专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US06191847B1 Fixed optic sensor system and distributed sensor network 有权
标题翻译：固定光传感器系统和分布式传感器网络
公开(公告)号：US06191847B1
公开(公告)日：2001-02-20
申请号：US09246063
申请日：1999-02-08
申请人： Jose L. Melendez , Richard A. Carr , Patrick Paul Smith , Dwight U. Bartholomew , John H. Berlien, Jr. , Frederick F. Geyer , Paul S. Breedlove
发明人： Jose L. Melendez , Richard A. Carr , Patrick Paul Smith , Dwight U. Bartholomew , John H. Berlien, Jr. , Frederick F. Geyer , Paul S. Breedlove
IPC分类号： G01N2100
CPC分类号： G01N21/6428 , A61B5/0022 , G01N21/553
摘要： A fixed optic sensor system (200) comprising a sensor system (210), and electronic sub-system (205) and a communications means (215). The system can be used for detecting the presence of various sample (236) properties and in that regard has widespread application by leveraging off various miniaturized sensor configurations including surface plasmon resonance (50), fluorescence (80), light transmission (125) and others (150). In one embodiment, the communications means (215) is a wireless transmitter/receiver. In another embodiment, a hand held instrument (358) can be used on-site and communicates with the sensor (350) to receive sample (352) related data and transmit it to a remote processing system (370) for further analysis. In yet another embodiment, a hand held instrument (403) has a plurality of cardiac marker binding ligands (400) deposited on the sensor/sample interface providing a medical diagnosis and point-of-care device (403).
摘要翻译：一种包括传感器系统（210）和电子子系统（205）和通信装置（215）的固定光学传感器系统（200）。该系统可用于检测各种样品（236）性能的存在，并且在这方面通过利用包括表面等离子体共振（50），荧光（80），光透射（125）等的各种小型化传感器配置而广泛应用（150）。在一个实施例中，通信装置（215）是无线发射机/接收机。在另一个实施例中，可以在现场使用手持式仪器（358）并与传感器（350）通信以接收样品（352）相关数据并将其发送到远程处理系统（370）以进行进一步分析。在另一个实施方案中，手持式仪器（403）具有沉积在传感器/样品界面上的多个心脏标记结合配体（400），提供医疗诊断和点护理装置（403）。

2. 发明授权

US5946083A Fixed optic sensor system and distributed sensor network 失效
标题翻译：固定光传感器系统和分布式传感器网络
公开(公告)号：US5946083A
公开(公告)日：1999-08-31
申请号：US942563
申请日：1997-10-01
申请人： Jose L. Melendez , Richard A. Carr , Patrick Paul Smith , Dwight U. Bartholomew , John H. Berlien, Jr. , Frederick F. Geyer , Paul S. Breedlove
发明人： Jose L. Melendez , Richard A. Carr , Patrick Paul Smith , Dwight U. Bartholomew , John H. Berlien, Jr. , Frederick F. Geyer , Paul S. Breedlove
IPC分类号： G01N21/55 , G01N21/64 , G01N21/00
CPC分类号： G01N21/6428 , G01N21/553 , A61B5/0022
摘要： A fixed optic sensor system (200) comprising a sensor system (210), and electronic sub-system (205) and a communications means (215). The system can be used for detecting the presence of various sample (236) properties and in that regard has widespread application by leveraging off various miniaturized sensor configurations including surface plasmon resonance (50), fluorescence (80), light transmission (125) and others (150). In one embodiment, the communications means (215) is a wireless transmitter/receiver. In another embodiment, a hand held instrument (358) can be used on-site and communicates with the sensor (350) to receive sample (352) related data and transmit it to a remote processing system (370) for further analysis. In yet another embodiment, a hand held instrument (403) has a plurality of cardiac marker binding ligands (400) deposited on the sensor/sample interface providing a medical diagnosis and point-of-care device (403).
摘要翻译：一种包括传感器系统（210）和电子子系统（205）和通信装置（215）的固定光学传感器系统（200）。该系统可用于检测各种样品（236）性能的存在，并且在这方面通过利用包括表面等离子体共振（50），荧光（80），光透射（125）等的各种小型化传感器配置而广泛应用（150）。在一个实施例中，通信装置（215）是无线发射机/接收机。在另一个实施例中，可以在现场使用手持式仪器（358）并与传感器（350）通信以接收样品（352）相关数据并将其发送到远程处理系统（370）以进行进一步分析。在另一个实施方案中，手持式仪器（403）具有沉积在传感器/样品界面上的多个心脏标记结合配体（400），提供医疗诊断和点护理装置（403）。

