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1. 发明申请

US20050118293A1 Methods and compositions comprising Ilex 失效
标题翻译：包含Ilex的方法和组合物
公开(公告)号：US20050118293A1
公开(公告)日：2005-06-02
申请号：US10972986
申请日：2004-10-25
申请人： Robert Gow , George Sypert , John Pierce , Dan Li , Xun Yan , Rodger Marentis
发明人： Robert Gow , George Sypert , John Pierce , Dan Li , Xun Yan , Rodger Marentis
IPC分类号： A23F3/36 , A61K36/00 , A61K36/185 , A61K35/78
CPC分类号： A61K36/185
摘要： The present invention comprises methods for making compositions derived from Ilex species, particularly Ilex paraguariensis, having lowered caffeine and tannin concentrations, compositions made by such methods, oral delivery formulations, and methods of use of such compositions. In particular, the present invention comprises methods for making maté compositions that have a predetermined characeteristic, such as a lowered amount of caffeine, elevated amounts of caffeoyls, and/or lowered amounts of tannin compounds compared to the native maté plant materials. Further, the invention comprises methods of additional processing steps to produce compositions having a predetermined alkaloid ratio or profiles to meet particular considerations for final products. The compositions of the present invention may be processed for specific uses such as tablets or other oral delivery vehicles. These compositions may be used in methods for treatment of physiological and medical conditions.
摘要翻译：本发明包括用于制备衍生自具有降低的咖啡因和单宁浓度的Ilex种，特别是白僵菌的组合物的组合物的方法，通过这些方法制备的组合物，口服递送制剂和使用该组合物的方法。特别地，本发明包括与天然植物材料相比制备具有预定特征的，例如降低量的咖啡因，升高的咖啡因量和/或降低量的单宁化合物的方法。此外，本发明包括另外的加工步骤的方法，以生产具有预定生物碱比例或轮廓的组合物以满足最终产品的特定考虑。本发明的组合物可以用于特定用途，例如片剂或其它口服递送载体。这些组合物可用于治疗生理和医学状况的方法。

2. 发明申请

US20050089591A1 Methods and compositions comprising Ilex 失效
标题翻译：包含Ilex的方法和组合物
公开(公告)号：US20050089591A1
公开(公告)日：2005-04-28
申请号：US10970017
申请日：2004-10-21
申请人： Robert Gow , George Sypert , John Pierce , Dan Li , Xun Yan , Rodger Marentis
发明人： Robert Gow , George Sypert , John Pierce , Dan Li , Xun Yan , Rodger Marentis
IPC分类号： A23F3/00 , A61K31/522 , A61K36/00 , A61K36/185 , A61K35/78
CPC分类号： A61K36/185
摘要： The present invention comprises methods for making compositions derived from Ilex species, particularly Ilex paraguariensis, having lowered caffeine and tannin concentrations, compositions made by such methods, oral delivery formulations, and methods of use of such compositions. In particular, the present invention comprises methods for making maté compositions that have a predetermined characeteristic, such as a lowered amount of caffeine, elevated amounts of caffeoyls, and/or lowered amounts of tannin compounds compared to the native maté plant materials. Further, the invention comprises methods of additional processing steps tp produce compositions having a predetermined alkaloid ratio or profiles to meet particular considerations for final products. The compositions of the present invention may be processed for specific uses such as tablets or other oral delivery vehicles. These compositions may be used in methods for treatment of physiological and medical conditions.
摘要翻译：本发明包括用于制备衍生自具有降低的咖啡因和单宁浓度的Ilex种，特别是白僵菌的组合物的组合物的方法，通过这些方法制备的组合物，口服递送制剂和使用该组合物的方法。特别地，本发明包括与天然植物材料相比制备具有预定特征的，例如降低量的咖啡因，升高的咖啡因量和/或降低量的单宁化合物的方法。此外，本发明包括附加处理步骤的方法，tp产生具有预定生物碱比例或分布的组合物以满足最终产品的特定考虑。本发明的组合物可以用于特定用途，例如片剂或其它口服递送载体。这些组合物可用于治疗生理和医学状况的方法。

