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1. 发明申请

US20120064099A1 COMPOUNDS THAT INHIBIT NFKB AND BACE1 ACTIVITY 有权
标题翻译：禁止NFκB和BACE1活性的化合物
公开(公告)号：US20120064099A1
公开(公告)日：2012-03-15
申请号：US13094504
申请日：2011-04-26
申请人： Donald W. Landry , Tae-Wan Kim , Shi Xian Deng , Gangli Gong , Jeremy C. Hwang , Yuli Xie , Yidong Liu , K. Alison Rinderspacher
发明人： Donald W. Landry , Tae-Wan Kim , Shi Xian Deng , Gangli Gong , Jeremy C. Hwang , Yuli Xie , Yidong Liu , K. Alison Rinderspacher
IPC分类号： A61K39/00 , A61K31/542 , A61K31/47 , A61P29/00 , C07D215/36 , A61P35/00 , A61P25/28 , A61P37/02 , C12N5/02 , C07D513/04
CPC分类号： C07D215/40 , A61K31/47 , C07D401/12 , C07D409/12
摘要： The present invention relates to compounds with activity as BACE1 and NFκB modulators, and methods for treating, preventing, or ameliorating neurodegenerative diseases, such as Alzheimer's disease. The present invention is also directed to the treatment of diseases related to dysfunction of cell proliferation, the immune system and/or inflammation using such compounds or pharmaceutical compositions containing such candidate compounds.
摘要翻译：本发明涉及具有BACE1和NFκB调节剂活性的化合物，以及治疗，预防或改善神经变性疾病如阿尔茨海默氏病的方法。本发明还涉及使用这些化合物或包含这些候选化合物的药物组合物治疗与细胞增殖功能障碍，免疫系统和/或炎症有关的疾病。

2. 发明申请

US20120214186A1 METHODS AND COMPOSITIONS FOR DETECTING AND QUANTIFYING sAPPbeta 审中-公开
标题翻译：用于检测和定量sAPPbeta的方法和组合物
公开(公告)号：US20120214186A1
公开(公告)日：2012-08-23
申请号：US13372147
申请日：2012-02-13
申请人： Tae-Wan Kim , Jeremy C. Hwang
发明人： Tae-Wan Kim , Jeremy C. Hwang
IPC分类号： C12Q1/37 , G01N21/25 , G01N21/64 , G01N33/573
CPC分类号： G01N33/6896 , C07K16/18 , C07K2317/34 , G01N33/5058 , G01N2333/4709 , G01N2333/96425
摘要： The present invention provides methods (assays) for detecting and/or quantifying sAPPβ, a secreted β-secretase (BACE1) cleavage fragment of the β-amyloid precursor protein (APP), in a biological sample. One such method includes contacting a biological sample with a first antibody that selectively binds to a BACE1 cleavage site on sAPPβ and detecting the presence of the antibody. Also provided are compositions, including antibodies that selectively bind to the BACE1 cleavage site of sAPPβ. Kits containing such compositions are also provided. Methods of diagnosing a neurodegenerative disease, such as AD, using the methods and compositions of the present invention are further provided. Methods for identifying BACE1 modulators, candidate compounds that are BACE1 modulators, and methods for treating, preventing or ameliorating neurodegenerative disease, such as AD, using such compounds or pharmaceutical compositions containing such compounds are also provided.
摘要翻译：本发明提供了用于检测和/或定量生物样品中β-淀粉样蛋白前体蛋白（APP）的分泌型和分泌型（BACE1）切割片段的sAPP和bgr的方法（测定）。一种这样的方法包括使生物样品与在sAPP和bgr上选择性结合BACE1切割位点的第一抗体接触; 并检测抗体的存在。还提供了组合物，包括选择性结合sAPP和bgr的BACE1切割位点的抗体。还提供了含有这些组合物的试剂盒。进一步提供使用本发明的方法和组合物诊断神经变性疾病如AD的方法。还提供了鉴定BACE1调节剂的方法，BACE1调节剂的候选化合物，以及使用这些化合物或含有这些化合物的药物组合物治疗，预防或改善神经变性疾病如AD的方法。

