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1. 发明授权

US5529752A Analytical work station 失效
标题翻译：分析工作站
公开(公告)号：US5529752A
公开(公告)日：1996-06-25
申请号：US361980
申请日：1994-12-22
申请人： George Pontis , Michael Lacy , Vladimir Drbal , Calvin Chow , Thomas Smith , Rick Smethers , Debra A. Ross , Gregory Kirk , Jonathan Briggs , Lev Leytes , Suresh N. Mehta
发明人： George Pontis , Michael Lacy , Vladimir Drbal , Calvin Chow , Thomas Smith , Rick Smethers , Debra A. Ross , Gregory Kirk , Jonathan Briggs , Lev Leytes , Suresh N. Mehta
IPC分类号： G01N33/53 , G01N33/543 , G01N35/00 , G01N35/10
CPC分类号： G01N35/00009 , G01N33/5302 , G01N33/54366 , G01N35/00029 , G01N2035/00138 , G01N2035/00485 , Y10S435/97 , Y10T436/11 , Y10T436/112499 , Y10T436/25 , Y10T436/25375
摘要： This invention encompasses a work station for conducting assays which comprises filtering assembly, a slide reading assembly, and a slide with a porous filter membrane wherein the slide has a means for aligning the slide within the filter assembly to filter reagents on predetermined portions of the porous filter membrane and also to position the slide in the slide reading assembly so that detection will occur in those same predetermined locations.
摘要翻译：本发明包括用于进行测定的工作站，其包括过滤组件，滑动读取组件和具有多孔过滤膜的滑块，其中滑块具有用于使过滤器组件内的滑块对准在多孔过滤器的预定部分上过滤试剂的装置过滤膜并且还将滑块定位在滑动读取组件中，使得检测将发生在那些相同的预定位置。

2. 发明授权

US4676640A Fluctuation analysis for enhanced particle detection 失效
标题翻译：增强粒子检测的波动分析
公开(公告)号：US4676640A
公开(公告)日：1987-06-30
申请号：US650320
申请日：1984-09-12
申请人： Jonathan Briggs
发明人： Jonathan Briggs
IPC分类号： G01J1/00 , G01J1/42 , G01N15/14 , G01N21/64 , G01N33/48 , G01N33/483 , G01N33/49 , G01N33/53 , G01N33/536 , G01N33/542
CPC分类号： G01N33/542 , G01N21/64
摘要： An improvement is disclosed in a method for measuring intensity fluctuations of an electromagnetic signal of wavelength between about 350 nm to 1200 nm from a liquid medium. The improvement comprises autocorrelating the intensity of the signal over a non-zero interval the duration of which is short compared to the mean duration of the fluctuations. The method has particular applciations in the diagnostic area, particularly where such fluctuations are a result of the presence of fluroscent particles in a liquid medium. Methods are also disclosed for determining an analyte in a sample suspected of containing such analyte.
摘要翻译：在从液体介质测量波长在约350nm至1200nm之间的电磁信号的强度波动的方法中公开了一种改进。该改进包括在非零间隔上自动相关信号的强度，其持续时间与波动的平均持续时间相比较短。该方法在诊断区域中具有特别的应用，特别是在这种波动是液体介质中存在微生物颗粒的结果的情况下。还公开了用于确定怀疑含有此类分析物的样品中的分析物的方法。

3. 发明授权

US4560881A Method and apparatus for enhanced detection of electromagnetic signals 失效
标题翻译：用于增强电磁信号检测的方法和装置
公开(公告)号：US4560881A
公开(公告)日：1985-12-24
申请号：US589183
申请日：1984-03-13
申请人： Jonathan Briggs
发明人： Jonathan Briggs
IPC分类号： G01N21/51 , G01B11/08 , G01J1/00 , G01N15/02 , G01N21/47 , G01N21/64 , G02B27/48 , F21V9/16
CPC分类号： G01N21/64 , G02B27/48 , G01N2015/0222 , G01N21/47 , G01N21/6428 , G01N2201/06113
摘要： A method and apparatus are described for enhanced detection relative to background radiation, of electromagnetic signals from an emitter of radiation in response to incident radiation. The method and apparatus have particular applicability in the field of particle detection, e.g. fluorescent particle detection.
摘要翻译：描述了一种方法和装置，用于相对于背景辐射增强对响应于入射辐射的辐射发射器的电磁信号的检测。该方法和装置在颗粒检测领域中具有特别的适用性。荧光粒子检测。

