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1. 发明申请

US20120064099A1 COMPOUNDS THAT INHIBIT NFKB AND BACE1 ACTIVITY 有权
标题翻译：禁止NFκB和BACE1活性的化合物
公开(公告)号：US20120064099A1
公开(公告)日：2012-03-15
申请号：US13094504
申请日：2011-04-26
申请人： Donald W. Landry , Tae-Wan Kim , Shi Xian Deng , Gangli Gong , Jeremy C. Hwang , Yuli Xie , Yidong Liu , K. Alison Rinderspacher
发明人： Donald W. Landry , Tae-Wan Kim , Shi Xian Deng , Gangli Gong , Jeremy C. Hwang , Yuli Xie , Yidong Liu , K. Alison Rinderspacher
IPC分类号： A61K39/00 , A61K31/542 , A61K31/47 , A61P29/00 , C07D215/36 , A61P35/00 , A61P25/28 , A61P37/02 , C12N5/02 , C07D513/04
CPC分类号： C07D215/40 , A61K31/47 , C07D401/12 , C07D409/12
摘要： The present invention relates to compounds with activity as BACE1 and NFκB modulators, and methods for treating, preventing, or ameliorating neurodegenerative diseases, such as Alzheimer's disease. The present invention is also directed to the treatment of diseases related to dysfunction of cell proliferation, the immune system and/or inflammation using such compounds or pharmaceutical compositions containing such candidate compounds.
摘要翻译：本发明涉及具有BACE1和NFκB调节剂活性的化合物，以及治疗，预防或改善神经变性疾病如阿尔茨海默氏病的方法。本发明还涉及使用这些化合物或包含这些候选化合物的药物组合物治疗与细胞增殖功能障碍，免疫系统和/或炎症有关的疾病。

2. 发明申请

US20110071124A1 Compounds that Inhibit Production of sAPPB and AB and Uses Thereof 审中-公开
标题翻译：抑制sAPPB和AB生产的化合物及其用途
公开(公告)号：US20110071124A1
公开(公告)日：2011-03-24
申请号：US12858837
申请日：2010-08-18
申请人： Tae-wan Kim , Donald W. Landry , Jeremy C. Hwang , Shi Xian Deng , Gangli Gong , Yuli Xie , Yidong Liu , Alison Rinderspacher
发明人： Tae-wan Kim , Donald W. Landry , Jeremy C. Hwang , Shi Xian Deng , Gangli Gong , Yuli Xie , Yidong Liu , Alison Rinderspacher
IPC分类号： A61K31/40 , A61K31/445 , A61K31/397 , A61K31/165 , A61K31/138 , A61K31/495 , A61K31/41 , A61K31/4184 , A61K31/35 , A61P25/28 , C12N9/99
CPC分类号： A61K31/535 , A61K31/351 , A61K31/395 , A61K31/40 , A61K31/4178 , A61K31/496
摘要： The present invention relates to compounds with activity as inhibitors of sAPPβ and Aβ production, and methods for treating, preventing, or ameliorating neurodegenerative diseases, such as Alzheimer's disease and pharmaceutical compositions containing such candidate compounds.
摘要翻译：本发明涉及具有作为sAPP和bgr的抑制剂活性的化合物。和A＆bgr 生产和治疗，预防或改善神经变性疾病如阿尔茨海默氏病的方法和含有这些候选化合物的药物组合物。

