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1. 发明授权

US5814521A Metal ion determination by sandwich aggregation assay 失效
标题翻译：夹心聚集法测定金属离子
公开(公告)号：US5814521A
公开(公告)日：1998-09-29
申请号：US703982
申请日：1996-08-28
申请人： Eddy Chapoteau , Jonathan Craine , Bronislaw P. Czech , Anand Kumar , Koon-wah Leong
发明人： Eddy Chapoteau , Jonathan Craine , Bronislaw P. Czech , Anand Kumar , Koon-wah Leong
IPC分类号： G01N31/00 , G01N21/77 , G01N21/82 , G01N33/543 , G01N33/84 , G01N33/20 , G01N35/546
CPC分类号： G01N21/82 , G01N33/54313 , G01N33/84 , G01N2800/04 , Y10S436/909
摘要： The present invention relates to a method for the determination of polyvalent metal ions using a sandwich aggregation assay. One or more chelating agents capable of forming at least 2:1 or higher ratio stoichiometry complexes with polyvalent metal ions are attached to a suitable carrier such as latex particles through covalent bonds or by non-covalent interactions, such as hydophobic interactions. Upon complexation with the metal ions, the carriers of the complexing agent aggregate, causing an increase in light absorbance or light scattering which is proportional to the concentration of metal ions in the test sample. The measurement of the light absorbance or light scattering by a suitable instrument, such as a spectrophotometer or nephelometer provides a means for measuring the concentration of metal ions.
摘要翻译：本发明涉及使用夹心聚集测定法测定多价金属离子的方法。能够与多价金属离子形成至少2:1或更高比例化学计量配合物的一种或多种螯合剂通过共价键或通过非共价相互作用例如疏水相互作用连接到合适的载体如胶乳颗粒上。当与金属离子络合时，络合剂的载体聚集，引起与测试样品中金属离子浓度成比例的吸光度或光散射的增加。通过合适的仪器（例如分光光度计或浊度计）测量吸光度或光散射提供了测量金属离子浓度的方法。

2. 发明授权

US07943022B2 Analyte test strip with improved reagent deposition 有权
标题翻译：分析物测试条，具有改进的试剂沉积
公开(公告)号：US07943022B2
公开(公告)日：2011-05-17
申请号：US11849949
申请日：2007-09-04
申请人： Maria Teodorczyk , Remedios Dato , Koon-wah Leong
发明人： Maria Teodorczyk , Remedios Dato , Koon-wah Leong
IPC分类号： G01N27/26 , G01N33/487
CPC分类号： C12Q1/001 , G01N27/3272 , G01N33/521
摘要： An analyte, system, strip and method are described. In one example, an analyte test strip is provided that includes a substrate, electrically conductive material and an isolated portion of the electrically conductive material. The substrate has a generally planar surface that extends from a first end to a second end. The electrically conductive material is disposed on the generally planar surface to define a plurality of electrodes spaced apart from each other. The isolated portion of the electrically conductive material is disposed between at least two electrodes so that the isolated portion is not in electrical communication with the plurality of electrodes.
摘要翻译：描述了分析物，系统，条和方法。在一个实例中，提供分析物测试条，其包括基底，导电材料和导电材料的隔离部分。衬底具有从第一端延伸到第二端的大致平坦的表面。导电材料设置在大致平坦的表面上以限定彼此间隔开的多个电极。导电材料的隔离部分设置在至少两个电极之间，使得隔离部分不与多个电极电连通。

3. 发明申请

US20090101681A1 Liquid Dispensing Tip With Reservoir 审中-公开
标题翻译：液体分配头与水库
公开(公告)号：US20090101681A1
公开(公告)日：2009-04-23
申请号：US12248935
申请日：2008-10-10
申请人： Remedios Dato , Koon-wah Leong
发明人： Remedios Dato , Koon-wah Leong
IPC分类号： B65D47/18
CPC分类号： B01L3/0272 , B01L2200/087 , B01L2300/047 , B65D47/18
摘要： The present invention includes devices for containing and dispensing liquid solutions. The devices of the invention increase ease of sample volume control and, hence, application thereof while minimizing any sample spillage or fluid migration up the side of the dispensing tip. Furthermore, the devices provide ensure adequate sample volume.
摘要翻译：本发明包括用于容纳和分配液体溶液的装置。本发明的装置增加了样品体积控制的便利性，并因此增加了其应用，同时最小化分配尖端侧面的任何样品溢出或流体迁移。此外，这些设备提供足够的样品体积。

