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1. 发明授权

US06885455B2 Self-calibration of an optical-based sensor using a total internal reflection (TIR) signature 有权
标题翻译：使用全内反射（TIR）签名的光学传感器的自校准
公开(公告)号：US06885455B2
公开(公告)日：2005-04-26
申请号：US10301979
申请日：2002-11-22
申请人： Dwight U. Bartholomew , Keren Deng
发明人： Dwight U. Bartholomew , Keren Deng
IPC分类号： G01N21/55
CPC分类号： G01N21/553 , G01N21/43 , G01N2201/12723
摘要： A surface plasmon resonance sensor or critical angle sensor has a reflecting surface which is optically flat and exposed to air on one side. Light reflecting from a sensing surface of the sensor which impinges on the reflecting surface at an angle which is less than the critical angle passes into the air whereas light which impinges at an angle which is equal to or greater than the critical angle is reflected onto a photodetector. The critical angle reflection from the reflecting surface provides a total internal reflection (TIR) characteristic which is used to calibrate the sensor.
摘要翻译：表面等离子体共振传感器或临界角传感器具有光学平坦且在一侧暴露于空气的反射表面。从传感器的感测表面反射的光以小于临界角的角度撞击在反射表面上，而以等于或大于临界角的角度照射的光被反射到光电探测器来自反射表面的临界角反射提供了用于校准传感器的全内反射（TIR）特性。

2. 发明授权

US06574575B2 Method for rapid calibration of beverage dispensing machine 有权
标题翻译：饮料分配机快速校准方法
公开(公告)号：US06574575B2
公开(公告)日：2003-06-03
申请号：US09962418
申请日：2001-09-25
申请人： Keren Deng , Dwight U. Bartholomew
发明人： Keren Deng , Dwight U. Bartholomew
IPC分类号： G01L2500
CPC分类号： A47J31/402 , G01N21/274 , G01N21/553 , G01N21/85 , G01N33/143
摘要： A rapid sensor calibration technique applied prior to each Sensor 9 measuring a beverage in which water (zero Brix), at same temperature as beverage, is drawn from a Water Supply 3 via Valve 6 and passed over the fixed optic Sensor 9 in order to reference out any sensor temperature changes or beverage temperature changes or sensor surface fouling by the dispensed beverage. This technique of continuous and multiple calibrations, provides an enhanced “beverage dispensing system” calibration beyond that achievable using known calibration methods associated with automatically sensing and controlling beverage quality for soft drinks from a fountain dispenser using, for example, water at a specific temperature to initially calibrate Sensor 9, or using a high quality beverage, from a bottle, for example, at a known Brix level to initially calibrate Sensor 9.
摘要翻译：在每个传感器9测量饮料之前应用的快速传感器校准技术，其中在与饮料相同的温度下的水（零白利糖度）通过阀6从供水管3抽出并通过固定光学传感器9以参考任何传感器温度变化或饮料温度变化或传感器表面被分配的饮料污染。这种连续和多次校准技术提供了一种增强的“饮料分配系统”校准，超出了使用已知的校准方法可以实现的校准方法，该校准方法与使用例如在特定温度下的水从喷泉分配器自动感测和控制饮料质量相关联初始校准传感器9，或使用高品质饮料，例如以已知的白利糖度水平从瓶中校准传感器9。

