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1. 发明授权

US06183774B2 Stabilizing vitamin A derivatives by encapsulation in lipid vesicles formed with alkylammonium fatty acid salts 有权
标题翻译：通过包封在用烷基铵脂肪酸盐形成的脂质囊泡中来稳定维生素A衍生物
公开(公告)号：US06183774B2
公开(公告)日：2001-02-06
申请号：US09375683
申请日：1999-08-17
申请人： Duncan T. Aust , Michael A. Ross , James M. Wilmott , James A. Hayward
发明人： Duncan T. Aust , Michael A. Ross , James M. Wilmott , James A. Hayward
IPC分类号： A61K9127
CPC分类号： A61K9/1272
摘要： The present invention provides for vitamin A derivative selected from the group consisting of retinol, retinyl ester and any combination thereof incorporated into liposomes formed with alkylammonium fatty acid salts, and methods for manufacturing same. The liposomes of the invention may deliver vitamin A derivative materials at the occurrence of a preset triggering condition. Preferred liposomes of the invention are cationic liposomes. The preferred liposomes of the invention are formed with alkylammonium fatty acid salts, e.g., trialkylammonium fatty acid salts of long chain amides. The encapsulated vitamin A derivative is thus stabilized by the liposomes. The present invention thus also provides a method of stabilizing vitamin A derivative be encapsulation in such liposomes. The liposomes of the invention are used to provide topical skin treatment formulations useful in the treatment of skin.
摘要翻译：本发明提供了选自视黄醇，视黄酯以及与烷基铵脂肪酸盐形成的脂质体中的任意组合的维生素A衍生物及其制造方法。本发明的脂质体可以在预设的触发条件发生时递送维生素A衍生物质。本发明优选的脂质体是阳离子脂质体。本发明优选的脂质体由烷基铵脂肪酸盐形成，例如长链酰胺的三烷基铵脂肪酸盐。包封的维生素A衍生物因此被脂质体稳定。因此，本发明还提供了一种将维生素A衍生物稳定化在这种脂质体中的方法。本发明的脂质体用于提供用于治疗皮肤的局部皮肤治疗制剂。

2. 发明授权

US07175834B2 Sunscreen composition with enhanced SPF and water resistant properties 有权
标题翻译：具有增强SPF和防水性能的防晒组合物
公开(公告)号：US07175834B2
公开(公告)日：2007-02-13
申请号：US11114668
申请日：2005-04-26
申请人： Duncan T. Aust , James M. Wilmott , James A. Hayward
发明人： Duncan T. Aust , James M. Wilmott , James A. Hayward
IPC分类号： A61Q17/04 , A61Q17/00 , A61Q19/00 , A61K8/00 , A61K8/04
CPC分类号： A61K8/044 , A61K8/73 , A61K2800/413 , A61Q17/04 , B82Y5/00
摘要： The present invention relates to a sunscreen formulation which exhibits superior ultraviolet protection and water resistance than prior art sunscreen compositions. The sunscreen formulation comprises (a) a dispersion comprising a sunscreen active agent and (b) a base composition comprising a rheological modifying agent and water. The sunscreen formulation is substantially free of surfactants. According to a preferred embodiment, the sunscreen active agent is ethylhexylmethoxycinnamate, butylmethoxydibenzoylmethane, or a combination thereof. The sunscreen formulation preferably comprises a phosphorylated starch derivative as a rheological modifying agent. Another embodiment of the present invention is a method of protecting skin or hair from ultraviolet radiation by applying an effective amount of the sunscreen formulation of the present invention to the skin or hair.
摘要翻译：本发明涉及与现有技术的防晒组合物相比表现出优异的紫外线防护性和耐水性的防晒制剂。防晒制剂包含（a）包含防晒活性剂的分散体和（b）包含流变改性剂和水的基础组合物。防晒制剂基本上不含表面活性剂。根据优选的实施方案，防晒活性剂是甲氧基肉桂酸乙基己酯，丁基甲氧基二苯甲酰甲烷或其组合。防晒制剂优选包含作为流变改性剂的磷酸化淀粉衍生物。本发明的另一个实施方案是通过将有效量的本发明的防晒制剂施用于皮肤或毛发来保护皮肤或头发免受紫外线辐射的方法。