3. 发明授权

US09410135B2 Thermophilic mutants of Trichoderma reesei endoglucanase I 有权
标题翻译：里氏木霉内切葡聚糖酶I的嗜热突变体
公开(公告)号：US09410135B2
公开(公告)日：2016-08-09
申请号：US13822623
申请日：2011-08-11
申请人： Harshal Akshay Chokhawala , Tae-Wan Kim , Harvey W. Blanch , Douglas S. Clark
发明人： Harshal Akshay Chokhawala , Tae-Wan Kim , Harvey W. Blanch , Douglas S. Clark
IPC分类号： C12N9/42 , C12P7/10 , C12P19/14
CPC分类号： C12N9/2437 , C12N9/244 , C12P7/10 , C12P19/14 , C12P2201/00 , C12Y302/01004 , C12Y302/01006 , Y02E50/16
摘要： The present disclosure relates to mutant thermostable glycosyl hydrolases family 7 enzymes, including mutant Trichoderma reesei endoglucanase I. In particular, the present disclosure relates to mutant thermostable enzymes, compositions containing the enzymes, and methods of use thereof.
摘要翻译：本公开涉及突变型热稳定糖基水解酶家族7酶，包括突变型里氏木霉内切葡聚糖酶I.特别地，本公开涉及突变热稳定酶，含有酶的组合物及其使用方法。

4. 发明授权

US08355755B2 Mobile terminal 有权
标题翻译：移动终端
公开(公告)号：US08355755B2
公开(公告)日：2013-01-15
申请号：US12716227
申请日：2010-03-02
申请人： Ha-Yong Kim , Yong-Duck Cha , Jong-Hwan Kim , Tae-Wan Kim
发明人： Ha-Yong Kim , Yong-Duck Cha , Jong-Hwan Kim , Tae-Wan Kim
IPC分类号： H04M1/00
CPC分类号： H04M1/022 , G06F1/1616 , G06F1/1641 , H04M2250/12 , H04M2250/16
摘要： Disclosed is a mobile terminal including, first and second bodies rotatably coupled to each other, and a driving unit configured to allow a relative rotation of the first and second bodies between a closed configuration and an open configuration, the first and second bodies being overlaid by each other in the closed configuration and rotated away from each other in the open configuration, wherein the driving unit includes rotation motion units connected to each of the first and second bodies and configured to generate the relative rotation, and slide motion units cooperatively operating with the rotation motion unit and configured to relatively slide the first and second bodies with respect to the driving unit between the closed configuration and the open configuration.
摘要翻译：公开了一种移动终端，其包括彼此可旋转地联接的第一和第二主体，以及被配置为允许第一和第二主体在关闭配置和打开配置之间的相对旋转的驱动单元，第一和第二主体被覆盖在彼此处于闭合构造并且在打开构造中彼此旋转，其中驱动单元包括连接到第一和第二主体中的每一个并且被配置为产生相对旋转的旋转运动单元，并且与滑动运动单元协同操作旋转运动单元并且被配置为在关闭配置和打开配置之间相对于驱动单元相对滑动第一和第二主体。

5. 发明申请

US20100136637A1 RECOMBINANT MICROORGANISM HAVING A PRODUCING ABILITY OF POLYLACTATE OR ITS COPOLYMERS AND METHOD FOR PREPARING POLYACTATE OR ITS COPOLYMERS USING THE SAME 审中-公开
标题翻译：具有聚乙烯酯或其共聚物生产能力的重组微生物及其制备聚氨酯或其共聚物的方法
公开(公告)号：US20100136637A1
公开(公告)日：2010-06-03
申请号：US12451825
申请日：2008-12-30
申请人： Si-Jae Park , Taek-Ho Yang , Sang-Hyun Lee , Eun-Jung Lee , Hye-Ok Kang , Tae-Wan Kim
发明人： Si-Jae Park , Taek-Ho Yang , Sang-Hyun Lee , Eun-Jung Lee , Hye-Ok Kang , Tae-Wan Kim
IPC分类号： C12P7/62 , C12N1/00 , C12N15/74 , C12N1/21
CPC分类号： C12P7/625 , C12N9/10 , C12N9/1029
摘要： Provided are a recombinant microorganism capable of producing polylactate (PLA) or hydroxyalkanoate-lactate copolymers and a method of preparing PLA or hydroxyalkanoate-lactate copolymers using the same. The recombinant microorganism has both a gene encoding a propionyl-CoA transferase from Megasphaera elsdenii and a gene encoding a polyhydroxyalkanoate (PHA) synthase using lactyl-CoA as a substrate.A propionyl-CoA transferase from Megasphaera elsdenii is introduced into the recombinant microorganism to effectively provide lactyl-CoA, thereby enabling efficient preparation of PLA or PLA copolymers.
摘要翻译：提供能够生产聚乳酸（PLA）或羟基链烷酸酯 - 乳酸共聚物的重组微生物，以及使用其制备PLA或羟基链烷酸酯 - 乳酸共聚物的方法。重组微生物具有使用乳酸-CoA作为底物的来自Megasphaera elsdenii的编码丙酰基-CoA转移酶的基因和编码聚羟基链烷酸酯（PHA）合酶的基因。将来自Megasphaera elsdenii的丙酰辅酶A转移酶引入重组微生物中以有效提供乳酰辅酶A，从而能够有效制备PLA或PLA共聚物。