4. 发明授权

US06837988B2 Biological fluid sampling and analyte measurement devices and methods 有权
标题翻译：生物液体取样和分析物测量装置及方法
公开(公告)号：US06837988B2
公开(公告)日：2005-01-04
申请号：US09879146
申请日：2001-06-12
申请人： Koon-wah Leong , Robert Shartle
发明人： Koon-wah Leong , Robert Shartle
IPC分类号： G01N27/28 , A61B5/00 , A61B5/1473 , A61B5/15 , A61B5/151 , G01N27/327 , G01N27/416 , G01N33/48 , A61B5/05
CPC分类号： A61B5/1486 , A61B5/14514 , A61B5/14532
摘要： A device for sampling a biological fluid and measuring a target analyte within the biological fluid is provided. The device has at least one micro-piercing member used to penetrate the skin to a selected depth and access biological fluid, a sampling means and a measuring means. The sampling means comprises a fluid transfer medium, such as a hydrophilic porous material, by which sampled biological fluid is transferred from the micro-piercing member to the measuring means. The measuring means includes an electrochemical cell having at least one porous electrode and, typically, a reagent material, where the electrochemical cell is configured so as to make an electrochemical measurement of a target analyte in accessed biological fluid present therein. Methods of sampling biological fluids within the skin and measuring the sampled fluids are also provided, as well as kits comprising one or more of the inventive devices.
摘要翻译：提供了用于对生物流体进行取样并测量生物流体内的目标分析物的装置。该装置具有至少一个微穿孔构件，用于将皮肤穿透到选定的深度并进入生物流体，采样装置和测量装置。采样装置包括诸如亲水性多孔材料的流体转移介质，通过该流体转移介质将采样的生物流体从微穿孔构件转移到测量装置。测量装置包括具有至少一个多孔电极和通常为试剂材料的电化学电池，其中电化学电池被配置为对其中存在的存取的生物流体中的目标分析物进行电化学测量。还提供了对皮肤内的生物流体进行取样并测量取样的流体的方法，以及包括一个或多个本发明装置的试剂盒。

5. 发明授权

US08173008B2 Method for determining an analyte in a bodily fluid sample using an analyte test strip with combination electrode contact and meter identification feature 有权
标题翻译：使用具有组合电极接触和仪表识别特征的分析物测试条来确定体液样品中分析物的方法
公开(公告)号：US08173008B2
公开(公告)日：2012-05-08
申请号：US12491026
申请日：2009-06-24
申请人： Koon-wah Leong
发明人： Koon-wah Leong
IPC分类号： G01N27/26 , G01N33/50
CPC分类号： G01N33/48771
摘要： A method for determining an analyte in a bodily fluid sample includes inserting the analyte test strip into a test meter. The insertion is such that an electrical connector pin of the test meter travels along an electrical contact pad of the analyte test strip, and across a meter identification feature disposed on the electrical contact pad, during the insertion. Moreover, during the insertion, a signal processing module of the test meter measures an electrical characteristic via the electrical connector pin as the electrical connector pin travels along the electrical contact pad and across the meter identification feature. The method also includes identifying the analyte test strip, using the signal processing module, based on the electrical characteristic measured as the analyte test strip is inserted into the test meter and, thereafter, applying the bodily fluid sample to the analyte test strip upon notification by the test meter that the identification indicates that such applying is appropriate. The method then includes determining an analyte in the bodily fluid sample using the test meter only if the identification indicates that such determining is appropriate. The electrical contact pad of the analyte test strip employed in the method has a predetermined contact electrical characteristic value and the meter identification feature of the analyte test strip has a predetermined identification feature electrical characteristic value that is dissimilar from the predetermined contact electrical characteristic, thus providing for identification of the analyte test strip by the test meter.
摘要翻译：用于测定体液样品中的分析物的方法包括将分析物测试条插入测试仪中。该插入使得测试仪的电连接器针沿着分析物测试条的电接触垫并且在插入期间跨越设置在电接触垫上的电表识别特征传播。此外，在插入期间，随着电连接器引脚沿着电接触垫行进并跨越电表识别特征，测试仪的信号处理模块经由电连接器引脚测量电特性。该方法还包括基于当分析物测试条插入到测试仪中时测量的电特性，使用信号处理模块来识别分析物测试条，然后在通过下述方式将体液样品施加到分析物测试条上：该测试仪器的识别表明此类应用是合适的。该方法然后包括使用测试仪器确定体液样品中的分析物，只要该识别指示该确定是合适的。在该方法中使用的分析物测试条的电接触垫具有预定的接触电特性值，并且分析物测试条的仪表识别特征具有与预定接触电特性不相似的预定识别特征电特性值，从而提供用于通过测试仪识别分析物测试条。