3. 发明授权

US6071535A Lipid vesicles formed with alkylammonium fatty acid salts 有权
标题翻译：由烷基铵脂肪酸盐形成的脂质囊泡
公开(公告)号：US6071535A
公开(公告)日：2000-06-06
申请号：US255160
申请日：1999-02-22
申请人： James A. Hayward , David C. Watkins , Duncan T. Aust
发明人： James A. Hayward , David C. Watkins , Duncan T. Aust
IPC分类号： A61K9/127 , A61K7/00 , A61K9/133
CPC分类号： A61K9/1272 , Y10S514/88 , Y10S514/881
摘要： The present invention provides for liposomes formed with alkylammonium fatty acid salts, and methods for manufacturing same. The liposomes of the invention may deliver entrapped load material or materials at the occurrence of a preset triggering condition. Preferred liposomes of the invention are cationic liposomes. The preferred liposomes of the invention are formed with alkylammonium fatty acid salts, e.g., trialkylammonium fatty acid salts of long chain amides. The liposomes of the invention are used to encapsulate both hydrophobic and hydrophilic load materials. The liposomes formed accordingly are capable of delivering their loads upon the occurrence of a trigger or control condition.
摘要翻译：本发明提供用烷基铵脂肪酸盐形成的脂质体及其制造方法。本发明的脂质体可以在预设触发条件发生时传送截留的负载材料或材料。本发明优选的脂质体是阳离子脂质体。本发明优选的脂质体由烷基铵脂肪酸盐形成，例如长链酰胺的三烷基铵脂肪酸盐。本发明的脂质体用于包封疏水和亲水负载材料。相应形成的脂质体能够在发生触发或控制条件时递送其负载。

4. 发明授权

US08420400B2 System and method for authenticating tablets 有权
标题翻译：用于验证平板电脑的系统和方法
公开(公告)号：US08420400B2
公开(公告)日：2013-04-16
申请号：US11954055
申请日：2007-12-11
申请人： James A. Hayward , Ming-Hwa Liang , Stephane Shu-Kin-So
发明人： James A. Hayward , Ming-Hwa Liang , Stephane Shu-Kin-So
IPC分类号： G01N33/00 , C12Q1/68
CPC分类号： C12Q1/6816 , C08K5/09 , C09D7/63 , C09D11/03 , Y10T436/14 , Y10T436/143333 , Y10T442/2508 , C12Q2563/185
摘要： A method for authenticating and verifying a pharmaceutical item to be genuine is described. The method for authenticating a tablet comprises applying a particular nucleic acid material associated with a particular sequence of nucleic acid bases to a tablet or capsule. The method also comprises collecting a sample of the tablet and verifying the tablet is genuine by detecting the particular nucleic acid material.
摘要翻译：描述了用于认证和验证正品的药物的方法。用于鉴定片剂的方法包括将与特定的核酸碱基序列相关联的特定核酸材料施用于片剂或胶囊。该方法还包括收集片剂样品并通过检测特定的核酸材料来验证片剂是真实的。

5. 发明申请

US20120052125A1 Cholesteryl Sulfate-Containing Composition As A Haemostatic 审中-公开
标题翻译：含有硫酸胆固醇的组合物作为止血剂
公开(公告)号：US20120052125A1
公开(公告)日：2012-03-01
申请号：US13055951
申请日：2009-08-04
申请人： Martin Wieland , James A. Hayward
发明人： Martin Wieland , James A. Hayward
IPC分类号： A61K31/575 , A61K9/14 , B05D3/00 , B29C71/00 , B29C35/16 , A61K9/00 , A61P7/04
CPC分类号： A61L15/44 , A61L15/20 , A61L15/28 , A61L15/32 , A61L24/0015 , A61L24/08 , A61L24/102 , A61L27/20 , A61L27/24 , A61L27/54 , A61L2300/222 , A61L2300/418 , A61L2300/45 , A61L2400/04
摘要： The present invention relates to a composition comprising a wound dressing device and cholesteryl sulfate and especially to a composition containing cholesteryl sulfate and at least one carrier material for use as a haemostatic agent, as well as to a method for its preparation and use.
摘要翻译：本发明涉及包含伤口敷料装置和胆固醇硫酸盐的组合物，特别涉及含有胆固醇硫酸盐和至少一种用作止血剂的载体材料的组合物，以及其制备和使用方法。