3. 发明授权

US6097479A Critical angle sensor 失效
标题翻译：临界角传感器
公开(公告)号：US6097479A
公开(公告)日：2000-08-01
申请号：US942159
申请日：1997-10-01
申请人： Jose L. Melendez , Richard A. Carr , Dwight U. Bartholomew
发明人： Jose L. Melendez , Richard A. Carr , Dwight U. Bartholomew
IPC分类号： G01N21/27 , G01N21/43 , G01N21/41
CPC分类号： G01N21/43
摘要： Disclosed is an integrated miniaturized biochemical sensor (50) which can be used to make critical angle measurements resulting from the differences in refractive index between the sensor's housing (55) and a given sample (40). In one embodiment, the sensor includes a device platform (111) over which an encapsulating and light transmissive housing (115) is formed to enclose the various sensor components including a light source (105), and a photodetector (107), a signal processing unit (95) and a temperature sensor (95). In another embodiment the housing (115) has a reflective mirrored surface (119) which focuses the light (117) from the light source (105) onto a sensing surface (121) which is in interact with the sample (40) of interest. Light incident from the sensing surface (121) is directed at the photodetector (107,159) which may be an array or single cell. A temperature sensor (95) may also be included and coupled to the platform (111).
摘要翻译：公开了一种集成的小型生物化学传感器（50），其可用于进行由传感器壳体（55）和给定样品（40）之间的折射率差异导致的临界角度测量。在一个实施例中，传感器包括设备平台（111），在其上形成封装和透光外壳（115）以封闭包括光源（105）和光电检测器（107）的各种传感器部件，信号处理单元（95）和温度传感器（95）。在另一个实施例中，外壳（115）具有将来自光源（105）的光（117）聚焦到与感兴趣的样品（40）相互作用的感测表面（121）上的反射镜面（119）。从感测表面（121）入射的光指向可以是阵列或单个单元的光电检测器（107,159）。还可以包括温度传感器（95）并且耦合到平台（111）。

4. 发明授权

US06415235B1 Fixed optic sensor system and distributed sensor network 失效
标题翻译：固定光传感器系统和分布式传感器网络
公开(公告)号：US06415235B1
公开(公告)日：2002-07-02
申请号：US08959949
申请日：1997-10-29
申请人： Dwight U. Bartholomew , Jose L. Melendez , Richard A. Carr
发明人： Dwight U. Bartholomew , Jose L. Melendez , Richard A. Carr
IPC分类号： G01N2155
CPC分类号： G01N21/553
摘要： A sensor control and data analysis system (100) for detecting and analyzing various (bio)chemical properties of a given sample substance (107) using an integrated SPR sensor (50) or other miniaturized sensor configuration. In one embodiment, raw sensor data from the sensing device (105) is transferred to a remote processing system (111), such as a desktop computer, having a display (125), keyboard or other user control and data entry device (123), internal storage area (127), internal microprocessor (117) and a communications means (129). The processing system (111) runs a software application program (115) that receives the raw sample data and perform qualitative and quantitative analysis to render meaningful information about the sample substance.
摘要翻译：一种传感器控制和数据分析系统（100），用于使用集成的SPR传感器（50）或其它小型化传感器配置来检测和分析给定样品物质（107）的各种（生物）化学性质。在一个实施例中，来自感测设备（105）的原始传感器数据被传送到具有显示器（125），键盘或其他用户控制和数据输入设备（123）的远程处理系统（111），例如台式计算机，，内部存储区域（127），内部微处理器（117）和通信装置（129）。处理系统（111）运行软件应用程序（115），其接收原始样本数据并进行定性和定量分析以呈现关于样本物质的有意义的信息。

