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1. 发明申请

US20070090646A1 COUPLING HAVING ANGULARLY ORIENTED CAVITY 有权
标题翻译：具有正向导向的空腔的联接
公开(公告)号：US20070090646A1
公开(公告)日：2007-04-26
申请号：US11553012
申请日：2006-10-26
申请人： Douglas Dole , Michael Porter , Scott Madara , William Nagle , John Pierce , William McPoyle
发明人： Douglas Dole , Michael Porter , Scott Madara , William Nagle , John Pierce , William McPoyle
IPC分类号： F16L23/00
CPC分类号： F16L21/065 , F16L17/04 , F16L23/08 , Y10T29/49948
摘要： A coupling for joining pipe elements in end to end relation is disclosed. The coupling includes interconnectable coupling segments having connection members at opposite ends. The connection members are tightenable for drawing the segments toward one another and into engagement with the pipe elements. Each segment has a concavity positioned between inwardly projecting arcuate surfaces that engage grooves in the pipe elements. The concavities house a sealing member that extends circumferentially around the pipe elements. Angularly oriented surfaces are positioned adjacent to the connection members. The surfaces on facing segments engage one another and cause the segments to rotate in opposite directions about an axis perpendicular to the pipe elements. The concavities are angularly oriented with respect to the axis so that when the segments rotate, the cavities receive the sealing member without distorting it. A method of joining pipe elements end to end is also disclosed.
摘要翻译：公开了一种用于以端对端关系连接管元件的联接器。联接器包括在相对端具有连接构件的可互连联接段。连接构件是可收紧的，用于将段拉向彼此并与管道元件接合。每个段具有定位在接合管元件中的槽的向内突出的弧形表面之间的凹陷。凹部容纳围绕管元件周向延伸的密封构件。角度方向的表面邻近连接构件定位。相对的区段上的表面彼此接合并且使得区段围绕垂直于管道元件的轴在相反的方向上旋转。凹部相对于轴线成角度地定向，使得当片段旋转时，空腔容纳密封构件而不使其变形。还公开了一种将管元件端对端连接的方法。

2. 发明授权

US07381434B2 Methods and compositions of Areca catechu 失效
标题翻译： Areca儿茶素的方法和组成
公开(公告)号：US07381434B2
公开(公告)日：2008-06-03
申请号：US10818439
申请日：2004-04-05
申请人： Robert T. Gow , Brian Pierce , John Pierce , William Birdsall
发明人： Robert T. Gow , Brian Pierce , John Pierce , William Birdsall
IPC分类号： A61K36/88 , A61K36/00 , A61K31/44
CPC分类号： A61K36/889 , A23K20/116 , A23L33/105
摘要： This invention comprises methods and compositions of Areca catechu . Methods of the present invention comprise extracting plant material of Areca catechu so that compositions having characteristics different from those of native plant materials are obtained. Compositions comprising food aids and other dietary supplements are also taught.
摘要翻译：本发明包括Areca儿茶素的方法和组合物。本发明的方法包括提取Areca儿茶素的植物材料，从而获得具有与天然植物材料不同的特征的组合物。还教导了包含食物辅助剂和其他膳食补充剂的组合物。

3. 发明授权

US07037524B2 Oral delivery of a botanical 失效
标题翻译：口服交付植物药
公开(公告)号：US07037524B2
公开(公告)日：2006-05-02
申请号：US10273981
申请日：2002-10-18
申请人： Robert Gow , John Pierce , Brian Pierce , William Birdsall
发明人： Robert Gow , John Pierce , Brian Pierce , William Birdsall
IPC分类号： A61K9/20 , A61K9/26 , A61K35/78
CPC分类号： A61K36/67 , A61K31/365 , A61K31/366 , A61K36/28 , A61K36/48 , A61K45/06 , C07D309/32 , C07D309/38 , C07D309/40 , C07D407/06 , A61K2300/00
摘要： A method of producing a processed kava product involves using an extraction solvent, such as liquid CO2, to preferentially extract different kavalactones from the source material at different rates. By controlling the extraction parameters and stopping the extraction before all of the kavalactones have been extracted or allowing the extracted kavalactones to be preferentially precipitated in one or more collection environments, a processed kava product can be produced that has a kavalactone distribution profile that can differ substantially from that of the source material. As a result, roots from a less desirable kava cultivar can be used to produce a processed kava product which has a kavalactone distribution profile that is similar to that of a highly desired cultivar. The kava paste can be further processed to produce a dry flowable powder suitable for use in, e.g., a tableting formula. A rapid dissolve tablet formulation for use in the delivery of kavalactones and other botanicals is also disclosed.
摘要翻译：一种生产加工过的卡瓦产品的方法包括使用萃取溶剂，例如液体CO 2，以不同的速率从源材料中优先提取不同的kavalactones。通过控制提取参数并在所有的Kavalactone已被提取之前停止提取，或允许提取的kavalactones在一个或多个收集环境中优先沉淀，可以生产具有可以基本上不同的Kavalactone分布分布的加工的卡瓦尔产物从源材料。结果，来自较不理想的卡拉品种的根可以用于生产加工的卡瓦产品，其具有与高度期望的品种相似的考卡内酯分布轮廓。可以进一步处理卡瓦酱以产生适用于例如压片配方的干燥可流动粉末。还公开了用于输送卡维内酯和其它植物药物的快速溶解片剂制剂。