3. 发明授权

US6127203A Thermoplastic mounting of a semiconductor die to a substrate having a mismatched coefficient of thermal expansion 失效
标题翻译：将半导体管芯热塑性安装到具有不匹配的热膨胀系数的衬底上
公开(公告)号：US6127203A
公开(公告)日：2000-10-03
申请号：US304953
申请日：1999-05-05
申请人： Chang-Feng Wan , Richard Scott List , Curtis Gene Garrett , Dwight U. Bartholomew
发明人： Chang-Feng Wan , Richard Scott List , Curtis Gene Garrett , Dwight U. Bartholomew
IPC分类号： H01L21/58 , H01L21/324
CPC分类号： H01L24/83 , H01L24/29 , H01L2224/2919 , H01L2224/32145 , H01L2224/8319 , H01L2224/8385 , H01L2924/01005 , H01L2924/01006 , H01L2924/01013 , H01L2924/01015 , H01L2924/0103 , H01L2924/01033 , H01L2924/01049 , H01L2924/01051 , H01L2924/01052 , H01L2924/0132 , H01L2924/0665 , H01L2924/07802 , H01L2924/10253 , H01L2924/12043 , H01L2924/14 , H01L2924/351
摘要： This invention relates to mounting integrated circuits (IC) to multi-chip modules (MCM) or substrates. More specifically, it provides a method of mounting a semiconductor die such as a thin slice of Mercury Cadmium Telluride (MCT) to a silicon semiconductor substrate, a read-out integrated circuit (ROIC), using a thermoplastic to reduce stress on the MCT caused by mismatched Coefficients of Thermal Expansion (CTE). This process provides for an array of infrared photodetectors on a material such as MCT to be mounted to a read-out integrated circuit (ROIC) using the Vertical Integrated Photodiode (VIP) approach to FPAs, while allowing double sided interdiffusion of CdTe for surface passivation to reduce dark currents and improve performance, without the problems associated with mismatched coefficients of thermal expansion during high temperature processes.
摘要翻译：本发明涉及将集成电路（IC）安装到多芯片模块（MCM）或基板上。更具体地，它提供了一种将半导体管芯如汞碲化镉（MCT）的薄片安装到硅半导体衬底，读出集成电路（ROIC），使用热塑性材料以减少MCT上的应力的方法，通过不匹配的热膨胀系数（CTE）。该过程提供了在诸如MCT的材料上的红外光电检测器阵列，其将使用针对FPAs的垂直集成光电二极管（VIP）方法安装到读出集成电路（ROIC），同时允许CdTe用于表面钝化的双面相互扩散以减少暗电流并提高性能，而没有与高温过程中热膨胀系数不匹配相关的问题。

4. 发明授权

US5946083A Fixed optic sensor system and distributed sensor network 失效
标题翻译：固定光传感器系统和分布式传感器网络
公开(公告)号：US5946083A
公开(公告)日：1999-08-31
申请号：US942563
申请日：1997-10-01
申请人： Jose L. Melendez , Richard A. Carr , Patrick Paul Smith , Dwight U. Bartholomew , John H. Berlien, Jr. , Frederick F. Geyer , Paul S. Breedlove
发明人： Jose L. Melendez , Richard A. Carr , Patrick Paul Smith , Dwight U. Bartholomew , John H. Berlien, Jr. , Frederick F. Geyer , Paul S. Breedlove
IPC分类号： G01N21/55 , G01N21/64 , G01N21/00
CPC分类号： G01N21/6428 , G01N21/553 , A61B5/0022
摘要： A fixed optic sensor system (200) comprising a sensor system (210), and electronic sub-system (205) and a communications means (215). The system can be used for detecting the presence of various sample (236) properties and in that regard has widespread application by leveraging off various miniaturized sensor configurations including surface plasmon resonance (50), fluorescence (80), light transmission (125) and others (150). In one embodiment, the communications means (215) is a wireless transmitter/receiver. In another embodiment, a hand held instrument (358) can be used on-site and communicates with the sensor (350) to receive sample (352) related data and transmit it to a remote processing system (370) for further analysis. In yet another embodiment, a hand held instrument (403) has a plurality of cardiac marker binding ligands (400) deposited on the sensor/sample interface providing a medical diagnosis and point-of-care device (403).
摘要翻译：一种包括传感器系统（210）和电子子系统（205）和通信装置（215）的固定光学传感器系统（200）。该系统可用于检测各种样品（236）性能的存在，并且在这方面通过利用包括表面等离子体共振（50），荧光（80），光透射（125）等的各种小型化传感器配置而广泛应用（150）。在一个实施例中，通信装置（215）是无线发射机/接收机。在另一个实施例中，可以在现场使用手持式仪器（358）并与传感器（350）通信以接收样品（352）相关数据并将其发送到远程处理系统（370）以进行进一步分析。在另一个实施方案中，手持式仪器（403）具有沉积在传感器/样品界面上的多个心脏标记结合配体（400），提供医疗诊断和点护理装置（403）。

