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1. 发明授权

US06416974B1 Tango 71 nucleic acids 失效
标题翻译：探戈71核酸
公开(公告)号：US06416974B1
公开(公告)日：2002-07-09
申请号：US09130491
申请日：1998-08-06
申请人： Douglas A. Holtzman , Andrew D. J. Goodearl
发明人： Douglas A. Holtzman , Andrew D. J. Goodearl
IPC分类号： C12P2106
CPC分类号： C12N9/6489 , A01K2217/05 , A61K38/00 , C07K14/47 , C07K14/70578 , C07K2319/00
摘要： The invention relates to Tango-71, Tango-73, Tango-74, Tango-76, and Tango-83 polypeptides, nucleic acid molecules encoding Tango-71, Tango-73, Tango-74, Tango-76, and Tango-83, and uses thereof.
摘要翻译：本发明涉及Tango-71，Tango-73，Tango-74，Tango-76和Tango-83多肽，编码Tango-71，Tango-73，Tango-74，Tango-76和Tango-83的核酸分子，及其用途。

2. 发明申请

US20100291579A1 Novel genes encoding proteins having prognostic, diagnostic, preventive, therapeutic, and other uses 审中-公开
标题翻译：编码具有预后，诊断，预防，治疗和其他用途的蛋白质的新基因
公开(公告)号：US20100291579A1
公开(公告)日：2010-11-18
申请号：US12803671
申请日：2010-07-01
申请人： Christopher C. Fraser , Sean Anthony McCarthy , John D. Sharp , Thomas M. Barnes , Nicholas C. Wrighton , Charles R. Mackay , Kevin R. Leiby , Douglas A. Holtzman
发明人： Christopher C. Fraser , Sean Anthony McCarthy , John D. Sharp , Thomas M. Barnes , Nicholas C. Wrighton , Charles R. Mackay , Kevin R. Leiby , Douglas A. Holtzman
IPC分类号： C12Q1/68 , G01N33/53 , C12P21/06 , C12N5/10 , C12N5/02 , C12N15/63 , C07K14/435 , C07K16/18 , C07K1/00 , C07H21/04
CPC分类号： C07K16/18
摘要： The invention provides isolated nucleic acid molecules and polypeptide molecules. The invention also provides antisense nucleic acid molecules, expression vectors containing the nucleic acid molecules of the invention, host cells into which the expression vectors have been introduced, and non-human transgenic animals in which a nucleic acid molecule of the invention has been introduced or disrupted. The invention still further provides isolated polypeptides, fusion polypeptides, antigenic peptides and antibodies. Diagnostic, screening and therapeutic methods utilizing compositions of the invention are also provided.
摘要翻译：本发明提供分离的核酸分子和多肽分子。本发明还提供反义核酸分子，含有本发明的核酸分子的表达载体，已经引入了表达载体的宿主细胞和其中引入了本发明的核酸分子的非人转基因动物，或中断了本发明还进一步提供分离的多肽，融合多肽，抗原肽和抗体。还提供利用本发明组合物的诊断，筛选和治疗方法。

