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1. 发明申请

US20050101980A1 Method and apparatus for improving success rate of blood yield from a fingerstick 有权
标题翻译：用于提高指尖成功率的方法和装置
公开(公告)号：US20050101980A1
公开(公告)日：2005-05-12
申请号：US10363509
申请日：2002-06-12
申请人： Don Alden , Dominique Freeman , Paul Lum , Vladimir Drbal , Dirk Boecker , Edward Verdonk
发明人： Don Alden , Dominique Freeman , Paul Lum , Vladimir Drbal , Dirk Boecker , Edward Verdonk
IPC分类号： A61B5/15 , A61B17/32
CPC分类号： A61B5/150022 , A61B5/150061 , A61B5/150068 , A61B5/150083 , A61B5/150099 , A61B5/150167 , A61B5/150427 , A61B5/150503
摘要： Blood samples can be collected without substantial contamination from ambient air, such that the blood sample may be analysed accurately for gaseous components such as oxygen and carbon dioxide. An embodiment of the device has integrated actuation, lancing, and sample acquisition components, which in some embodiments are miniatuized and/or disposable.
摘要翻译：可以收集血液样本而没有来自环境空气的实质污染，使得可以准确地分析血液样品用于气体组分如氧气和二氧化碳。该装置的一个实施例具有集成的致动，采血和采样部件，其在一些实施例中是微型化和/或一次性的。

2. 发明申请

US20050101979A1 Blood sampling apparatus and method 有权
标题翻译：采血仪及方法
公开(公告)号：US20050101979A1
公开(公告)日：2005-05-12
申请号：US10363508
申请日：2002-06-12
申请人： Don Alden , Dominique Freeman , Paul Lum , Vladimir Drbal , Dirk Boecker
发明人： Don Alden , Dominique Freeman , Paul Lum , Vladimir Drbal , Dirk Boecker
IPC分类号： A61B5/151 , A61B5/15 , A61B5/155 , A61B17/32
CPC分类号： A61B5/15186 , A61B5/150022 , A61B5/150099 , A61B5/150152 , A61B5/150167 , A61B5/15019 , A61B5/150213 , A61B5/150221 , A61B5/150229 , A61B5/150412 , A61B5/150435 , A61B5/150503 , A61B5/150572 , A61B5/150916 , A61B5/15111 , A61B5/15117 , A61B5/15146 , A61B5/15151 , A61B5/15174
摘要： Blood samples can be collected without substantial contamination from ambient air, such that the blood sample may be analysed accurately for gaseous components such as oxygen and carbon dioxide. An embodiment of th device has integrated actuation, lancing, and sample acquisition components, which in some embodiments are miniaturized and/or disposable.
摘要翻译：可以收集血液样本而没有来自环境空气的实质污染，使得可以准确地分析血液样品用于气体组分如氧气和二氧化碳。该装置的一个实施例具有集成的致动，采血和采样部件，其在一些实施例中是小型化和/或一次性的。

3. 发明授权

US07682318B2 Blood sampling apparatus and method 有权
标题翻译：采血仪及方法
公开(公告)号：US07682318B2
公开(公告)日：2010-03-23
申请号：US10363508
申请日：2002-06-12
申请人： Don Alden , Dominique M. Freeman , Paul Lum , Vladimir Drbal , Catherine K. Templin , Dirk Boecker
发明人： Don Alden , Dominique M. Freeman , Paul Lum , Vladimir Drbal , Catherine K. Templin , Dirk Boecker
IPC分类号： A61B5/00
CPC分类号： A61B5/15186 , A61B5/150022 , A61B5/150099 , A61B5/150152 , A61B5/150167 , A61B5/15019 , A61B5/150213 , A61B5/150221 , A61B5/150229 , A61B5/150412 , A61B5/150435 , A61B5/150503 , A61B5/150572 , A61B5/150916 , A61B5/15111 , A61B5/15117 , A61B5/15146 , A61B5/15151 , A61B5/15174
摘要： Blood samples can be collected without substantial contamination from ambient air, such that the blood sample may be analyzed accurately for gaseous components such as oxygen and carbon dioxide. An embodiment of the device has integrated actuation, lancing, and sample acquisition components, which in some embodiments are miniaturized and/or disposable.
摘要翻译：可以收集血液样本而没有来自环境空气的实质污染，使得可以准确地分析血液样品用于气体组分如氧气和二氧化碳。该装置的一个实施例具有集成的致动，采血和采样部件，其在一些实施例中是小型化和/或一次性的。

