HYDROSTATIC PRESSURE 审中-公开
标题翻译：通过替代静水压力来提取生物分子复合物
公开(公告)号：US20090286301A1
公开(公告)日：2009-11-19
申请号：US12437162
申请日：2009-05-07
申请人： Feng Tao , Richard Schumacher , Nathan Lawrence , Vera Gross , Gary Smejkal , Alexander Lazarev , Rui Han
发明人： Feng Tao , Richard Schumacher , Nathan Lawrence , Vera Gross , Gary Smejkal , Alexander Lazarev , Rui Han
IPC分类号： C12N9/20 , C12N9/24 , C12N9/50 , C12N5/06
CPC分类号： C12N1/066 , C12N13/00
摘要： Extraction methods that allow a molecular complex (e.g., an organelle) to be extracted from a sample by employing pressure cycling are described.
摘要翻译：描述了允许通过使用压力循环从样品中提取分子复合物（例如细胞器）的提取方法。

4. 发明授权

US09995661B2 Flow-through high hydrostatic pressure microfluidic sample preparation device and related methods therefor 有权
公开(公告)号：US09995661B2
公开(公告)日：2018-06-12
申请号：US13212934
申请日：2011-08-18
申请人： Edmund Y. Ting , Alexander Lazarev
发明人： Edmund Y. Ting , Alexander Lazarev
IPC分类号： G01N1/00 , G01N1/28 , G01N35/10
CPC分类号： G01N1/286 , G01N35/1095 , Y10T436/25
摘要： Described herein is a sample preparation device including a sample delivery source, an inline means of transferring the sample from the sample source into a deformable channel within a pressure vessel, and out of the channel into downstream analysis components, a deformable channel disposed within the pressure vessel, the deformable channel having an inlet end and an outlet end fluidly connectable to high pressure valves and a means to measure the fluid pressure within the deformable channel, an external source of a controlled pressurized fluid fluidly connectable to the pressure vessel and a controller system that monitors and controls the sample fluid pressure by control of the external pressure vessel fluid.

5. 发明申请

US20120122705A1 FLOW-THROUGH HIGH HYDROSTATIC PRESSURE MICROFLUIDIC SAMPLE PREPARATION DEVICE AND RELATED METHODS THEREFOR 有权
标题翻译：流动性高静电压力微流体样品制备装置及其相关方法
公开(公告)号：US20120122705A1
公开(公告)日：2012-05-17
申请号：US13212934
申请日：2011-08-18
申请人： Edmund Y. Ting , Alexander Lazarev
发明人： Edmund Y. Ting , Alexander Lazarev
IPC分类号： C40B30/00 , G01N1/00 , G01N33/566 , G01N33/559 , G01N33/48 , C12Q1/68 , C12Q1/37 , G01N27/447 , G01N31/00 , C12M1/34
CPC分类号： G01N1/286 , G01N35/1095 , Y10T436/25
摘要： Described herein is a sample preparation device including a sample delivery source, an inline means of transferring the sample from the sample source into a deformable channel within a pressure vessel, and out of the channel into downstream analysis components, a deformable channel disposed within the pressure vessel, the deformable channel having an inlet end and an outlet end fluidly connectable to high pressure valves and a means to measure the fluid pressure within the deformable channel, an external source of a controlled pressurized fluid fluidly connectable to the pressure vessel and a controller system that monitors and controls the sample fluid pressure by control of the external pressure vessel fluid.
摘要翻译：本文描述了一种样品制备装置，其包括样品输送源，将样品从样品源转移到压力容器内的可变形通道中的在线装置，并且从通道进入下游分析部件，设置在压力范围内的可变形通道容器，可变形通道具有流体连接到高压阀的入口端和出口端，以及测量可变形通道内的流体压力的装置，可流体连接到压力容器的受控加压流体的外部源和控制器系统其通过控制外部压力容器流体来监测和控制样品流体压力。

6. 发明授权

US10105704B2 System and method for microplate pressurization 有权
公开(公告)号：US10105704B2
公开(公告)日：2018-10-23
申请号：US13282904
申请日：2011-10-27
申请人： Edmund Y. Ting , Alexander Lazarev
发明人： Edmund Y. Ting , Alexander Lazarev
IPC分类号： B01L3/00 , G01N1/28 , B01L9/00
摘要： A pressurizable sample system includes a microplate having a planar plate surface and several sample wells. Each sample well has a flange positioned circumferentially around an outer surface of the sample well and against the planar plate surface. The sample system further includes a capping plate with a planar cap surface and several caps projecting from the planar cap surface. Each cap has a geometrical configuration in complementary correspondence with the configuration of the sample well.

7. 发明申请

US20120103113A1 SYSTEM AND METHOD FOR MICROPLATE PRESSURIZATION 审中-公开
标题翻译：微波加压的系统和方法
公开(公告)号：US20120103113A1
公开(公告)日：2012-05-03
申请号：US13282904
申请日：2011-10-27
申请人： Edmund Y. Ting , Alexander Lazarev
发明人： Edmund Y. Ting , Alexander Lazarev
IPC分类号： G01N1/28 , B01L3/00
CPC分类号： B01L3/50853 , B01L3/50851 , B01L9/50 , B01L2200/021 , B01L2200/0631 , B01L2200/0678 , B01L2200/0689 , B01L2200/141 , B01L2300/042 , B01L2300/048 , B01L2300/123 , B01L2300/14 , B01L2400/0487 , G01N1/28
摘要： A pressurizable sample system includes a microplate having a planar plate surface and several sample wells. Each sample well has a flange positioned circumferentially around an outer surface of the sample well and against the planar plate surface. The sample system further includes a capping plate with a planar cap surface and several caps projecting from the planar cap surface. Each cap has a geometrical configuration in complementary correspondence with the configuration of the sample well.
摘要翻译：可加压的样品系统包括具有平板表面和几个样品孔的微孔板。每个样品阱具有围绕样品阱的外表面周围定位并且抵靠平板表面的凸缘。样品系统还包括具有平面盖表面的盖板和从平面盖表面突出的多个盖。每个盖具有与样品阱的构造互补对应的几何构型。

