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1. 发明授权

US07229456B2 Medical instrument for dissecting tissue 有权
标题翻译：用于解剖组织的医疗器械
公开(公告)号：US07229456B2
公开(公告)日：2007-06-12
申请号：US10196109
申请日：2002-07-16
申请人： Dieter Lang , Uwe Bacher , Fridolin Anders
发明人： Dieter Lang , Uwe Bacher , Fridolin Anders
IPC分类号： A61B17/32
CPC分类号： A61B17/1611 , A61B17/1688 , A61B2017/2902 , A61B2017/2904
摘要： A medical instrument for dissecting tissue in the human or animal body comprises a shaft. At least one movable tool is arranged at a distal end of the shaft. At least one movable grip element is arranged at a proximal end of the shaft. A force transmission element extends along the shaft, which force transmission element is movable relative to the latter and transmits thrust and/or tension forces and whose proximal end is non-positively joined to the at least one movable grip element and whose distal end is non-positively joined to the at least one movable tool. The shaft is further provided with a bend at least one point between the distal end and the proximal end. The force transmission element is configured, at least in the region of the bend, as a flexible tubular element conforming to the bend, which is guided in contact with the shaft. According to a second variant, a flattened and flexible configuration is given to the force transmission element in the region of the bend, at least locally transversely to the plane of curvature of the bend, and the force transmission element extends continuously in axial direction, transversely to the plane of curvature, at least over the inner diameter of the shaft in the region of the bend.
摘要翻译：用于解剖人或动物体中的组织的医疗器械包括轴。至少一个可移动工具布置在轴的远端。至少一个可动夹紧元件布置在轴的近端。力传递元件沿着轴延伸，该力传递元件相对于该传动元件可移动，并且传递推力和/或张力，并且其近端与所述至少一个可动把手元件非正向接合，并且其远端不是 - 正向连接到所述至少一个可移动工具。轴还在远端和近端之间至少有一个点设有弯曲部。至少在弯曲区域中，力传递元件被构造为与弯曲部接触的引导件的柔性管状元件。根据第二种变型，在弯曲区域中至少部分横向于弯曲曲面的局部向力传递元件施加平坦且柔性的构造，并且力传递元件在轴向方向上连续延伸至少在弯曲区域内的轴的内径上。

2. 发明授权

US06500189B1 Medical instrument for dissecting tissue 有权
标题翻译：用于解剖组织的医疗器械
公开(公告)号：US06500189B1
公开(公告)日：2002-12-31
申请号：US09563755
申请日：2000-05-01
申请人： Dieter Lang , Uwe Bacher , Fridolin Anders
发明人： Dieter Lang , Uwe Bacher , Fridolin Anders
IPC分类号： A61B1732
CPC分类号： A61B17/1611 , A61B17/1688 , A61B2017/2902 , A61B2017/2904
摘要： A medical instrument for dissecting tissue in the human or animal body comprises a shaft. At least one movable tool is arranged at a distal end of the shaft. At least one movable grip element is arranged at a proximal end of the shaft. A force transmission element extends along the shaft, which force transmission element is movable relative to the latter and transmits thrust and/or tension forces and whose proximal end is non-positively joined to the at least one movable grip element and whose distal end is non-positively joined to the at least one movable tool. The shaft is further provided with a bend at at least one point between the distal end and the proximal end. The force transmission element is configured, at least in the region of the bend, as a flexible tubular element conforming to the bend, which is guided in contact with the shaft. According to a second variant, a flattened and flexible configuration is given to the force transmission element in the region of the bend, at least locally transversely to the plane of curvature of the bend, and the force transmission element extends continuously in axial direction, transversely to the plane of curvature, at least over the inner diameter of the shaft in the region of the bend.
摘要翻译：用于解剖人或动物体中的组织的医疗器械包括轴。至少一个可移动工具布置在轴的远端。至少一个可动夹紧元件布置在轴的近端。力传递元件沿着轴延伸，该力传递元件相对于该传动元件可移动，并且传递推力和/或张力，并且其近端与所述至少一个可动把手元件非正向接合，并且其远端不是 - 正向连接到所述至少一个可移动工具。轴在远端和近端之间的至少一个点处进一步设置有弯曲部。至少在弯曲区域中，力传递元件被构造为与弯曲部接触的引导件的柔性管状元件。根据第二种变型，在弯曲区域中至少部分横向于弯曲曲面的局部向力传递元件施加平坦且柔性的构造，并且力传递元件在轴向方向上连续延伸至少在弯曲区域内的轴的内径上。