3. 发明申请

US20090162878A1 METHODS AND COMPOSITIONS FOR DETECTING AND QUANTIFYING SAPPB 审中-公开
标题翻译：用于检测和定量SAPPB的方法和组合物
公开(公告)号：US20090162878A1
公开(公告)日：2009-06-25
申请号：US12353162
申请日：2009-01-13
申请人： Tae-wan Kim , Jeremy C. Hwang
发明人： Tae-wan Kim , Jeremy C. Hwang
IPC分类号： G01N33/53 , C07K16/18 , C07D251/54
CPC分类号： G01N33/6896 , C07K16/18 , C07K2317/34 , G01N33/5058 , G01N2333/4709 , G01N2333/96425
摘要： The present invention provides methods (assays) for detecting and/or quantifying sAPPβ, a secreted β-secretase (BACE1) cleavage fragment of the β-amyloid precursor protein (APP), in a biological sample. One such method includes contacting a biological sample with a first antibody that selectively binds to a BACE1 cleavage site on sAPPβ and detecting the presence of the antibody. Also provided are compositions, including antibodies that selectively bind to the BACE1 cleavage site of sAPPβ. Kits containing such compositions are also provided. Methods of diagnosing a neurodegenerative disease, such as AD, using the methods and compositions of the present invention are further provided. Methods for identifying BACE1 modulators, candidate compounds that are BACE1 modulators, and methods for treating, preventing or ameliorating neurodegenerative disease, such as AD, using such compounds or pharmaceutical compositions containing such compounds are also provided.
摘要翻译：本发明提供了用于检测和/或定量生物样品中β-淀粉样蛋白前体蛋白（APP）的分泌的β-分泌酶（BACE1）切割片段的sAPPβ的方法（测定）。一种这样的方法包括使生物样品与选择性结合sAPPbeta上的BACE1切割位点的第一抗体接触并检测抗体的存在。还提供了组合物，包括选择性结合sAPPβ的BACE1切割位点的抗体。还提供了含有这些组合物的试剂盒。进一步提供使用本发明的方法和组合物诊断神经变性疾病如AD的方法。还提供了鉴定BACE1调节剂的方法，BACE1调节剂的候选化合物，以及使用这些化合物或含有这些化合物的药物组合物治疗，预防或改善神经变性疾病如AD的方法。

4. 发明申请

US20120214186A1 METHODS AND COMPOSITIONS FOR DETECTING AND QUANTIFYING sAPPbeta 审中-公开
标题翻译：用于检测和定量sAPPbeta的方法和组合物
公开(公告)号：US20120214186A1
公开(公告)日：2012-08-23
申请号：US13372147
申请日：2012-02-13
申请人： Tae-Wan Kim , Jeremy C. Hwang
发明人： Tae-Wan Kim , Jeremy C. Hwang
IPC分类号： C12Q1/37 , G01N21/25 , G01N21/64 , G01N33/573
CPC分类号： G01N33/6896 , C07K16/18 , C07K2317/34 , G01N33/5058 , G01N2333/4709 , G01N2333/96425
摘要： The present invention provides methods (assays) for detecting and/or quantifying sAPPβ, a secreted β-secretase (BACE1) cleavage fragment of the β-amyloid precursor protein (APP), in a biological sample. One such method includes contacting a biological sample with a first antibody that selectively binds to a BACE1 cleavage site on sAPPβ and detecting the presence of the antibody. Also provided are compositions, including antibodies that selectively bind to the BACE1 cleavage site of sAPPβ. Kits containing such compositions are also provided. Methods of diagnosing a neurodegenerative disease, such as AD, using the methods and compositions of the present invention are further provided. Methods for identifying BACE1 modulators, candidate compounds that are BACE1 modulators, and methods for treating, preventing or ameliorating neurodegenerative disease, such as AD, using such compounds or pharmaceutical compositions containing such compounds are also provided.
摘要翻译：本发明提供了用于检测和/或定量生物样品中β-淀粉样蛋白前体蛋白（APP）的分泌型和分泌型（BACE1）切割片段的sAPP和bgr的方法（测定）。一种这样的方法包括使生物样品与在sAPP和bgr上选择性结合BACE1切割位点的第一抗体接触; 并检测抗体的存在。还提供了组合物，包括选择性结合sAPP和bgr的BACE1切割位点的抗体。还提供了含有这些组合物的试剂盒。进一步提供使用本发明的方法和组合物诊断神经变性疾病如AD的方法。还提供了鉴定BACE1调节剂的方法，BACE1调节剂的候选化合物，以及使用这些化合物或含有这些化合物的药物组合物治疗，预防或改善神经变性疾病如AD的方法。

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