4. 发明授权

US07699791B2 Method and apparatus for improving success rate of blood yield from a fingerstick 有权
标题翻译：用于提高指尖成功率的方法和装置
公开(公告)号：US07699791B2
公开(公告)日：2010-04-20
申请号：US10363509
申请日：2002-06-12
申请人： Don Alden , Dominique M. Freeman , Paul Lum , Vladimir Drbal , Dirk Boecker , Edward D. Verdonk
发明人： Don Alden , Dominique M. Freeman , Paul Lum , Vladimir Drbal , Dirk Boecker , Edward D. Verdonk
IPC分类号： A61B5/00
CPC分类号： A61B5/150022 , A61B5/150061 , A61B5/150068 , A61B5/150083 , A61B5/150099 , A61B5/150167 , A61B5/150427 , A61B5/150503
摘要： Blood samples can be collected without substantial contamination from ambient air, such that the blood sample may be analyzed accurately for gaseous components such as oxygen and carbon dioxide. An embodiment of the device has integrated actuation, lancing, and sample acquisition components, which in some embodiments are miniatuized and/or disposable.
摘要翻译：可以收集血液样本而没有来自环境空气的实质污染，使得可以准确地分析血液样品用于气体组分如氧气和二氧化碳。该装置的一个实施例具有集成的致动，采血和采样部件，其在一些实施例中是微型化和/或一次性的。

5. 发明授权

US07344894B2 Thermal regulation of fluidic samples within a diagnostic cartridge 有权
标题翻译：诊断墨盒内流体样品的热调节
公开(公告)号：US07344894B2
公开(公告)日：2008-03-18
申请号：US09981440
申请日：2001-10-16
申请人： Michael Greenstein , Frederick Stawitcke , Vladimir Drbal , Ganapati R. Mauze , Rick Pittaro , Richard Pering , Ed Verdonk , Don Alden , Frank Ingle , Klaus Stefan Drese , Hans-Joachim Hartmann , Olaf Soerensen
发明人： Michael Greenstein , Frederick Stawitcke , Vladimir Drbal , Ganapati R. Mauze , Rick Pittaro , Richard Pering , Ed Verdonk , Don Alden , Frank Ingle , Klaus Stefan Drese , Hans-Joachim Hartmann , Olaf Soerensen
IPC分类号： G01N33/543
CPC分类号： B01L7/00 , B01L3/5027 , B01L2300/1822 , B01L2300/1827 , B01L2300/1861 , B01L2300/1872
摘要： A method and miniature analytical device with thermal regulation of reactant using a localized heat source capable of emitting electromagnetic radiation, such as light emitting diodes (“LED”s) and vertical cavity surface emitting lasers (“VCSEL”s), generating internal heat, such as resistive, inductive and Peltier heaters, or external heating. The miniature analytical device comprises of array of temperature-controlled zones to restrict the volume heated and localize the heating by having the localized heat source comprise an array of emitters or heaters.
摘要翻译：使用能够发射电磁辐射的局部热源的反应物的热调节方法和微型分析装置，例如发光二极管（“LED”）和垂直腔表面发射激光器（“VCSEL”），产生内部热量，例如电阻式，感应型和珀耳帖式加热器，或外部加热。微型分析装置包括温度控制区的阵列，以通过使局部热源包括发射器或加热器的阵列来限制加热的体积并定位加热。

