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1. 发明授权

US09637468B2 Process for manufacturing 5-(2,6-di-4-morpholinyl-4-pyrimidinyl)-4-trifluoromethylpyridin-2-amine 有权
公开(公告)号：US09637468B2
公开(公告)日：2017-05-02
申请号：US14437177
申请日：2013-10-21
申请人： Dietmar Flubacher , Nicole Bieri , Murat Acemoglu , Pascal Michel , Rasmus Mose , Hans Stettler , Maria Caterina Testa , Joerg Brozio , Frank Schaefer
发明人： Dietmar Flubacher , Nicole Bieri , Murat Acemoglu , Pascal Michel , Rasmus Mose , Hans Stettler , Maria Caterina Testa , Joerg Brozio , Frank Schaefer
IPC分类号： C07D401/04 , C07D213/75 , C07F5/02 , C07D413/14 , A61K31/5377 , A61K31/506 , A61K31/4433 , A61K31/444 , C07D401/14 , C07D239/28 , C07D239/42
CPC分类号： C07D401/04 , C07D213/75 , C07D239/28 , C07D239/42 , C07D401/14 , C07F5/025
摘要： The invention discloses improved processes for manufacturing a compound, 5-(2,6-Di-4-morpholinyl-4-pyrimidinyl)-4-trifluoromethylpyridin-2-amine, its monohydrochloride salt and intermediates thereof.

2. 发明申请

US20150246897A1 Process for Manufacturing 5-(2,6-Di-4-morpholinyl-4-pyrimidinyl)-4-trifluoromethylpyridin-2-amine 有权
标题翻译：制备5-（2,6-二-4-吗啉基-4-嘧啶基）-4-三氟甲基吡啶-2-胺的方法
公开(公告)号：US20150246897A1
公开(公告)日：2015-09-03
申请号：US14437177
申请日：2013-10-21
申请人： Dietmar FLUBACHER , Nicole BIERI , Murat ACEMOGLU , Pascal MICHEL , Rasmus MOSE , Hans STETTLER , Caterina Maria TESTA , Jörg BROZIO , Frank SCHAEFER
发明人： Flubacher Dietmar , Nicole Bieri , Murat Acemoglu , Pascal Michel , Rasmus Mose , Hans Stettler , Maria Caterina Testa , Joerg Brozio , Frank Schaefer
IPC分类号： C07D401/04 , C07F5/02 , C07D213/75
CPC分类号： C07D401/04 , C07D213/75 , C07D239/28 , C07D239/42 , C07D401/14 , C07F5/025
摘要： The invention discloses improved processes for manufacturing a compound, 5-(2,6-Di-4-morpholinyl-4-pyrimidinyl)-4-trifluoromethylpyridin-2-amine, its monohydrochloride salt and intermediates thereof.
摘要翻译：本发明公开了制备化合物5-（2,6-二 - 4-吗啉基-4-嘧啶基）-4-三氟甲基吡啶-2-胺，其单盐酸盐及其中间体的改进方法。

