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1. 发明授权

US5213115A Inflation system for a balloon catheter 失效
标题翻译：气球导管系统
公开(公告)号：US5213115A
公开(公告)日：1993-05-25
申请号：US601431
申请日：1990-10-23
申请人： Duane Zytkovicz , Thomas J. McEvoy , Gregory G. Brucker
发明人： Duane Zytkovicz , Thomas J. McEvoy , Gregory G. Brucker
IPC分类号： A61M25/00 , A61F2/958 , A61M5/48
CPC分类号： A61M25/104 , A61M25/01 , A61M25/1018 , A61M5/488
摘要： An inflation system for pressurization and depressurization of a balloon catheter. The inflation system includes a syringe, including a syringe barrel, a plunger with expandable thread, a handle with cam, a syringe end cap, pressure gauge, flexible tubing, and connectors. The syringe is structured such that part of the syringe barrel has an internal thread which engages the expandable threads of the plunger. In the disengaged mode, the plunger slides freely within the syringe barrel allowing for rapid motion to purge, pressurize, or depressurize the inflation system. Once pressure reaches a predetermined level in the system, the cam on the handle causes the threads to automatically lock against the syringe barrel, and continued pressurization or depressurization is accomplished by the rotation of the plunger handle with respect to the syringe barrel. One advantage of the inflation system is that only one step is necessary for locking the syringe for controlled pressurization and depressurization.
摘要翻译：用于气囊导管加压和减压的充气系统。充气系统包括注射器，包括注射器筒，具有可扩展螺纹的柱塞，具有凸轮的手柄，注射器端盖，压力计，柔性管和连接器。注射器被构造成使得注射器筒的一部分具有接合柱塞的可膨胀螺纹的内螺纹。在分离模式中，柱塞在注射器筒内自由滑动，允许快速运动以吹扫，加压或减压充气系统。一旦压力在系统中达到预定水平，手柄上的凸轮就会导致螺纹自动锁定注射器筒，并且通过柱塞手柄相对于注射器筒的旋转来实现持续的加压或减压。膨胀系统的一个优点是只需要一个步骤来锁定注射器以进行受控的加压和减压。

2. 发明授权

US5279563A Digital display for an inflation system for a balloon catheter 失效
标题翻译：用于气囊导管的充气系统的数字显示器
公开(公告)号：US5279563A
公开(公告)日：1994-01-18
申请号：US887763
申请日：1992-05-22
申请人： Gregory G. Brucker , Duane Zytkoviez , Thomas J. McEvoy
发明人： Gregory G. Brucker , Duane Zytkoviez , Thomas J. McEvoy
IPC分类号： A61F2/958 , A61M29/00
CPC分类号： A61M25/10184 , A61M25/1018 , A61M25/10182 , A61M25/10187 , A61M25/10188 , A61M2205/50
摘要： An inflation system for pressurization and depressurization of a balloon catheter. The inflation system includes a syringe, including a syringe barrel, a plunger with expandable thread, a handle with cam, a syringe end cap, and a digital pressure gauge. The syringe is structured such that part of the syringe barrel has an internal thread which engages the expandable threads of the plunger. In the disengaged mode, the plunger slides freely within the syringe barrel allowing for rapid motion to purge, pressurize, or depressurize the inflation system. Once pressure reaches a predetermined level in the system, the cam on the handle causes the threads to automatically lock against the syringe barrel, and continued pressurization or depressurization is accomplished by the rotation of the plunger handle with respect to the syringe barrel. One advantage of the inflation system is that only one step is necessary for locking the syringe for controlled pressurization and depressurization. A digital display engages to a pressure port to indicate the pressure and displays absolute pressure and elapsed time at absolute pressure. In addition, the digital display provides for a communication interface to a data acquisition system such as a personal computer to record date, time and pressure over finite term periods.
摘要翻译：用于气囊导管加压和减压的充气系统。充气系统包括注射器，包括注射器筒，具有可扩张螺纹的柱塞，带凸轮的手柄，注射器端盖和数字压力计。注射器被构造成使得注射器筒的一部分具有接合柱塞的可膨胀螺纹的内螺纹。在分离模式中，柱塞在注射器筒内自由滑动，允许快速运动以吹扫，加压或减压充气系统。一旦压力在系统中达到预定水平，手柄上的凸轮就会导致螺纹自动锁定注射器筒，并且通过柱塞手柄相对于注射器筒的旋转来实现持续的加压或减压。膨胀系统的一个优点是只需要一个步骤来锁定注射器以进行受控的加压和减压。数字显示器与压力端口接合以指示压力，并在绝对压力下显示绝对压力和经过时间。此外，数字显示器提供与诸如个人计算机的数据采集系统的通信接口，以在有限期间内记录日期，时间和压力。