3. 发明授权

US09173680B2 Seal for a trocar sleeve and such trocar sleeve 有权
标题翻译：套管针套和这种套管针套的密封
公开(公告)号：US09173680B2
公开(公告)日：2015-11-03
申请号：US11744061
申请日：2007-05-03
申请人： Dieter Lang
发明人： Dieter Lang
IPC分类号： A61B1/00 , A61M5/178 , A61B17/34 , A61M39/06
CPC分类号： A61B17/3498 , A61B17/3423 , A61B17/3462 , A61B2017/3464 , A61M39/0613
摘要： A seal for a trocar sleeve comprises a sealing body which, in the direction of a longitudinal center axis of the sealing body, has a first axial end and a second axial end and, between said first and second ends, an elastic sealing element which, in a radially inner area relative to the longitudinal center axis, defines a passage for an instrument. Said sealing element has a substantially tubular hollow space whose radially inner wall area annularly surrounds the passage, and said hollow space contains a fluid and and has a radially inner wall area annularly surrounding the passage, and a radially outer wall area on a radially outer side of the hollow space, the radially outer wall area having a wall thickness larger than a wall thickness of the radially inner wall area.
摘要翻译：套针套管的密封件包括：密封体，其在密封体的纵向中心轴线的方向上具有第一轴向端部和第二轴向端部，并且在所述第一和第二端部之间具有弹性密封元件，在相对于纵向中心轴线的径向内部区域中限定用于仪器的通道。所述密封元件具有基本上管状的中空空间，其径向内壁区域环形地围绕通道，并且所述中空空间包含流体，并且具有环形环绕通道的径向内壁区域，径向外侧壁区域在径向外侧所述径向外壁区域的壁厚大于所述径向内壁区域的壁厚。

4. 发明授权

US08329716B2 Hetaryloxy-substituted phenylamino pyrimidines as Rho kinase inhibitors 失效
标题翻译：甲氧基取代的苯基氨基嘧啶作为Rho激酶抑制剂
公开(公告)号：US08329716B2
公开(公告)日：2012-12-11
申请号：US11547975
申请日：2005-03-30
申请人： Hartmut Schirok , Martin Radtke , Joachim Mittendorf , Raimund Kast , Johannes-Peter Stasch , Mark Jean Gnoth , Klaus Münter , Dieter Lang , Santiago Figueroa Perez , Michael Thutewohl , Samir Bennabi , Heimo Ehmke
发明人： Hartmut Schirok , Martin Radtke , Joachim Mittendorf , Raimund Kast , Johannes-Peter Stasch , Mark Jean Gnoth , Klaus Münter , Dieter Lang , Santiago Figueroa Perez , Michael Thutewohl , Samir Bennabi , Heimo Ehmke
IPC分类号： C07D471/04 , A61K31/437
CPC分类号： C07D471/04
摘要： The invention relates to hetaryloxy-substituted phenylaminopyrimidines, to a process for their preparation and to their use for preparing medicaments for the treatment and/or prophylaxis of diseases in humans and animals, in particular cardiovascular disorders.
摘要翻译：本发明涉及苯甲酰氧基取代的苯基氨基嘧啶，其制备方法及其用于制备用于治疗和/或预防人和动物疾病，特别是心血管疾病的药物。

5. 发明授权

US08318761B2 Substituted arylsulfonamides as antiviral agents 有权
标题翻译：取代的芳基磺酰胺作为抗病毒剂
公开(公告)号：US08318761B2
公开(公告)日：2012-11-27
申请号：US12203793
申请日：2008-09-03
申请人： Niels Svenstrup , Holger Zimmermann , Dagmar Karthaus , Andreas Goeller , Dirk Heimbach , Kerstin Henninger , Dieter Lang , Daniela Paulsen , Bernd Riedl , Rudolf Schohe-Loop , Joachim Schuhmacher , Tobias Wunberg
发明人： Niels Svenstrup , Holger Zimmermann , Dagmar Karthaus , Andreas Goeller , Dirk Heimbach , Kerstin Henninger , Dieter Lang , Daniela Paulsen , Bernd Riedl , Rudolf Schohe-Loop , Joachim Schuhmacher , Tobias Wunberg
IPC分类号： A01N43/40 , A61K31/435 , A61K31/44
CPC分类号： C07D413/04 , C07D213/73
摘要： The invention relates to substituted arylsulfonamides of formula (I) and methods for their preparation as well as their use for the production of medicaments for the treatment and/or prophylaxis of diseases, especially for use as antiviral agents, particularly against cytomegaloviruses.
摘要翻译：本发明涉及式（I）的取代芳基磺酰胺及其制备方法及其用于生产用于治疗和/或预防疾病的药物的用途，特别是用作抗病毒剂，特别是用于巨细胞病毒的药物。

