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1. 发明授权

US5262330A Colorimetric methods and reagents for the assay of calcium in a test sample 失效
标题翻译：用于测试样品中钙的比色法和试剂
公开(公告)号：US5262330A
公开(公告)日：1993-11-16
申请号：US842860
申请日：1992-02-27
申请人： Eddy Chapoteau , Bronislaw P. Czech , Wolodymyr I. Zazulak
发明人： Eddy Chapoteau , Bronislaw P. Czech , Wolodymyr I. Zazulak
IPC分类号： G01N21/78 , C07C245/08 , G01N31/00 , G01N31/22 , G01N33/84 , C09B29/00 , G01N33/20
CPC分类号： G01N33/84 , C07C245/08 , G01N31/22 , G01N2800/04
摘要： A chromogenic compound found to be especially selective in the determination of calcium in blood of the general formula (I): ##STR1## where: R is hydrogen or lower alkyl;X is CH.sub.2, CH.sub.2 CH.sub.2, CH.dbd.CH, O, S, SO.sub.2, S--S, or NR;X is CH, C--OH or N;M is p-nitrophenylazo, 2,4-dinitrophenylazo, 2,4,6-trinitrophenylazo, p-nitrostyryl, p-benzoquinoneimino, bis-(4-dimethylaminophenyl) hydroxymethyl, 3-phenylisothiazolyl-5-azo, thiazolyl-5-azo, or isothiazolyl-5-azo;k is 1;l is 0 or 1; andn is 0 or 1.

2. 发明授权

US5814521A Metal ion determination by sandwich aggregation assay 失效
标题翻译：夹心聚集法测定金属离子
公开(公告)号：US5814521A
公开(公告)日：1998-09-29
申请号：US703982
申请日：1996-08-28
申请人： Eddy Chapoteau , Jonathan Craine , Bronislaw P. Czech , Anand Kumar , Koon-wah Leong
发明人： Eddy Chapoteau , Jonathan Craine , Bronislaw P. Czech , Anand Kumar , Koon-wah Leong
IPC分类号： G01N31/00 , G01N21/77 , G01N21/82 , G01N33/543 , G01N33/84 , G01N33/20 , G01N35/546
CPC分类号： G01N21/82 , G01N33/54313 , G01N33/84 , G01N2800/04 , Y10S436/909
摘要： The present invention relates to a method for the determination of polyvalent metal ions using a sandwich aggregation assay. One or more chelating agents capable of forming at least 2:1 or higher ratio stoichiometry complexes with polyvalent metal ions are attached to a suitable carrier such as latex particles through covalent bonds or by non-covalent interactions, such as hydophobic interactions. Upon complexation with the metal ions, the carriers of the complexing agent aggregate, causing an increase in light absorbance or light scattering which is proportional to the concentration of metal ions in the test sample. The measurement of the light absorbance or light scattering by a suitable instrument, such as a spectrophotometer or nephelometer provides a means for measuring the concentration of metal ions.
摘要翻译：本发明涉及使用夹心聚集测定法测定多价金属离子的方法。能够与多价金属离子形成至少2:1或更高比例化学计量配合物的一种或多种螯合剂通过共价键或通过非共价相互作用例如疏水相互作用连接到合适的载体如胶乳颗粒上。当与金属离子络合时，络合剂的载体聚集，引起与测试样品中金属离子浓度成比例的吸光度或光散射的增加。通过合适的仪器（例如分光光度计或浊度计）测量吸光度或光散射提供了测量金属离子浓度的方法。

