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1. 发明授权

US06175420B1 Optical sensors for cell processing systems 失效
标题翻译：用于细胞处理系统的光学传感器
公开(公告)号：US06175420B1
公开(公告)日：2001-01-16
申请号：US09082086
申请日：1998-05-20
申请人： Donald Barry , Glen Jorgensen , Bruce H. Edwards , Jeremy Fennelly
发明人： Donald Barry , Glen Jorgensen , Bruce H. Edwards , Jeremy Fennelly
IPC分类号： G01N2159
CPC分类号： G01N21/31
摘要： An optical sensor is disclosed for use in an interactive cell processing system that includes a plurality of sensors arranged for monitoring and providing sensor data to a control module that directs processing of biological cells. The sensors including an optical sensor for characterizing a fluid transferred in a sterile manner during the processing. The optical sensor includes a light source, a light detector, a cuvette and a control circuit. The light source is connected to a control circuit and is constructed and arranged to emit light of at least one selected wavelength directed toward the fluid. The cuvette is constructed as a part of a fluid distribution manifold that includes several conduits for transferring the sterile fluid during the processing, wherein the cuvette is constructed and arranged to convey the fluid. The light detector is connected to the control circuit and is constructed and arranged to detect light that was emitted from the source and has interacted with the fluid flowing inside the cuvette. The control circuit is constructed and arranged to characterize the fluid in the cuvette based on the detected light.
摘要翻译：公开了一种用于交互式电池处理系统中的光学传感器，该系统包括多个传感器，其布置成用于监视并向控制模块提供传感器数据，该控制模块指导生物细胞的处理。传感器包括用于表征处理期间以无菌方式转移的流体的光学传感器。光学传感器包括光源，光检测器，比色皿和控制电路。光源连接到控制电路，并被构造和布置成发射指向流体的至少一个选定波长的光。试管被构造为流体分配歧管的一部分，其包括用于在处理期间传送无菌流体的多个导管，其中反应杯被构造和布置成输送流体。光检测器连接到控制电路，并被构造和布置成检测从源发射并与在比色皿内流动的流体相互作用的光。控制电路被构造和布置成基于检测到的光来表征比色皿中的流体。

2. 发明授权

US06425414B2 Fluid management systems 失效
标题翻译：流体管理系统
公开(公告)号：US06425414B2
公开(公告)日：2002-07-30
申请号：US09849955
申请日：2001-05-04
申请人： Glen Jorgensen , Donald Barry , Jeremy Fennelly , Roy E. Martin, III , Mark Susser
发明人： Glen Jorgensen , Donald Barry , Jeremy Fennelly , Roy E. Martin, III , Mark Susser
IPC分类号： F17D114
CPC分类号： B04B7/08 , A61M1/0222 , A61M1/3687 , A61M1/3692 , A61M1/3693 , A61M1/3695 , A61M1/3696 , A61M1/3698 , A61M2202/0429 , A61M2205/128 , A61M2205/3393 , B04B5/0428 , B04B5/0442 , G01N2035/00217 , Y10S277/907 , Y10T137/87249 , A61M2202/0064
摘要： A device is provided for distributing a fluids from different sources to different destinations. The device receives fluids from a plurality of different sources and distributes the fluids out of a port to a destination. The device also receives fluid from the destination and transfers the fluid to another port out to another destination.
摘要翻译：提供了一种用于将流体从不同源分配到不同目的地的装置。该装置从多个不同的源接收流体并将流体从端口分配到目的地。该设备还从目的地接收流体，并将流体转移到另一个端口到另一个目的地。