3. 发明申请

US20050089584A1 Methods and compositions for oral delivery of Areca and mate' or theobromine 失效
标题翻译：口服阿尔卡和配伍或可可碱的方法和组合物
公开(公告)号：US20050089584A1
公开(公告)日：2005-04-28
申请号：US10945378
申请日：2004-09-20
申请人： Robert Gow , John Pierce , George Sypert
发明人： Robert Gow , John Pierce , George Sypert
IPC分类号： A61K31/366 , A61K31/522 , A61K36/00 , A61K36/185 , A61K36/889 , A61K45/06 , C07D309/32 , C07D309/38 , C07D309/40 , C07D407/06 , A61K35/78
CPC分类号： C07D407/06 , A61K31/366 , A61K36/185 , A61K36/889 , A61K45/06 , C07D309/32 , C07D309/38 , C07D309/40 , Y02A50/473 , A61K2300/00
摘要： The present invention comprises methods and compositions comprising Areca extract compositions and compositions comprising extracts of Ilex paraguariensis or theobromine. Methods of the invention comprise methods of making pharmaceutical or nutriceutical products comprising Areca catechu extract compositions and mate' extract compositions or theobromine, and methods of use of the extracted products and pharmaceutical and nutriceutical products. The present invention also comprises methods for treating conditions related to mental and physical fatigue and obesity, as well as, enhancement of mental focus, cognition, and a sense of well being, comprising administering the compositions of the present invention.
摘要翻译：本发明包括方法和组合物，其包含阿尔卡提取物组合物和包含白藜芦醇或可可碱的提取物的组合物。本发明的方法包括制备包括槟榔芹提取物组合物和伴侣提取物组合物或可可碱的药物或营养产品的方法，以及使用提取产物和药物和营养产品的方法。本发明还包括治疗与精神和身体疲劳和肥胖有关的病症的方法，以及提高精神焦虑，认知和感觉，包括施用本发明的组合物。

4. 发明申请

US20050037025A1 Methods and compositions comprising kava and mate' or theobromine 审中-公开
标题翻译：包含卡瓦和伴侣或可可碱的方法和组合物
公开(公告)号：US20050037025A1
公开(公告)日：2005-02-17
申请号：US10945108
申请日：2004-09-20
申请人： Robert Gow , John Pierce , George Sypert
发明人： Robert Gow , John Pierce , George Sypert
IPC分类号： A61K31/366 , A61K36/185 , A61K36/67 , A61K45/06 , A61K35/78
CPC分类号： A61K45/06 , A61K31/366 , A61K36/185 , A61K36/67 , A61K2300/00
摘要： The present invention comprises compositions comprising combinations of compositions of extracts of kava mate' extract compositions or theobromine. The invention further comprises methods for treating conditions related to mental and physical fatigue, anxiety, muscle tension, nervous depression, headache, obesity, and mild pain as well a enhancement of cognition and mental focus comprising administering effective amounts of the compositions of the present invention.
摘要翻译：本发明包括包含卡马姆提取物组合物或可可碱提取物的组合物的组合的组合物。本发明还包括用于治疗与精神和身体疲劳，焦虑，肌肉紧张，神经抑郁，头痛，肥胖和轻度疼痛相关的病症的方法，以及增强认知和精神焦虑，包括施用有效量的本发明组合物。

5. 发明申请

US20050069596A1 Compositions and methods comprising kava and anti-anxiety compounds 审中-公开
标题翻译：包含卡瓦和抗焦虑化合物的组合物和方法
公开(公告)号：US20050069596A1
公开(公告)日：2005-03-31
申请号：US10945106
申请日：2004-09-20
申请人： Robert Gow , John Pierce , George Sypert
发明人： Robert Gow , John Pierce , George Sypert
IPC分类号： A61K31/366 , A61K36/67 , A61K45/06 , C07D309/32 , C07D309/38 , C07D309/40 , C07D407/06 , A61K35/78
CPC分类号： C07D407/06 , A61K31/366 , A61K36/67 , A61K45/06 , C07D309/32 , C07D309/38 , C07D309/40 , A61K2300/00
摘要： The present invention comprises compositions comprising combinations of kava extract compositions in combination with one or more anxiolytics and methods for treating conditions related to the various anxiety disorders comprising administering the compositions of the present invention. The invention further provides methods for enhancing the therapeutic activity of an anxiolytic comprising administering the anxiolyitc in combination with extract of Piper methysticin.
摘要翻译：本发明包括包含与一种或多种抗焦虑药组合的卡拉提取物组合物和用于治疗与各种焦虑症有关的病症的方法的组合的组合物，包括施用本发明的组合物。本发明还提供了用于增强抗焦虑药治疗活性的方法，其包括将焦虑药与哌啶甲硫氨酸的提取物组合施用。