3. 发明授权

US6017338A Fluid cooled and perfused tip for a catheter 失效
标题翻译：用于导管的流体冷却和灌注末端
公开(公告)号：US6017338A
公开(公告)日：2000-01-25
申请号：US496947
申请日：1995-06-30
申请人： Gregory G. Brucker , Jerome Philip Saul , Steven D. Savage
发明人： Gregory G. Brucker , Jerome Philip Saul , Steven D. Savage
IPC分类号： A61B18/12 , A61B5/042 , A61B17/00 , A61B18/00 , A61B18/14 , A61F2/30 , A61M1/00 , A61M25/00 , A61B17/39
CPC分类号： A61B18/1492 , A61M25/0068 , A61M25/0069 , A61M25/0082 , A61B18/1402 , A61B2017/00084 , A61B2017/22038 , A61B2018/00005 , A61B2018/00011 , A61B2018/00029 , A61B2018/00065 , A61B2018/00357 , A61B2018/00577 , A61B2018/00791 , A61B2018/00982 , A61B2018/1253 , A61B2018/1467 , A61B2218/002 , A61B5/042 , A61F2002/30968 , A61M1/0084 , A61M2025/0073
摘要： The invention relates to an ablation catheter which controls the temperature and reduces the coagulation of biological fluids on a tip of a catheter, prevents the impedance rise of tissue in contact with the catheter tip, and maximizes the potential energy transfer to the tissue, thereby allowing an increase in the lesion size produced by the ablation. The ablation catheter includes a catheter body. The ablation catheter also includes a tip for monitoring electrical potentials, and applying electrical energy to a biological tissue. A fluid source is positioned at one end of the catheter for supplying a fluid flow through the catheter to the tip means. Passages are positioned within the tip in a variety of manners for directing the fluid flow through the tip means to the exterior surface of the tip to control the temperature and form a protective fluid layer around the tip. Monitoring structure is also positioned within the tip structure for measurement of the electrical potentials in a biological tissue. Ablation structure is also positioned within the tip for application of ablative energy to the biological tissue.
摘要翻译：本发明涉及一种消融导管，其控制温度并减少导管尖端上的生物流体的凝结，防止与导管尖端接触的组织的阻抗上升，并使能量传递到组织最大化，从而允许消融产生的损伤尺寸增加。消融导管包括导管体。消融导管还包括用于监测电势并将电能施加到生物组织的尖端。流体源位于导管的一端，用于将通过导管的流体流提供给尖端装置。通道以各种方式定位在尖端内，用于将流体流动通过尖端装置引导到尖端的外表面，以控制温度并在尖端周围形成保护性流体层。监测结构也位于尖端结构内，用于测量生物组织中的电位。消融结构也位于用于向生物组织施加烧蚀能量的尖端内。

4. 发明授权

US5830209A Multi-fiber laser catheter 失效
标题翻译：多光纤激光导管
公开(公告)号：US5830209A
公开(公告)日：1998-11-03
申请号：US529810
申请日：1995-09-18
申请人： Steven D. Savage , Gregory G. Brucker
发明人： Steven D. Savage , Gregory G. Brucker
IPC分类号： A61B17/00 , A61B17/22 , A61B18/00 , A61B18/24 , A61B17/36
CPC分类号： A61B18/24 , A61B2017/00092 , A61B2017/00243 , A61B2017/22038 , A61B2018/00011
摘要： Laser catheters according to the invention include multiple optical fibers for delivery of laser energy to a pre-determined treatment site in the therapeutic treatment of cardiac tissue. A fixation device fixes the distal end of the catheter to the treatment site. Temperature sensing devices disposed on the fixation device provide a temperature depth profile of the tissue treatment site, which can be used to control the treatment. Multi-piece, single-piece and porous tip catheters are disclosed.
摘要翻译：根据本发明的激光导管包括用于在心脏组织的治疗性治疗中将激光能量传递到预定治疗部位的多根光纤。固定装置将导管的远端固定到治疗部位。设置在固定装置上的温度感测装置提供可用于控制处理的组织处理部位的温度深度分布。公开了多片，单件和多孔尖端导管。