6. 发明授权

US08198267B2 Substituted oxazolidinones and their use 失效
标题翻译：取代恶唑烷酮及其用途
公开(公告)号：US08198267B2
公开(公告)日：2012-06-12
申请号：US12665728
申请日：2008-06-13
申请人： Swen Allerheiligen , Marcus Bauser , Hartmut Schirok , Michael Härter , Stephan Siegel , Ulrich Rester , Christoph Gerdes , Stefan Heitmeier , Georges Von Degenfeld , Anja Buchmüller , Elke Dittrich-Wengenroth , Uwe Saatman , Julia Strassburger , Mark Jean Gnoth , Dieter Lang
发明人： Swen Allerheiligen , Marcus Bauser , Hartmut Schirok , Michael Härter , Stephan Siegel , Ulrich Rester , Christoph Gerdes , Stefan Heitmeier , Georges Von Degenfeld , Anja Buchmüller , Elke Dittrich-Wengenroth , Uwe Saatman , Julia Strassburger , Mark Jean Gnoth , Dieter Lang
IPC分类号： C07D413/14 , A61K31/4439 , A61P7/02
CPC分类号： C07D413/14
摘要： The invention relates to novel substituted oxazolidinones, to processes for preparation thereof, to the use thereof for treatment and/or prophylaxis of diseases, and to the use thereof for producing medicaments for treatment and/or prophylaxis of diseases, especially of thromboembolic disorders.
摘要翻译：本发明涉及新型取代的恶唑烷酮，其制备方法，其用于治疗和/或预防疾病的用途及其用于制备用于治疗和/或预防疾病，特别是血栓栓塞性疾病的药物的用途。

7. 发明授权

US08084481B2 Substituted arylimidazolone and triazolone as inhibitors of vasopressin receptors 有权
标题翻译：取代的芳基咪唑啉酮和三唑酮作为加压素受体的抑制剂
公开(公告)号：US08084481B2
公开(公告)日：2011-12-27
申请号：US12301616
申请日：2007-05-21
申请人： Heinrich Meier , Eckhard Bender , Ulf Brüggemeier , Ingo Flamme , Dagmar Karthaus , Peter Kolkhof , Daniel Meibom , Dirk Schneider , Verena Voehringer , Chantal Fürstner , Jörg Keldenich , Dieter Lang , Elisabeth Pook , Carsten Schmeck
发明人： Heinrich Meier , Eckhard Bender , Ulf Brüggemeier , Ingo Flamme , Dagmar Karthaus , Peter Kolkhof , Daniel Meibom , Dirk Schneider , Verena Voehringer , Chantal Fürstner , Jörg Keldenich , Dieter Lang , Elisabeth Pook , Carsten Schmeck
IPC分类号： A61K31/41 , A61K31/415 , C07D249/00 , C07D233/00
CPC分类号： C07D249/12 , C07D233/70 , C07D401/12 , C07D403/12 , C07D409/04 , C07D409/14
摘要： The present application relates to novel, substituted 4-arylimidazol-2-ones and 5-aryl-1,2,4-triazolones, processes for the production thereof, the use thereof alone or in combinations for the treatment and/or prevention of diseases and the use thereof for the production of medicaments for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of cardiovascular diseases.
摘要翻译：本申请涉及新的取代的4-芳基咪唑-2-酮和5-芳基-1,2,4-三唑烷酮，其制备方法，其单独使用或组合用于治疗和/或预防疾病以及其用于生产用于治疗和/或预防疾病的药物的用途，特别是用于治疗和/或预防心血管疾病。