3. 发明授权

US06852074B1 Biological processing apparatus for expressing fluid material 失效
标题翻译：用于表达流体物质的生物处理装置
公开(公告)号：US06852074B1
公开(公告)日：2005-02-08
申请号：US09082200
申请日：1998-05-20
申请人： Glen Jorgenson , Donald Barry , Bruce H. Edwards , John P. O'Brien , Victor Sacco, Jr.
发明人： Glen Jorgenson , Donald Barry , Bruce H. Edwards , John P. O'Brien , Victor Sacco, Jr.
IPC分类号： A61M1/02 , A61M1/36 , B04B5/04 , B04B11/00 , B04B15/02
CPC分类号： B04B5/0428 , A61M1/0222 , A61M1/3687 , A61M1/3692 , A61M1/3693 , A61M1/3696 , A61M1/3698 , A61M2202/0429 , A61M2205/128 , A61M2205/3393 , B04B5/0442 , A61M2202/0064
摘要： A method and apparatus for selectively expressing one or more selected fluid materials out of a fluid container, including a centrifuge rotor having a round centrifuge chamber of selected volume, a round expandable enclosure disposed within the centrifuge chamber having a rotation axis coincident with the central rotation axis and a flexible wall, a pump for controllably pumping a selected volume of expresser fluid into and out of the expandable enclosure wherein the fluid container is receivable within the centrifuge chamber, and a retaining mechanism for holding the fluid container within the centrifuge chamber in a coaxial position. The flexible wall of the fluid container is in contact with the flexible wall of the expandable enclosure.
摘要翻译：一种用于从流体容器中选择性地表达一种或多种所选择的流体材料的方法和装置，包括具有选定体积的圆形离心机室的离心机转子，设置在离心机室内的圆形可膨胀外壳，其具有与中心旋转重合的旋转轴线轴和柔性壁，泵，用于可控地将选定体积的表达流体泵入和流出可扩张外壳，其中流体容器可接收在离心机室内;以及保持机构，用于将流体容器保持在离心机室内同轴位置。流体容器的柔性壁与可膨胀外壳的柔性壁接触。

4. 发明申请

US20070262531A1 Rotating seals for cell processing systems 失效
标题翻译：电池处理系统的旋转密封
公开(公告)号：US20070262531A1
公开(公告)日：2007-11-15
申请号：US11635218
申请日：2006-12-06
申请人： Glen Jorgensen , Donald Barry , Mark Susser
发明人： Glen Jorgensen , Donald Barry , Mark Susser
IPC分类号： F16J15/34
CPC分类号： B04B7/08 , A61M1/0222 , A61M1/3687 , A61M1/3692 , A61M1/3693 , A61M1/3695 , A61M1/3696 , A61M1/3698 , A61M2202/0429 , A61M2205/128 , A61M2205/3393 , B04B5/0428 , B04B5/0442 , G01N2035/00217 , Y10S277/907 , Y10T137/87249 , A61M2202/0064
摘要： The invention provides an improved rotating seal apparatus including a plurality of concentrically spaced annular rotating seals. The invention also provides a rotating seal apparatus including a pressurized annular chamber surrounding an annular rotating seal.
摘要翻译：本发明提供一种改进的旋转密封装置，其包括多个同心间隔的环形旋转密封件。本发明还提供一种旋转密封装置，其包括围绕环形旋转密封件的加压环形室。

5. 发明申请

US20050143244A1 Apparatus and method for expressing fluid materials 审中-公开
标题翻译：用于表达流体材料的装置和方法
公开(公告)号：US20050143244A1
公开(公告)日：2005-06-30
申请号：US11053064
申请日：2005-02-07
申请人： Glen Jorgensen , Donald Barry , Bruce Edwards , John O'Brien , Victor Sacco
发明人： Glen Jorgensen , Donald Barry , Bruce Edwards , John O'Brien , Victor Sacco
IPC分类号： A61M1/02 , A61M1/36 , B04B5/04 , B01D43/00
CPC分类号： B04B5/0428 , A61M1/0222 , A61M1/3687 , A61M1/3692 , A61M1/3693 , A61M1/3696 , A61M1/3698 , A61M2202/0429 , A61M2205/128 , A61M2205/3393 , B04B5/0442 , A61M2202/0064
摘要： A method and apparatus for selectively expressing one ore more selected fluid materials out of a fluid container, including a centrifuge rotor having a round centrifuge chamber of selected volume, a round expandable enclosure disposed within the centrifuge chamber having a rotation axis coincident with the central rotation axis and a flexible wall, a pump for controllably pumping a selected volume of expressor fluid into and out of the expandable enclosure wherein the fluid container is receivable within the centrifuge chamber, and a retaining mechanism for holding the fluid container within the centrifuge chamber in a coaxial position. The flexible wall of the fluid container is in contact with the flexible wall of the expandable enclosure.
摘要翻译：一种用于从流体容器中选择性地表达一个或多个选定的流体材料的方法和装置，包括具有选定体积的圆形离心机室的离心机转子，设置在离心机室内的圆形可膨胀外壳，其具有与中心旋转重合的旋转轴线轴和柔性壁，用于可控地将选定体积的表达流体输入和流出可扩张外壳的泵，其中流体容器可接收在离心机室内，以及保持机构，用于将流体容器保持在离心机室内同轴位置。流体容器的柔性壁与可膨胀外壳的柔性壁接触。