4. 发明授权

US07001620B2 Kavalactone product 失效
标题翻译：卡维拉内产品
公开(公告)号：US07001620B2
公开(公告)日：2006-02-21
申请号：US10408900
申请日：2003-04-08
申请人： Robert Gow , John Pierce , Brian Pierce , William Birdsall
发明人： Robert Gow , John Pierce , Brian Pierce , William Birdsall
IPC分类号： A61K35/78
CPC分类号： C07D407/06 , A61K31/365 , A61K31/366 , A61K36/185 , A61K36/21 , A61K36/258 , A61K36/28 , A61K36/41 , A61K36/46 , A61K36/48 , A61K36/481 , A61K36/67 , A61K36/74 , A61K36/76 , A61K36/888 , A61K36/889 , A61K36/8988 , A61K36/9066 , A61K45/06 , C07D309/32 , C07D309/38 , C07D309/40 , A61K2300/00
摘要： The present invention is a method for enhancing the efficacy of an active ingredient in a human comprising: administering to said human a product comprising: a kavalactone component and an active ingredient, wherein said active ingredient is selected from the group consisting of a therapeutic, a pharmaceutical, a nutraceutical and a botanical, and wherein said kavalactone component comprises a methysticin component, a dihydromethysticin component, a desmethoxyyangonin component, a yangonin component, a dihydrokavain component, and a kavain component, and wherein said kavalactone component is between about 0.1% to about 75%, by mass, of said product.
摘要翻译：本发明是一种增强人体活性成分的功效的方法，包括：向所述人施用包含：维生酮内酯组分和活性成分的产品，其中所述活性成分选自治疗剂，药物，营养保健品和植物药，其中所述的卡维内酯组分包含蛋黄成分，二氢羟孕酮组分，脱甲氧基杨酮组分，阴离子组分，二氢酮素组分和酒精组分，并且其中所述的卡维内酯组分为约0.1％至约75％的所述产品。

5. 发明授权

US5683941A Self-aligned polycide process that utilizes a planarized layer of material to expose polysilicon structures to a subsequently deposited metal layer that is reacted to form the metal silicide 失效
标题翻译：自对准多晶硅方法，其利用平坦化的材料层将多晶硅结构暴露于随后沉积的金属层，其反应形成金属硅化物
公开(公告)号：US5683941A
公开(公告)日：1997-11-04
申请号：US678417
申请日：1996-07-02
申请人： Dah-Bin Kao , John Pierce
发明人： Dah-Bin Kao , John Pierce
IPC分类号： H01L21/28 , H01L21/321 , H01L21/768 , H01L21/8234 , H01L21/8238 , H01L21/44
CPC分类号： H01L21/76889 , H01L21/28052 , H01L21/321 , H01L21/823443 , H01L21/823835
摘要： The process for forming a layer of metal silicide over polysilicon structures, such as gates and interconnect lines, is simplified by forming a layer of insulation material over the polysilicon structures, removing the layer of insulation material until the layer of insulation material is substantially planar and the thickness of the insulation material over the polysilicon structures is within a predetermined thickness range, etching the planarized layer of insulation material until portions of the polysilicon structures are exposed, depositing a layer of metal over the resulting structure, and then reacting the metal layer with the polysilicon structures to form the layer of metal silicide.
摘要翻译：通过在多晶硅结构上形成绝缘材料层，去除绝缘材料层直到绝缘材料层基本上是平面的，简化了在多晶硅结构上形成金属硅化物层（例如栅极和互连线）的工艺，多晶硅结构上的绝缘材料的厚度在预定的厚度范围内，蚀刻绝缘材料的平坦化层，直到多晶硅结构的部分露出，在所得结构上沉积一层金属，然后使金属层与多晶硅结构形成金属硅化物层。