6. 发明申请

US20050053678A1 Methods and compositions for betel nut chewing gum 审中-公开
标题翻译：槟榔口香糖的方法和成分
公开(公告)号：US20050053678A1
公开(公告)日：2005-03-10
申请号：US10945109
申请日：2004-09-20
申请人： Robert Gow , John Pierce , George Sypert
发明人： Robert Gow , John Pierce , George Sypert
IPC分类号： A61K31/366 , A61K36/67 , A61K36/889 , A61K45/06 , C07D309/32 , C07D309/38 , C07D309/40 , C07D407/06 , A61K35/78 , A61K9/68
CPC分类号： C07D407/06 , A61K31/366 , A61K36/67 , A61K36/889 , A61K45/06 , C07D309/32 , C07D309/38 , C07D309/40 , A61K2300/00
摘要： The present invention relates to methods and compositions comprising Areca catechu extracts and Piper betel extracts. Compositions comprise Areca catechu extracts that comprise alkaloid compounds in ratios that are different from the ratios found in native Areca plant material. Methods of the present invention comprise extractions of Areca catechu and Piper betel, making the compositions comprising Areca catechu and Piper betel and methods of providing compositions that mimic the effects in humans of chewing betel quid and have reduced carcinogenicity.
摘要翻译：本发明涉及包括青蒿素提取物和per el提取物的方法和组合物。组合物包括含有不同于天然植物材料中比例的比例的生物碱化合物的Areca儿茶素提取物。本发明的方法包括提取槟榔芹和琵琶槟榔，使得组合物包括槟榔槟榔和琵琶槟榔，以及提供模仿人类对咀嚼槟榔碱的作用并具有降低的致癌性的组合物的方法。

7. 发明授权

US07294353B2 Methods and compositions comprising ilex 失效
标题翻译：包含ilex的方法和组合物
公开(公告)号：US07294353B2
公开(公告)日：2007-11-13
申请号：US10970017
申请日：2004-10-21
申请人： Robert T. Gow , George W. Sypert , John Pierce , Dan Li , Xun Yan , Rodger M. Marentis
发明人： Robert T. Gow , George W. Sypert , John Pierce , Dan Li , Xun Yan , Rodger M. Marentis
IPC分类号： A61K36/00
CPC分类号： A61K36/185
摘要： The present invention comprises methods for making compositions derived from Ilex species, particularly Ilex paraguariensis, having lowered caffeine and tannin concentrations, compositions made by such methods, oral delivery formulations, and methods of use of such compositions. In particular, the present invention comprises methods for making maté compositions that have a predetermined characeteristic, such as a lowered amount of caffeine, elevated amounts of caffeoyls, and/or lowered amounts of tannin compounds compared to the native maté plant materials. Further, the invention comprises methods of additional processing steps tp produce compositions having a predetermined alkaloid ratio or profiles to meet particular considerations for final products. The compositions of the present invention may be processed for specific uses such as tablets or other oral delivery vehicles. These compositions may be used in methods for treatment of physiological and medical conditions.
摘要翻译：本发明包括用于制备衍生自具有降低的咖啡因和单宁浓度的Ilex种，特别是白僵菌的组合物的组合物的方法，通过这些方法制备的组合物，口服递送制剂和使用该组合物的方法。特别地，本发明包括与天然植物材料相比制备具有预定特征的，例如降低量的咖啡因，升高的咖啡因量和/或降低量的单宁化合物的方法。此外，本发明包括附加处理步骤的方法，tp产生具有预定生物碱比例或分布的组合物以满足最终产品的特定考虑。本发明的组合物可以用于特定用途，例如片剂或其它口服递送载体。这些组合物可用于治疗生理和医学状况的方法。

8. 发明授权

US07279184B2 Methods and compositions comprising Ilex 失效
标题翻译：包含Ilex的方法和组合物
公开(公告)号：US07279184B2
公开(公告)日：2007-10-09
申请号：US10972986
申请日：2004-10-25
申请人： Robert T. Gow , George W. Sypert , John Pierce , Dan Li , Xun Yan , Rodger M. Marentis
发明人： Robert T. Gow , George W. Sypert , John Pierce , Dan Li , Xun Yan , Rodger M. Marentis
IPC分类号： A61K36/00
CPC分类号： A61K36/185
摘要： The present invention comprises methods for making compositions derived from Ilex species, particularly Ilex paraguariensis, having lowered caffeine and tannin concentrations, compositions made by such methods, oral delivery formulations, and methods of use of such compositions. In particular, the present invention comprises methods for making maté compositions that have a predetermined characeteristic, such as a lowered amount of caffeine, elevated amounts of caffeoyls, and/or lowered amounts of tannin compounds compared to the native maté plant materials. Further, the invention comprises methods of additional processing steps to produce compositions having a predetermined alkaloid ratio or profiles to meet particular considerations for final products. The compositions of the present invention may be processed for specific uses such as tablets or other oral delivery vehicles. These compositions may be used in methods for treatment of physiological and medical conditions.
摘要翻译：本发明包括用于制备衍生自具有降低的咖啡因和单宁浓度的Ilex种，特别是白僵菌的组合物的组合物的方法，通过这些方法制备的组合物，口服递送制剂和使用该组合物的方法。特别地，本发明包括与天然植物材料相比制备具有预定特征的，例如降低量的咖啡因，升高的咖啡因量和/或降低量的单宁化合物的方法。此外，本发明包括另外的加工步骤的方法，以生产具有预定生物碱比例或轮廓的组合物以满足最终产品的特定考虑。本发明的组合物可以用于特定用途，例如片剂或其它口服递送载体。这些组合物可用于治疗生理和医学状况的方法。

