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    • 7. 发明申请
    • Process for producing 1,2-dialkoxy-3-fluorobenzene
    • 1,2-二烷氧基-3-氟苯的制备方法
    • US20090227817A1
    • 2009-09-10
    • US12379553
    • 2009-02-24
    • Mingjian QiuWei ZhangZhaohui ChenChunshan ZhangYali Zhang
    • Mingjian QiuWei ZhangZhaohui ChenChunshan ZhangYali Zhang
    • C07C43/225C07C39/26
    • C07C39/27C07C41/16C07C41/26C07C43/225C07C43/23
    • The present invention relates to a process for producing a 2-fluoro-6-halophenol as an intermediate; a process for producing a 2-alkoxy-3-fluorophenol and further a 1,2-dialkoxy-3-fluorobenzene from the 2-fluoro-6-halophenol; a second process for producing a 1,2-dialkoxy-3-fluorobenzene from the 2-fluoro-6-halophenol; and a 2-alkoxy-3-fluorophenol. The 2-fluoro-6-halophenol can be obtained using a 2-fluorophenol as a starting material and through a sulfonation reaction, a halogenation reaction, and a deprotection reaction. The 2-fluoro-6-halophenol is alkyl-etherified, and subsequently the halogen atom is converted into a hydroxyl group to obtain the 2-alkoxy-3-fluorophenol, which is further alkyl-etherified to thereby obtain the 1,2-dialkoxy-3-fluorobenzene. Alternatively, a 1,2-dialkoxy-3-fluorobenzene is also obtained by converting the halogen atom of the 2-fluoro-6-halophenol into a hydroxyl group to thereby form 3-fluorocatechol and subsequently alkyl-etherifying two hydroxyl groups thereof. The processes of the invention realize low production costs and high process yields, and thus are suitable for industrial production of a 1,2-dialkoxy-3-fluorobenzene.
    • 本发明涉及作为中间体的2-氟-6-卤代苯酚的制造方法。 从2-氟-6-卤苯酚制备2-烷氧基-3-氟苯酚和1,2-二烷氧基-3-氟苯的方法; 从2-氟-6-卤代苯酚制备1,2-二烷氧基-3-氟苯的第二种方法; 和2-烷氧基-3-氟苯酚。 2-氟-6-卤代苯酚可以使用2-氟苯酚作为原料,通过磺化反应,卤化反应和脱保护反应得到。 2-氟-6-卤代苯酚被烷基醚化,随后将卤素原子转化为羟基,得到2-烷氧基-3-氟苯酚,进一步进行烷基醚化,从而得到1,2-二烷氧基 -3-氟苯。 或者,也可以通过将2-氟-6-卤代苯酚的卤素原子转化为羟基,从而形成3-氟邻苯二酚,然后将其两个羟基烷基醚化,得到1,2-二烷氧基-3-氟苯。 本发明的方法实现了低生产成本和高工艺产率,因此适用于1,2-二烷氧基-3-氟苯的工业生产。