4. 发明授权

US4739171A Limited volume method and apparatus for particle counting 失效
标题翻译：有限体积法和粒子计数装置
公开(公告)号：US4739171A
公开(公告)日：1988-04-19
申请号：US789994
申请日：1985-10-22
申请人： Jonathan Briggs
发明人： Jonathan Briggs
IPC分类号： G01N21/64 , G01N33/542 , G01T1/10
CPC分类号： G01N33/542 , G01N21/6428 , G01N2201/08
摘要： A method and apparatus for determining the presence of particles in a fluorescent dispersion which exceed either a predetermined fluorescence intensity or size are disclosed. The method and apparatus involve the irradiation of the dispersion with excitation light, the examination of the fluorescent light entering an optical fiber from a portion of the excited region small enough to permit only a low probability that more than one particle of interest is present in the volume during a predetermined period of time, and the measurement of the emitted fluorescence entering the fiber, substantially free of excitation light, to the extent that the fluorescence differs in intensity from that of the dispersion in the absence of the particle.
摘要翻译：公开了一种用于确定荧光分散体中超过预定荧光强度或尺寸的颗粒的存在的方法和装置。该方法和装置包括用激发光照射分散体，从激发区域的一部分进入光纤的荧光的检查小到足以允许仅有一个以上感兴趣的颗粒存在的可能性低在预定时间段内的体积，以及基本上不含激发光的进入纤维的发射荧光的测量，使得在不存在颗粒的情况下荧光的强度与分散体的强度不同。

5. 发明授权

US4737464A Solid-state optical assay imaging apparatus 失效
标题翻译：固态光学测定成像装置
公开(公告)号：US4737464A
公开(公告)日：1988-04-12
申请号：US780485
申请日：1985-09-26
申请人： Harden M. McConnell , Jonathan Briggs , John W. Parce
发明人： Harden M. McConnell , Jonathan Briggs , John W. Parce
IPC分类号： G01N21/25 , G01N21/27 , G01N21/00
CPC分类号： G01N21/253 , G01N21/272 , G01N21/6428 , G01N2201/0461 , Y10S436/805 , Y10S436/807 , Y10T436/11
摘要： An apparatus for determining a characteristic of a signal modulating component related to an analyte of interest at an assay site by measuring light modulated by the component. A light source uniformly illuminates the assay site and a reference site. The light is directed from the sites onto a group of memory cells on the surface of a random access memory. The memory cells will decay from a logical 1 to a logical 0 due to the light over a period of time which is a function of the intensity of the light and the reference voltage of the memory cells marking the difference between a 1 and a 0. The digital state of each of the memory cells in the group is measured a predetermined exposure time. The measured states of a group of memory cells corresponding to the assay site are compared to the memory cell states for a reference group. The measured states are then analyzed to determine a characteristic of the analyte.
摘要翻译：一种用于通过测量由该组分调制的光来确定在测定部位与感兴趣分析物相关的信号调节成分的特征的装置。光源均匀地照射了测定部位和参考部位。光从站点引导到随机存取存储器表面上的一组存储器单元上。存储器单元将由于在一段时间内的光而从逻辑1衰减到逻辑0，该时间段是光的强度和记录单元的参考电压的函数，标记1和0之间的差。在预定的曝光时间内测量组中的每个存储单元的数字状态。将对应于测定位点的一组存储器单元的测量状态与参考组的存储器单元状态进行比较。然后分析测量的状态以确定分析物的特征。

6. 发明授权

US6043036A Method of sequencing nucleic acids by shift registering 失效
标题翻译：通过移位登记测序核酸的方法
公开(公告)号：US6043036A
公开(公告)日：2000-03-28
申请号：US977931
申请日：1997-11-24
申请人： Randy M. McCormick , Jonathan Briggs
发明人： Randy M. McCormick , Jonathan Briggs
IPC分类号： C12Q1/68 , C12P19/34
CPC分类号： C12Q1/6869 , G06F19/22
摘要： The present invention describes a method of sequencing nucleic acids in which mixtures of oligonucleotide fragments are derived from sequencing reactions using combinations of the 2',3'-dideoxynucleoside 5'-triphosphate or 3' deoxynucleoside 5'-triphosphate terminators and appropriate concentrations of four dNTPs (2'-deoxynucleoside 5' triphosphates, e.g., dATP, dCTP, dGTP, dTTP, dITP, 7-deaza-GTP). These fragments are generated by enzymatic extension of a primer hybridized to the single-stranded template DNA to be sequenced. In contrast to common slab gel sequencing methods, the method of the instant invention does not require precise alignment of the four separation sets of the terminated fragments to permit deduction of the DNA sequence. In addition, the method possesses inherent redundancy in the separations, which facilitates sequence assignment by resolving sequence uncertainties or anomalies.
摘要翻译：本发明描述了使用2'，3'-双脱氧核苷5'-三磷酸终止子和3'脱氧核苷5'-三磷酸终止子的组合以及合适浓度的4个核苷酸的序列来测序核酸的方法，其中寡核苷酸片段的混合物来源于测序反应 dNTPs（2'-脱氧核苷5'三磷酸，例如dATP，dCTP，dGTP，dTTP，dITP，7-脱氮-GTP）。这些片段通过与要测序的单链模板DNA杂交的引物的酶促延伸产生。与普通平板凝胶测序方法相反，本发明的方法不需要对终止的片段的四个分离组进行精确的比对以允许推断DNA序列。此外，该方法在分离中具有固有的冗余性，这有助于通过解析序列不确定性或异常来进行序列分配。

