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1. 发明申请

US20130137752A1 RNA Interference Mediated Inhibition of Catenin (Cadherin-Associated Protein), Beta 1 (CTNNB1) Gene Expression Using Short Interfering Nucleic Acid (siNA) 有权
公开(公告)号：US20130137752A1
公开(公告)日：2013-05-30
申请号：US13813465
申请日：2011-08-02
申请人： Duncan Brown , James J. Cunningham , Marian Gindy , Victoria Pickering , Matthew G. Stanton , Steven M. Stirdivant , Walter R. Strapps
发明人： Duncan Brown , James J. Cunningham , Marian Gindy , Victoria Pickering , Matthew G. Stanton , Steven M. Stirdivant , Walter R. Strapps
IPC分类号： C12N15/113
CPC分类号： C12N15/1138 , C12N15/113 , C12N2310/14 , C12N2310/315 , C12N2310/321 , C12N2310/332 , C12N2310/346 , C12N2310/3521 , C12N2320/32
摘要： The present invention relates to compounds, compositions, and methods for the study, diagnosis, and treatment of traits, diseases and conditions that respond to the modulation of CTNNB1 gene expression and/or activity, and/or modulate a beta-catenin gene expression pathway. Specifically, the invention relates to double-stranded nucleic acid molecules including small nucleic acid molecules, such as short interfering nucleic acid (siNA), short interfering RNA (siRNA), double-stranded RNA (dsRNA), micro-RNA (miRNA), and short hairpin RNA (shRNA) molecules that are capable of mediating or that mediate RNA interference (RNAi) against CTNNB1 gene expression.

2. 发明授权

US08518907B2 RNA interference mediated inhibition of catenin (cadherin-associated protein), beta 1 (CTNNB1) gene expression using short interfering nucleic acid (siNA) 有权
标题翻译：使用短干扰核酸（siNA）的RNA干扰介导的连环素（钙粘蛋白相关蛋白），β1（CTNNB1）基因表达的抑制
公开(公告)号：US08518907B2
公开(公告)日：2013-08-27
申请号：US13813465
申请日：2011-08-02
申请人： Duncan Brown , James J. Cunningham , Marian Gindy , Victoria Pickering , Matthew G. Stanton , Steven M. Stirdivant , Walter R. Strapps
发明人： Duncan Brown , James J. Cunningham , Marian Gindy , Victoria Pickering , Matthew G. Stanton , Steven M. Stirdivant , Walter R. Strapps
IPC分类号： C12N15/11 , A61K48/00 , C07H21/02 , C07H21/04
CPC分类号： C12N15/1138 , C12N15/113 , C12N2310/14 , C12N2310/315 , C12N2310/321 , C12N2310/332 , C12N2310/346 , C12N2310/3521 , C12N2320/32
摘要： The present invention relates to compounds, compositions, and methods for the study, diagnosis, and treatment of traits, diseases and conditions that respond to the modulation of CTNNB1 gene expression and/or activity, and/or modulate a beta-catenin gene expression pathway. Specifically, the invention relates to double-stranded nucleic acid molecules including small nucleic acid molecules, such as short interfering nucleic acid (siNA), short interfering RNA (siRNA), double-stranded RNA (dsRNA), micro-RNA (miRNA), and short hairpin RNA (shRNA) molecules that are capable of mediating or that mediate RNA interference (RNAi) against CTNNB1 gene expression.
摘要翻译：本发明涉及用于研究，诊断和治疗对CTNNB1基因表达和/或活性的调节作用和/或调节β-连环蛋白基因表达途径的性状，疾病和病症的化合物，组合物和方法。具体地说，本发明涉及包括小核酸分子，如短干扰核酸（siNA），短干扰RNA（siRNA），双链RNA（dsRNA），微RNA（miRNA）等双链核酸分子，和能够介导或介导针对CTNNB1基因表达的RNA干扰（RNAi）的短发夹RNA（shRNA）分子。