6. 发明授权

US07361307B2 Biological fluid constituent sampling and measurement devices 有权
标题翻译：生物流体成分采样和测量装置
公开(公告)号：US07361307B2
公开(公告)日：2008-04-22
申请号：US10886789
申请日：2004-07-07
申请人： Robert Shartle , Koon-wah Leong , Ernest J. Kiser
发明人： Robert Shartle , Koon-wah Leong , Ernest J. Kiser
IPC分类号： G01N33/48
CPC分类号： A61B5/1486 , A61B5/14514 , A61B5/14532 , A61B5/14546 , A61B5/150022 , A61B5/150282 , A61B5/150358 , A61B5/150755 , A61B5/150984 , A61B5/15142 , A61B5/15186 , A61B5/157 , A61B2562/0295 , Y10T436/144444
摘要： A device for accessing biological fluid, sampling biological fluid constituents and determining the concentration of at least one target constituent within the accessed biological fluid is provided. The device has at least one micro-piercing member used to penetrate the skin to a selected depth and to access biological fluid, a constituent sampling means and a constituent measuring means. The constituent sampling means comprises a constituent transfer medium, such as a hydrophilic gel material, by which sampled constituents are transferred from the micro-piercing member to the measuring means. The measuring means includes an electrochemical cell having at least one porous electrode through which at least one sampled constituent is caused to enter into the electrochemical cell. Methods of sampling constituents within the skin and measuring the sampled constituents, as well as kits for practicing the invention are provided.
摘要翻译：提供了用于访问生物流体的装置，取样生物流体成分并确定所访问的生物流体中至少一种目标成分的浓度。该装置具有至少一个微穿刺构件，用于将皮肤穿透到选定的深度并且访问生物流体，构成采样装置和构成测量装置。组分采样装置包括诸如亲水性凝胶材料的组成转印介质，通过该组分转移介质将取样的组分从微穿孔构件转移到测量装置。测量装置包括具有至少一个多孔电极的电化学电池，使至少一个采样成分进入电化学电池。提供了对皮肤内的成分进行取样并测量取样成分的方法，以及用于实施本发明的试剂盒。

7. 发明申请

US20050255453A1 Multilayer reagent test strips and methods for using the same to quantify glycated protein in a physiological sample 审中-公开
标题翻译：多层试剂试纸和使用该试纸的方法用于定量生理样品中的糖化蛋白质
公开(公告)号：US20050255453A1
公开(公告)日：2005-11-17
申请号：US11185239
申请日：2005-07-19
申请人： Suyue Qian , Sherry Guo , Koon-wah Leong
发明人： Suyue Qian , Sherry Guo , Koon-wah Leong
IPC分类号： G01N33/48 , C12M1/34 , C12Q1/26 , C12Q1/28 , C12Q1/37 , G01N33/49 , G01N33/52 , G01N33/543 , G01N33/68 , C12Q1/00
CPC分类号： C12Q1/37 , C12Q1/26 , G01N33/526 , G01N33/54366
摘要： Multilayer reagent test strips for quantitating glycated protein in a fluid sample, as well as methods for using the same, are provided. The subject multilayer test strips include at least a filter layer, a proteinase layer and a ketoamine oxidase signal producing and fluid flow control system layer. In using the subject test strips, a fluid sample is applied to the test strip and a signal is generated that can be employed to quantitate the glycated protein level in the sample. The quantitated glycated protein level can then be employed to determine the amount of glycated protein in the fluid sample. Also provided are kits and systems that include the subject test strips and find use in practicing the subject methods. The subject compositions and methods find use in glycated protein monitoring applications, among other utilities.
摘要翻译：提供了用于定量流体样品中的糖化蛋白质的多层试剂试纸，以及使用它们的方法。主题多层测试条至少包括过滤层，蛋白酶层和酮胺氧化酶信号产生和流体流动控制系统层。在使用主题测试条时，将流体样品施加到测试条上，并产生可用于定量样品中糖基化蛋白质水平的信号。然后可以使用定量的糖基化蛋白水平来确定流体样品中糖化蛋白的量。还提供了包括主题测试条的试剂盒和系统，并用于实践主题方法。主题组合物和方法可用于糖化蛋白质监测应用以及其他实用工具。

8. 发明授权

US06743597B1 Compositions containing a urea derivative dye for detecting an analyte and methods for using the same 有权
公开(公告)号：US06743597B1
公开(公告)日：2004-06-01
申请号：US09593827
申请日：2000-06-13
申请人： Sherry X. Guo , Koon-wah Leong
发明人： Sherry X. Guo , Koon-wah Leong
IPC分类号： C12Q154
CPC分类号： C12Q1/28 , G01N33/521
摘要： Compositions, reagent test strips, analyte detection systems and kits of the same, as well as methods for their use in the detection of an analyte in a sample, are provided. The subject compositions are characterized by having a positively charged porous matrix and a urea derivative dye on at least one surface of the matrix, where in many preferred embodiments the urea derivative dye is a negatively charged urea derivative dye. In many preferred embodiments, the subject compositions further include at least one additional reagent member of a peroxide producing signal producing system, e.g., an analyte oxidase and/or a peroxidase. The subject compositions, test strips, analyte detection systems and kits find use in the detection of a wide variety of analytes in a sample, such as a physiological sample, e.g., blood or a fraction thereof.