6. 发明申请

US20090042191A1 SYSTEM AND METHOD FOR SECURE DOCUMENT PRINTING AND DETECTION 有权
标题翻译：用于安全文件打印和检测的系统和方法
公开(公告)号：US20090042191A1
公开(公告)日：2009-02-12
申请号：US11954044
申请日：2007-12-11
申请人： James A. Hayward , Ming-Hwa Liang , John Davis
发明人： James A. Hayward , Ming-Hwa Liang , John Davis
IPC分类号： C12Q1/68 , G01N33/00
CPC分类号： C12Q1/6816 , C08K5/09 , C09D7/63 , C09D11/03 , C09D11/38 , Y10T436/14 , Y10T436/143333 , Y10T442/2508 , C12Q2563/185
摘要： A method for authenticating and verifying an item to be genuine is described. The method for authenticating the item comprises applying a particular nucleic acid material associated with a particular sequence of nucleic acid bases to ink within an ink cartridge or a toner compound within a toner housing. The method also comprises collecting a sample of either the ink or toner compound and verifying the ink or toner is genuine by detecting the particular nucleic acid material.
摘要翻译：描述用于认证和验证正品的物品的方法。用于认证该项目的方法包括将与特定核酸碱基序列相关联的特定核酸材料施加到墨盒内的墨盒或调色剂外壳内的调色剂化合物中。该方法还包括收集油墨或调色剂化合物的样品，并通过检测特定的核酸材料来验证油墨或调色剂是真实的。

7. 发明授权

US5874105A Lipid vesicles formed with alkylammonium fatty acid salts 失效
标题翻译：由烷基铵脂肪酸盐形成的脂质囊泡
公开(公告)号：US5874105A
公开(公告)日：1999-02-23
申请号：US594175
申请日：1996-01-31
申请人： David C. Watkins , Thomas J. Vichroski , James A. Hayward
发明人： David C. Watkins , Thomas J. Vichroski , James A. Hayward
IPC分类号： A61K9/127
CPC分类号： A61K9/1272
摘要： A liposome for use in encapsulating both hydrophobic and hydrophilic substances (i.e., a "payload"),is disclosed which is capable of delivering their load upon the occurrence of a trigger or control condition. The liposomes are formed to stably encapsulate a particular active agent to form a delivery vehicle for the agent. The liposomes of the delivery vehicle are stable in a particular environment but become unstable or permeable if passed from the stable environment (e.g., characteristic of a particular pH and/or temperature and/or ionic strength) to a changed or unstable environment, thereby delivering their payload.
摘要翻译：公开了一种用于封装疏水和亲水物质（即“有效载荷”）的脂质体，其能够在发生触发或控制条件时传递其负载。形成脂质体以稳定地包封特定的活性剂以形成药剂的递送载体。递送载体的脂质体在特定环境中是稳定的，但是如果从稳定的环境（例如，特定的pH和/或温度和/或离子强度的特征）传递到改变或不稳定的环境，则其变得不稳定或可渗透，由此递送他们的有效载荷。

8. 发明申请

US20100285985A1 Methods and Systems for the Generation of Plurality of Security Markers and the Detection Therof 审中-公开
标题翻译：用于生成多种安全标记的方法和系统及其检测方法
公开(公告)号：US20100285985A1
公开(公告)日：2010-11-11
申请号：US12690799
申请日：2010-01-20
申请人： Minghwa Liang , James A. Hayward , Lawrence Jung
发明人： Minghwa Liang , James A. Hayward , Lawrence Jung
IPC分类号： C40B30/04 , C40B50/00 , C40B50/06 , C40B40/06
CPC分类号： G07D7/14 , C08L89/00 , C09D7/65 , C09D11/00 , C12Q1/6816 , C12Q2563/185
摘要： This invention pertains to methods for generating large quantities of DNA security markers by combinatorial variation techniques using polymorphic fragment length DNA for unique identification security marker applications such as explosive ink used in dye/smoke pack and cash carrying boxes.
摘要翻译：本发明涉及通过使用多态性片段长度DNA的组合变异技术产生大量DNA安全标记的方法，用于独特的鉴定安全标记应用，例如用于染料/烟雾包装和现金携带盒中的爆炸性油墨。

