专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US5145787A Method for determining the concentration of cations in a sample 失效
标题翻译：确定样品中阳离子浓度的方法
公开(公告)号：US5145787A
公开(公告)日：1992-09-08
申请号：US803134
申请日：1991-12-05
申请人： Eddy Chapoteau , Bronislaw P. Czech , Carl R. Gebauer , Koon-Wah Leong , Anand Kumar
发明人： Eddy Chapoteau , Bronislaw P. Czech , Carl R. Gebauer , Koon-Wah Leong , Anand Kumar
IPC分类号： C07D498/08 , C07D498/18 , G01N33/52 , G01N33/84
CPC分类号： C07D498/08 , C07D498/18 , G01N33/521 , G01N33/84
摘要： The invention is reagents and procedures for determining an amount of cations present in a sample, the reagent including one or more chromogenic crypt and compounds of formula I ##STR1## wherein k and j, either same or different, are equal to 1 to about 5;m and n, either same or different, are equal to 0 to about 4;a and e, either same or different, are equal to 0 to about 2;b and d, either same or different, are equal to 0 to about 5;R, either same or different, is hydrogen, lower alkyl, lower alkylidene, lower alkenyl, allyl, or aryl; and--Q-- is ##STR2## wherein X is CH, N, or COH; and Y includes ##STR3## except that when Q is ##STR4## wherein Y is p-nitrophenylazo, 3-phenylisothiazolyl-5-azo, isothiazolyl-5-azo, thiazolyl-5-azo, 2,4,6-trinitrophenylazo, p-nitrostyryl, p-benzoquinonemonoimino or bis-(p-dimethylaminophenyl)hydroxymethyl, then the following condition cannot be present: that simultaneously b is equal to 0 to 1, d is equal to 0 or 1, j is equal to 1, n is equal to 1 or 2, a is equal to 1, e is equal to 1, k is equal to 1 and m is equal to 2.
摘要翻译：本发明是用于确定样品中存在的阳离子量的试剂和方法，试剂包括一个或多个显色隐窝和式I（I）的化合物，其中相同或不同的k和j等于1 至约5; m和n相同或不同，等于0至约4; a和e相同或不同，等于0至约2; b和d相同或不同，等于0至约5; R，相同或不同，为氢，低级烷基，低级亚烷基，低级烯基，烯丙基或芳基; 和-Q-是，其中X是CH，N或COH; 并且Y包括，不同之处在于Q是，其中Y是对硝基苯基偶氮，3-苯基异噻唑-5-偶氮，异噻唑-5-偶氮，噻唑基-5 （2,4,6-三硝基苯基偶氮），对硝基苯乙烯基，对苯醌二亚氨基亚氨基或双 - （对二甲基氨基苯基）羟甲基，则不能存在以下条件：同时b等于0至1，d等于 0或1，j等于1，n等于1或2，a等于1，e等于1，k等于1，m等于2。

2. 发明授权

US5045475A Reagent for determining cations 失效
标题翻译：用于确定阳离子的试剂
公开(公告)号：US5045475A
公开(公告)日：1991-09-03
申请号：US201576
申请日：1988-06-01
申请人： Eddy Chapoteau , Bronislaw P. Czech , Carl R. Gebauer , Koon-Wah Leong , Anand Kumar
发明人： Eddy Chapoteau , Bronislaw P. Czech , Carl R. Gebauer , Koon-Wah Leong , Anand Kumar
IPC分类号： C07D498/08 , C07D498/18 , G01N33/52 , G01N33/84
CPC分类号： C07D498/08 , C07D498/18 , G01N33/521 , G01N33/84
摘要： The invention is reagents and procedures for determining an amount of cations present in a sample, the reagent including one or more chromogenic cryptand compounds of formula I ##STR1## wherein k and j, either same or different, are equal to 1 to about 5;m and n, either same or different, are equal to 0 to about 4;a and e, either same or different, are equal to 0 to about 2;b and d, either same or different, are equal to 0 to about 5;R, either same or different, is hydrogen, lower alkyl, lower alkylidene, lower alkenyl, allyl, or aryl; and--Q-- is ##STR2## wherein X and CH, N, or COH; and Y includes ##STR3## except that when Q is ##STR4## wherein Y is p-nitrophenylazo, 3-phenylisothiazolyl-5-azo, isothiazolyl-5-azo, thiazolyl-5-azo, 2,4,6-trinitrophenylazo, p-nitrostyryl, p-benzoquinonemonoimino or bis-(p-dimethylaminophenyl)hydroxymethyl, then the following condition cannot be present: that simultaneously b is equal to 0 or 1, d is equal to 0 or 1, j is equal to 1, n is equal to 1 or 2, a is equal to 1, e is equal to 1, k is equal to 1 and m is equal to 2.
摘要翻译：本发明是用于测定样品中存在的阳离子量的试剂和方法，该试剂包括一种或多种式I（I）的显色隐窝化合物，其中相同或不同的k和j相同或不同，约5; m和n相同或不同，等于0至约4; a和e相同或不同，等于0至约2; b和d相同或不同，等于0至约5; R，相同或不同，为氢，低级烷基，低级亚烷基，低级烯基，烯丙基或芳基; 和-Q-是，其中X和CH，N或COH; 并且Y包括，不同之处在于Q是，其中Y是对硝基苯基偶氮，3-苯基异噻唑-5-偶氮，异噻唑-5-偶氮，噻唑基-5 （2,4,6-三硝基苯基偶氮），对硝基苯乙烯基，对苯醌二亚氨基亚氨基或双 - （对二甲基氨基苯基）羟甲基，则不能存在以下条件：同时b等于0或1，d等于 0或1，j等于1，n等于1或2，a等于1，e等于1，k等于1，m等于2。