3. 发明申请

US20090286956A1 DELTA3, FTHMA-070, TANGO85, TANGO77, SPOIL, NEOKINE, TANGO129, and INTEGRIN ALPHA SUBUNIT Protein and nucleic acid molecules and uses thereof 有权
标题翻译： DELTA3，FTHMA-070，TANGO85，TANGO77，SPOIL，NEOKINE，TANGO129和INTEGRIN ALPHA SUBUNIT蛋白质和核酸分子及其用途
公开(公告)号：US20090286956A1
公开(公告)日：2009-11-19
申请号：US11974478
申请日：2007-10-12
申请人： Sean A. McCarthy , David P. Gearing , Douglas A. Holtzman , Yang Pan , Samantha J. Busfield , Thomas M. Barnes , Charles R. Mackay , Jose M. Lora
发明人： Sean A. McCarthy , David P. Gearing , Douglas A. Holtzman , Yang Pan , Samantha J. Busfield , Thomas M. Barnes , Charles R. Mackay , Jose M. Lora
IPC分类号： C07K14/705
CPC分类号： C12Q1/48 , A61K38/00 , C07K14/47 , C07K2319/00 , C12Q1/6876
摘要： The invention provides novel Delta3, FTHMA-070, Tango85, Tango77, SPOIL, NEOKINE, Tango129 and A259 polypeptides, proteins, and nucleic acid molecules. In addition to isolated, full-length Delta3, FTHMA-070, Tango85, Tango77, SPOIL, NEOKINE, Tango129 and A259 proteins, the invention further provides isolated Delta3, FTHMA-070, Tango85, Tango77, SPOIL, NEOKINE, Tango129 and A259 fusion proteins, antigenic peptides and anti-Delta3, FTHMA-070, Tango85, Tango77, SPOIL, NEOKINE, Tango129 and A259 antibodies. The invention also provides Delta3, FTHMA-070, Tango85, Tango77, SPOIL, NEOKINE, Tango129 and A259 nucleic acid molecules, recombinant expression vectors containing a nucleic acid molecule of the invention, host cells into which the expression vectors have been introduced and non-human transgenic animals in which a Delta3, FTHMA-070, Tango85, Tango77, SPOIL, NEOKINE, Tango129 or A259 gene has been introduced or disrupted. Diagnostic, screening and therapeutic methods utilizing compositions of the invention are also provided.
摘要翻译：本发明提供新颖的Delta3，FTHMA-070，Tango85，Tango77，SPOIL，NEOKINE，Tango129和A259多肽，蛋白质和核酸分子。除了分离的全长Delta3，FTHMA-070，Tango85，Tango77，SPOIL，NEOKINE，Tango129和A259蛋白外，本发明还提供了分离的Delta3，FTHMA-070，Tango85，Tango77，SPOIL，NEOKINE，Tango129和A259融合蛋白质，抗原肽和抗Delta3，FTHMA-070，Tango85，Tango77，SPOIL，NEOKINE，Tango129和A259抗体。本发明还提供了Delta3，FTHMA-070，Tango85，Tango77，SPOIL，NEOKINE，Tango129和A259核酸分子，含有本发明的核酸分子的重组表达载体，已经引入表达载体的宿主细胞，已经引入或破坏了Delta3，FTHMA-070，Tango85，Tango77，SPOIL，NEOKINE，Tango129或A259基因的人类转基因动物。还提供利用本发明组合物的诊断，筛选和治疗方法。

4. 发明授权

US5969123A Nucleic acid molecules derived from a brain tissue library 失效
标题翻译：衍生自脑组织库的核酸分子
公开(公告)号：US5969123A
公开(公告)日：1999-10-19
申请号：US36089
申请日：1998-03-06
申请人： Douglas A. Holtzman
发明人： Douglas A. Holtzman
IPC分类号： C07K14/47 , C07H21/02 , C07H21/04
CPC分类号： C07K14/47
摘要： The invention provides nucleic acid molecules derived from a brain tissue library. The nucleic acid molecules are used in applications such as diagnostic methods, screening assays and as hybridization probes and primers.
摘要翻译：本发明提供衍生自脑组织文库的核酸分子。核酸分子用于诊断方法，筛选试验和杂交探针和引物等应用中。