9. 发明申请

US20090139300A1 AUTO-CALIBRATING METERING SYSTEM AND METHOD OF USE 有权
标题翻译：自动校准计量系统及其使用方法
公开(公告)号：US20090139300A1
公开(公告)日：2009-06-04
申请号：US11947964
申请日：2007-11-30
申请人： Jerry T. Pugh , Koon-wah Leong , Arjuna Karunaratne
发明人： Jerry T. Pugh , Koon-wah Leong , Arjuna Karunaratne
IPC分类号： G01F25/00
CPC分类号： G01N33/48771
摘要： A method of auto-calibrating a meter is provided herein. The method can include disposing a sensor within a sensor dispenser associated with a tag element wherein the tag element is configured to store a plurality of sensor-specific information as well as communicate the information to a meter. Next, the method can include placing the sensor dispenser into communication with a meter which is configured to receive and retain a sensor from the sensor dispenser, and also configured to receive the sensor-specific information from the tag element thereby allowing the meter to perform an auto-calibration procedure which is at least partially dependent upon the sensor-specific information. Similarly, a system for auto-calibrating a meter is also provided herein. Additionally, various embodiments of a meter and various embodiments a sensor dispenser are also provided herein.
摘要翻译：本文提供了一种自动校准仪表的方法。该方法可以包括将传感器设置在与标签元件相关联的传感器分配器内，其中标签元件被配置为存储多个传感器特定信息以及将该信息传送到仪表。接下来，该方法可以包括将传感器分配器放置成与计量器通信，该计量器被配置为从传感器分配器接收和保持传感器，并且还被配置为从标签元件接收传感器特定信息，从而允许仪表执行至少部分依赖于传感器特定信息的自动校准程序。类似地，本文还提供了用于自动校准仪表的系统。此外，本文还提供了仪表的各种实施例和各种实施例的传感器分配器。

10. 发明授权

US06875613B2 Biological fluid constituent sampling and measurement devices and methods 有权
标题翻译：生物流体成分采样和测量装置及方法
公开(公告)号：US06875613B2
公开(公告)日：2005-04-05
申请号：US09879188
申请日：2001-06-12
申请人： Robert Shartle , Koon-wah Leong , Ernest J. Kiser
发明人： Robert Shartle , Koon-wah Leong , Ernest J. Kiser
IPC分类号： G01N33/48 , A61B5/00 , A61B5/1473 , A61B5/15 , A61B5/151 , A61B17/062 , G01N27/28 , G01N27/327 , G01N33/487
CPC分类号： A61B5/1486 , A61B5/14514 , A61B5/14532 , A61B5/14546 , A61B5/150022 , A61B5/150282 , A61B5/150358 , A61B5/150755 , A61B5/150984 , A61B5/15142 , A61B5/15186 , A61B5/157 , A61B2562/0295 , Y10T436/144444
摘要： A device for accessing biological fluid, sampling biological fluid constituents and determining the concentration of at least one target constituent within the accessed biological fluid is provided. The device has at least one micro-piercing member used to penetrate the skin to a selected depth and to access biological fluid, a constituent sampling means and a constituent measuring means. The constituent sampling means comprises a constituent transfer medium, such as a hydrophilic gel material, by which sampled constituents are transferred from the micro-piercing member to the measuring means. The measuring means includes an electrochemical cell having at least one porous electrode through which at least one sampled constituent is caused to enter into the electrochemical cell. Methods of sampling constituents within the skin and measuring the sampled constituents, as well as kits for practicing the invention are provided.
摘要翻译：提供了用于访问生物流体的装置，取样生物流体成分并确定所访问的生物流体中至少一种目标成分的浓度。该装置具有至少一个微穿刺构件，用于将皮肤穿透到选定的深度并且访问生物流体，构成采样装置和构成测量装置。组分采样装置包括诸如亲水性凝胶材料的组成转印介质，通过该组分转移介质将取样的组分从微穿孔构件转移到测量装置。测量装置包括具有至少一个多孔电极的电化学电池，使至少一个采样成分进入电化学电池。提供了对皮肤内的成分进行取样并测量取样成分的方法，以及用于实施本发明的试剂盒。

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