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1. 发明授权

US07427497B2 In vitro metabolic engineering on microscale devices 有权
标题翻译：微量装置上的体外代谢工程
公开(公告)号：US07427497B2
公开(公告)日：2008-09-23
申请号：US10287440
申请日：2002-11-01
申请人： Jonathan S. Dordick , Aravind Srinivasan , Jungbae Kim , David H. Sherman , Douglas S. Clark
发明人： Jonathan S. Dordick , Aravind Srinivasan , Jungbae Kim , David H. Sherman , Douglas S. Clark
IPC分类号： C12N11/18 , C12N1/00
CPC分类号： B01J19/0093 , B01J19/0046 , B01J2219/00317 , B01J2219/00364 , B01J2219/00497 , B01J2219/00527 , B01J2219/00533 , B01J2219/00536 , B01J2219/00585 , B01J2219/00596 , B01J2219/00644 , B01J2219/00691 , B01J2219/0072 , B01J2219/00722 , B01J2219/00725 , B01J2219/00743 , B01J2219/00835 , B01J2219/00837 , B01J2219/0086 , B01L3/5027 , B01L3/5085 , B01L2300/069 , B01L2300/0819 , B01L2300/0829
摘要： Disclosed herein is a microfluidics device that can be used to prepare natural products and their analogs. The device comprises the enzymes of a biosynthetic pathway immobilized thereon and a means for sequentially directing a starting material and each ensuing reaction product to the enzymes of the biosynthetic pathway in the order corresponding to the steps of the biosynthetic pathway. The device can thus be used to prepare the natural product using the natural starting material of the biosynthetic pathway or analogs of the natural product using an unnatural starting material. Alternatively, artificial pathways can be created by immobilizing an appropriate selection of enzymes on the device in an order whereby each subsequent enzyme can catalyze a reaction with the product of the prior enzyme. Novel chemical entities can be prepared from these artificial pathways.
摘要翻译：本文公开了可用于制备天然产物及其类似物的微流体装置。该装置包括固定在其上的生物合成途径的酶，以及以与生物合成途径的步骤相应的顺序将原料和每个随后的反应产物顺序地引导到生物合成途径的酶的装置。因此，该装置可以用于使用天然起始物质的天然产物或天然产物的类似物使用非天然原料制备天然产物。或者，可以通过以适当顺序的酶固定适当选择的酶在装置上来产生人工途径，其中每个随后的酶可以催化与先前酶的产物的反应。这些人造途径可以制备新的化学物质。

2. 发明授权

US06465625B1 Taxol derivatives 失效
标题翻译：紫杉醇衍生物
公开(公告)号：US06465625B1
公开(公告)日：2002-10-15
申请号：US09596545
申请日：2000-06-19
申请人： Jonathan S. Dordick , Douglas S. Clark , Peter C. Michels , Yuri L. Khmelnitsky
发明人： Jonathan S. Dordick , Douglas S. Clark , Peter C. Michels , Yuri L. Khmelnitsky
IPC分类号： C07H1708
CPC分类号： C07D493/04 , C07D305/14 , C07H13/06 , C07H13/08 , C07H13/10 , C07H15/18 , C07H15/26 , C07H17/04 , C07H17/08 , C07H19/16
摘要： Highly specific biocatalytic reactions have been used to create a population of taxol derivatives.
摘要翻译：已经使用高度特异性的生物催化反应来产生一群紫杉醇衍生物