3. 发明授权

US5145787A Method for determining the concentration of cations in a sample 失效
标题翻译：确定样品中阳离子浓度的方法
公开(公告)号：US5145787A
公开(公告)日：1992-09-08
申请号：US803134
申请日：1991-12-05
申请人： Eddy Chapoteau , Bronislaw P. Czech , Carl R. Gebauer , Koon-Wah Leong , Anand Kumar
发明人： Eddy Chapoteau , Bronislaw P. Czech , Carl R. Gebauer , Koon-Wah Leong , Anand Kumar
IPC分类号： C07D498/08 , C07D498/18 , G01N33/52 , G01N33/84
CPC分类号： C07D498/08 , C07D498/18 , G01N33/521 , G01N33/84
摘要： The invention is reagents and procedures for determining an amount of cations present in a sample, the reagent including one or more chromogenic crypt and compounds of formula I ##STR1## wherein k and j, either same or different, are equal to 1 to about 5;m and n, either same or different, are equal to 0 to about 4;a and e, either same or different, are equal to 0 to about 2;b and d, either same or different, are equal to 0 to about 5;R, either same or different, is hydrogen, lower alkyl, lower alkylidene, lower alkenyl, allyl, or aryl; and--Q-- is ##STR2## wherein X is CH, N, or COH; and Y includes ##STR3## except that when Q is ##STR4## wherein Y is p-nitrophenylazo, 3-phenylisothiazolyl-5-azo, isothiazolyl-5-azo, thiazolyl-5-azo, 2,4,6-trinitrophenylazo, p-nitrostyryl, p-benzoquinonemonoimino or bis-(p-dimethylaminophenyl)hydroxymethyl, then the following condition cannot be present: that simultaneously b is equal to 0 to 1, d is equal to 0 or 1, j is equal to 1, n is equal to 1 or 2, a is equal to 1, e is equal to 1, k is equal to 1 and m is equal to 2.
摘要翻译：本发明是用于确定样品中存在的阳离子量的试剂和方法，试剂包括一个或多个显色隐窝和式I（I）的化合物，其中相同或不同的k和j等于1 至约5; m和n相同或不同，等于0至约4; a和e相同或不同，等于0至约2; b和d相同或不同，等于0至约5; R，相同或不同，为氢，低级烷基，低级亚烷基，低级烯基，烯丙基或芳基; 和-Q-是，其中X是CH，N或COH; 并且Y包括，不同之处在于Q是，其中Y是对硝基苯基偶氮，3-苯基异噻唑-5-偶氮，异噻唑-5-偶氮，噻唑基-5 （2,4,6-三硝基苯基偶氮），对硝基苯乙烯基，对苯醌二亚氨基亚氨基或双 - （对二甲基氨基苯基）羟甲基，则不能存在以下条件：同时b等于0至1，d等于 0或1，j等于1，n等于1或2，a等于1，e等于1，k等于1，m等于2。

4. 发明授权

US5045475A Reagent for determining cations 失效
标题翻译：用于确定阳离子的试剂
公开(公告)号：US5045475A
公开(公告)日：1991-09-03
申请号：US201576
申请日：1988-06-01
申请人： Eddy Chapoteau , Bronislaw P. Czech , Carl R. Gebauer , Koon-Wah Leong , Anand Kumar
发明人： Eddy Chapoteau , Bronislaw P. Czech , Carl R. Gebauer , Koon-Wah Leong , Anand Kumar
IPC分类号： C07D498/08 , C07D498/18 , G01N33/52 , G01N33/84
CPC分类号： C07D498/08 , C07D498/18 , G01N33/521 , G01N33/84
摘要： The invention is reagents and procedures for determining an amount of cations present in a sample, the reagent including one or more chromogenic cryptand compounds of formula I ##STR1## wherein k and j, either same or different, are equal to 1 to about 5;m and n, either same or different, are equal to 0 to about 4;a and e, either same or different, are equal to 0 to about 2;b and d, either same or different, are equal to 0 to about 5;R, either same or different, is hydrogen, lower alkyl, lower alkylidene, lower alkenyl, allyl, or aryl; and--Q-- is ##STR2## wherein X and CH, N, or COH; and Y includes ##STR3## except that when Q is ##STR4## wherein Y is p-nitrophenylazo, 3-phenylisothiazolyl-5-azo, isothiazolyl-5-azo, thiazolyl-5-azo, 2,4,6-trinitrophenylazo, p-nitrostyryl, p-benzoquinonemonoimino or bis-(p-dimethylaminophenyl)hydroxymethyl, then the following condition cannot be present: that simultaneously b is equal to 0 or 1, d is equal to 0 or 1, j is equal to 1, n is equal to 1 or 2, a is equal to 1, e is equal to 1, k is equal to 1 and m is equal to 2.
摘要翻译：本发明是用于测定样品中存在的阳离子量的试剂和方法，该试剂包括一种或多种式I（I）的显色隐窝化合物，其中相同或不同的k和j相同或不同，约5; m和n相同或不同，等于0至约4; a和e相同或不同，等于0至约2; b和d相同或不同，等于0至约5; R，相同或不同，为氢，低级烷基，低级亚烷基，低级烯基，烯丙基或芳基; 和-Q-是，其中X和CH，N或COH; 并且Y包括，不同之处在于Q是，其中Y是对硝基苯基偶氮，3-苯基异噻唑-5-偶氮，异噻唑-5-偶氮，噻唑基-5 （2,4,6-三硝基苯基偶氮），对硝基苯乙烯基，对苯醌二亚氨基亚氨基或双 - （对二甲基氨基苯基）羟甲基，则不能存在以下条件：同时b等于0或1，d等于 0或1，j等于1，n等于1或2，a等于1，e等于1，k等于1，m等于2。