8. 发明申请

US20110172207A1 SUBSTITUTED PYRAZOLAMIDES AND THEIR USE 有权
标题翻译：取代的吡唑并胺及其用途
公开(公告)号：US20110172207A1
公开(公告)日：2011-07-14
申请号：US12884113
申请日：2010-09-16
申请人： Rudolf SCHOHE-LOOP , Reinhold Welker , Arnold Paessens , Marcus Bauser , Friederike Stoll , Frank Dittmer , Kerstin Henninger , Daniela Paulsen , Dieter Lang
发明人： Rudolf SCHOHE-LOOP , Reinhold Welker , Arnold Paessens , Marcus Bauser , Friederike Stoll , Frank Dittmer , Kerstin Henninger , Daniela Paulsen , Dieter Lang
IPC分类号： A61K31/4155 , C07D413/06 , C07D403/06 , C07D417/06 , A61K31/5377 , A61K31/553 , A61K31/427 , A61K31/5386 , A61K31/541 , A61K31/496 , A61P31/12 , A61P31/18
CPC分类号： C07D231/14 , A61K31/4155 , C07D401/06 , C07D403/06 , C07D413/06 , C07D417/06 , C07D451/06 , C07D491/08 , C07D498/08
摘要： The present invention relates to novel substituted pyrazolamides, methods for their preparation, their use for the treatment and/or prophylaxis of diseases, as well as their use for the manufacture of medicaments for the treatment and/or prophylaxis of diseases, especially of retroviral diseases, in humans and/or animals.
摘要翻译：本发明涉及新型取代的吡唑啉酰胺，其制备方法，其用于治疗和/或预防疾病的用途，以及其用于制备用于治疗和/或预防疾病尤其是逆转录病毒疾病的药物的用途，在人类和/或动物中。

9. 发明申请

US20110130377A1 SUBSTITUTED ARYLOXAZOLES AND THEIR USE 失效
标题翻译：替代阿魏洛尔及其使用
公开(公告)号：US20110130377A1
公开(公告)日：2011-06-02
申请号：US12671019
申请日：2008-07-17
申请人： Peter Nell , Walter Hübsch , Barbara Albrecht-Küpper , Jorg Keldenich , Alexandros Vakalopoulos , Frank Süssmeier , Katja Zimmermann , Dieter Lang , Daniel Meibom
发明人： Peter Nell , Walter Hübsch , Barbara Albrecht-Küpper , Jorg Keldenich , Alexandros Vakalopoulos , Frank Süssmeier , Katja Zimmermann , Dieter Lang , Daniel Meibom
IPC分类号： A61K31/4439 , C07D413/12 , C07D413/14 , A61P9/00 , A61P9/12 , A61P9/10 , A61P3/04 , A61P3/10 , A61P3/06
CPC分类号： A61K31/4439 , A61K31/695 , A61K45/06 , C07D413/12 , C07D413/14 , C07D419/14 , C07F7/10
摘要： The present application relates to novel substituted aryloxazole derivatives, a method for the production thereof, the use thereof for the treatment and/or prophylaxis of diseases and the use thereof for the production of drugs for the treatment and/or prophylaxis of diseases, preferably for the treatment and/or prevention of cardiovascular and metabolic disorders.
摘要翻译：本申请涉及新型取代的芳基恶唑衍生物，其制备方法，其用于治疗和/或预防疾病的用途及其用于生产用于治疗和/或预防疾病的药物的用途，优选用于治疗和/或预防心血管和代谢紊乱。

10. 发明申请

US20100298293A1 SUBSTITUTED OXAZOLIDINONES AND THEIR USE 失效
标题翻译：替代奥昔洛芬及其使用
公开(公告)号：US20100298293A1
公开(公告)日：2010-11-25
申请号：US12665728
申请日：2008-06-13
申请人： Swen Allerheiligen , Marcus Bauser , Hartmut Schirok , Michael Härter , Stephan Siegel , Ulrich Rester , Christoph Gerdes , Stefan Heitmeier , Georges Von Degenfeld , Anja Buchmüller , Elke Dittrich-Wengenroth , Uwe Saatman , Julia Strassburger , Mark Jean Gnoth , Dieter Lang
发明人： Swen Allerheiligen , Marcus Bauser , Hartmut Schirok , Michael Härter , Stephan Siegel , Ulrich Rester , Christoph Gerdes , Stefan Heitmeier , Georges Von Degenfeld , Anja Buchmüller , Elke Dittrich-Wengenroth , Uwe Saatman , Julia Strassburger , Mark Jean Gnoth , Dieter Lang
IPC分类号： A61K31/553 , A01N1/02 , A61K31/5377 , A61K31/497 , A61K31/513 , A61K31/454 , A61K31/4439 , C07D413/12 , A61P7/02
CPC分类号： C07D413/14
摘要： The invention relates to novel substituted oxazolidinones, to processes for preparation thereof, to the use thereof for treatment and/or prophylaxis of diseases, and to the use thereof for producing medicaments for treatment and/or prophylaxis of diseases, especially of thromboembolic disorders.
摘要翻译：本发明涉及新型取代的恶唑烷酮，其制备方法，其用于治疗和/或预防疾病的用途及其用于制备用于治疗和/或预防疾病，特别是血栓栓塞性疾病的药物的用途。

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