3. 发明授权

US08993690B2 Soft thermoplastic polyurethane based on the ester of a tricarboxylic acid 有权
标题翻译：基于三羧酸酯的软质热塑性聚氨酯
公开(公告)号：US08993690B2
公开(公告)日：2015-03-31
申请号：US13266199
申请日：2010-04-26
申请人： Bin-Eric Chen , Frank Schaefer , Dirk Kempfert , Christoph Bahr , Guenter Scholz , Teruya Ohkuwa , Martin Vallo , Carsten Guenther , Harald Schulz , Yasuyuki Suzuki , Tien Kuan Lim
发明人： Bin-Eric Chen , Frank Schaefer , Dirk Kempfert , Christoph Bahr , Guenter Scholz , Teruya Ohkuwa , Martin Vallo , Carsten Guenther , Harald Schulz , Yasuyuki Suzuki , Tien Kuan Lim
IPC分类号： C08L75/06 , C08K5/11 , C08G18/42 , C08G18/48 , C08G18/66 , C08G18/76 , C08J3/18 , C08K5/00
CPC分类号： C08G18/664 , C08G18/0895 , C08G18/4238 , C08G18/4854 , C08G18/6674 , C08G18/7657 , C08G18/7671 , C08G18/797 , C08G2120/00 , C08J3/18 , C08J2375/04 , C08K5/0016 , C08K5/005 , C08K5/11 , C08L75/04
摘要： The invention refers to a thermoplastic polyurethane produced from at least an organic diisocyanate and a compound which is reactive toward isocyanates, wherein the polyurethane comprises the ester of a tricarboxylic acid with at least one alcohol and wherein all acid groups of the tricarboxylic acid are esterified with an alcohol. The invention further refers to a process for producing the respective polyurethane, products comprising this thermoplastic polyurethane and the use of the ester of a tricarboxylic acid as plasticizer in thermoplastic polyurethanes.
摘要翻译：本发明涉及由至少一种有机二异氰酸酯制得的热塑性聚氨酯和对异氰酸酯具有反应性的化合物，其中该聚氨酯包含三羧酸与至少一种醇的酯，其中三羧酸的所有酸基均被一个酒精。本发明还涉及生产各种聚氨酯的方法，包括该热塑性聚氨酯的产品以及三羧酸酯作为热塑性聚氨酯的增塑剂的用途。

4. 发明授权

US08123963B2 Method for producing a semiconductor component and a semiconductor component produced according to the method 有权
标题翻译：用于制造根据该方法制造的半导体部件和半导体部件的方法
公开(公告)号：US08123963B2
公开(公告)日：2012-02-28
申请号：US12152241
申请日：2008-05-12
申请人： Hubert Benzel , Heribert Weber , Hans Artmann , Frank Schaefer
发明人： Hubert Benzel , Heribert Weber , Hans Artmann , Frank Schaefer
IPC分类号： H01L21/302 , B81C1/00
CPC分类号： G01L9/0042 , B81B2201/0264 , B81B2203/0127 , B81B2203/0315 , B81C1/00047 , B81C1/00595 , B81C2201/0115 , G01L9/0045 , H01L21/3063
摘要： A method for producing a semiconductor component includes forming an n-doped layer in a p-doped layer of the semiconductor component, wherein the n-doped layer comprises at least one of: a sieve-like layer or a network-like layer. The method also includes porously etching the p-doped layer between the material of the n-doped layer to form a top electrode, and forming a cavity below the n-doped layer.
摘要翻译：一种制造半导体部件的方法包括在所述半导体部件的p掺杂层中形成n掺杂层，其中所述n掺杂层包括以下中的至少一种：筛状层或网状层。该方法还包括在n掺杂层的材料之间对p-掺杂层进行腐蚀蚀刻以形成顶部电极，以及在n-掺杂层下方形成空腔。

5. 发明申请

US20120015029A1 DIRECT COMPRESSION FORMULATION AND PROCESS 审中-公开
标题翻译：直接压缩配方和工艺
公开(公告)号：US20120015029A1
公开(公告)日：2012-01-19
申请号：US13185817
申请日：2011-07-19
申请人： Sabine Pfeffer , Frank Schaefer , Ricardo Schneeberger , Paul Allen Sutton , Martin Friedrich Trueby , Wolfgang Wirth
发明人： Sabine Pfeffer , Frank Schaefer , Ricardo Schneeberger , Paul Allen Sutton , Martin Friedrich Trueby , Wolfgang Wirth
IPC分类号： A61K9/20 , A61P3/10 , A61P3/04 , A61P25/00 , A61P19/10 , A61P25/16 , A61P25/28 , A61P9/00 , A61K31/40 , A61P19/02
CPC分类号： A61K9/2018 , A61K9/2054 , A61K31/195 , A61K31/40 , A61K31/4439 , Y10T428/2982
摘要： This invention relates to tablets especially tablets formed by direct compression of a dipeptidylpeptidase IV (DPP-IV) inhibitor compound, a process for the preparation thereof, to new pharmaceutical formulations, and new tableting powders comprising DPP-IV inhibitor formulations capable of being directly compressed into tablets. The invention relates further to a process for preparing the tablets by blending the active ingredient and specific excipients into the new formulations and then directly compressing the formulations into the direct compression tablets. The invention also relates to vildagliptin particle size distribution and a new crystal form of vildagliptin particularly adapted for the preparation of improved tablets and other pharmaceutical compositions.
摘要翻译：本发明涉及片剂，特别是通过直接压制二肽基肽酶IV（DPP-IV）抑制剂化合物，其制备方法，新药物制剂和包含能直接压制的DPP-IV抑制剂制剂的新型压片粉末形成的片剂成片。本发明还涉及通过将活性成分和特定赋形剂混合到新制剂中然后将制剂直接压制成直接压制片剂来制备片剂的方法。本发明还涉及维格列汀的粒度分布和新型晶体形式的维格列汀，特别适用于制备改进的片剂和其它药物组合物。