5. 发明授权

US07618432B2 Valvuloplasty devices and methods 有权
标题翻译：瓣膜成形术装置及方法
公开(公告)号：US07618432B2
公开(公告)日：2009-11-17
申请号：US10856494
申请日：2004-05-27
申请人： Wesley Pedersen , Robert A. Van Tassel , Robert S. Schwartz , Gregory G. Brucker , Skott E. Greenhalgh
发明人： Wesley Pedersen , Robert A. Van Tassel , Robert S. Schwartz , Gregory G. Brucker , Skott E. Greenhalgh
IPC分类号： A61M29/00 , A61F2/06
CPC分类号： A61B17/22 , A61B17/3207 , A61B17/320725 , A61B2017/00783 , A61B2017/22051 , A61B2017/22061 , A61B2017/22098 , A61F2/013 , A61F2/2433 , A61M25/10 , A61M25/1002 , A61M25/104 , A61M29/02 , A61M2025/1059
摘要： The present invention provides an aortic valvuloplasty catheter which, in one preferred embodiment, has a tapered distal balloon segment that anchors within the left ventricle outflow track of the patient's heart and a rounded proximal segment which conforms to the aortic sinuses forcing the valve leaflets open. In addition, this embodiment of the valvuloplasty catheter includes a fiber-based balloon membrane, a distal pigtail end hole catheter tip, and a catheter sheath.
摘要翻译：本发明提供了一种主动脉瓣膜成形术导管，其在一个优选实施例中具有楔形的远侧气囊段，其锚定在患者心脏的左心室流出轨道内，并且圆形近端段符合主动脉窦，迫使瓣膜小叶开放。此外，瓣膜成形术导管的该实施例包括纤维基球囊膜，远端猪尾端孔导管末端和导管鞘。

6. 发明授权

US07338485B2 Cardiac lesions with continuity testing 失效
标题翻译：具有连续性测试的心脏病变
公开(公告)号：US07338485B2
公开(公告)日：2008-03-04
申请号：US11066959
申请日：2005-02-25
申请人： Gregory G. Brucker , Robert H. Svenson
发明人： Gregory G. Brucker , Robert H. Svenson
IPC分类号： A61B18/22
CPC分类号： A61B18/22 , A61B18/20 , A61B18/24 , A61B2017/00026 , A61B2017/00243 , A61B2017/00247 , A61B2017/306 , A61B2018/00196 , A61B2018/00392 , A61B2018/00636
摘要： A method and apparatus for treating in situ biologic tissue include identifying a patient with a condition susceptible to treatment by forming a lesion in the tissue and accessing a surface of the tissue. A lesion formation tool is positioned against the accessed surface. The tool includes an optical fiber for guiding a coherent waveform of a selected wavelength to a fiber tip for discharge of light energy from the fiber tip. The wavelength is selected for the light energy to penetrate a full thickness of the tissue to form a volume of necrosed tissue through the thickness of the tissue. The tool further includes a guide tip coupled to the fiber tip. The guide tip is adapted to have a discharge bore aligned with the fiber tip to define an unobstructed light pathway from the fiber tip to the tissue surface. The guide tip is further adapted to be placed against the tissue surface with the guide tip slidable along the tissue surface in atraumatic sliding engagement with the discharge bore opposing the tissue surface. The lesion formation tool is manipulated to draw the guide tip over the tissue surface in a pathway while maintaining the discharge bore opposing the tissue surface to form a transmural lesion in the tissue extending a length of the pathway.
摘要翻译：用于治疗原位生物组织的方法和装置包括通过在组织中形成病变并进入组织的表面来识别具有易于治疗的病症的患者。病变形成工具抵靠所访问的表面定位。该工具包括用于将所选波长的相干波形引导到光纤尖端的光纤，用于从光纤尖端排出光能。选择波长以使光能穿透组织的整个厚度，以通过组织的厚度形成一定数量的坏死组织。该工具还包括连接到纤维尖端的引导尖端。引导尖端适于具有与纤维末端对准的排出孔，以限定从纤维尖端到组织表面的无阻碍的光路径。引导尖端进一步适于放置在组织表面上，其中引导尖端沿组织表面滑动，与组织表面相对的排出孔以无创的方式滑动接合。操纵损伤形成工具以将引导尖端在通道中的组织表面上拉伸，同时保持排出孔与组织表面相对，以在组织中形成延伸通路长度的跨壁损伤。