5. 发明授权

US08076086B2 Methods of modulating the activity of TANGO332 失效
标题翻译：调节TANGO332活性的方法
公开(公告)号：US08076086B2
公开(公告)日：2011-12-13
申请号：US11499835
申请日：2006-08-04
申请人： Susan J. Kirst , Douglas A. Holtzman , Christopher C. Fraser , John D. Sharp , Thomas S. Barnes
发明人： Susan J. Kirst , Douglas A. Holtzman , Christopher C. Fraser , John D. Sharp , Thomas S. Barnes
IPC分类号： G01N33/53 , A61K38/00 , C07K17/00
CPC分类号： C07K16/18 , A01K2217/05 , A61K38/00 , C07K14/47 , C07K16/28 , G01N33/5058
摘要： The invention provides isolated nucleic acids encoding a variety of proteins and nucleic acids having diagnostic, preventive, therapeutic, and other uses. These nucleic acids and proteins are useful for diagnosis, prevention, and therapy of a number of human and other animal disorders. The invention also provides antisense nucleic acid molecules, expression vectors containing the nucleic acid molecules of the invention, host cells into which the expression vectors have been introduced, and non-human transgenic animals in which a nucleic acid molecule of the invention has been introduced or disrupted. The invention still further provides isolated polypeptides, fusion polypeptides, antigenic peptides and antibodies. Diagnostic, screening, and therapeutic methods utilizing compositions of the invention are also provided. The nucleic acids and polypeptides of the present invention are useful as modulating agents in regulating a variety of cellular processes.
摘要翻译：本发明提供编码具有诊断，预防，治疗和其它用途的各种蛋白质和核酸的分离的核酸。这些核酸和蛋白质可用于诊断，预防和治疗许多人类和其他动物疾病。本发明还提供反义核酸分子，含有本发明的核酸分子的表达载体，已经引入了表达载体的宿主细胞和其中引入了本发明的核酸分子的非人转基因动物，或中断了本发明还进一步提供分离的多肽，融合多肽，抗原肽和抗体。还提供了利用本发明组合物的诊断，筛选和治疗方法。本发明的核酸和多肽可用作调节各种细胞过程的调节剂。

6. 发明申请

US20080293077A1 Novel genes encoding proteins having prognostic, diagnostic, preventive, therapeutic and other uses 审中-公开
标题翻译：编码具有预后，诊断，预防，治疗和其他用途的蛋白质的新型基因
公开(公告)号：US20080293077A1
公开(公告)日：2008-11-27
申请号：US12214717
申请日：2008-06-20
申请人： Douglas A. Holtzman , David P. Gearing , Yang Pan
发明人： Douglas A. Holtzman , David P. Gearing , Yang Pan
IPC分类号： G01N33/53 , C12N15/11 , C12N15/00 , C12N5/06 , C07K14/00 , C07K16/18 , C12P21/04 , G01N33/566 , G01N33/00
CPC分类号： C07K14/47 , A61K38/00 , C07K14/475 , C07K14/52 , C07K14/705 , C12N2799/027 , Y02A50/411 , Y10T436/143333
摘要： The invention relates to the discovery and characterization of several genes and the polypeptides they encode: thymotaxin (Tango-45), Tango-63d, Tango-63e, Tango-67, and huchordin (Tango-66). Thymotaxin is a new member of the C-C family of chemokines. Tango-63d and Tango-63e are two novel polypeptides within the tumor necrosis factor (TNF) receptor superfamily. Tango-67 is related to a number of growth factors, particularly members of the connective tissue growth factor family. Huchordin is related to chordin, a known protein that is involved in the induction of twinned axes, can completely rescue axial development in ventralized embryos, is a potent dorsalizing factor, and plays a crucial role in regulating cell-cell interactions in the organizing centers of head, trunk, and tail development. The invention encompasses nucleic acid molecules encoding nucleic acids and polypeptides of the invention, or mutant forms thereof that encode dysfunctional receptor polypeptides, vectors containing these nucleic acid molecules, cells harboring recombinant DNA molecules encoding nucleic acids or polypeptides of the invention, or mutant forms thereof, host fusion proteins that include functional or dysfunctional polypeptides of the invention, transgenic animals that express nucleic acids or polypeptides of the invention, screening methods and therapeutic methods employing the nucleic acid molecules and polypeptides described above, substantially purified nucleic acids and polypeptides of the invention, and therapeutic compositions containing these nucleic acid molecules and polypeptides.
摘要翻译：本发明涉及几种基因及其编码的多肽的发现和表征：胸腺素（Tango-45），Tango-63d，Tango-63e，Tango-67和huchordin（Tango-66）。胸腺激素是C-C家族趋化因子的新成员。 Tango-63d和Tango-63e是肿瘤坏死因子（TNF）受体超家族中的两种新型多肽。探戈67与一些生长因子有关，特别是结缔组织生长因子家族成员。 Huchordin与参与诱导孪生轴的已知蛋白质有关，可以完全消除腹侧胚胎的轴向发育，是一种强有力的背景因子，在调节组织中心的细胞 - 细胞相互作用中起关键作用头，躯干和尾巴发展。本发明包括编码本发明的核酸和多肽的核酸分子，或其编码功能障碍受体多肽的突变形式，含有这些核酸分子的载体，携带编码本发明的核酸或多肽的重组DNA分子的细胞，或其突变形式，包括本发明的功能性或功能失调多肽的宿主融合蛋白，表达本发明的核酸或多肽的转基因动物，使用上述核酸分子和多肽的筛选方法和治疗方法，本发明的基本纯化的核酸和多肽以及含有这些核酸分子和多肽的治疗组合物。