6. 发明申请

US20060263262A1 Microfluidics structure and method 审中-公开
标题翻译：微流体结构与方法
公开(公告)号：US20060263262A1
公开(公告)日：2006-11-23
申请号：US11401698
申请日：2006-04-10
申请人： Vladimir Drbal
发明人： Vladimir Drbal
IPC分类号： B01L3/02
CPC分类号： B01L3/50273 , B01L3/502715 , B01L2200/027 , B01L2400/0487 , B01L2400/0655
摘要： A liquid-filled microfluidics assembly and method of forming the same are disclosed. The assembly includes a non-metallic substrate having a liquid-filled microfluidics structure that includes a microchannel and a chamber in fluid communication therewith, and a metal tube embedded in the substrate, communicating with the chamber and sealed by crimping at a region along its length, thus to seal the structure adjacent the chamber. In forming the assembly, a polymer substrate having a microfluidics structure including a microchannel and a chamber in fluid communication therewith is molded around a metal tube communicating the chamber with a port at which liquid can be drawn or pumped into the structure. The structure is filled by drawing or pumping liquid into the structure through the port, and liquid in the structure, adjacent the chamber, is sealed by crimping the tube.
摘要翻译：公开了一种液体填充微流体组件及其形成方法。该组件包括具有液体填充的微流体结构的非金属基底，该液体填充微流体结构包括微通道和与其流体连通的室，以及镶嵌在基底中的金属管，与该腔连通并通过在其长度的区域，从而密封邻近室的结构。在形成组件时，具有包括微通道的微流体结构和与其流体连通的室的聚合物基板被模制在金属管的周围，该金属管与可将液体抽吸或泵入结构的端口连通。该结构通过端口将液体吸入或泵送到结构体中而填充，并且通过压接管将密封在结构体中的邻近室的液体被密封。

7. 发明授权

US07001344B2 Blood sampling device with diaphragm actuated lancet 有权
公开(公告)号：US07001344B2
公开(公告)日：2006-02-21
申请号：US10173236
申请日：2002-06-12
申请人： Dominique M. Freeman , Vladimir Drbal
发明人： Dominique M. Freeman , Vladimir Drbal
IPC分类号： A61B5/00
CPC分类号： A61B5/15142 , A61B5/150022 , A61B5/150099 , A61B5/150221 , A61B5/150412 , A61B5/150503 , A61B5/150572 , A61B5/150809 , A61B5/150824 , A61B5/150832 , A61B5/15109 , A61B5/15121 , A61B5/15123 , A61B5/15125 , A61B5/15144
摘要： A device and method to obtain a blood sample in a sealed configuration. The device includes a sampling assembly having a driver, a lancet, and a blood reservoir, and a pad having a proximal side and a distal side. The proximal side of the pad conforms to the shape of a skin area, and the distal side is attached to the sampling assembly. The pad and the sampling assembly are configured to provide a sealed configuration around the skin area for transferring blood from the skin area to the blood reservoir.

8. 发明授权

US5529752A Analytical work station 失效
标题翻译：分析工作站
公开(公告)号：US5529752A
公开(公告)日：1996-06-25
申请号：US361980
申请日：1994-12-22
申请人： George Pontis , Michael Lacy , Vladimir Drbal , Calvin Chow , Thomas Smith , Rick Smethers , Debra A. Ross , Gregory Kirk , Jonathan Briggs , Lev Leytes , Suresh N. Mehta
发明人： George Pontis , Michael Lacy , Vladimir Drbal , Calvin Chow , Thomas Smith , Rick Smethers , Debra A. Ross , Gregory Kirk , Jonathan Briggs , Lev Leytes , Suresh N. Mehta
IPC分类号： G01N33/53 , G01N33/543 , G01N35/00 , G01N35/10
CPC分类号： G01N35/00009 , G01N33/5302 , G01N33/54366 , G01N35/00029 , G01N2035/00138 , G01N2035/00485 , Y10S435/97 , Y10T436/11 , Y10T436/112499 , Y10T436/25 , Y10T436/25375
摘要： This invention encompasses a work station for conducting assays which comprises filtering assembly, a slide reading assembly, and a slide with a porous filter membrane wherein the slide has a means for aligning the slide within the filter assembly to filter reagents on predetermined portions of the porous filter membrane and also to position the slide in the slide reading assembly so that detection will occur in those same predetermined locations.
摘要翻译：本发明包括用于进行测定的工作站，其包括过滤组件，滑动读取组件和具有多孔过滤膜的滑块，其中滑块具有用于使过滤器组件内的滑块对准在多孔过滤器的预定部分上过滤试剂的装置过滤膜并且还将滑块定位在滑动读取组件中，使得检测将发生在那些相同的预定位置。