5. 发明授权

US5073501A Method for determining the concentration of cations in a sample 失效
标题翻译：确定样品中阳离子浓度的方法
公开(公告)号：US5073501A
公开(公告)日：1991-12-17
申请号：US304356
申请日：1989-01-30
申请人： Eddy Chapoteau , Bronislaw P. Czech , Carl R. Gebauer , Koon-Wah Leong , Anand Kumar
发明人： Eddy Chapoteau , Bronislaw P. Czech , Carl R. Gebauer , Koon-Wah Leong , Anand Kumar
IPC分类号： C07D498/08 , C07D498/18 , G01N33/52 , G01N33/84
CPC分类号： C07D498/08 , C07D498/18 , G01N33/521 , G01N33/84
摘要： The invention is reagents and procedures for determining an amount of cations present in a sample, the reagent including one or more chromogenic cryptand compounds of formula I ##STR1## wherein k and j, either same or different, are equal to 1 to about 5;m and n, either same or different, are equal to 0 to about 4;a and e, either same or different, are equal to 0 to about 2;b and d, either same or different, are equal to 0 to about 5;R, either same or different, is hydrogen.lower alkyl, lower alkylidene, lower alkenyl, allyl, or aryl; and-Q- is ##STR2## wherein X is CH, N, or COH; and Y includes ##STR3## except that when Q is ##STR4## wherein Y is p-nitrophenylazo, 3-phenylisothiazolyl-5-azo, isothiazolyl-5-azo, thiazolyl-5-azo, 2,4,6-trinitrophenylazo, p-nitrostyryl, p-benzoquinonemonoimino or bis-(p-dimethylaminophenyl)hydroxymethyl, then the following condition cannot be present: that simultaneously b is equal to 0 or 1, d is equal to 0 or 1, j is equal to 1, n is equal to 1 or 2, a is equal to 1, e is equal to 1, k is equal to 1 and m is equal to 2.
摘要翻译：本发明是用于测定样品中存在的阳离子量的试剂和方法，该试剂包括一种或多种式I（I）的显色隐窝化合物，其中相同或不同的k和j相同或不同，约5; m和n相同或不同，等于0至约4; a和e相同或不同，等于0至约2; b和d相同或不同，等于0至约5; R相同或不同，是氢。低级烷基，低级亚烷基，低级烯基，烯丙基或芳基; 和-Q-是，其中X是CH，N或COH; 并且Y包括，不同之处在于Q是，其中Y是对硝基苯基偶氮，3-苯基异噻唑-5-偶氮，异噻唑-5-偶氮，噻唑基-5 （2,4,6-三硝基苯基偶氮），对硝基苯乙烯基，对苯醌二亚氨基亚氨基或双 - （对二甲基氨基苯基）羟甲基，则不能存在以下条件：同时b等于0或1，d等于 0或1，j等于1，n等于1或2，a等于1，e等于1，k等于1，m等于2。

6. 发明授权

US5187103A Colorimetric method and reagent for the assay of lithium in a test sample 失效
标题翻译：在测试样品中用于测定锂的颜料方法和试剂
公开(公告)号：US5187103A
公开(公告)日：1993-02-16
申请号：US648073
申请日：1991-01-31
申请人： Bronislaw P. Czech , Eddy Chapoteau , Anand Kumar
发明人： Bronislaw P. Czech , Eddy Chapoteau , Anand Kumar
IPC分类号： C07D498/08 , C07D498/18 , G01N31/00 , G01N31/22 , G01N33/52 , G01N33/84
CPC分类号： C07D498/08 , G01N33/52 , G01N33/84
摘要： A chromogenic cryptand found to be especially selective in the determination of lithium in blood of the general formula (I): ##STR1## where: n=1 or 2,R.sub.1 and R.sub.2, same or different, are hydrogen, lower alkyl, lower alkenyl, or lower alkylidene; andQ is a chromogenic moiety capable of providing a detectable response upon complexation of said compound with lithium ion and has the structure: ##STR2## wherein: X is CH, C--OH or N; and Z is p-nitrophenylazo, 2,4-dinitrophenylazo, 2,4,6-trinitrophenylazo, p-nitrostyryl, p-benzoquinonemonoimino, bis-(4-dimethylaminophenyl) hydroxymethyl, 3-phenylisothiazolyl-5-azo, thiazolyl-5-azo; or isothiazolyl-5-azo.A reagent composition and synthesis of a preferred chromogenic cryptand are also disclosed.