6. 发明申请

US20110163255A1 METHOD FOR PROTEIN PURIFICATION UNDER DENATURING CONDITIONS 审中-公开
标题翻译：在去除条件下蛋白质纯化的方法
公开(公告)号：US20110163255A1
公开(公告)日：2011-07-07
申请号：US13000259
申请日：2009-06-26
申请人： Thomas Deutschmann , Frank Schaefer , Helena Block
发明人： Thomas Deutschmann , Frank Schaefer , Helena Block
IPC分类号： C09K15/22 , H01F1/00 , C09K15/32
CPC分类号： C07K1/22 , B01D15/3828 , B01D15/426
摘要： The invention relates to a method for the preparation of an application buffer for the purification of proteins by means of immobilized metal ion affinity chromatography (IMAC) under denaturing conditions, which is characterized in that a defined amount of a buffer concentrate having a defined pH value is mixed with a defined amount of a urea concentrate, whereby an application buffer having a defined pH value is provided. According to the invention, a corresponding kit is provided in addition. The components are stable in storage and by mixing produce an application buffer having a defined composition and a defined pH value. The need for pH adjustment or a new preparation is eliminated. The invention can thus be used in an automated manner and as a closed kit concept.
摘要翻译：本发明涉及一种在变性条件下通过固定金属离子亲和层析（IMAC）制备用于纯化蛋白质的应用缓冲液的方法，其特征在于定义量的具有确定的pH值的缓冲浓缩物与规定量的尿素浓缩物混合，由此提供具有确定的pH值的施用缓冲液。根据本发明，另外提供相应的试剂盒。这些组分在储存中是稳定的并且通过混合产生具有确定的组成和定义的pH值的应用缓冲液。消除了对pH调节或新制剂的需要。因此，本发明可以以自动化的方式和作为封闭的工具箱概念使用。

7. 发明申请

US20090247581A1 Organic Compounds 审中-公开
标题翻译：有机化合物
公开(公告)号：US20090247581A1
公开(公告)日：2009-10-01
申请号：US12085056
申请日：2006-11-16
申请人： Mahavir Prashad , Yugang Liu , Bin Hu , Michael J. Girgis , Frank Schaefer
发明人： Mahavir Prashad , Yugang Liu , Bin Hu , Michael J. Girgis , Frank Schaefer
IPC分类号： C07D211/26 , A61K31/445
CPC分类号： C07D211/26 , C07B57/00
摘要： The present invention relates to a process for the synthesis of (S)-2′[2-1-(methyl-2-piperidyl) ethyl] cinnamanilide (I) or salts or pharmaceutically acceptable prodrugs thereof:
摘要翻译：本发明涉及合成（S）-2'[2-1-（甲基-2-哌啶基）乙基]肉桂酰苯胺（I）或其盐或其药学上可接受的前药的方法：