5. 发明授权

US06943887B2 Surface plasmon resonance sensor having real-time referencing 有权
标题翻译：表面等离子体共振传感器具有实时参考
公开(公告)号：US06943887B2
公开(公告)日：2005-09-13
申请号：US10300978
申请日：2002-11-21
申请人： John G. Quinn , Dwight U. Bartholomew , Richard A. Carr
发明人： John G. Quinn , Dwight U. Bartholomew , Richard A. Carr
IPC分类号： G01N21/55 , G01N27/17
CPC分类号： G01N21/553
摘要： A disposable, portable, miniature surface plasmon resonance sensor (30) having real-time referencing capability in the presence of any interaction, without changing the sensing surface condition is disclosed herein. The sensor (30) includes an electromagnetic radiation source (32) which generates a beam of electromagnetic radiation (52) that passes through a liquid crystal switch that includes a polarizer, plates and liquid crystal material sandwiched between the plates. The liquid crystal switch is disposed between the source (32) and an array of detectors (48). The liquid crystal switch has the ability to switch between a first and a second state of polarized radiation such that it provides the transverse magnetic component of the electromagnetic radiation for detection of SPR on a target element and, in the alternative, provides the transverse electric component of the electromagnetic radiation to determine a reference signal for the sensor (30). The polarized radiation is directed toward a layer (44) of a conductive material capable of sustaining surface plasmon resonance and reflected off layer (44) towards an array of electromagnetic radiation detectors (48) to make a determination of a property of the targeted element adjacent to layer (44) and produce an output signal in response to the received reflected electromagnetic radiation (52) indicative of the presence of, or representative of the concentration or a concentration range of, the targeted element.
摘要翻译：本文公开了一种在任何相互作用下具有实时参考能力的一次性便携式微型表面等离子体共振传感器（30），而不改变传感表面条件。传感器（30）包括电磁辐射源（32），其产生通过液晶开关的电磁辐射束（52），该液晶开关包括夹在板之间的偏振器，板和液晶材料。液晶开关设置在源极（32）和检测器阵列（48）之间。液晶开关具有在偏振辐射的第一和第二状态之间切换的能力，使得其提供用于检测目标元件上的SPR的电磁辐射的横向磁性分量，并且替代地，提供横向电气部件以确定传感器（30）的参考信号。极化辐射被引向能够维持表面等离子体共振和反射离开层（44）的导电材料的层（44）朝向电磁辐射检测器（48）的阵列，以确定邻近的目标元素的性质到层（44）并且响应于所接收的反映的电磁辐射（52）产生指示所述目标元件的存在或代表所述目标元件的浓度或浓度范围的输出信号。

6. 发明授权

US6111248A Self-contained optical sensor system 失效
标题翻译：独立的光学传感器系统
公开(公告)号：US6111248A
公开(公告)日：2000-08-29
申请号：US942091
申请日：1997-10-01
申请人： Jose L. Melendez , Richard A. Carr
发明人： Jose L. Melendez , Richard A. Carr
IPC分类号： G01N21/55 , G01N21/85 , G01N21/00 , H01J3/14
CPC分类号： G01N21/8507 , G01N21/553 , G01N2021/7786
摘要： A self-contained optical sensor (5) with a device platform (7) and an encapsulating light transmissive housing (9) formed therein is disclosed in conjunction with several sensor configurations including fluorescence-based, surface plasmon resonance based and light transmissive (bio) chemical sensor applications. The sensor (10) has at least one light source (20), a photodetector (25), a power source (18) and a display (50) which are embedded in an encapsulating housing (14). In other embodiments, a signal processing unit (35), converter circuit (30) and wireless Communications means (40, 45) are also included in the housing (14).
摘要翻译：公开了一种具有设备平台（7）和形成在其中的封装光透射壳体（9）的独立的光学传感器（5），其包括基于荧光的，基于表面等离子体共振的和透光的（bio）化学传感器应用。传感器（10）具有嵌入在封装壳体（14）中的至少一个光源（20），光电检测器（25），电源（18）和显示器（50）。在其它实施例中，信号处理单元（35），转换器电路（30）和无线通信装置（40,45）也包括在外壳（14）中。