7. 发明授权

US5643197A Fluid cooled and perfused tip for a catheter 失效
标题翻译：用于导管的流体冷却和灌注末端
公开(公告)号：US5643197A
公开(公告)日：1997-07-01
申请号：US361329
申请日：1994-12-21
申请人： Gregory G. Brucker , Jerome Philip Saul , Steven D. Savage
发明人： Gregory G. Brucker , Jerome Philip Saul , Steven D. Savage
IPC分类号： A61B18/12 , A61B5/042 , A61B17/00 , A61B18/00 , A61B18/14 , A61F2/30 , A61M1/00 , A61M25/00 , A61B17/20
CPC分类号： A61B18/1492 , A61M25/0068 , A61M25/0069 , A61M25/0082 , A61B18/1402 , A61B2017/00084 , A61B2017/22038 , A61B2018/00005 , A61B2018/00011 , A61B2018/00029 , A61B2018/00065 , A61B2018/00357 , A61B2018/00577 , A61B2018/00791 , A61B2018/00982 , A61B2018/1253 , A61B2018/1467 , A61B2218/002 , A61B5/042 , A61F2002/30968 , A61M1/0084 , A61M2025/0073
摘要： The invention relates to an ablation catheter which controls the temperature and reduces the coagulation of biological fluids on a tip of a catheter, prevents the impedance rise of tissue in contact with the catheter tip, and maximizes the energy transfer to the tissue, thereby allowing an increase in the lesion size produced by the ablation. The ablation catheter includes a tip for applying electrical energy to biological tissue. Passages are positioned within the tip in a variety of manners for directing a fluid flow through the tip to the exterior surface of the tip to control the temperature and form a protective fluid layer around the tip. Monitoring structure is also positioned within the tip for measurement of the electrical potentials in a biological tissue. Ablation electrode structure is also positioned within the tip for application of ablative energy to the biological tissue. A flexible, extended embodiment electrode provides the capability to form deep, linear lesions along a portion of a heart wall during ablation for the treatment of particular arrhythmias.
摘要翻译：本发明涉及一种消融导管，其控制温度并减少导管尖端上生物流体的凝结，防止与导管尖端接触的组织的阻抗上升，并使能量传递到组织最大化，从而允许增加消融产生的病变大小。消融导管包括用于向生物组织施加电能的尖端。通道以各种方式定位在尖端内，用于将流体流动通过尖端到顶部的外表面，以控制温度并在尖端周围形成保护性流体层。监测结构也位于尖端内，用于测量生物组织中的电位。消融电极结构也位于尖端内，用于向生物组织施加烧蚀能量。灵活的，延伸的实施例电极提供了在消融期间沿着心壁的一部分形成深的线性损伤以用于治疗特定心律失常的能力。

8. 发明授权

US5507725A Steerable catheter 失效
标题翻译：导向导管
公开(公告)号：US5507725A
公开(公告)日：1996-04-16
申请号：US173250
申请日：1993-12-22
申请人： Steven D. Savage , Gregory G. Brucker
发明人： Steven D. Savage , Gregory G. Brucker
IPC分类号： A61M25/01 , A61M25/092 , A61M37/00
CPC分类号： A61M25/0144 , A61M25/0147
摘要： The invention relates to a steering system for a catheter tip. The system includes wire members that extend through a catheter wall that are used to pull a distal portion of the catheter tip causing controlled, predetermined bending at the tip. Anchoring members located near the catheter tip connect the distal end of the catheter with wire members. The steering system also contains control members which are located at a proximal portion of the catheter and are used to control the pull on the wire members. Steering enhancement members are also included in the steering system which facilitate the bending of the catheter wall.
摘要翻译：本发明涉及一种用于导管尖端的转向系统。该系统包括延伸通过导管壁的线构件，其用于拉动导管末端的远端部分，从而在尖端处引起受控的预定弯曲。位于导管尖端附近的锚固构件将导管的远端与导线构件连接。转向系统还包含位于导管的近端部分的控制构件，并用于控制线构件上的拉动。转向增强构件也包括在便于导管壁弯曲的转向系统中。