3. 发明授权

US5778558A Pellet cooling method and apparatus using alternate hot and cool air streams 失效
标题翻译：颗粒冷却方法和使用交替的热和冷空气流的设备
公开(公告)号：US5778558A
公开(公告)日：1998-07-14
申请号：US786867
申请日：1997-01-23
申请人： LaVon G. Wenger , Douglas S. Clark , Nicholas B. Scott
发明人： LaVon G. Wenger , Douglas S. Clark , Nicholas B. Scott
IPC分类号： A23K1/20 , F26B17/14 , F26B25/10 , F26B3/00
CPC分类号： F26B17/14 , F26B25/10
摘要： A pellet conditioning device (10) for the cooling and/or drying of preformed discrete pellets (148) is provided which includes an upright pellet-receiving bin (12) with a dual grate assembly (18) therein. The assembly (18) includes a stationary first grate comprising a plurality of upright, apertured grate wall members (86), and a shiftable second grate including a plurality of elongated, obliquely oriented plates (106) located between and in spanning relationship to adjacent pairs of the wall members (86). Shifting structure (20) is provided for selective and sequential translational, rectilinear shifting movement of the lower margins (110) of the plates (106) so as to successively open and close a pellet passageway (117) adjacent each lower margin (110). A duct and fan arrangement (38) is also provided with the bin (12) so as to draw cooling air currents through the grate assembly (18) and pellets (148) therein. The plates (106) may also be shifted upwardly to their maximum extent in order to dislodge pellet bridges above the grate assembly (18). In another embodiment a conditioning device (12a) includes alternately operable hot and cool air introduction assemblies (152, 154) disposed along the opposed ends of bin (12a). In operation, relatively hot air currents are delivered beneath the grate assembly (18) via assembly (152), whereupon the later is closed; the cool air inlet assembly (154) is then opened so as to cause introduction of ambient air into and through the bin (12a).
摘要翻译：提供了一种用于冷却和/或干燥预成型离散颗粒（148）的颗粒调节装置（10），其包括在其中具有双格栅组件（18）的直立颗粒接收容器（12）。组件（18）包括固定的第一格栅，该固定的第一格栅包括多个竖立的，有孔的格栅壁构件（86）和可移位的第二格栅，该第二格栅包括多个细长的倾斜取向的板（106）的壁构件（86）。提供移位结构（20）用于板（106）的下边缘（110）的选择性和顺序平移，直线移动运动，以便连续地打开和关闭每个下边缘（110）附近的颗粒通道（117）。管道和风扇装置（38）还设置有箱（12），以便将冷却空气流通过炉排组件（18）和其中的颗粒（148）。板（106）也可以向上移动到其最大程度，以便移除格栅组件（18）上方的颗粒桥。在另一个实施例中，调节装置（12a）包括沿着箱体（12a）的相对端设置的可互换操作的热和冷空气引入组件（152,154）。在操作中，通过组件（152）在炉排组件（18）下面传送相对热的气流，随后关闭; 然后打开冷空气入口组件（154），以便使环境空气引入并通过箱体（12a）。

4. 发明授权

US4185123A High-output method for producing dense, uniformly layered meat analogue product 失效
标题翻译：生产稠密，均匀分层的肉类类似产品的高产量方法
公开(公告)号：US4185123A
公开(公告)日：1980-01-22
申请号：US900071
申请日：1978-04-26
申请人： La Von G. Wenger , Douglas S. Clark , Bobbie W. Hauck
发明人： La Von G. Wenger , Douglas S. Clark , Bobbie W. Hauck
IPC分类号： A23J3/22 , A23J3/26 , B29C47/60 , B30B11/24 , A23J3/00 , A23P1/00
CPC分类号： B29C47/0825 , A23J3/227 , A23J3/26 , B29C47/60 , B30B11/24 , B29C47/0016 , Y10S426/802
摘要： A commercially feasible, high-output extrusion apparatus and method is provided for producing vegetable protein based meat analogue products characterized by discrete, untwisted, manually separable meat-like layers and at relatively high production rates. The method involves passing hot, moist, pretreated vegetable protein material through an extruder barrel and causing formation of a first choke of the material intermediate the ends of the barrel, subdivision of the material downstream of the first choke point in the presence of steam for thorough cooking and moisturizing of the material, rechoking of the subdivided material adjacent the extrusion end of the barrel, and extrusion of the material as a dense, layered meat analogue product. The apparatus preferably includes a plurality of especially configured, axially aligned screw elements within the extruder barrel, including an intermediate cut-flight screw for forming the first choke and an axial extension or die spacer at the extrusion end of the barrel for facilitating layering of the end product. The overall production apparatus advantageously includes a pair of extruders for sequentially denaturing the vegetable protein based material and rendering the same hot and flowable, whereupon the hot material can be extruded as a layered meat analogue product from the second extruder.
摘要翻译：提供了一种商业上可行的高产出挤出装置和方法，用于生产基于离散的，无捻的，可手动分离的肉类层的植物蛋白质肉类似产品，并以相对较高的生产率。该方法包括将热的，潮湿的预处理的植物蛋白材料通过挤出机机筒，并引起材料的端部之间的材料的第一扼流圈的形成，在存在蒸汽的情况下将第一阻塞点下游的材料细分为彻底材料的烹饪和保湿，邻近挤出端的细分材料的重新挤压，以及将材料挤压成致密的层状肉类似物产品。该设备优选地包括在挤出机机筒内的多个特别构造的轴向对准的螺杆元件，包括用于形成第一扼流圈的中间切割螺旋螺钉和在筒的挤出端处的轴向延伸或模具间隔件，以便于分层成品。整个生产设备有利地包括一对挤出机，用于使基于植物蛋白质的材料顺序变性并使其具有相同的热和流动性，因此热材料可以作为来自第二挤出机的层状肉类似物产品被挤出。