8. 发明授权

US09458190B2 Extraction and partitioning of molecules 有权
标题翻译：分子的提取和分配
公开(公告)号：US09458190B2
公开(公告)日：2016-10-04
申请号：US12131604
申请日：2008-06-02
申请人： Alexander Lazarev , Vera Gross
发明人： Alexander Lazarev , Vera Gross
IPC分类号： C07K1/14
CPC分类号： C07K1/145
摘要： Methods of extracting a component of interest from a plurality of components are described.
摘要翻译：描述了从多个部件中提取关注部件的方法。

9. 发明申请

US20090188999A1 DEVICES, METHODS AND APPLICATIONS FOR EXTRACTION OF MOLECULES FROM POLYMERIC GEL ELECTROPHORETIC MEDIA 有权
标题翻译：从聚合胶体电泳介质中提取分子的装置，方法和应用
公开(公告)号：US20090188999A1
公开(公告)日：2009-07-30
申请号：US12302414
申请日：2007-05-29
申请人： Alexander Lazarev , Thomas Rejtar , Barry L. Karger
发明人： Alexander Lazarev , Thomas Rejtar , Barry L. Karger
IPC分类号： B02C19/00 , B02C23/02 , B02C18/00
CPC分类号： B01L3/502 , B01L2200/06 , B01L2300/0832 , B01L2400/0409 , G01N1/34 , G01N35/0099
摘要： A device and method to provide a simplified wash process and controlled disintegration of a soft substance, such as a gel, are disclosed. In use, a block of, e.g., gel matrix is placed in the device and washed with a series of appropriate solutions to remove interfering contaminants. The washing liquid is removed through a deformable narrow opening in the bottom of the device, and, subsequently, the gel block is extruded through the deformable narrow opening, by a physical force, such as centrifugal force, a vacuum or positive pressure from a gas or liquid, etc., resulting in fragmentation of the gel block into a series of particles of similar size. The fragmentation of the gel results from shear forces exerted onto the gel block traveling through the deformable narrow opening in the device. The rate of such fragmentation and resulting fragment size can be controlled by extruding the gel block using a predefined level of force as well as by controlling the dimensions and shape of the narrow opening (s) in the device.
摘要翻译：公开了一种提供简化的洗涤过程并控制软物质如凝胶的分解的装置和方法。在使用中，将一块例如凝胶基质置于装置中并用一系列适当的溶液洗涤以除去干扰的污染物。洗涤液体通过设备底部的可变形的窄开口被去除，随后，凝胶块通过物理力，例如离心力，来自气体的真空或正压挤压通过可变形的窄开口或液体等，导致凝胶块破碎成一系列类似尺寸的颗粒。凝胶的断裂是由施加在凝胶块上的剪切力所引起的，该凝胶块穿过装置中的可变形的窄开口。可以通过使用预定水平的力挤出凝胶块以及通过控制装置中的窄开口的尺寸和形状来控制这种碎裂和所得碎片尺寸的速率。

10. 发明授权

US08231070B2 Devices, methods and applications for extraction of molecules from polymeric gel electrophoretic media 有权
标题翻译：用于从聚合凝胶电泳介质中提取分子的装置，方法和应用
公开(公告)号：US08231070B2
公开(公告)日：2012-07-31
申请号：US12302414
申请日：2007-05-29
申请人： Alexander Lazarev , Thomas Rejtar , Barry L. Karger
发明人： Alexander Lazarev , Thomas Rejtar , Barry L. Karger
IPC分类号： B02C19/00
CPC分类号： B01L3/502 , B01L2200/06 , B01L2300/0832 , B01L2400/0409 , G01N1/34 , G01N35/0099
摘要： A device and method to provide a simplified wash process and controlled disintegration of a soft substance, such as a gel, are disclosed. In use, a block of, e.g., gel matrix is placed in the device and washed with a series of appropriate solutions to remove interfering contaminants. The washing liquid is removed through a deformable narrow opening in the bottom of the device, and, subsequently, the gel block is extruded through the deformable narrow opening, by a physical force, such as centrifugal force, a vacuum or positive pressure from a gas or liquid, etc., resulting in fragmentation of the gel block into a series of particles of similar size. The fragmentation of the gel results from shear forces exerted onto the gel block traveling through the deformable narrow opening in the device. The rate of such fragmentation and resulting fragment size can be controlled by extruding the gel block using a predefined level of force as well as by controlling the dimensions and shape of the narrow opening (s) in the device.
摘要翻译：公开了一种提供简化的洗涤过程并控制软物质如凝胶的分解的装置和方法。在使用中，将一块例如凝胶基质置于装置中并用一系列适当的溶液洗涤以除去干扰的污染物。洗涤液体通过设备底部的可变形的窄开口被去除，随后，凝胶块通过物理力，例如离心力，来自气体的真空或正压挤压通过可变形的窄开口或液体等，导致凝胶块破碎成一系列类似尺寸的颗粒。凝胶的断裂是由施加在凝胶块上的剪切力所引起的，该凝胶块穿过装置中的可变形的窄开口。可以通过使用预定水平的力挤出凝胶块以及通过控制装置中的窄开口的尺寸和形状来控制这种碎裂和所得碎片尺寸的速率。

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