7. 发明授权

US5560811A Capillary electrophoresis apparatus and method 失效
标题翻译：毛细管电泳仪及方法
公开(公告)号：US5560811A
公开(公告)日：1996-10-01
申请号：US408683
申请日：1995-03-21
申请人： Jonathan Briggs , Randy M. McCormick , David W. Hoyt
发明人： Jonathan Briggs , Randy M. McCormick , David W. Hoyt
IPC分类号： B82B1/00 , G01N27/447 , G01N35/00 , B01D57/02 , B01D59/42 , C07K1/26 , C25B7/00
CPC分类号： G01N27/44782 , B01L9/065 , G01N27/44743 , G01N2035/00237
摘要： This invention involves method and apparatus for multiplexing electrophoresis analysis. An array of samples in multi well plates are simultaneously transferred to an array of electrophoresis column where electrophoresis is simultaneously carried out followed by analysis of the columns. The methods and apparatus of this invention are, for example, useful for DNA analysis, including sequencing, and for measuring reactions between specifically binding proteins and their binding partners.
摘要翻译：本发明涉及多重电泳分析的方法和装置。同时将多孔板中的样品阵列转移到电泳柱阵列，同时进行电泳，然后分析色谱柱。本发明的方法和装置例如可用于DNA分析，包括测序，以及用于测量特异性结合蛋白质及其结合配偶体之间的反应。

8. 发明授权

US4956275A Migratory detection immunoassay 失效
标题翻译：迁移检测免疫测定
公开(公告)号：US4956275A
公开(公告)日：1990-09-11
申请号：US38294
申请日：1987-04-14
申请人： Robert F. Zuk , Richard D. Armenta , Jonathan Briggs
发明人： Robert F. Zuk , Richard D. Armenta , Jonathan Briggs
IPC分类号： G01N33/543 , G01N33/558 , G01N37/00
CPC分类号： G01N33/54386 , G01N33/558 , Y10S435/805 , Y10S435/97 , Y10S436/807 , Y10S436/81
摘要： Novel methods and devices are provided for detecting analytes, where the sample is placed upstream from a reagent which is a component of a signal-producing system. The detection zone is provided upstream from the sample, where the amount of reagent which becomes bound at two sites is determined and the two values used for an accurate determination of an analyte.
摘要翻译：提供了用于检测分析物的新方法和装置，其中将样品置于作为信号产生系统的组分的试剂的上游。检测区设置在样品的上游，其中确定在两个位点处结合的试剂的量，并且将两个值用于准确测定分析物。

9. 发明授权

US4564598A Limited volume method for particle counting 失效
标题翻译：有限体积法计算粒子
公开(公告)号：US4564598A
公开(公告)日：1986-01-14
申请号：US397285
申请日：1982-07-12
申请人： Jonathan Briggs
发明人： Jonathan Briggs
IPC分类号： G01N15/14 , G01N15/02 , G01N15/06 , G01N21/64 , G01N33/48 , G01N33/49 , G01N33/542 , G01N33/543 , G01N33/50
CPC分类号： G01N21/6428 , G01N33/542 , G01N2015/0222 , G01N2021/6484 , G01N2201/08 , Y10S436/805
摘要： A method and apparatus for determining the presence of particles in a fluorescent dispersion which exceed either a predetermined fluorescence intensity or size are disclosed. The method and apparatus involve the irradiation of the dispersion with excitation light, the examination of the fluorescent light entering an optical fiber from a portion of the excited region small enough to permit only a low probability that more than one particle of interest is present in the volume during a predetermined period of time, and the measurement of the emitted fluorescence entering the fiber, substantially free of excitation light, to the extent that the fluorescence differs in intensity from that of the dispersion in the absence of the particle.
摘要翻译：公开了一种用于确定荧光分散体中超过预定荧光强度或尺寸的颗粒的存在的方法和装置。该方法和装置包括用激发光照射分散体，从激发区域的一部分进入光纤的荧光的检查小到足以允许仅有一个以上感兴趣的颗粒存在的可能性低在预定时间段内的体积，以及基本上不含激发光的进入纤维的发射荧光的测量，使得在不存在颗粒的情况下荧光的强度与分散体的强度不同。

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