7. 发明申请

US20110065124A1 Novel genes encoding proteins having prognostic, diagnostic, preventive, therapeutic, and other uses 有权
标题翻译：编码具有预后，诊断，预防，治疗和其他用途的蛋白质的新基因
公开(公告)号：US20110065124A1
公开(公告)日：2011-03-17
申请号：US12800681
申请日：2010-05-20
申请人： Douglas A. Holtzman , John D. Sharp , Kevin R. Leiby , Steven Bossone , Yang Pan , Thomas M. Barnes , Christopher C. Fraser , Nicholas Wrighton , Paul S. Myers , Gillian Kingsbury
发明人： Douglas A. Holtzman , John D. Sharp , Kevin R. Leiby , Steven Bossone , Yang Pan , Thomas M. Barnes , Christopher C. Fraser , Nicholas Wrighton , Paul S. Myers , Gillian Kingsbury
IPC分类号： G01N33/53 , C12N15/12 , C12N5/07 , C07K14/435 , C07K16/18 , C12P21/00 , G01N33/68 , G01N33/00
CPC分类号： C07K14/7151 , A01K2217/05 , A61K38/00 , C07K14/47 , C07K14/705 , C07K14/78 , C07K2319/00 , Y10T436/143333
摘要： The invention provides isolated TANGO 239, TANGO 219, TANGO 232, TANGO 281, A236 (INTERCEPT 236), TANGO 300, TANGO 353, TANGO 393, TANGO 402, TANGO 351 and TANGO 509 nucleic acid molecules and polypeptide molecules. The invention also provides antisense nucleic acid molecules, expression vectors containing the nucleic acid molecules of the invention, host cells into which the expression vectors have been introduced, and non-human transgenic animals in which a nucleic acid molecule of the invention has been introduced or disrupted. The invention still further provides isolated polypeptides, fusion polypeptides, antigenic peptides and antibodies. Diagnostic, screening and therapeutic methods utilizing compositions of the invention are also provided.
摘要翻译：本发明提供了分离的TANGO 239，TANGO 219，TANGO 232，TANGO 281，A236（INTERCEPT 236），TANGO 300，TANGO 353，TANGO 393，TANGO 402，TANGO 351和TANGO 509核酸分子和多肽分子。本发明还提供反义核酸分子，含有本发明的核酸分子的表达载体，已经引入了表达载体的宿主细胞和其中引入了本发明的核酸分子的非人转基因动物，或中断了本发明还进一步提供分离的多肽，融合多肽，抗原肽和抗体。还提供利用本发明组合物的诊断，筛选和治疗方法。