6. 外观设计

USD615519S1 Mobile phone 有权
公开(公告)号：USD615519S1
公开(公告)日：2010-05-11
申请号：US29340299
申请日：2009-07-16
申请人： Tae-Wan Kim , Seung-Min Park , Seog-Guen Kim
设计人： Tae-Wan Kim , Seung-Min Park , Seog-Guen Kim

7. 发明申请

US20100035811A1 Phosphoinositide Modulation For The Treatment Of Neurodegenerative Diseases 有权
标题翻译：磷酸肌醇调节治疗神经退行性疾病
公开(公告)号：US20100035811A1
公开(公告)日：2010-02-11
申请号：US12467583
申请日：2009-05-18
申请人： Tae-Wan Kim , Gilbert DiPaolo , Min Suk Kang , Diego Ezequiel Berman , Laura Beth Johnson McIntire
发明人： Tae-Wan Kim , Gilbert DiPaolo , Min Suk Kang , Diego Ezequiel Berman , Laura Beth Johnson McIntire
IPC分类号： A61K38/02 , A61K38/16 , A61K31/13 , A61P25/28 , A61P25/00 , A61K31/7012
CPC分类号： A61K31/663
摘要： The present invention relates to the use of agents that inhibit the toxic effects of amyloid oligomers by increasing intracellular levels of phosphoinositol 4-phosphate (PI(4)P, or “PIP”) and/or phosphotidylinositol 4,5-biphosphate (PI(4,5)P2 or “PIP2”), the use of such agents for the treatment of neurodegenerative diseases, methods of treating neurodegenerative diseases by administration of agents which alter lipid metabolism, and methods of identifying agents which alter the association of presenilins with γ-secretase and lipid rafts.
摘要翻译：本发明涉及通过增加细胞内磷酸肌醇4-磷酸（PI（4）P或“PIP”）和/或磷脂酰肌醇4,5-二磷酸（PI（4） 4,5）P2或“PIP2”），使用这些药物治疗神经变性疾病，通过施用改变脂质代谢的药物来治疗神经变性疾病的方法，以及鉴定改变前列素与γ的关联的药物的方法分泌酶和脂筏。

8. 发明申请

US20050092571A1 Vehicle air conditioner using variable control compressor 审中-公开
标题翻译：车用空调采用变频控制压缩机
公开(公告)号：US20050092571A1
公开(公告)日：2005-05-05
申请号：US10962027
申请日：2004-10-08
申请人： Tae-Wan Kim
发明人： Tae-Wan Kim
IPC分类号： B60H1/32 , F16D28/00 , F16D37/00
CPC分类号： F16D37/008 , B60H1/3222
摘要： The vehicle air conditioner includes a compressor that compresses the refrigerant of an air conditioner by receiving rotational force from the engine. A clutch transmits or isolates the rotational force of the engine to a compressor shaft by using an operational fluid. A shearing force of the operational fluid varies according to the variation of the magnetic field. A controller varies the shearing force of the operational fluid by adjusting the magnetic field according to the cooling load.
摘要翻译：车辆空调包括压缩机，其通过从发动机接受旋转力来压缩空调的制冷剂。离合器通过使用操作流体将发动机的旋转力传递或隔离到压缩机轴。工作流体的剪切力根据磁场的变化而变化。控制器通过根据冷却负载调整磁场来改变操作流体的剪切力。