3. 发明申请

US20160317444A1 Liposomal Formulations for Allosteric AKT Inhibitors 审中-公开
标题翻译：变构AKT抑制剂的脂质体制剂
公开(公告)号：US20160317444A1
公开(公告)日：2016-11-03
申请号：US15103911
申请日：2014-12-12
申请人： Michael Hughes SMITH , Marian GINDY , MERCK SHARP & DOHME CORP.
发明人： Michael Hughes Smith , Marian Gindy
IPC分类号： A61K9/127 , A61K31/4375 , A61K9/00
CPC分类号： A61K9/1277 , A61K9/0019 , A61K9/127 , A61K9/1271 , A61K9/1273 , A61K9/5123 , A61K31/4375 , A61K47/14
摘要： Disclosed herein is a lipid nanoparticle (LNP) composition comprising (a) an Akt inhibitor; (b) DSPC; (c) cholesterol; and (d) PEG-DMG. Also disclosed herein is a method for preparing the lipid composition using a scalable tangential flow micro-mixing technology.
摘要翻译：本文公开了一种脂质纳米颗粒（LNP）组合物，其包含（a）Akt抑制剂; （b）DSPC; （c）胆固醇; 和（d）PEG-DMG。本文还公开了使用可伸缩切向流微混合技术制备脂质组合物的方法。

4. 发明授权

US09943490B2 Composite flash-precipitated nanoparticles 有权
公开(公告)号：US09943490B2
公开(公告)日：2018-04-17
申请号：US12265206
申请日：2008-11-05
申请人： Robert K. Prud'homme , Marian Gindy , Ying Liu
发明人： Robert K. Prud'homme , Marian Gindy , Ying Liu
IPC分类号： B05D7/00 , A61K9/51 , A61K49/00 , A61K49/18
CPC分类号： A61K9/5153 , A61K49/0019 , A61K49/0065 , A61K49/0093 , A61K49/1857 , Y10T428/2991
摘要： The invention described herein relates to sterically stabilized colloidal constructs comprising preformed colloidal particles encapsulated within a polymeric shell. The constructs, which are controllably sized, are nanoparticles comprising hydrophobic elements, electrostatically charged particles with hydrophobic surfaces, hydrophobic inorganic nanostructures, and amphiphilic copolymers with hydrophobic domains and hydrophilic domains. The constructs are made by a process that allows for the simultaneous encapsulation of a preformed colloidal agent as well as a dissolved hydrophobic active within the core of the polymeric nanoparticle. Among the actives incorporated in various embodiments are organic fluorescent dyes, metal nanostructures and superparamagnetic materials for use in combined fluorescence, optical and magnetic resonance imaging applications, and hydrophobic drugs for therapeutic applications.

5. 发明申请

US20160361411A1 LIPID NANOPARTICLE VACCINE ADJUVANTS AND ANTIGEN DELIVERY SYSTEMS 审中-公开
公开(公告)号：US20160361411A1
公开(公告)日：2016-12-15
申请号：US15120954
申请日：2015-02-23
申请人： Marian Gindy , Danilo R. Casimiro , Andrew Bett , Jan H. Ter Meulen
发明人： Marian Gindy , Danilo R. Casimiro , Andrew Bett , Jan H. Ter Meulen
IPC分类号： A61K39/39 , A61K31/451 , A61K39/29 , A61K39/12 , C12N7/00 , A61K9/50 , A61K31/80
摘要： The instant invention provides for novel lipid nanoparticle (LNP) formulations, containing cationic lipids, for use as vaccine adjuvants and/or as antigen delivery systems. It is an object of the instant invention to provide LNP formulations that demonstrate enhancements in humoral and cellular immunogenicity of vaccine antigens, particularly subunit vaccine antigens, when utilized alone or in combination with immunostimulatory agents (e.g. small molecule or oligonucleotide TLR agonists). The instant invention further identifies physical and chemical properties of the LNP formulations that can be manipulated to enhance antigen efficiency and adjuvant tolerability in vivo.
摘要翻译：本发明提供了用作疫苗佐剂和/或作为抗原递送系统的新型脂质纳米颗粒（LNP）制剂，其含有阳离子脂质。本发明的目的是提供当单独使用或与免疫刺激剂（例如小分子或寡核苷酸TLR激动剂）组合使用时，证明疫苗抗原，特别是亚单位疫苗抗原的体液和细胞免疫原性增强的LNP制剂。本发明进一步鉴定LNP制剂的物理和化学性质，其可被操作以增强体内抗原效率和佐剂耐受性。