8. 发明申请

US20110020798A1 Novel italy, LOR-2, strife, trash, BDSF, LRSG, and STMST protein and nucleic acid molecules and uses therefor 审中-公开
标题翻译：新意大利，LOR-2，冲突，垃圾，BDSF，LRSG和STMST蛋白质和核酸分子及其用途
公开(公告)号：US20110020798A1
公开(公告)日：2011-01-27
申请号：US12653955
申请日：2009-12-18
申请人： Douglas A. Holtzman , Sean A. McCarthy , Kyle J. MacBeth , Samantha J. Busfield , Yang Pan , David White , Mehran M. Khodadoust , Wei Gu
发明人： Douglas A. Holtzman , Sean A. McCarthy , Kyle J. MacBeth , Samantha J. Busfield , Yang Pan , David White , Mehran M. Khodadoust , Wei Gu
IPC分类号： C12Q1/68 , G01N33/566 , C12N5/10 , C12P21/02 , C07K16/18 , C07H21/00 , C07K14/47 , C12N15/63
CPC分类号： C12N9/0022 , A01K2217/05 , A61K38/00 , C07K14/47 , C07K14/4702 , C07K14/525 , C07K14/705 , C07K14/70575 , C07K14/70578 , C07K14/723 , C07K2319/00 , Y02A50/411
摘要： Novel ITALY, LOR-2, STRIFE, TRASH, BDSF, LRSG, and STMST polypeptides, proteins, and nucleic acid molecules are disclosed. In addition to isolated, full-length ITALY, LOR-2, STRIFE, TRASH, BDSF, LRSG, and STMST proteins, the invention further provides isolated ITALY, LOR-2, STRIFE, TRASH, BDSF, LRSG, and STMST fusion proteins, antigenic peptides and anti-ITALY, LOR-2, STRIFE, TRASH, BDSF, LRSG, and STMST antibodies. The invention also provides ITALY, LOR-2, STRIFE, TRASH, BDSF, LRSG, and STMST nucleic acid molecules, recombinant expression vectors containing a nucleic acid molecule of the invention, host cells into which the expression vectors have been introduced and non-human transgenic animals in which an ITALY, LOR-2, STRIFE, TRASH, BDSF, LRSG, and STMST gene has been introduced or disrupted. Diagnostic, screening and therapeutic methods utilizing compositions of the invention are also provided.
摘要翻译：公开了新型意大利，LOR-2，STRIFE，TRASH，BDSF，LRSG和STMST多肽，蛋白质和核酸分子。除了分离的全长ITALY，LOR-2，STRIFE，TRASH，BDSF，LRSG和STMST蛋白之外，本发明还提供了分离的ITALY，LOR-2，STRIFE，TRASH，BDSF，LRSG和STMST融合蛋白，抗原肽和抗ITALY，LOR-2，STRIFE，TRASH，BDSF，LRSG和STMST抗体。本发明还提供意大利，LOR-2，STRIFE，TRASH，BDSF，LRSG和STMST核酸分子，含有本发明的核酸分子的重组表达载体，已经引入表达载体的非宿主细胞其中引入或破坏意大利，LOR-2，STRIFE，TRASH，BDSF，LRSG和STMST基因的转基因动物。还提供利用本发明组合物的诊断，筛选和治疗方法。

