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1. 发明授权

US06594006B1 Method and array for detecting the position of a plane scanned with a laser scanner 失效
标题翻译：用于检测用激光扫描器扫描的平面的位置的方法和阵列
公开(公告)号：US06594006B1
公开(公告)日：2003-07-15
申请号：US09744122
申请日：2001-03-16
申请人： Dirk Muehlhoff , Guenther Rudolph , Stefan Schmidt , Gerhard Doering , Guenter Berthel , Thomas Hartmann
发明人： Dirk Muehlhoff , Guenther Rudolph , Stefan Schmidt , Gerhard Doering , Guenter Berthel , Thomas Hartmann
IPC分类号： G01B1126
CPC分类号： G05B19/402 , G05B2219/37558 , G05B2219/37563 , G05B2219/50028 , G05B2219/50133 , G05D3/12
摘要： A method and an arrangement for detecting the position of the plane XY of an object, which plane XY is to be scanned, and for its positioning in the focal plane X′Y′ of a laser scanner, preferably for a laser scanning microscope. According to the disclosure, it is provided in a method of the type described above that, after a rough orientation of the object carried out by placing on an object holder, a laser beam is directed successively in time to at least three different points P1, P2 . . . Pn located in the scan plane XY of the object and, in doing so, each of the reflections proceeding from the points P1, P2 . . . Pn is imaged on a position-sensitive detector, an actual position value is determined at the detector for each reflection and is compared with a stored reference position value, adjustment commands for changing the inclination of the object holder are obtained from the deviations of the actual position values from the reference position values, and the inclination of the object holder is changed on the basis of these adjustment commands until points P1, P2 . . . Pn are located in the focal plane X′Y′ of the laser scanner.
摘要翻译：一种用于检测物体的平面XY的位置的方法和装置，该平面XY将被扫描平面XY，并且用于其定位在激光扫描仪的焦平面X'Y'中，优选地用于激光扫描显微镜。根据本发明，提供了一种上述类型的方法，在通过放置在物体保持器上进行物体的粗略取向之后，将激光束在时间上连续地指向至少三个不同点P1， P2。。。 Pn位于物体的扫描平面XY中，并且在这样做时，每个反射从点P1，P2进行。。。 Pn在位置敏感检测器上成像，在检测器处为每次反射确定实际位置值，并与存储的参考位置值进行比较，从实际的偏差获得用于改变物体保持器的倾斜度的调节命令基准位置值的位置值，并且基于这些调整指令改变对象保持器的倾斜直到点P1，P2。。。 Pn位于激光扫描器的焦平面X'Y'中。

2. 发明授权

US06483588B1 Arrangement for detecting biomolecular reactions and interactions 失效
标题翻译：检测生物分子反应和相互作用的布置
公开(公告)号：US06483588B1
公开(公告)日：2002-11-19
申请号：US09344650
申请日：1999-06-25
申请人： Dieter Graefe , Gunther Elender , Wolfgang Grau , Hans-Juergen Dobschal , Guenter Berthel
发明人： Dieter Graefe , Gunther Elender , Wolfgang Grau , Hans-Juergen Dobschal , Guenter Berthel
IPC分类号： G01N2100
CPC分类号： G01N21/45 , G01N21/31
摘要： An arrangement for the detection of biomolecular reactions and interactions using the RS screening method and comprises a specimen plate or microtiter plate (PP or MTP), a white light source with subsequently arranged illumination beam path, a splitter plate on which the PP or the MTP is set for generating a detection beam path, and optical means for imaging the measurement beam path and reference beam path on a spatially resolving detector array of a CCD camera which is connected with an evaluating unit or with a computer for determining measurement values. The arrangement particularly provides optical imaging elements for imaging the measurement beam path and reference beam path at different positions on the detector array of the CCD camera simultaneously and without overlap, a monochromator which comprises a plurality of interference filters and which is arranged subsequent to the light source in the illumination beam path; a component assembly which collimates the illumination beam path, is formed of optical elements and is arranged between the monochromator and the splitter plate; and specimen plate or microtiter plate, and an optical imaging element for complete spatal separation of the measurement beam path and reference beam path in, or in the vicinity of, an intermediate inage plane or aperture diaphragm plane.
摘要翻译：使用RS筛选方法检测生物分子反应和相互作用的装置，包括样品板或微量滴定板（PP或MTP），具有随后布置的照明光束路径的白色光源，分离板，PP或MTP 被设置用于产生检测光束路径，以及光学装置，用于在与评估单元或计算机连接以确定测量值的CCD照相机的空间分辨检测器阵列上成像测量光束路径和参考光束路径。该装置特别提供光学成像元件，用于在CCD照相机的检测器阵列上的不同位置上成像测量光束路径和参考光束路径，并且不重叠;单色器，其包括多个干涉滤光器，并且布置在光之后照明光束路径中的源; 准直照明光束路径的部件组件由光学元件形成，并且布置在单色器和分离板之间; 和样品板或微量滴定板，以及光学成像元件，用于在测量光束路径和参考光束路径之间完全空间分离中间平面或孔径光阑平面中或其附近。

3. 发明授权

US6018388A Microtiter plate 失效
标题翻译：微量滴定板
公开(公告)号：US6018388A
公开(公告)日：2000-01-25
申请号：US252311
申请日：1999-02-18
申请人： Bernd Nawracala , Manfred Berndt , Guenter Gauglitz , Gunther Elender , Dieter Graefe , Guenter Berthel
发明人： Bernd Nawracala , Manfred Berndt , Guenter Gauglitz , Gunther Elender , Dieter Graefe , Guenter Berthel
IPC分类号： G01N21/03 , B01L3/00 , G01M17/007 , G01N21/25 , G01N21/27 , G01N21/45
CPC分类号： G01N21/45 , B01L3/5085 , G01N21/253
摘要： A microtiter plate is formed of a bottom plate which is transparent for light and a cavity plate which is open at two surfaces facing one another and which has a matrix-shaped arrangement of cavities or wells. The bottom plate and cavity plate are fixedly connected with one another in a liquid-tight manner. The bottom plate has a thickness of from 0.01 mm to approximately 5 mm and has planar surfaces without structures. It has, at its first surface facing the wells, a layer system formed of at least two layers with different indexes of refraction. The bottom plate is provided at its second surface remote of the wells with a coating which sharply reduces the reflectivity of this surface. The bottom plate is recessed into the lower part of the cavity plate in such a way that it does not project over a support surface located in the cavity plate.
摘要翻译：微量滴定板由对于光是透明的底板和在彼此面对的两个表面开口并具有矩形排列的空腔或孔的空腔板形成。底板和腔板以液密方式相互固定连接。底板的厚度为0.01mm至约5mm，并且具有没有结构的平面表面。在其面向井的第一表面处，具有由至少两层不同折射率形成的层系统。底板在其远离井的第二表面处设置有涂层，其大大降低了该表面的反射率。底板以空腔板的下部凹入，使得其不突出在位于空腔板中的支撑表面上。

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