5. 发明授权

US06943887B2 Surface plasmon resonance sensor having real-time referencing 有权
标题翻译：表面等离子体共振传感器具有实时参考
公开(公告)号：US06943887B2
公开(公告)日：2005-09-13
申请号：US10300978
申请日：2002-11-21
申请人： John G. Quinn , Dwight U. Bartholomew , Richard A. Carr
发明人： John G. Quinn , Dwight U. Bartholomew , Richard A. Carr
IPC分类号： G01N21/55 , G01N27/17
CPC分类号： G01N21/553
摘要： A disposable, portable, miniature surface plasmon resonance sensor (30) having real-time referencing capability in the presence of any interaction, without changing the sensing surface condition is disclosed herein. The sensor (30) includes an electromagnetic radiation source (32) which generates a beam of electromagnetic radiation (52) that passes through a liquid crystal switch that includes a polarizer, plates and liquid crystal material sandwiched between the plates. The liquid crystal switch is disposed between the source (32) and an array of detectors (48). The liquid crystal switch has the ability to switch between a first and a second state of polarized radiation such that it provides the transverse magnetic component of the electromagnetic radiation for detection of SPR on a target element and, in the alternative, provides the transverse electric component of the electromagnetic radiation to determine a reference signal for the sensor (30). The polarized radiation is directed toward a layer (44) of a conductive material capable of sustaining surface plasmon resonance and reflected off layer (44) towards an array of electromagnetic radiation detectors (48) to make a determination of a property of the targeted element adjacent to layer (44) and produce an output signal in response to the received reflected electromagnetic radiation (52) indicative of the presence of, or representative of the concentration or a concentration range of, the targeted element.
摘要翻译：本文公开了一种在任何相互作用下具有实时参考能力的一次性便携式微型表面等离子体共振传感器（30），而不改变传感表面条件。传感器（30）包括电磁辐射源（32），其产生通过液晶开关的电磁辐射束（52），该液晶开关包括夹在板之间的偏振器，板和液晶材料。液晶开关设置在源极（32）和检测器阵列（48）之间。液晶开关具有在偏振辐射的第一和第二状态之间切换的能力，使得其提供用于检测目标元件上的SPR的电磁辐射的横向磁性分量，并且替代地，提供横向电气部件以确定传感器（30）的参考信号。极化辐射被引向能够维持表面等离子体共振和反射离开层（44）的导电材料的层（44）朝向电磁辐射检测器（48）的阵列，以确定邻近的目标元素的性质到层（44）并且响应于所接收的反映的电磁辐射（52）产生指示所述目标元件的存在或代表所述目标元件的浓度或浓度范围的输出信号。

6. 发明授权

US06415235B1 Fixed optic sensor system and distributed sensor network 失效
标题翻译：固定光传感器系统和分布式传感器网络
公开(公告)号：US06415235B1
公开(公告)日：2002-07-02
申请号：US08959949
申请日：1997-10-29
申请人： Dwight U. Bartholomew , Jose L. Melendez , Richard A. Carr
发明人： Dwight U. Bartholomew , Jose L. Melendez , Richard A. Carr
IPC分类号： G01N2155
CPC分类号： G01N21/553
摘要： A sensor control and data analysis system (100) for detecting and analyzing various (bio)chemical properties of a given sample substance (107) using an integrated SPR sensor (50) or other miniaturized sensor configuration. In one embodiment, raw sensor data from the sensing device (105) is transferred to a remote processing system (111), such as a desktop computer, having a display (125), keyboard or other user control and data entry device (123), internal storage area (127), internal microprocessor (117) and a communications means (129). The processing system (111) runs a software application program (115) that receives the raw sample data and perform qualitative and quantitative analysis to render meaningful information about the sample substance.
摘要翻译：一种传感器控制和数据分析系统（100），用于使用集成的SPR传感器（50）或其它小型化传感器配置来检测和分析给定样品物质（107）的各种（生物）化学性质。在一个实施例中，来自感测设备（105）的原始传感器数据被传送到具有显示器（125），键盘或其他用户控制和数据输入设备（123）的远程处理系统（111），例如台式计算机，，内部存储区域（127），内部微处理器（117）和通信装置（129）。处理系统（111）运行软件应用程序（115），其接收原始样本数据并进行定性和定量分析以呈现关于样本物质的有意义的信息。