7. 发明授权

US5898503A Surface plasmon resonance sensor with interchangeable optical element 失效
标题翻译：具有可互换光学元件的表面等离子体共振传感器
公开(公告)号：US5898503A
公开(公告)日：1999-04-27
申请号：US72656
申请日：1998-05-05
申请人： Robert C. Keller , Jose L. Melendez , Richard A. Carr
发明人： Robert C. Keller , Jose L. Melendez , Richard A. Carr
IPC分类号： G01N21/55 , G01N21/17
CPC分类号： G01N21/553
摘要： A surface plasmon resonance (SPR) sensor includes a transparent base housing 12 and a detachable optical housing 19. Radiation from a radiation source 10, disposed within base housing 12, is polarized by polarizing filter 16 and passes through the interface between base housing 12 and optical housing 19. The polarized radiation 18 is reflected from a mirror 20 onto a SPR layer 22, which is formed on an exterior surface of optical housing 19. Layer 22 comprises a thin layer of a conductive material. Radiation 24 reflected from SPR layer 22 re-enters housing 19 and strikes an array 28 of photodetectors. From the intensity of radiation at each photodetector, one can determine the index of refraction of the substance on the opposite side of SPR layer 22.
摘要翻译：表面等离子体共振（SPR）传感器包括透明底座壳体12和可拆卸的光学壳体19.设置在基座壳体12内的辐射源10的辐射被偏振滤光器16极化，并通过基底壳体12和光学外壳19.偏振辐射18从反射镜20反射到形成在光学外壳19的外表面上的SPR层22.层22包括导电材料的薄层。从SPR层22反射的辐射24重新进入壳体19并撞击光电检测器的阵列28。根据每个光电检测器的辐射强度，可以确定物质在SPR层22相反侧的折射率。

8. 发明授权

US06326612B1 System and method for optical sensing utilizing a portable, detachable sensor cartridge 有权
标题翻译：使用便携式可拆卸传感器盒的光学感测的系统和方法
公开(公告)号：US06326612B1
公开(公告)日：2001-12-04
申请号：US09416560
申请日：1999-10-12
申请人： Jerome L. Elkind , Richard A. Carr , Jose L. Melendez
发明人： Jerome L. Elkind , Richard A. Carr , Jose L. Melendez
IPC分类号： G01N2100
CPC分类号： G01N21/645 , G01N21/05 , G01N21/43 , G01N21/553
摘要： Disclosed is a sensing system and method utilizing a sensor cartridge (10) for making analytical measurements regarding one or more samples (50) of interest, the cartridge (10) comprising an opaque housing (12) having an opening (32), the opening (32) allowing access to one or more electrically conductive contacts (34) and one or more fluidic connectors (36) disposed within the housing (12) and mechanically aligned to the electrically conductive contacts (34), a flow cell (56) having one or more channels connected to the one or more fluidic connectors (36), and a fixed optic sensor (68, 58, 72, 74) disposed within said housing (12) and aligned to a sensing surface on the flow cell. The fixed optic sensor may be, for example, a surface plasmon resonance sensor, a critical angle sensor, or a fluorescence-based sensor. In one embodiment of the present invention, the one or more electrically conductive contacts (32) comprise card-edge contacts (34). In an alternative embodiment of the present invention, the one or more electrically conductive contacts comprise conductive pins (124) intended to be inserted into a socket (128) of a reporter unit (130). Because the optic sensor is pre-aligned, e.g., a sensing surface portion of the optic sensor is mounted on the flow cell, and at least one of the fluid connectors is aligned to the electrical contacts, the cartridge can be easily replaced on a host unit to allow, e.g., field analysis of multiple fluids.
摘要翻译：公开了一种感测系统和方法，其利用传感器盒（10）用于对感兴趣的一个或多个样品（50）进行分析测量，所述盒（10）包括具有开口（32）的不透明壳体（12），所述开口（32），允许访问一个或多个导电触头（34）和设置在所述壳体（12）内并与所述导电触头（34）机械对准的一个或多个流体连接器（36），流动池（56）连接到所述一个或多个流体连接器（36）的一个或多个通道以及设置在所述壳体（12）内并且与所述流动池上的感测表面对准的固定光学传感器（68,58,72,74）。固定光学传感器可以是例如表面等离子体共振传感器，临界角度传感器或基于荧光的传感器。在本发明的一个实施例中，一个或多个导电触头（32）包括卡边缘触点（34）。在本发明的替代实施例中，一个或多个导电触头包括用于插入报告器单元（130）的插座（128）中的导电引脚（124）。因为光学传感器是预先对准的，例如，光学传感器的感测表面部分安装在流动池上，并且流体连接器中的至少一个与电触点对准，可以容易地在主机上更换盒单位允许，例如，多种流体的现场分析。