6. 发明授权

US07029707B2 Method of producing a processed kava product having an altered kavalactone distribution and processed kava products produced using the same 失效
标题翻译：制备具有改变的卡维内酯分布的加工的卡瓦产品的方法和使用其制备的加工的卡瓦产品
公开(公告)号：US07029707B2
公开(公告)日：2006-04-18
申请号：US10263579
申请日：2002-10-03
申请人： Robert Gow , John Pierce , Brian Pierce , William Birdsall
发明人： Robert Gow , John Pierce , Brian Pierce , William Birdsall
IPC分类号： A61K35/78
CPC分类号： C07D407/06 , A61K31/365 , A61K31/366 , A61K36/28 , A61K36/48 , A61K36/67 , A61K45/06 , C07D309/32 , C07D309/38 , C07D309/40 , A61K2300/00
摘要： A method of producing a processed kava product involves using an extraction solvent, such as liquid CO2, to preferentially extract different kavalactones from the source material at different rates. By controlling the extraction parameters and stopping the extraction before all of the kavalactones have been extracted or allowing the extracted kavalactones to be preferentially precipitated in one or more collection environments, a processed kava product can be produced that has a kavalactone distribution profile that can differ substantially from that of the source material. As a result, roots from a less desirable kava cultivar can be used to produce a processed kava product which has a kavalactone distribution profile that is similar to that of a highly desired cultivar. The kava paste can be further processed to produce a dry flowable powder suitable for use in, e.g., a tableting formula. A rapid dissolve tablet formulation for use in the delivery of kavalactones is also disclosed.
摘要翻译：一种生产加工过的卡瓦产品的方法包括使用萃取溶剂，例如液体CO 2，以不同的速率从源材料中优先提取不同的kavalactones。通过控制提取参数并在所有的Kavalactone已被提取之前停止提取，或允许提取的kavalactones在一个或多个收集环境中优先沉淀，可以生产具有可以基本上不同的Kavalactone分布分布的加工的卡瓦尔产物从源材料。结果，来自较不理想的卡拉品种的根可以用于生产加工的卡瓦产品，其具有与高度期望的品种相似的考卡内酯分布轮廓。可以进一步处理卡瓦酱以产生适用于例如压片配方的干燥可流动粉末。还公开了一种用于投放kavalactones的快速溶解片剂制剂。

7. 发明申请

US20050118293A1 Methods and compositions comprising Ilex 失效
标题翻译：包含Ilex的方法和组合物
公开(公告)号：US20050118293A1
公开(公告)日：2005-06-02
申请号：US10972986
申请日：2004-10-25
申请人： Robert Gow , George Sypert , John Pierce , Dan Li , Xun Yan , Rodger Marentis
发明人： Robert Gow , George Sypert , John Pierce , Dan Li , Xun Yan , Rodger Marentis
IPC分类号： A23F3/36 , A61K36/00 , A61K36/185 , A61K35/78
CPC分类号： A61K36/185
摘要： The present invention comprises methods for making compositions derived from Ilex species, particularly Ilex paraguariensis, having lowered caffeine and tannin concentrations, compositions made by such methods, oral delivery formulations, and methods of use of such compositions. In particular, the present invention comprises methods for making maté compositions that have a predetermined characeteristic, such as a lowered amount of caffeine, elevated amounts of caffeoyls, and/or lowered amounts of tannin compounds compared to the native maté plant materials. Further, the invention comprises methods of additional processing steps to produce compositions having a predetermined alkaloid ratio or profiles to meet particular considerations for final products. The compositions of the present invention may be processed for specific uses such as tablets or other oral delivery vehicles. These compositions may be used in methods for treatment of physiological and medical conditions.
摘要翻译：本发明包括用于制备衍生自具有降低的咖啡因和单宁浓度的Ilex种，特别是白僵菌的组合物的组合物的方法，通过这些方法制备的组合物，口服递送制剂和使用该组合物的方法。特别地，本发明包括与天然植物材料相比制备具有预定特征的，例如降低量的咖啡因，升高的咖啡因量和/或降低量的单宁化合物的方法。此外，本发明包括另外的加工步骤的方法，以生产具有预定生物碱比例或轮廓的组合物以满足最终产品的特定考虑。本发明的组合物可以用于特定用途，例如片剂或其它口服递送载体。这些组合物可用于治疗生理和医学状况的方法。