5. 发明授权

US09410135B2 Thermophilic mutants of Trichoderma reesei endoglucanase I 有权
标题翻译：里氏木霉内切葡聚糖酶I的嗜热突变体
公开(公告)号：US09410135B2
公开(公告)日：2016-08-09
申请号：US13822623
申请日：2011-08-11
申请人： Harshal Akshay Chokhawala , Tae-Wan Kim , Harvey W. Blanch , Douglas S. Clark
发明人： Harshal Akshay Chokhawala , Tae-Wan Kim , Harvey W. Blanch , Douglas S. Clark
IPC分类号： C12N9/42 , C12P7/10 , C12P19/14
CPC分类号： C12N9/2437 , C12N9/244 , C12P7/10 , C12P19/14 , C12P2201/00 , C12Y302/01004 , C12Y302/01006 , Y02E50/16
摘要： The present disclosure relates to mutant thermostable glycosyl hydrolases family 7 enzymes, including mutant Trichoderma reesei endoglucanase I. In particular, the present disclosure relates to mutant thermostable enzymes, compositions containing the enzymes, and methods of use thereof.
摘要翻译：本公开涉及突变型热稳定糖基水解酶家族7酶，包括突变型里氏木霉内切葡聚糖酶I.特别地，本公开涉及突变热稳定酶，含有酶的组合物及其使用方法。

6. 发明申请

US20150211037A1 POLYPEPTIDES FOR USE IN THE DECONSTRUCTION OF CELLULOSE 有权
标题翻译：用于分解纤维素的多肽
公开(公告)号：US20150211037A1
公开(公告)日：2015-07-30
申请号：US13813154
申请日：2011-07-14
申请人： Joel Edward Graham , Melinda E. Clark , Frank Thomson Robb , Douglas S. Clark , Harvey W. Blanch
发明人： Joel Edward Graham , Melinda E. Clark , Frank Thomson Robb , Douglas S. Clark , Harvey W. Blanch
IPC分类号： C12P19/14 , C13K1/02 , C12N9/42 , C12P19/02
CPC分类号： C12P19/14 , C12N9/2402 , C12N9/2437 , C12P7/00 , C12P19/02 , C13K1/02
摘要： Hydrolysis and degradation of cellulose-containing biomass by use of a polypeptide having cellulase activity is provided. Also provided are polypeptides having cellulase activity, such as archaeal cellulases, polynucleotides encoding the polypeptides, and compositions containing the polypeptides, and methods of use thereof.
摘要翻译：提供了通过使用具有纤维素酶活性的多肽来水解和降解含纤维素的生物质。还提供了具有纤维素酶活性的多肽，例如古细菌纤维素酶，编码多肽的多核苷酸，以及含有该多肽的组合物及其使用方法。

7. 发明申请

US20110045554A1 HETEROLOGOUS EXPRESSION OF EXTREMOPHILE HEAT SHOCK PROTEINS AND CHAPERONES IN MICROORGANISMS TO INCREASE TOLERANCE TO TOXIC COMPOUNDS 有权
标题翻译：微生物中超临界热休克蛋白和葛根酮的异位表达增加对毒性化合物的耐受性
公开(公告)号：US20110045554A1
公开(公告)日：2011-02-24
申请号：US12528620
申请日：2008-02-26
申请人： Douglas S. Clark , Timothy Whitehead , Frank T. Robb , Pongpan Laksanalamai , Anchalee Jiemjit
发明人： Douglas S. Clark , Timothy Whitehead , Frank T. Robb , Pongpan Laksanalamai , Anchalee Jiemjit
IPC分类号： C12P7/64 , C12P1/00 , C12P7/26 , C12P7/16 , C12P7/06 , C12P5/00 , C12P1/04 , C12P1/02 , C12N15/63 , C12N1/00 , C12N1/21 , C12N1/15 , C12N1/19 , C12N1/13 , C12N15/81 , C12N15/74 , C12N15/80 , C12N15/70
CPC分类号： C07K14/195 , Y02E50/17
摘要： The invention provides methods and compositions for increasing tolerance of microorganisms to toxic agents, such as solvents; and for increasing production of solvents from solvent-generating microorganisms. The methods comprise engineering a microorganism of interest to express a heterologous heat-shock protein/chaperone, e.g., Group II chaperonin or a prefoldin such as γ-prefoldin, where the heterologous protein is from an extremophile, such as an archaean.
摘要翻译：本发明提供了增加微生物对毒性剂如溶剂的耐受性的方法和组合物; 并用于增加溶剂产生微生物的溶剂生产。所述方法包括将感兴趣的微生物工程化以表达异源热休克蛋白/伴侣，例如II型伴侣蛋白或诸如γ-预折蛋白之类的预折合蛋白，其中异源蛋白质来自极端亲本，例如古细菌。