7. 发明授权

US5959340A Thermoplastic mounting of a semiconductor die to a substrate having a mismatched coefficient of thermal expansion 失效
公开(公告)号：US5959340A
公开(公告)日：1999-09-28
申请号：US707815
申请日：1996-08-30
申请人： Chang-Feng Wan , Richard Scott List , Curtis Gene Garrett , Dwight U. Bartholomew
发明人： Chang-Feng Wan , Richard Scott List , Curtis Gene Garrett , Dwight U. Bartholomew
IPC分类号： H01L21/58 , H01L31/00
CPC分类号： H01L24/83 , H01L24/29 , H01L2224/2919 , H01L2224/32145 , H01L2224/8319 , H01L2224/8385 , H01L2924/01005 , H01L2924/01006 , H01L2924/01013 , H01L2924/01015 , H01L2924/0103 , H01L2924/01033 , H01L2924/01049 , H01L2924/01051 , H01L2924/01052 , H01L2924/0132 , H01L2924/0665 , H01L2924/07802 , H01L2924/10253 , H01L2924/12043 , H01L2924/14 , H01L2924/351
摘要： This invention relates to mounting integrated circuits (IC) to multi-chip modules (MCM) or substrates. More specifically, it provides a method of mounting a semiconductor die such as a thin slice of Mercury Cadmium Telluride (MCT) to a silicon semiconductor substrate, a read-out integrated circuit (ROIC), using a thermoplastic to reduce stress on the MCT caused by mismatched Coefficients of Thermal Expansion (CTE). This process provides for an array of infrared photodetectors on a material such as MCT to be mounted to a read-out integrated circuit (ROIC) using the Vertical Integrated Photodiode (VIP) approach to FPAs, while allowing double sided interdiffusion of CdTe for surface passivation to reduce dark currents and improve performance, without the problems associated with mismatched coefficients of thermal expansion during high temperature processes.

8. 发明授权

US06594018B1 Miniature integrated multiple channel surface plasmon resonance liquid sensor 有权
标题翻译：微型集成多通道表面等离子体共振液体传感器
公开(公告)号：US06594018B1
公开(公告)日：2003-07-15
申请号：US09774970
申请日：2001-01-31
申请人： Dwight U. Bartholomew
发明人： Dwight U. Bartholomew
IPC分类号： G01N2155
CPC分类号： G01N21/553
摘要： A surface plasmon resonance sensor capable of determining the property of several liquids at varying times or simultaneously without the need for a reflecting surface is incorporated herein. This sensor includes at least one electromagnetic radiation source which generates a beam of electromagnetic radiation that passes through a filter and a polarizer disposed between the source and an array of detectors. The filter prevents electromagnetic radiation at the absorbed frequency from striking the array. A film of a conductive material capable of sustaining surface plasmon resonance has a first surface and a second surface. Liquids are deposited on the first surface, while the second surface reflects at least part of the beam of electromagnetic radiation generated by the source. The array of electromagnetic radiation detectors detect part of the beam of electromagnetic radiation to make a determination of a property of the plurality of liquids and produce an output signal in response to the received portion of the reflected electromagnetic radiation indicative of the presence of, or representative of the concentration or a concentration range of, the liquid. This array may be one, two, or three dimensional. In the instance where more than one electromagnetic radiation sources are used, a controller switches each source on and off so that all sources are turned on simultaneously or in a sequential order.
摘要翻译：本文结合了能够在变化的时间或同时确定几种液体的性质而不需要反射表面的表面等离子体共振传感器。该传感器包括至少一个电磁辐射源，其产生穿过过滤器的电磁辐射束和设置在源和检测器阵列之间的偏振器。过滤器防止吸收频率处的电磁辐射撞击阵列。能够维持表面等离子体共振的导电材料的膜具有第一表面和第二表面。液体沉积在第一表面上，而第二表面反射由源产生的电磁辐射束的至少一部分。电磁辐射检测器阵列检测电磁辐射束的一部分，以确定多个液体的性质，并响应于反射电磁辐射的接收部分而产生输出信号，该部分表示存在或代表的浓度或浓度范围的液体。该阵列可以是一维，二维或三维。在使用多于一个电磁辐射源的情况下，控制器开启和关闭每个电源，以便所有电源同时或按顺序接通。