8. 发明申请

US20050089584A1 Methods and compositions for oral delivery of Areca and mate' or theobromine 失效
标题翻译：口服阿尔卡和配伍或可可碱的方法和组合物
公开(公告)号：US20050089584A1
公开(公告)日：2005-04-28
申请号：US10945378
申请日：2004-09-20
申请人： Robert Gow , John Pierce , George Sypert
发明人： Robert Gow , John Pierce , George Sypert
IPC分类号： A61K31/366 , A61K31/522 , A61K36/00 , A61K36/185 , A61K36/889 , A61K45/06 , C07D309/32 , C07D309/38 , C07D309/40 , C07D407/06 , A61K35/78
CPC分类号： C07D407/06 , A61K31/366 , A61K36/185 , A61K36/889 , A61K45/06 , C07D309/32 , C07D309/38 , C07D309/40 , Y02A50/473 , A61K2300/00
摘要： The present invention comprises methods and compositions comprising Areca extract compositions and compositions comprising extracts of Ilex paraguariensis or theobromine. Methods of the invention comprise methods of making pharmaceutical or nutriceutical products comprising Areca catechu extract compositions and mate' extract compositions or theobromine, and methods of use of the extracted products and pharmaceutical and nutriceutical products. The present invention also comprises methods for treating conditions related to mental and physical fatigue and obesity, as well as, enhancement of mental focus, cognition, and a sense of well being, comprising administering the compositions of the present invention.
摘要翻译：本发明包括方法和组合物，其包含阿尔卡提取物组合物和包含白藜芦醇或可可碱的提取物的组合物。本发明的方法包括制备包括槟榔芹提取物组合物和伴侣提取物组合物或可可碱的药物或营养产品的方法，以及使用提取产物和药物和营养产品的方法。本发明还包括治疗与精神和身体疲劳和肥胖有关的病症的方法，以及提高精神焦虑，认知和感觉，包括施用本发明的组合物。

9. 发明申请

US20050078874A1 Method and apparatus for encoding and decoding subband decompositions of signals 有权
标题翻译：对信号的子带分解进行编码和解码的方法和装置
公开(公告)号：US20050078874A1
公开(公告)日：2005-04-14
申请号：US10924322
申请日：2004-08-23
申请人： Robert Buccigrossi , Bao Lerner , John Pierce
发明人： Robert Buccigrossi , Bao Lerner , John Pierce
IPC分类号： G06K9/36 , G06K9/46 , H04N7/26
CPC分类号： H04N19/63 , H04N19/647
摘要： An aspect of the present invention includes a method of encoding coefficients of a subband decomposition, to prepare the coefficients for compression. Another aspect of the present invention includes an inverse method of decoding coefficients of a subband decomposition, after they have been decompressed. Particular features and other aspects of the present invention are indicated in the specification, including the drawings and claims.
摘要翻译：本发明的一个方面包括对子带分解的系数进行编码的方法，以准备用于压缩的系数。本发明的另一方面包括在解压缩之后对子带分解的系数进行解码的逆方法。在本说明书中指出了本发明的特征和其它方面，包括附图和权利要求。

10. 发明授权

US07294353B2 Methods and compositions comprising ilex 失效
标题翻译：包含ilex的方法和组合物
公开(公告)号：US07294353B2
公开(公告)日：2007-11-13
申请号：US10970017
申请日：2004-10-21
申请人： Robert T. Gow , George W. Sypert , John Pierce , Dan Li , Xun Yan , Rodger M. Marentis
发明人： Robert T. Gow , George W. Sypert , John Pierce , Dan Li , Xun Yan , Rodger M. Marentis
IPC分类号： A61K36/00
CPC分类号： A61K36/185
摘要： The present invention comprises methods for making compositions derived from Ilex species, particularly Ilex paraguariensis, having lowered caffeine and tannin concentrations, compositions made by such methods, oral delivery formulations, and methods of use of such compositions. In particular, the present invention comprises methods for making maté compositions that have a predetermined characeteristic, such as a lowered amount of caffeine, elevated amounts of caffeoyls, and/or lowered amounts of tannin compounds compared to the native maté plant materials. Further, the invention comprises methods of additional processing steps tp produce compositions having a predetermined alkaloid ratio or profiles to meet particular considerations for final products. The compositions of the present invention may be processed for specific uses such as tablets or other oral delivery vehicles. These compositions may be used in methods for treatment of physiological and medical conditions.
摘要翻译：本发明包括用于制备衍生自具有降低的咖啡因和单宁浓度的Ilex种，特别是白僵菌的组合物的组合物的方法，通过这些方法制备的组合物，口服递送制剂和使用该组合物的方法。特别地，本发明包括与天然植物材料相比制备具有预定特征的，例如降低量的咖啡因，升高的咖啡因量和/或降低量的单宁化合物的方法。此外，本发明包括附加处理步骤的方法，tp产生具有预定生物碱比例或分布的组合物以满足最终产品的特定考虑。本发明的组合物可以用于特定用途，例如片剂或其它口服递送载体。这些组合物可用于治疗生理和医学状况的方法。

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