6. 发明申请

US20100330368A1 Composite Flash-Precipitated Nanoparticles 有权
标题翻译：复合闪烁沉淀纳米颗粒
公开(公告)号：US20100330368A1
公开(公告)日：2010-12-30
申请号：US12265206
申请日：2008-11-05
申请人： Robert K. Prud'homme , Marian Gindy , Ying Liu
发明人： Robert K. Prud'homme , Marian Gindy , Ying Liu
IPC分类号： B32B15/04
CPC分类号： A61K9/5153 , A61K49/0019 , A61K49/0065 , A61K49/0093 , A61K49/1857 , Y10T428/2991
摘要： The invention described herein relates to sterically stabilized colloidal constructs comprising preformed colloidal particles encapsulated within a polymeric shell. The constructs, which are controllably sized, are nanoparticles comprising hydrophobic elements, electrostatically charged particles with hydrophobic surfaces, hydrophobic inorganic nanostructures, and amphiphilic copolymers with hydrophobic domains and hydrophilic domains. The constructs are made by a process that allows for the simultaneous encapsulation of a preformed colloidal agent as well as a dissolved hydrophobic active within the core of the polymeric nanoparticle. Among the actives incorporated in various embodiments are organic fluorescent dyes, metal nanostructures and superparamagnetic materials for use in combined fluorescence, optical and magnetic resonance imaging applications, and hydrophobic drugs for therapeutic applications.
摘要翻译：本文描述的本发明涉及包含预先形成的包封在聚合物壳内的胶体颗粒的空间稳定的胶体构造物。可控制尺寸的构造体是包含疏水性元素的纳米颗粒，具有疏水表面的带静电荷的颗粒，疏水性无机纳米结构和具有疏水域和亲水结构域的两亲共聚物。构建体通过允许预先形成的胶体剂以及在聚合物纳米颗粒的核心内的溶解的疏水性活性物质同时包封的方法制备。在各种实施方案中引入的活性物质是用于组合荧光，光学和磁共振成像应用的有机荧光染料，金属纳米结构和超顺磁性材料，以及用于治疗应用的疏水性药物。

7. 发明申请

US20110022129A1 NANOPARTICLES FOR PHOTODYNAMIC THERAPY 审中-公开
标题翻译：光化疗治疗纳米颗粒
公开(公告)号：US20110022129A1
公开(公告)日：2011-01-27
申请号：US12741334
申请日：2008-11-05
申请人： Robert K. Prud'homme , Marian Gindy , Baris Ungun , Stephanie Budijono , Ying Liu
发明人： Robert K. Prud'homme , Marian Gindy , Baris Ungun , Stephanie Budijono , Ying Liu
IPC分类号： A61N5/06 , C12N13/00
CPC分类号： A61K9/0009
摘要： Embodiments of the invention include nanoparticulate products of a flash nanoprecipitation process, the products comprising, in combination, pre-formed nanoparticles having properties of an upconversion phosphor and a hydrophobic organic compound having the properties of a photosensitizer, and a method of photodynamic therapy comprising the use of the nanoparticulate products is described.
摘要翻译：本发明的实施方案包括快速纳米颗粒沉积方法的纳米颗粒产物，该组合物包含具有上转换荧光体和具有光敏剂性质的疏水性有机化合物的特性的预形成纳米颗粒，以及包含描述了纳米颗粒产品的使用。

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