3. 发明授权

US5073501A Method for determining the concentration of cations in a sample 失效
标题翻译：确定样品中阳离子浓度的方法
公开(公告)号：US5073501A
公开(公告)日：1991-12-17
申请号：US304356
申请日：1989-01-30
申请人： Eddy Chapoteau , Bronislaw P. Czech , Carl R. Gebauer , Koon-Wah Leong , Anand Kumar
发明人： Eddy Chapoteau , Bronislaw P. Czech , Carl R. Gebauer , Koon-Wah Leong , Anand Kumar
IPC分类号： C07D498/08 , C07D498/18 , G01N33/52 , G01N33/84
CPC分类号： C07D498/08 , C07D498/18 , G01N33/521 , G01N33/84
摘要： The invention is reagents and procedures for determining an amount of cations present in a sample, the reagent including one or more chromogenic cryptand compounds of formula I ##STR1## wherein k and j, either same or different, are equal to 1 to about 5;m and n, either same or different, are equal to 0 to about 4;a and e, either same or different, are equal to 0 to about 2;b and d, either same or different, are equal to 0 to about 5;R, either same or different, is hydrogen.lower alkyl, lower alkylidene, lower alkenyl, allyl, or aryl; and-Q- is ##STR2## wherein X is CH, N, or COH; and Y includes ##STR3## except that when Q is ##STR4## wherein Y is p-nitrophenylazo, 3-phenylisothiazolyl-5-azo, isothiazolyl-5-azo, thiazolyl-5-azo, 2,4,6-trinitrophenylazo, p-nitrostyryl, p-benzoquinonemonoimino or bis-(p-dimethylaminophenyl)hydroxymethyl, then the following condition cannot be present: that simultaneously b is equal to 0 or 1, d is equal to 0 or 1, j is equal to 1, n is equal to 1 or 2, a is equal to 1, e is equal to 1, k is equal to 1 and m is equal to 2.
摘要翻译：本发明是用于测定样品中存在的阳离子量的试剂和方法，该试剂包括一种或多种式I（I）的显色隐窝化合物，其中相同或不同的k和j相同或不同，约5; m和n相同或不同，等于0至约4; a和e相同或不同，等于0至约2; b和d相同或不同，等于0至约5; R相同或不同，是氢。低级烷基，低级亚烷基，低级烯基，烯丙基或芳基; 和-Q-是，其中X是CH，N或COH; 并且Y包括，不同之处在于Q是，其中Y是对硝基苯基偶氮，3-苯基异噻唑-5-偶氮，异噻唑-5-偶氮，噻唑基-5 （2,4,6-三硝基苯基偶氮），对硝基苯乙烯基，对苯醌二亚氨基亚氨基或双 - （对二甲基氨基苯基）羟甲基，则不能存在以下条件：同时b等于0或1，d等于 0或1，j等于1，n等于1或2，a等于1，e等于1，k等于1，m等于2。