9. 发明申请

US20090220977A1 Novel genes encoding proteins having prognostic, diagnostic, preventive, therapeutic, and other uses 审中-公开
标题翻译：编码具有预后，诊断，预防，治疗和其他用途的蛋白质的新基因
公开(公告)号：US20090220977A1
公开(公告)日：2009-09-03
申请号：US12319689
申请日：2009-01-09
申请人： Christopher C. Fraser , Sean Anthony McCarthy , John D. Sharp , Thomas M. Barnes , Nicholas C. Wrighton , Charles R. Mackay , Kevin R. Leiby , Douglas A. Holtzman
发明人： Christopher C. Fraser , Sean Anthony McCarthy , John D. Sharp , Thomas M. Barnes , Nicholas C. Wrighton , Charles R. Mackay , Kevin R. Leiby , Douglas A. Holtzman
IPC分类号： C12Q1/68 , G01N33/53 , C12N5/10 , C12N15/63 , C07K14/435 , C07K16/00 , C07H21/04
CPC分类号： C07K16/18
摘要： The invention provides isolated nucleic acid molecules and polypeptide molecules. The invention also provides antisense nucleic acid molecules, expression vectors containing the nucleic acid molecules of the invention, host cells into which the expression vectors have been introduced, and non-human transgenic animals in which a nucleic acid molecule of the invention has been introduced or disrupted. The invention still further provides isolated polypeptides, fusion polypeptides, antigenic peptides and antibodies. Diagnostic, screening and therapeutic methods utilizing compositions of the invention are also provided.
摘要翻译：本发明提供分离的核酸分子和多肽分子。本发明还提供反义核酸分子，含有本发明的核酸分子的表达载体，已经引入了表达载体的宿主细胞和其中引入了本发明的核酸分子的非人转基因动物，或中断了本发明还进一步提供分离的多肽，融合多肽，抗原肽和抗体。还提供利用本发明组合物的诊断，筛选和治疗方法。

10. 发明申请

US20080213778A1 Novel genes encoding proteins having prognostic, diagnostic, preventive, therapeutic, and other uses 审中-公开
标题翻译：编码具有预后，诊断，预防，治疗和其他用途的蛋白质的新基因
公开(公告)号：US20080213778A1
公开(公告)日：2008-09-04
申请号：US11983233
申请日：2007-11-08
申请人： Douglas A. Holtzman , John D. Sharp , Kevin R. Leiby , Steven Bossone , Yang Pan , Thomas M. Barnes , Christopher C. Fraser , Nicholas Wrighton , Paul S. Myers , Gillian Kingsbury
发明人： Douglas A. Holtzman , John D. Sharp , Kevin R. Leiby , Steven Bossone , Yang Pan , Thomas M. Barnes , Christopher C. Fraser , Nicholas Wrighton , Paul S. Myers , Gillian Kingsbury
IPC分类号： C12N15/11 , C12N5/00 , C12N1/00 , C07K14/00 , C07K16/00 , C12P21/02 , G01N33/53 , C12Q1/68
CPC分类号： C07K14/7151 , A01K2217/05 , A61K38/00 , C07K14/47 , C07K14/705 , C07K14/78 , C07K2319/00 , Y10T436/143333
摘要： The invention provides isolated TANGO 239, TANGO 219, TANGO 232, TANGO 281, A236 (INTERCEPT 236), TANGO 300, TANGO 353, TANGO 393, TANGO 402, TANGO 351 and TANGO 509 nucleic acid molecules and polypeptide molecules. The invention also provides antisense nucleic acid molecules, expression vectors containing the nucleic acid molecules of the invention, host cells into which the expression vectors have been introduced, and non-human transgenic animals in which a nucleic acid molecule of the invention has been introduced or disrupted. The invention still further provides isolated polypeptides, fusion polypeptides, antigenic peptides and antibodies. Diagnostic, screening and therapeutic methods utilizing compositions of the invention are also provided.
摘要翻译：本发明提供了分离的TANGO 239，TANGO 219，TANGO 232，TANGO 281，A236（INTERCEPT 236），TANGO 300，TANGO 353，TANGO 393，TANGO 402，TANGO 351和TANGO 509核酸分子和多肽分子。本发明还提供反义核酸分子，含有本发明的核酸分子的表达载体，已经引入了表达载体的宿主细胞和其中引入了本发明的核酸分子的非人转基因动物，或中断了本发明还进一步提供分离的多肽，融合多肽，抗原肽和抗体。还提供利用本发明组合物的诊断，筛选和治疗方法。

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