9. 发明授权

US07037524B2 Oral delivery of a botanical 失效
标题翻译：口服交付植物药
公开(公告)号：US07037524B2
公开(公告)日：2006-05-02
申请号：US10273981
申请日：2002-10-18
申请人： Robert Gow , John Pierce , Brian Pierce , William Birdsall
发明人： Robert Gow , John Pierce , Brian Pierce , William Birdsall
IPC分类号： A61K9/20 , A61K9/26 , A61K35/78
CPC分类号： A61K36/67 , A61K31/365 , A61K31/366 , A61K36/28 , A61K36/48 , A61K45/06 , C07D309/32 , C07D309/38 , C07D309/40 , C07D407/06 , A61K2300/00
摘要： A method of producing a processed kava product involves using an extraction solvent, such as liquid CO2, to preferentially extract different kavalactones from the source material at different rates. By controlling the extraction parameters and stopping the extraction before all of the kavalactones have been extracted or allowing the extracted kavalactones to be preferentially precipitated in one or more collection environments, a processed kava product can be produced that has a kavalactone distribution profile that can differ substantially from that of the source material. As a result, roots from a less desirable kava cultivar can be used to produce a processed kava product which has a kavalactone distribution profile that is similar to that of a highly desired cultivar. The kava paste can be further processed to produce a dry flowable powder suitable for use in, e.g., a tableting formula. A rapid dissolve tablet formulation for use in the delivery of kavalactones and other botanicals is also disclosed.
摘要翻译：一种生产加工过的卡瓦产品的方法包括使用萃取溶剂，例如液体CO 2，以不同的速率从源材料中优先提取不同的kavalactones。通过控制提取参数并在所有的Kavalactone已被提取之前停止提取，或允许提取的kavalactones在一个或多个收集环境中优先沉淀，可以生产具有可以基本上不同的Kavalactone分布分布的加工的卡瓦尔产物从源材料。结果，来自较不理想的卡拉品种的根可以用于生产加工的卡瓦产品，其具有与高度期望的品种相似的考卡内酯分布轮廓。可以进一步处理卡瓦酱以产生适用于例如压片配方的干燥可流动粉末。还公开了用于输送卡维内酯和其它植物药物的快速溶解片剂制剂。

10. 发明授权

US07001620B2 Kavalactone product 失效
标题翻译：卡维拉内产品
公开(公告)号：US07001620B2
公开(公告)日：2006-02-21
申请号：US10408900
申请日：2003-04-08
申请人： Robert Gow , John Pierce , Brian Pierce , William Birdsall
发明人： Robert Gow , John Pierce , Brian Pierce , William Birdsall
IPC分类号： A61K35/78
CPC分类号： C07D407/06 , A61K31/365 , A61K31/366 , A61K36/185 , A61K36/21 , A61K36/258 , A61K36/28 , A61K36/41 , A61K36/46 , A61K36/48 , A61K36/481 , A61K36/67 , A61K36/74 , A61K36/76 , A61K36/888 , A61K36/889 , A61K36/8988 , A61K36/9066 , A61K45/06 , C07D309/32 , C07D309/38 , C07D309/40 , A61K2300/00
摘要： The present invention is a method for enhancing the efficacy of an active ingredient in a human comprising: administering to said human a product comprising: a kavalactone component and an active ingredient, wherein said active ingredient is selected from the group consisting of a therapeutic, a pharmaceutical, a nutraceutical and a botanical, and wherein said kavalactone component comprises a methysticin component, a dihydromethysticin component, a desmethoxyyangonin component, a yangonin component, a dihydrokavain component, and a kavain component, and wherein said kavalactone component is between about 0.1% to about 75%, by mass, of said product.
摘要翻译：本发明是一种增强人体活性成分的功效的方法，包括：向所述人施用包含：维生酮内酯组分和活性成分的产品，其中所述活性成分选自治疗剂，药物，营养保健品和植物药，其中所述的卡维内酯组分包含蛋黄成分，二氢羟孕酮组分，脱甲氧基杨酮组分，阴离子组分，二氢酮素组分和酒精组分，并且其中所述的卡维内酯组分为约0.1％至约75％的所述产品。

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