9. 发明授权

US06191847B1 Fixed optic sensor system and distributed sensor network 有权
标题翻译：固定光传感器系统和分布式传感器网络
公开(公告)号：US06191847B1
公开(公告)日：2001-02-20
申请号：US09246063
申请日：1999-02-08
申请人： Jose L. Melendez , Richard A. Carr , Patrick Paul Smith , Dwight U. Bartholomew , John H. Berlien, Jr. , Frederick F. Geyer , Paul S. Breedlove
发明人： Jose L. Melendez , Richard A. Carr , Patrick Paul Smith , Dwight U. Bartholomew , John H. Berlien, Jr. , Frederick F. Geyer , Paul S. Breedlove
IPC分类号： G01N2100
CPC分类号： G01N21/6428 , A61B5/0022 , G01N21/553
摘要： A fixed optic sensor system (200) comprising a sensor system (210), and electronic sub-system (205) and a communications means (215). The system can be used for detecting the presence of various sample (236) properties and in that regard has widespread application by leveraging off various miniaturized sensor configurations including surface plasmon resonance (50), fluorescence (80), light transmission (125) and others (150). In one embodiment, the communications means (215) is a wireless transmitter/receiver. In another embodiment, a hand held instrument (358) can be used on-site and communicates with the sensor (350) to receive sample (352) related data and transmit it to a remote processing system (370) for further analysis. In yet another embodiment, a hand held instrument (403) has a plurality of cardiac marker binding ligands (400) deposited on the sensor/sample interface providing a medical diagnosis and point-of-care device (403).
摘要翻译：一种包括传感器系统（210）和电子子系统（205）和通信装置（215）的固定光学传感器系统（200）。该系统可用于检测各种样品（236）性能的存在，并且在这方面通过利用包括表面等离子体共振（50），荧光（80），光透射（125）等的各种小型化传感器配置而广泛应用（150）。在一个实施例中，通信装置（215）是无线发射机/接收机。在另一个实施例中，可以在现场使用手持式仪器（358）并与传感器（350）通信以接收样品（352）相关数据并将其发送到远程处理系统（370）以进行进一步分析。在另一个实施方案中，手持式仪器（403）具有沉积在传感器/样品界面上的多个心脏标记结合配体（400），提供医疗诊断和点护理装置（403）。

10. 发明授权

US6097479A Critical angle sensor 失效
标题翻译：临界角传感器
公开(公告)号：US6097479A
公开(公告)日：2000-08-01
申请号：US942159
申请日：1997-10-01
申请人： Jose L. Melendez , Richard A. Carr , Dwight U. Bartholomew
发明人： Jose L. Melendez , Richard A. Carr , Dwight U. Bartholomew
IPC分类号： G01N21/27 , G01N21/43 , G01N21/41
CPC分类号： G01N21/43
摘要： Disclosed is an integrated miniaturized biochemical sensor (50) which can be used to make critical angle measurements resulting from the differences in refractive index between the sensor's housing (55) and a given sample (40). In one embodiment, the sensor includes a device platform (111) over which an encapsulating and light transmissive housing (115) is formed to enclose the various sensor components including a light source (105), and a photodetector (107), a signal processing unit (95) and a temperature sensor (95). In another embodiment the housing (115) has a reflective mirrored surface (119) which focuses the light (117) from the light source (105) onto a sensing surface (121) which is in interact with the sample (40) of interest. Light incident from the sensing surface (121) is directed at the photodetector (107,159) which may be an array or single cell. A temperature sensor (95) may also be included and coupled to the platform (111).
摘要翻译：公开了一种集成的小型生物化学传感器（50），其可用于进行由传感器壳体（55）和给定样品（40）之间的折射率差异导致的临界角度测量。在一个实施例中，传感器包括设备平台（111），在其上形成封装和透光外壳（115）以封闭包括光源（105）和光电检测器（107）的各种传感器部件，信号处理单元（95）和温度传感器（95）。在另一个实施例中，外壳（115）具有将来自光源（105）的光（117）聚焦到与感兴趣的样品（40）相互作用的感测表面（121）上的反射镜面（119）。从感测表面（121）入射的光指向可以是阵列或单个单元的光电检测器（107,159）。还可以包括温度传感器（95）并且耦合到平台（111）。

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