8. 发明授权

US07267958B2 Biocatalytic solgel microarrays 有权
公开(公告)号：US07267958B2
公开(公告)日：2007-09-11
申请号：US10287442
申请日：2002-11-01
申请人： Jonathan S. Dordick , Douglas S. Clark
发明人： Jonathan S. Dordick , Douglas S. Clark
IPC分类号： G01N33/53
CPC分类号： B01J19/0093 , B01J19/0046 , B01J2219/00317 , B01J2219/00364 , B01J2219/00497 , B01J2219/00527 , B01J2219/00533 , B01J2219/00536 , B01J2219/00585 , B01J2219/00596 , B01J2219/00644 , B01J2219/00691 , B01J2219/0072 , B01J2219/00722 , B01J2219/00725 , B01J2219/00743 , B01J2219/00835 , B01J2219/00837 , B01J2219/0086 , B01L3/5027 , B01L3/5085 , B01L2300/069 , B01L2300/0819 , B01L2300/0829
摘要： A system and method for conducting high-throughput interactions between test compositions and analytes, comprising one or more test compositions, and a plurality of independent micromatrices, wherein each said micromatrix encapsulates at least one said test composition; and said micromatrices are made of a material that is permeable to an analyte.

9. 发明授权

US06729903B1 Quick connect/disconnect electrical connector having an extended insulating tab 失效
标题翻译：快速连接/断开具有延长绝缘片的电连接器
公开(公告)号：US06729903B1
公开(公告)日：2004-05-04
申请号：US10309061
申请日：2002-12-04
申请人： Douglas S. Clark
发明人： Douglas S. Clark
IPC分类号： H01R1340
CPC分类号： H01R13/44 , H01R4/22 , H01R11/16 , H01R43/16 , Y10S439/937
摘要： A quick connect/disconnect conducting receptacle constructed in accordance with the present invention includes a conducting receptacle surrounded by an insulated cover having a defined length and an extended tab portion projecting from an upper edge of the insulating cover. Specifically, the conducting receptacle includes a central plate, as well as first and second curved fixing rims extending from and terminating above the central plate. The fixing rims are provided to clampingly engage a respective mating tab portion inserted into the conducting receptacle to form an electrical joint. In accordance with one form of the present invention, the extended tab portion is adapted to extend over an exposed surface of a mating tab portion in order to protect both a service technician from inadvertent contact with exposed conductive surfaces as well as preventing damage caused by grounding is an associated electrical component.
摘要翻译：根据本发明构造的快速连接/断开导电插座包括由具有限定长度的绝缘盖围绕的导电插座和从绝缘盖的上边缘突出的延伸突片部分。具体地，导电插座包括中心板以及从中心板上方延伸并终止于中心板上方的第一和第二弯曲固定边缘。设置固定边缘以夹紧地接合插入到导电插座中的相应配合片部分以形成电接头。根据本发明的一种形式，延伸突片部分适于在匹配突片部分的暴露表面上延伸，以便保护维修技术人员免受与暴露的导电表面的无意接触以及防止由接地引起的损坏是相关联的电气部件。

10. 外观设计

USD485654S1 Agitator assembly 失效
标题翻译：搅拌机总成
公开(公告)号：USD485654S1
公开(公告)日：2004-01-20
申请号：US29164502
申请日：2002-07-23
申请人： Douglas S. Clark , Jon D. Strait , S. Luke Bullock , Stephen D. Schober , Lisa Hood , Ted L. Hansen , Inho Andy Shin
设计人： Douglas S. Clark , Jon D. Strait , S. Luke Bullock , Stephen D. Schober , Lisa Hood , Ted L. Hansen , Inho Andy Shin

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