4. 发明授权

US4900818A Large scale synthesis of twelve member diazamonocyclic compounds 失效
标题翻译：大规模合成十二种二氮杂环化合物
公开(公告)号：US4900818A
公开(公告)日：1990-02-13
申请号：US319792
申请日：1989-03-06
申请人： Bronislaw P. Czech
发明人： Bronislaw P. Czech
IPC分类号： C07D273/00 , C07D273/08 , C07D291/02 , G01N27/333
CPC分类号： C07D273/00 , C07D291/02 , G01N27/3335
摘要： A process is disclosed for synthesizing large quantities of a compound of formula I ##STR1## wherein a solution of a compound of formula II ##STR2## is mixed with a solution of a compound of formula III ##STR3## under suitable process conditions, and wherein A, same or different, is N--R, O, S, CRR' or P(O)R, and R and R' are hydrogen, alkyl, alkylidene, aryl, tosyl, allyl or benzyl, and B is O.Compounds of formula I may be reduced to form an azacorand of formula IV ##STR4## wherein K and L, same or different, are N--R, O, S, CRR', or P(O)R, and R and R' are hydrogen, alkyl, alkylidene, aryl, tosyl, allyl or benzyl.Also disclosed in a compound of formula IV synthesized in accordance with the above procedure wherein K and L are not both O or S.
摘要翻译：公开了一种合成大量式I化合物I的方法，其中将式II化合物II的溶液与式III化合物III的溶液在合适的工艺条件下混合，其中A相同或不同，为NR，O，S，CRR'或P（O）R，R和R'为氢，烷基，亚烷基，芳基，甲苯磺酰基，烯丙基或苄基，B为O. 式I的化合物可以还原形成式IV的azacorand其中K和L相同或不同，是NR，O，S，CRR'或P（O）R，R和R'是氢，烷基，亚烷基，芳基，甲苯磺酰基，烯丙基或苄基。还公开在根据上述程序合成的式IV化合物中，其中K和L不同时为O或S.

5. 发明授权

US4845212A Process for the preparation of chromogenic cryptahemispherands 失效
标题翻译：制备发色隐孢子虫的方法
公开(公告)号：US4845212A
公开(公告)日：1989-07-04
申请号：US232976
申请日：1988-08-17
申请人： Bronislaw P. Czech
发明人： Bronislaw P. Czech
IPC分类号： C07D498/08
CPC分类号： C07D498/08
摘要： The invention relates to a process in which a variety of cryptahemispherands bearing a chromogenic group attached to the partially preorganized moiety may be synthesized. The procedure of the present invention allows preparation of preferred chromogenic cryptahemispherands of the general formula: ##STR1## wherein: R, is same or different, is hydrogen, lower alkyl, lower alkylidene, lower alkenyl, allyl, aryl, or benzyl;R', same or different, is hydrogen, lower alkyl, lower alkylidene, lower alkenyl, allyl, aryl, or benzyl;R", same or different, is hydrogen, lower alkyl, lower alkylidene, lower alkenyl, allyl, aryl, or benzyl;Z is halogen;Y is an electron withdrawing group, e.g., CN, NO.sub.2, CF.sub.3, COOR;m is 1 to 3;n is 1 to 3;a is 1 to 3;b is 1 to 3;k is 1 to 3;l is 1 to 3; andx is 2 to 4.
摘要翻译：本发明涉及一种方法，其中可以合成具有连接到部分预组织部分上的显色基团的各种cryptahemispherands。本发明的方法允许制备以下通式的优选显色隐孢子虫：其中：R 1相同或不同，为氢，低级烷基，低级亚烷基，低级烯基，烯丙基，芳基或苄基; R'相同或不同，是氢，低级烷基，低级亚烷基，低级烯基，烯丙基，芳基或苄基; R“相同或不同，为氢，低级烷基，低级亚烷基，低级烯基，烯丙基，芳基或苄基; Z是卤素; Y是吸电子基团，例如CN，NO 2，CF 3，COOR; m为1〜3; n为1〜3; a是1到3; b为1〜3; k为1〜3; l为1〜3; x为2〜4。