9. 发明授权

US6045756A Miniaturized integrated sensor platform 失效
公开(公告)号：US6045756A
公开(公告)日：2000-04-04
申请号：US942089
申请日：1997-10-01
申请人： Richard A. Carr , Jose L. Melendez , Kirk S. Laney
发明人： Richard A. Carr , Jose L. Melendez , Kirk S. Laney
IPC分类号： G01N21/77 , G01N21/78 , G01N21/27 , G01N21/00 , G01N21/01 , G01N21/64
CPC分类号： G01N21/7703 , G01N2201/0221 , Y10T29/49 , Y10T29/49131 , Y10T29/49769 , Y10T29/53039 , Y10T29/53087
摘要： A miniaturized integrated sensor (50) useful for indicating the presence of a sample analyte is disclosed. The sensor (50) has a platform (52) with an upper surface (53) and a detector (62), light source (60), waveguide (58), and reflective fixtures (60,62) embedded in the platform (52). The light source (60) is preferably a light emitting diode and sits in a cup-shaped dimple (68) that directs light from the light source (60) toward one of the reflective fixtures (64) to uniformly distribute light across the waveguide (58). The waveguide (58) is coupled to an upper surface (53) of the sensor platform (52) and is coated with a thin film of indicator chemistry (70) which interacts with the sample analyte to produce optic signal changes that are measurable by the detector (62). A lead frame (51) in the platform (52) has pins (54, 55, 56) which provide the interface to the outside world. In one embodiment, sensor package (100) has a unique shape that requires a predetermined insertion and removal into an instrument harness or other similar application.

10. 发明授权

US5912456A Integrally formed surface plasmon resonance sensor 失效
标题翻译：整体形成的表面等离子体共振传感器
公开(公告)号：US5912456A
公开(公告)日：1999-06-15
申请号：US820621
申请日：1997-03-19
申请人： Jose L. Melendez , Richard A. Carr , Robert C. Keller
发明人： Jose L. Melendez , Richard A. Carr , Robert C. Keller
IPC分类号： G01N21/27 , G01N21/55 , H01J3/14
CPC分类号： G01N21/553
摘要： A surface plasmon resonance sensor includes a light source 10 and a polarizer 18 for producing polarized light which passes through a transparent body 12 and strikes a thin conductive film 26 disposed on the exterior surface of the body 12. The film 26 exhibits surface plasmon resonance when the light strikes the film at a "resonance angle". By determining the angle at which surface plasmon resonance occurs, the refractive index of the material on the side of the film 26 opposite to the side which reflects the polarized light can be measured.
摘要翻译：表面等离子体共振传感器包括用于产生偏振光的光源10和偏振器18，偏振光通过透明体12并且撞击设置在主体12的外表面上的薄导电膜26.膜26表现出表面等离子体共振光线以“共振角度”拍摄。通过确定发生表面等离子体共振的角度，可以测量与反射偏振光的一侧相反的膜26侧的材料的折射率。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式