9. 发明授权

US5252293A Analytical slide with porous filter membrane 失效
标题翻译：分析幻灯片与多孔过滤膜
公开(公告)号：US5252293A
公开(公告)日：1993-10-12
申请号：US297767
申请日：1989-01-17
申请人： Vladimir Drbal , Calvin Chow , Rick Smethers , Debra A. Ross , Gregory Kirk , Briggs, Jonathan , Lev Leytes , Suresh N. Mehta
发明人： Vladimir Drbal , Calvin Chow , Rick Smethers , Debra A. Ross , Gregory Kirk , Briggs, Jonathan , Lev Leytes , Suresh N. Mehta
IPC分类号： G01N33/53 , G01N33/543 , G01N35/00 , C12Q1/00
CPC分类号： G01N35/00009 , G01N33/5302 , G01N33/54366 , G01N35/00029 , G01N2035/00138 , G01N2035/00485 , Y10S435/97 , Y10T436/11 , Y10T436/112499 , Y10T436/25 , Y10T436/25375
摘要： This invention encompasses a slide reading assembly, and a slide with a porous filter membrane wherein the slide has a means for aligning the slide within a filter assembly to filter reagents on predetermined portions of the porous filter membrane and also to position the slide in a slide reading assembly so that detection will occur in those same predetermined locations.
摘要翻译：本发明包括滑动读取组件和具有多孔过滤膜的滑块，其中滑块具有用于使过滤器组件内的滑块对准在多孔过滤膜的预定部分上过滤试剂的装置，并且还将滑块定位在滑块读取组件，使得检测将发生在那些相同的预定位置。

10. 发明授权

US4804197A Clamp device with radially split head 失效
标题翻译：带径向分流头的夹具
公开(公告)号：US4804197A
公开(公告)日：1989-02-14
申请号：US116021
申请日：1987-11-03
申请人： Vladimir Drbal
发明人： Vladimir Drbal
IPC分类号： H01R4/30 , B23B31/20
CPC分类号： H01R4/308 , Y10T279/17299 , Y10T279/17341 , Y10T403/535
摘要： A clamping device for supporting a workpiece in a clamped condition. The device includes a split head fastener composed of a head having exterior and interior surfaces, and a threaded shaft attached to the head and extending substantially normally from the interior surface. The head is segmented by slots extending from the exterior surface toward the interior surface, and further defines a passageway extending inwardly along the axis from the exterior surface. To clamp a workpiece in the device, a tightening member carried on the shaft is rotated to bring it into contact with the interior surface of the head, in an outer surface region thereof only. This contact forces the segments surrounding the passageway to pivot toward the axis of the passageway, causing clamping of a workpiece received in the passageway.
摘要翻译：一种用于在夹紧状态下支撑工件的夹紧装置。该装置包括由具有外表面和内表面的头部组成的分割头紧固件，以及附接到头部并且从内表面基本上正常延伸的螺纹轴。头部由从外表面向内表面延伸的狭槽分段，并且还限定从外表面沿轴线向内延伸的通道。为了将工件夹持在装置中，承载在轴上的紧固构件被旋转以使其仅在其外表面区域中与头部的内表面接触。该接触迫使围绕通道的段朝向通道的轴线枢转，从而夹紧接收在通道中的工件。

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