7. 发明授权

US5177221A Chromogenic hemispherands and their preparation 失效
标题翻译：显色半球及其制备
公开(公告)号：US5177221A
公开(公告)日：1993-01-05
申请号：US564203
申请日：1990-08-08
申请人： Donald J. Cram , Eddy Chapoteau , Bronislaw P. Czech , Carl R. Gebauer , Roger C. Helgeson , Anand Kumar , Koon-Wah Leong
发明人： Donald J. Cram , Eddy Chapoteau , Bronislaw P. Czech , Carl R. Gebauer , Roger C. Helgeson , Anand Kumar , Koon-Wah Leong
IPC分类号： C07D323/00 , C07D493/08 , C07D498/08 , G01N27/333
CPC分类号： C07D493/08 , C07D323/00 , G01N27/3335
摘要： The present invention resides in the discovery of a new class of compounds defined herein as "chromogenic hemispherands" useful for the measurement of ions, in particular, ions in aqueous solution, which have the structure ##STR1## wherein: R, same or different, is hydrogen, lower alkyl, lower alkylidene, lower alkenyl, allyl or aryl;R', same or different, is lower alkyl, lower alkylidene, lower alkenyl, allyl or aryl;R", same or different, is hydrogen, lower alkyl, lower alkylidene, lower alkenyl, allyl or aryl;Q is a chromogenic moiety capable of providing the appearance of or change in color, or which is otherwise capable of providing a detectable response in the presence of a particular cation;m is 1 to about 3;n is 0 to about 3;A is an aliphatic or aromatic subunit, e.g., ##STR2##
摘要翻译：本发明在于发现本文中定义的可用于测量离子，特别是水溶液中的离子的“显色半球”，其具有以下结构：其中：R相同或不同，是氢，低级烷基，低级亚烷基，低级烯基，烯丙基或芳基; R'相同或不同，为低级烷基，低级亚烷基，低级烯基，烯丙基或芳基; R“相同或不同，为氢，低级烷基，低级亚烷基，低级烯基，烯丙基或芳基; Q是能够提供颜色出现或变化的发色部分，或者否则能够在特定阳离子存在下提供可检测的响应; m为1〜3; n为0至约3; A是脂肪族或芳香族亚基，例如

8. 发明授权

US5011924A Chromogenic cryptahemispherands and their preparation 失效
标题翻译：显色隐窝和它们的制备
公开(公告)号：US5011924A
公开(公告)日：1991-04-30
申请号：US349465
申请日：1989-05-09
申请人： Donald J. Cram , Eddy Chapoteau , Bronislaw P. Czech , Carl R. Gebauer , Roger C. Helgeson , Anand Kumar , Koon-Wah Leong
发明人： Donald J. Cram , Eddy Chapoteau , Bronislaw P. Czech , Carl R. Gebauer , Roger C. Helgeson , Anand Kumar , Koon-Wah Leong
IPC分类号： C07D498/08 , G01N33/84
CPC分类号： C07D498/08 , G01N33/84
摘要： The present invention resides in the discovery of a new class of compounds defined herein as "chromogenic cryptahemispherands" useful for the measurement of ions, in particular, ions in aqueous solution, which have the structure ##STR1## wherein: R, same or different, is hydrogen, lower alkyl, lower alkylidene, lower alkenyl, allyl or aryl;R', same or different, is lower alkyl, lower alkylidene, lower alkenyl, allyl or aryl;R", same or different, is hydrogen, lower alkyl, lower alkylidene, lower alkenyl, allyl or aryl;Q is a chromogenic moiety capable of providing the appearance of or change in color, or which is otherwise capable of providing a detectable response in the presence of a particular cation;a, b, m and n, same or different, are 1 to about 3; and x, y, same or different, are 1 to about 4.A test device utilizing one or more of the compounds for performing such measurements is also disclosed.
摘要翻译：本发明在于在本文定义的一类新的化合物的发现，其可用于测量离子，特别是水溶液中的离子，其具有以下结构：其中：R相同或不同，是氢，低级烷基，低级亚烷基，低级烯基，烯丙基或芳基; R'相同或不同，为低级烷基，低级亚烷基，低级烯基，烯丙基或芳基; R“相同或不同，为氢，低级烷基，低级亚烷基，低级烯基，烯丙基或芳基; Q是能够提供颜色出现或变化的发色部分，或者否则能够在特定阳离子存在下提供可检测的响应; a，b，m和n相同或不同，为1〜3; x，y相同或不同，为1至约4.还公开了利用一种或多种化合物进行这种测量的测试装置。