9. 发明授权

US5935572A Composition containing protease separate from glycosidase for removing nits in treating lice infestation 失效
标题翻译：含有与糖苷酶分离的蛋白质的组合物用于在治疗虱子感染中除去尼丝
公开(公告)号：US5935572A
公开(公告)日：1999-08-10
申请号：US781643
申请日：1997-01-10
申请人： James A. Hayward , David C. Watkins
发明人： James A. Hayward , David C. Watkins
IPC分类号： A61K38/48 , A61K38/54 , A61P33/14 , A61K38/47 , C12N11/02
CPC分类号： A61K38/47 , A01N63/00 , A61K38/4873 , C12Y302/01014 , C12Y302/01017 , C12Y304/22002 , A61K9/127
摘要： A composition containing a protease and glycosidase is provided for removing nits in the treatment of lice infestation. The protease and glycosidase are separated from each other to prevent the protease from hydrolyzing the glycosidase Separation is accomplished by encapsulating either the protease or glycosidase in a lipidic bilayer vesicle while leaving the other outside the vesicle. The protease and glycosidase destroy complex carbohydrate and protein in nit shells, nit embryos and substances secreted by adult lice. In a method of treatment, an infestation site such as hair is treated with a pediculoside and then with the composition containing a protease and glycosidase, and nits are removed such as by washing.
摘要翻译：提供了含有蛋白酶和糖苷酶的组合物，用于在治疗虱子感染中除去尼丝。将蛋白酶和糖苷酶彼此分离，以防止蛋白酶水解糖苷酶。通过将蛋白酶或糖苷酶包封在脂质双层囊泡中，同时将另一个留在囊泡外部来实现分离。蛋白酶和糖苷酶破坏了硝基壳中的复合碳水化合物和蛋白质，硝基胚胎和成年虱子分泌的物质。在一种治疗方法中，用梭菌素处理诸如头发的侵染部位，然后用含有蛋白酶和糖苷酶的组合物进行处理，并通过洗涤来除去尼丝。

10. 发明授权

US5437867A Solubilizing, thickening and emulsifying cosmetic composition and process for preparation of same 失效
标题翻译：增溶，增稠和乳化化妆品组合物及其制备方法
公开(公告)号：US5437867A
公开(公告)日：1995-08-01
申请号：US33819
申请日：1993-03-19
申请人： Thomas J. Vichroski , Regina A. Costa , James A. Hayward
发明人： Thomas J. Vichroski , Regina A. Costa , James A. Hayward
IPC分类号： A61K8/33 , A61K8/81 , A61K9/10 , A61K9/107 , A61Q19/00
CPC分类号： A61K8/33 , A61K8/8147 , A61Q19/00 , A61K2800/262 , A61Q13/00 , Y10S514/937 , Y10S514/944
摘要： A cosmetic composition includes (a) ether alcohols conforming to the general formula C.sub.(n) H.sub.(2n+2) O.sub.(n/2), where n is an integer which ranges 4 to 12; (b) a homopolymer of acrylic acid cross-linked with an allyl ether of pentaerythritol or an allyl ether of sucrose, or copolymers of acrylic acid or acrylate derivative/acrylonitrile copolymers, or polyacrylic acid; (c) a fragrance oil or oils, or cosmetically acceptable oils or oily-type materials; and (d) water.
摘要翻译：化妆品组合物包括（a）符合通式C（n）H（2n + 2）O（n / 2）的醚醇，其中n为4-12的整数; （b）与季戊四醇或蔗糖烯丙基醚的烯丙基醚交联的丙烯酸均聚物，或丙烯酸或丙烯酸酯衍生物/丙烯腈共聚物或聚丙烯酸的共聚物; （c）香料油或油，或化妆品可接受的油或油性物质; 和（d）水。

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