6. 发明授权

US07425192B2 Apparatus for method for expressing fluid materials 失效
标题翻译：用于表达流体材料的方法的装置
公开(公告)号：US07425192B2
公开(公告)日：2008-09-16
申请号：US10914856
申请日：2004-08-09
申请人： Victor Sacco , Glen Jorgensen , Donald Barry , Bruce Edwards , John P. O'Brien
发明人： Victor Sacco , Glen Jorgensen , Donald Barry , Bruce Edwards , John P. O'Brien
IPC分类号： B04B11/00
CPC分类号： B04B5/0428 , A61M1/0222 , A61M1/3687 , A61M1/3692 , A61M1/3693 , A61M1/3696 , A61M1/3698 , A61M2202/0429 , A61M2205/128 , A61M2205/3393 , B04B5/0442 , A61M2202/0064
摘要： A method and apparatus for selectively expressing one or more selected fluid materials out of a fluid container, including a centrifuge rotor having a round centrifuge chamber of selected volume, a round expandable enclosure disposed within the centrifuge chamber having a rotation axis coincident with the central rotation axis and a flexible wall, a pump for controllably pumping a selected volume of expressor fluid into and out of the expandable enclosure wherein the fluid container is receivable with the centrifuge chamber, and a retaining mechanism for holding the fluid container within the centrifuge chamber in a coaxial position. The flexible wall of the fluid container is in contact with the flexible wall of the expandable enclosure.
摘要翻译：一种用于从流体容器中选择性地表达一种或多种所选择的流体材料的方法和装置，包括具有选定体积的圆形离心机室的离心机转子，设置在离心机室内的圆形可膨胀外壳，其具有与中心旋转重合的旋转轴线轴和柔性壁，用于可控地将选定体积的表达流体输入和流出扩展外壳的泵，其中流体容器可以用离心机容纳;以及保持机构，用于将流体容器保持在离心机室内同轴位置。流体容器的柔性壁与可膨胀外壳的柔性壁接触。

7. 发明申请

US20050009680A1 Apparatus for method for expressing fluid materials 失效
标题翻译：用于表达流体材料的方法的装置
公开(公告)号：US20050009680A1
公开(公告)日：2005-01-13
申请号：US10914856
申请日：2004-08-09
申请人： Victor Sacco , Glen Jorgensen , Donald Barry , Bruce Edwards , John O'Brien
发明人： Victor Sacco , Glen Jorgensen , Donald Barry , Bruce Edwards , John O'Brien
IPC分类号： A61M1/02 , A61M1/36 , B04B5/04 , B04B11/00
CPC分类号： B04B5/0428 , A61M1/0222 , A61M1/3687 , A61M1/3692 , A61M1/3693 , A61M1/3696 , A61M1/3698 , A61M2202/0429 , A61M2205/128 , A61M2205/3393 , B04B5/0442 , A61M2202/0064
摘要： A method and apparatus for selectively expressing one or more selected fluid materials out of a fluid container, including a centrifuge rotor having a round centrifuge chamber of selected volume, a round expandable enclosure disposed within the centrifuge chamber having a rotation axis coincident with the central rotation axis and a flexible wall, a pump for controllably pumping a selected volume of expressor fluid into and out of the expandable enclosure wherein the fluid container is receivable with the centrifuge chamber, and a retaining mechanism for holding the fluid container within the centrifuge chamber in a coaxial position. The flexible wall of the fluid container is in contact with the flexible wall of the expandable enclosure.
摘要翻译：一种用于从流体容器中选择性地表达一种或多种所选择的流体材料的方法和装置，包括具有选定体积的圆形离心机室的离心机转子，设置在离心机室内的圆形可膨胀外壳，其具有与中心旋转重合的旋转轴线轴和柔性壁，用于可控地将选定体积的表达流体输入和流出扩展外壳的泵，其中流体容器可以用离心机容纳;以及保持机构，用于将流体容器保持在离心机室内同轴位置。流体容器的柔性壁与可膨胀外壳的柔性壁接触。