9. 发明授权

US4994395A Chromogenic cryptand reagents and methods for determining cation concentrations in test samples containing interfering cations 失效
标题翻译：显色穴位试剂和测定含有干扰阳离子的试样中的阳离子浓度的方法
公开(公告)号：US4994395A
公开(公告)日：1991-02-19
申请号：US038741
申请日：1987-04-15
申请人： Eddy Chapoteau , Bronislaw P. Czech , Carl R. Gebauer , Koon-Wah Leong , Anand Kumar
发明人： Eddy Chapoteau , Bronislaw P. Czech , Carl R. Gebauer , Koon-Wah Leong , Anand Kumar
IPC分类号： G01N31/00 , C07D498/08 , C07D498/18 , G01N33/52 , G01N33/84
CPC分类号： C07D498/08 , G01N33/525 , G01N33/84 , Y10S436/805
摘要： The invention is reagents and procedures for determining an amount of cations present in a sample, the reagent comprising(a) one or more chromogenic cryptand compounds of formula I ##STR1## wherein k and j, either same or different, are equal to 1 to about 5;m and n, either same or different, are equal to 0 to about 4;a and e, either same or different, are equal to 0 to about 2;b and d, either same or different, are equal to 0 to about 5;R, either same or different, is hydrogen, lower alkyl, lower alkylidene, lower alkenyl, allyl, or aryl; and--Q-- is ##STR2## wherein X is CH, N, or COH; andY includes ##STR3## and (b) one or more interfering cation complexing compound masks.

10. 发明授权

US4808539A Compounds, reagents and procedures for determining cations 失效
标题翻译：用于确定阳离子的化合物，试剂和程序
公开(公告)号：US4808539A
公开(公告)日：1989-02-28
申请号：US38843
申请日：1987-04-15
申请人： Eddy Chapoteau , Bronislaw P. Czech , Carl R. Gebauer , Koon-Wah Leong , Anand Kumar
发明人： Eddy Chapoteau , Bronislaw P. Czech , Carl R. Gebauer , Koon-Wah Leong , Anand Kumar
IPC分类号： G01N31/00 , C07D498/08 , C07D498/18 , G01N33/52 , G01N33/84 , G01N33/20
CPC分类号： C07D498/08 , C07D498/18 , G01N33/521 , G01N33/84
摘要： The invention is reagents and procedures for determining an amount of cations present in a sample, the reagent comprising one or more chromogenic cryptand compounds of formula I ##STR1## wherein k and j, either same or different, are equal to 1 to about 5;m and n, either same or different, are equal to 0 to about 4;a and e, either same or different, are equal to 0 to about 2;b and d, either same or different, are equal to 0 to about 5;R, either same or different, is hydrogen, lower alkyl, lower alkylidene, lower alkenyl, allyl, or aryl; and-Q- is ##STR2## wherein X is CH, N, or COH; andY includes ##STR3## except that when Q is ##STR4## wherein Y is selected from the group consisting of p-nitrophenylazo, 3-phenylisothiazalyl -5-azo, isothiazolyl-5-azo, thiazolyl-5-azo, 2,4,6-trinitrophenylazo, p-nitrostyryl, p-benzoquinonemonoimino and bis-(p-dimethylaminophenyl)hydroxymethyl, then the following condition cannot be present: that simultaneously b is equal to 0 or 1, d is equal to 0 or 1, j is equal to 1, n is equal to 1 or 2, a is equal to 1, e is equal to 1, k is equal to 1 and m is equal to 2.

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