9. 发明申请

US20110046339A1 COPOLYMER CONTAINING 3-HYDROXYALKANOATE UNIT AND LACTATE UNIT, AND ITS MANUFACTURING METHOD 有权
标题翻译：含有三羟基烷酸酯单体和乳酸单体的共聚物及其制造方法
公开(公告)号：US20110046339A1
公开(公告)日：2011-02-24
申请号：US12312636
申请日：2007-11-21
申请人： Si-Jae Park , Taek-Ho Yang , Hye-ok Kang , Sang-Hyun Lee , Eun-Jeong Lee , Tae-Wan Kim , Sang-Yup Lee
发明人： Si-Jae Park , Taek-Ho Yang , Hye-ok Kang , Sang-Hyun Lee , Eun-Jeong Lee , Tae-Wan Kim , Sang-Yup Lee
IPC分类号： C08G63/06 , C12P7/62
CPC分类号： C08G63/06 , C12P7/625
摘要： The present invention relates to a copolymer comprising 3-hydroxyalkanoate monomer unit and lactate monomer unit, or their preparing method. More specifically, the present invention relates to a method for preparing a copolymer comprising lactate monomer and 3-hydroxyalkanoate monomer, wherein the method comprises culturing a cell or plant comprising the gene of enzyme converting lactate and 3-hydroxyalkanoate into lactyl-CoA and 3-hydroxyalkanoyl-CoA, respectively, and polyhydroxyalkanoate synthase gene together, and the copolymer made by the method. The copolymer of the present invention is a biodegradable polymer being able to be usefully used instead of conventional synthetic plastic, and the copolymer can be used also for medical use.
摘要翻译：本发明涉及包含3-羟基链烷酸酯单体单元和乳酸单体单元的共聚物或其制备方法。更具体地说，本发明涉及一种制备包含乳酸单体和3-羟基链烷酸酯单体的共聚物的方法，其中所述方法包括将包含转化乳酸酯和3-羟基链烷酸酯的酶的基因的细胞或植物培养成乳酰CoA和3- 羟基烷酰基-CoA和聚羟基链烷酸酯合酶基因，以及通过该方法制备的共聚物。本发明的共聚物是可以有效地代替常规合成塑料的可生物降解的聚合物，并且共聚物也可以用于医疗用途。

10. 发明申请

US20100222545A1 COPOLYMER COMPRISING 4-HYDROXYBUTYRATE UNIT AND LACTATE UNIT AND ITS MANUFACTURING METHOD 有权
标题翻译：包含4-羟基丁酸酯单体和乳液单元的共聚物及其制造方法
公开(公告)号：US20100222545A1
公开(公告)日：2010-09-02
申请号：US12312635
申请日：2007-11-21
申请人： Si-Jae Park , Taek-Ho Yang , Hye-Ok Kang , Sang-Hyun Lee , Eun-Jeong Lee , Tae-Wan Kim , Sang-Yup Lee
发明人： Si-Jae Park , Taek-Ho Yang , Hye-Ok Kang , Sang-Hyun Lee , Eun-Jeong Lee , Tae-Wan Kim , Sang-Yup Lee
IPC分类号： C08G63/06 , C12P7/62
CPC分类号： C08G63/06 , C12N9/1025 , C12N15/8243 , C12N15/8245 , C12P7/625
摘要： The present invention relates to a copolymer comprising 4-hydroxybutyrate monomer unit and lactate monomer unit, a copolymer 4-hydroxybutyrate monomer unit, lactate monomer unit and 3-hydroxyalkanoate, or their preparing method. More specifically, the present invention relates to a method for preparing a copolymer comprising lactate monomer; 4-hydroxybutyrate monomer; and optionally 3-hydroxyalkanoate, wherein the method comprises culturing a cell or plant comprising the gene of enzyme converting lactate and 3-hydroxyalkanoate into lactyl-CoA and 3-hydroxyalkanoyl-CoA, respectively, phosphotransbutylase gene, butyrate kinase gene and polyhydroxyalkanoate synthase gene together, and the copolymer made by the method. The copolymer of the present invention is a biodegradable polymer being able to be usefully used instead of conventional synthetic plastic, and the copolymer can be used for medical use.
摘要翻译：本发明涉及包含4-羟基丁酸酯单体单元和乳酸酯单体单元，共聚物4-羟基丁酸酯单体单元，乳酸酯单体单元和3-羟基链烷酸酯的共聚物或其制备方法。更具体地说，本发明涉及制备包含乳酸酯单体的共聚物的方法; 4-羟基丁酸酯单体; 和任选的3-羟基链烷酸酯，其中所述方法包括分别将含有转化乳酸盐和3-羟基链烷酸酯的酶的基因的细胞或植物分别培养成乳酰基-CoA和3-羟基烷酰基-CoA，磷酸转移酶基因，丁酸酯激酶基因和聚羟基链烷酸酯合酶基因和通过该方法制备的共聚物。本发明的共聚物是能够有效地代替常规合成塑料的可生物降解聚合物，该共聚物可用于医疗用途。

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