6. 发明授权

US07745219B2 Reagent composition for the analysis of residual white blood cells in leuko-reduced blood banking products 有权
标题翻译：用于分析白血病减少血库产品中残留白细胞的试剂组合物
公开(公告)号：US07745219B2
公开(公告)日：2010-06-29
申请号：US10896338
申请日：2004-07-21
申请人： Michael J. Sommer , Pasquale Degiorgio , Bronislaw P. Czech , Gena Fischer , E. Sabrinah Chapman , David Zelmanovic , Jolanta Kunicka
发明人： Michael J. Sommer , Pasquale Degiorgio , Bronislaw P. Czech , Gena Fischer , E. Sabrinah Chapman , David Zelmanovic , Jolanta Kunicka
IPC分类号： G01N33/48 , G01N33/49
CPC分类号： G01N33/5002 , G01N2015/1486 , G01N2015/1488 , Y10T436/101666 , Y10T436/107497
摘要： The enumeration and analysis of residual white blood cells in a sample of leukocyte-reduced blood products is conducted by forming a suspension of the leukocyte-reduced blood products with a sufficient amount of a lysing reagent. The lysing reagent comprises a buffer with a low molar concentration, and a non-ionic surfactant. The suspension of leukocyte-reduced blood products and the lysing reagent is incubated for a sufficient time at a temperature sufficient to selectively lyse the platelets and red blood cells without damaging the white blood cells. The white blood cells of the lysed blood products are then contacted with a suitable dye to stain the white blood cells and the number of stained white blood cells is measured. The lysing reagent is free of harsh organic solvents which can damage the plastic components of automated clinical analyzers.
摘要翻译：通过用足够量的裂解试剂形成白细胞减少的血液制品的悬浮液来进行白细胞减少的血液制品样品中的残余白细胞的计数和分析。裂解试剂包含具有低摩尔浓度的缓冲液和非离子表面活性剂。将白细胞减少的血液制品和裂解试剂的悬浮液在足以在不损伤白细胞的情况下足以选择性地裂解血小板和红细胞的温度下孵育足够的时间。然后将裂解的血液制品的白细胞与合适的染料接触以染色白细胞，并测量染色的白细胞数。裂解试剂不含苛刻的有机溶剂，可能会损坏自动化临床分析仪的塑料部件。

7. 发明授权

US5814521A Metal ion determination by sandwich aggregation assay 失效
标题翻译：夹心聚集法测定金属离子
公开(公告)号：US5814521A
公开(公告)日：1998-09-29
申请号：US703982
申请日：1996-08-28
申请人： Eddy Chapoteau , Jonathan Craine , Bronislaw P. Czech , Anand Kumar , Koon-wah Leong
发明人： Eddy Chapoteau , Jonathan Craine , Bronislaw P. Czech , Anand Kumar , Koon-wah Leong
IPC分类号： G01N31/00 , G01N21/77 , G01N21/82 , G01N33/543 , G01N33/84 , G01N33/20 , G01N35/546
CPC分类号： G01N21/82 , G01N33/54313 , G01N33/84 , G01N2800/04 , Y10S436/909
摘要： The present invention relates to a method for the determination of polyvalent metal ions using a sandwich aggregation assay. One or more chelating agents capable of forming at least 2:1 or higher ratio stoichiometry complexes with polyvalent metal ions are attached to a suitable carrier such as latex particles through covalent bonds or by non-covalent interactions, such as hydophobic interactions. Upon complexation with the metal ions, the carriers of the complexing agent aggregate, causing an increase in light absorbance or light scattering which is proportional to the concentration of metal ions in the test sample. The measurement of the light absorbance or light scattering by a suitable instrument, such as a spectrophotometer or nephelometer provides a means for measuring the concentration of metal ions.
摘要翻译：本发明涉及使用夹心聚集测定法测定多价金属离子的方法。能够与多价金属离子形成至少2:1或更高比例化学计量配合物的一种或多种螯合剂通过共价键或通过非共价相互作用例如疏水相互作用连接到合适的载体如胶乳颗粒上。当与金属离子络合时，络合剂的载体聚集，引起与测试样品中金属离子浓度成比例的吸光度或光散射的增加。通过合适的仪器（例如分光光度计或浊度计）测量吸光度或光散射提供了测量金属离子浓度的方法。

8. 发明授权

US5187103A Colorimetric method and reagent for the assay of lithium in a test sample 失效
标题翻译：在测试样品中用于测定锂的颜料方法和试剂
公开(公告)号：US5187103A
公开(公告)日：1993-02-16
申请号：US648073
申请日：1991-01-31
申请人： Bronislaw P. Czech , Eddy Chapoteau , Anand Kumar
发明人： Bronislaw P. Czech , Eddy Chapoteau , Anand Kumar
IPC分类号： C07D498/08 , C07D498/18 , G01N31/00 , G01N31/22 , G01N33/52 , G01N33/84
CPC分类号： C07D498/08 , G01N33/52 , G01N33/84
摘要： A chromogenic cryptand found to be especially selective in the determination of lithium in blood of the general formula (I): ##STR1## where: n=1 or 2,R.sub.1 and R.sub.2, same or different, are hydrogen, lower alkyl, lower alkenyl, or lower alkylidene; andQ is a chromogenic moiety capable of providing a detectable response upon complexation of said compound with lithium ion and has the structure: ##STR2## wherein: X is CH, C--OH or N; and Z is p-nitrophenylazo, 2,4-dinitrophenylazo, 2,4,6-trinitrophenylazo, p-nitrostyryl, p-benzoquinonemonoimino, bis-(4-dimethylaminophenyl) hydroxymethyl, 3-phenylisothiazolyl-5-azo, thiazolyl-5-azo; or isothiazolyl-5-azo.A reagent composition and synthesis of a preferred chromogenic cryptand are also disclosed.