8. 发明授权

US07479234B2 Method for producing cavities having optically transparent wall 有权
标题翻译：用于制造具有光学透明壁的空腔的方法
公开(公告)号：US07479234B2
公开(公告)日：2009-01-20
申请号：US10492009
申请日：2002-09-04
申请人： Hubert Benzel , Heribert Weber , Frank Schaefer
发明人： Hubert Benzel , Heribert Weber , Frank Schaefer
IPC分类号： H01B13/00
CPC分类号： B81C1/00047 , B81C1/00246 , B81C2201/0115 , B81C2201/014
摘要： A method is proposed which will enable cavities having optically transparent walls to be produced simply and cost-effectively in a component by using standard methods of microsystems technology. For this purpose, a silicon region is first produced, which is surrounded on all sides by at least one optically transparent cladding layer. At least one opening is then produced in the cladding layer. Over this opening, the silicon surrounded by the cladding layer is dissolved out, forming a cavity within the cladding layer. In this context, the cladding layer acts as an etch barrier layer.
摘要翻译：提出了一种通过使用微系统技术的标准方法，能够简单且成本有效地在部件中产生具有光学透明壁的空腔的方法。为此目的，首先制造出硅区域，其通过至少一个光学透明覆层在所有侧面上被包围。然后在包层中产生至少一个开口。在该开口上，由包覆层包围的硅被溶出，在包覆层内形成空腔。在本文中，包覆层用作蚀刻阻挡层。

9. 发明授权

US07300854B2 Method for producing a semiconductor component having a movable mass in particular, and semiconductor component produced according to this method 失效
标题翻译：特别是具有可移动质量的半导体部件的制造方法以及根据该方法制造的半导体部件
公开(公告)号：US07300854B2
公开(公告)日：2007-11-27
申请号：US10451775
申请日：2001-12-06
申请人： Hubert Benzel , Heribert Weber , Frank Schaefer
发明人： Hubert Benzel , Heribert Weber , Frank Schaefer
IPC分类号： H01L21/76 , H01L21/20 , H01L21/00
CPC分类号： B81C1/00492 , B81B2201/0235 , B81B2203/0315 , B81C2201/0115 , Y10S438/96
摘要： A method of producing a semiconductor component, e.g., a multilayer semiconductor component, and a semiconductor component produced by this method, where the semiconductor component has, e.g., a mobile mass, i.e., an oscillator structure.A method easily and inexpensively produce a micromechanical component having monocrystalline oscillator structures, such as an acceleration sensor or a rotational rate sensor for example, by surface micromechanics, a first porous layer is formed in the semiconductor component in a first step and a cavity, i.e., a cavern, is formed beneath or out of the first porous layer in the semiconductor component in a second step.
摘要翻译：制造半导体元件的方法，例如多层半导体元件，以及通过该方法制造的半导体元件，其中半导体元件具有例如移动质量，即振荡器结构。一种容易且廉价地制造具有单晶振荡器结构的微机械部件，例如加速度传感器或旋转速率传感器，例如通过表面微机械，在第一步骤和空腔中在半导体部件中形成第一多孔层，即在第二步骤中，在半导体部件中的第一多孔层的下面或外面形成有洞穴。

10. 发明授权

US07160750B2 Method of producing a semiconductor sensor component 有权
标题翻译：半导体传感器部件的制造方法
公开(公告)号：US07160750B2
公开(公告)日：2007-01-09
申请号：US10473762
申请日：2002-02-21
申请人： Hubert Benzel , Heribert Weber , Frank Schaefer
发明人： Hubert Benzel , Heribert Weber , Frank Schaefer
IPC分类号： H01L21/00
CPC分类号： B81C1/00047 , B81B2201/0278 , B81C2201/0115 , B81C2201/0139
摘要： A method for manufacturing a semiconductor component, such as, for example, a multilayer semiconductor component including a micromechanical component, such as, for example, a heat transfer sensor having a semiconductor substrate of silicon, and a sensor region. For inexpensive manufacture of a thermal insulation between the semiconductor substrate and the sensor region a porous layer is provided in the semiconductor component.
摘要翻译：一种半导体部件的制造方法，例如包括微机械部件的多层半导体部件，例如具有硅的半导体基板的传热传感器和传感器区域。为了廉价地制造半导体基板和传感器区域之间的绝热，在半导体部件中设置多孔层。

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