8. 发明授权

US06439577B2 Rotating seals for cell processing systems 失效
公开(公告)号：US06439577B2
公开(公告)日：2002-08-27
申请号：US09760684
申请日：2001-01-16
申请人： Glen Jorgensen , Donald Barry , Mark Susser
发明人： Glen Jorgensen , Donald Barry , Mark Susser
IPC分类号： F16J1534
CPC分类号： B04B7/08 , A61M1/0222 , A61M1/3687 , A61M1/3692 , A61M1/3693 , A61M1/3695 , A61M1/3696 , A61M1/3698 , A61M2202/0429 , A61M2205/128 , A61M2205/3393 , B04B5/0428 , B04B5/0442 , G01N2035/00217 , Y10S277/907 , Y10T137/87249 , A61M2202/0064
摘要： The invention provides an improved rotating seal apparatus including a plurality of concentrically spaced annular rotating seals. The invention also provides a rotating seal apparatus including a pressurized annular chamber surrounding an annular rotating seal.

9. 发明授权

US07594663B2 Rotating seals for cell processing systems 失效
公开(公告)号：US07594663B2
公开(公告)日：2009-09-29
申请号：US11635218
申请日：2006-12-06
申请人： Glen Jorgensen , Donald Barry , Mark Susser
发明人： Glen Jorgensen , Donald Barry , Mark Susser
IPC分类号： F16J15/34
CPC分类号： B04B7/08 , A61M1/0222 , A61M1/3687 , A61M1/3692 , A61M1/3693 , A61M1/3695 , A61M1/3696 , A61M1/3698 , A61M2202/0429 , A61M2205/128 , A61M2205/3393 , B04B5/0428 , B04B5/0442 , G01N2035/00217 , Y10S277/907 , Y10T137/87249 , A61M2202/0064
摘要： The invention provides an improved rotating seal apparatus including a plurality of concentrically spaced annular rotating seals. The invention also provides a rotating seal apparatus including a pressurized annular chamber surrounding an annular rotating seal.

10. 发明申请

US20060040818A1 Rotating seals for cell processing systems 审中-公开
公开(公告)号：US20060040818A1
公开(公告)日：2006-02-23
申请号：US11256880
申请日：2005-10-24
申请人： Glen Jorgensen , Donald Barry , Mark Susser
发明人： Glen Jorgensen , Donald Barry , Mark Susser
IPC分类号： B04B7/08
CPC分类号： B04B7/08 , A61M1/0222 , A61M1/3687 , A61M1/3692 , A61M1/3693 , A61M1/3695 , A61M1/3696 , A61M1/3698 , A61M2202/0429 , A61M2205/128 , A61M2205/3393 , B04B5/0428 , B04B5/0442 , G01N2035/00217 , Y10S277/907 , Y10T137/87249 , A61M2202/0064
摘要： The invention provides an improved rotating seal apparatus including a plurality of concentrically spaced annular rotating seals. The invention also provides a rotating seal apparatus including a pressurized annular chamber surrounding an annular rotating seal.

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