9. 发明授权

US5177221A Chromogenic hemispherands and their preparation 失效
标题翻译：显色半球及其制备
公开(公告)号：US5177221A
公开(公告)日：1993-01-05
申请号：US564203
申请日：1990-08-08
申请人： Donald J. Cram , Eddy Chapoteau , Bronislaw P. Czech , Carl R. Gebauer , Roger C. Helgeson , Anand Kumar , Koon-Wah Leong
发明人： Donald J. Cram , Eddy Chapoteau , Bronislaw P. Czech , Carl R. Gebauer , Roger C. Helgeson , Anand Kumar , Koon-Wah Leong
IPC分类号： C07D323/00 , C07D493/08 , C07D498/08 , G01N27/333
CPC分类号： C07D493/08 , C07D323/00 , G01N27/3335
摘要： The present invention resides in the discovery of a new class of compounds defined herein as "chromogenic hemispherands" useful for the measurement of ions, in particular, ions in aqueous solution, which have the structure ##STR1## wherein: R, same or different, is hydrogen, lower alkyl, lower alkylidene, lower alkenyl, allyl or aryl;R', same or different, is lower alkyl, lower alkylidene, lower alkenyl, allyl or aryl;R", same or different, is hydrogen, lower alkyl, lower alkylidene, lower alkenyl, allyl or aryl;Q is a chromogenic moiety capable of providing the appearance of or change in color, or which is otherwise capable of providing a detectable response in the presence of a particular cation;m is 1 to about 3;n is 0 to about 3;A is an aliphatic or aromatic subunit, e.g., ##STR2##
摘要翻译：本发明在于发现本文中定义的可用于测量离子，特别是水溶液中的离子的“显色半球”，其具有以下结构：其中：R相同或不同，是氢，低级烷基，低级亚烷基，低级烯基，烯丙基或芳基; R'相同或不同，为低级烷基，低级亚烷基，低级烯基，烯丙基或芳基; R“相同或不同，为氢，低级烷基，低级亚烷基，低级烯基，烯丙基或芳基; Q是能够提供颜色出现或变化的发色部分，或者否则能够在特定阳离子存在下提供可检测的响应; m为1〜3; n为0至约3; A是脂肪族或芳香族亚基，例如

10. 发明授权

US5064955A Large scale, non-chromatographic purification of chromogenic cryptahemispherands (1.1) and (2.1) 失效
标题翻译：大规模，非色谱纯化的非色谱纯化（1.1）和（2.1）
公开(公告)号：US5064955A
公开(公告)日：1991-11-12
申请号：US533058
申请日：1990-06-04
申请人： Bronislaw P. Czech
发明人： Bronislaw P. Czech
IPC分类号： C09B67/54 , C07D498/08
CPC分类号： C07D498/08
摘要： A process is disclosed for the non-chromatographic purification of chromogenic cryptahemispherands of the following general formula (II) which are capable of selective binding of sodium ion in aqueous solution: ##STR1## wherein: R, same or different, is hydrogen, lower alkyl, lower alkylidene, lower alkenyl, allyl, aryl or benzyl;R', same or different, is lower alkyl, lower alkylidene, lower alkenyl, allyl, aryl or benzyl;R", same or different, is hydrogen, lower alkyl, lower alkylidene, lower alkenyl, allyl, aryl or benzyl;Z is halogen;Y is electron withdrawing group, e.g. CN, NO.sub.2, CF.sub.3, COOR;m is 1 to 3;n is 1 to 3;a is 1 to 3;b is 1 to 3;k is 1 to 2;l is 1 to 2;k and l are not both 2; andx is 2 to 4.The compound of formula (II) is isolated from the reaction mixture by consecutive treatment of the crude reaction product with suitable solents in order to separate unreacted organic components, inorganic material, and polymers and provide a sodium-free final product.

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式