9. 发明授权

US5409008A Process and apparatus for mapping of tachyarrhythmia 失效
标题翻译：快速性心律失常的过程和仪器
公开(公告)号：US5409008A
公开(公告)日：1995-04-25
申请号：US83200
申请日：1993-06-25
申请人： Robert H. Svenson , Gregory G. Brucker , Steven D. Savage
发明人： Robert H. Svenson , Gregory G. Brucker , Steven D. Savage
IPC分类号： A61B5/0408 , A61B5/042 , A61B5/0478 , A61B5/0492 , A61B17/00 , A61B18/02 , A61B18/12 , A61B18/14 , A61B18/24 , A61M3/02 , A61M25/00 , A61N1/05 , A61B5/04 , A61N1/04
CPC分类号： A61B5/0422 , A61B18/1492 , A61N1/056 , A61B18/02 , A61B18/1402 , A61B18/24 , A61B2017/00243 , A61B2017/00292 , A61B2018/1266 , A61M3/0279
摘要： Process and apparatus for mapping of tachyarrhythmia, such as ventricular tachycardia. The apparatus is a mapping catheter which is a polymer member including a plurality of electrodes at a distal end. An upper ring is divided into at least bipolar poles for sensing endocardial potentials. A spaced lower unipolar ring senses intercardic potentials. The process provides for sensing of a QRS signal with the upper bipolar electrodes, and the unipolar ring provides for sensing of the EKG signal. The mapping catheter is of such a size that the mapping catheter can be inserted up and through a hand-held probe to steer and guide the mapping catheter. An interventional catheter will fit within the mapping catheter for ablation of arrhythmogenic sites. One embodiment is a laser delivery catheter which can include a fiber optic cable, a fixation wire, a metal sensing tip and an internal flushing lumen.
摘要翻译：快速心律失常的定位过程和装置，如室性心动过速。该装置是映射导管，其是在远端包括多个电极的聚合物构件。至少双极极分为上环，用于感应心内膜电位。间隔较低的单极环感知心电位。该过程提供了利用上双极电极感测QRS信号，并且单极环提供用于感测EKG信号。映射导管的尺寸使得映射导管可以插入上方并通过手持探针来引导和引导映射导管。介入导管将适合于映射导管，用于消融致心律失常部位。一个实施例是激光输送导管，其可以包括光纤电缆，固定线，金属感测尖端和内部冲洗腔。

10. 发明授权

US5290277A Multi-fiber linear array laser catheter connector 失效
标题翻译：多光纤线阵激光导管连接器
公开(公告)号：US5290277A
公开(公告)日：1994-03-01
申请号：US863098
申请日：1992-04-03
申请人： Charmaine Vercimak , Steven D. Savage , Gregory G. Brucker
发明人： Charmaine Vercimak , Steven D. Savage , Gregory G. Brucker
IPC分类号： A61B18/24 , G02B6/42 , A61B17/36
CPC分类号： G02B6/3624 , A61B18/24 , G02B6/4296 , G02B6/241 , G02B6/3628
摘要： A multi-fiber linear array laser catheter for use in irradiation of biological tissue where a circular laser beam is optically transformed to coincide with the cross-section of a linear array of optical fibers. The transformed laser beams are focused onto a linear connector and transmitted through a plurality of parallel optical fibers. Heat is extracted and drawn from the vicinity of the parallel optic fibers by metallic plates acting as heat sinks on opposing sides of the parallel optic fibers.
摘要翻译：一种用于生物组织照射的多光纤线阵激光导管，其中圆形激光束被光学变换以与光纤的线性阵列的横截面一致。变换的激光束聚焦在线性连接器上，并透过多个平行的光纤。通过在平行光纤的相对侧上作为散热器的金属板，从平行光纤的附近提取热量。

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