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1. 发明授权

US06682548B2 Medical instrument 失效
标题翻译：医疗仪器
公开(公告)号：US06682548B2
公开(公告)日：2004-01-27
申请号：US10314579
申请日：2002-12-09
申请人： Dieter Lang , Thomas Hopf , Michael Strobel
发明人： Dieter Lang , Thomas Hopf , Michael Strobel
IPC分类号： A61B1728
CPC分类号： A61B17/29 , A61B17/1608 , A61B18/1445 , A61B2017/2902 , A61B2017/292 , A61B2017/2939 , A61B2017/294
摘要： A medical instrument with a hollow shaft having at its proximal end a handle consisting of at least two gripping members and at its distal end a tool consisting of at lest two jaw members, where at least one jaw member of the tool is adjustable in relation to the at least one other jaw member of the tool for purposes of opening and closing by means of one rotatably shaped gripping member of the handle, and the at least one adjustable jaw member and the corresponding gripping member of the handle that serves to adjust the jaw member are connected to one another by means of two push-pull rods. In order to create a medical instrument that ensures a constantly sufficient transmission of power, it is proposed with the invention that the two push/pull rods are secured on contact points at intervals from one another above and below the pivot point of the adjustable jaw member on this jaw member in such a way that two straight lines each extending from the pivot point through one of the contact points form an angle (alpha+beta) of 110 to 160 degrees.
摘要翻译：具有空心轴的医疗器械，其近端具有由至少两个夹持构件组成的手柄，并且在其远端处具有由至少两个钳口构件组成的工具，其中该工具的至少一个钳口构件可相对于所述工具的至少一个其它钳口构件用于通过所述把手的一个可旋转形状的夹紧构件打开和关闭，以及所述至少一个可调整的钳口构件和用于调节所述钳口的所述手柄的相应夹持构件构件通过两个推拉杆彼此连接。为了产生确保持续充分的动力传递的医疗器械，本发明提出两个推/拉杆在可调颚构件的枢转点上方和下方彼此间隔地间隔地固定在接触点上在这个钳口构件上，使得从支点通过一个接触点延伸的两条直线形成110至160度的角度（α+β）。

2. 发明授权

US07662167B2 Medical instrument 失效
标题翻译：医疗仪器
公开(公告)号：US07662167B2
公开(公告)日：2010-02-16
申请号：US10626414
申请日：2003-07-24
申请人： Dieter Lang , Thomas Hopf
发明人： Dieter Lang , Thomas Hopf
IPC分类号： A61B17/28 , A61B17/32
CPC分类号： A61B17/1608 , A61B2017/2902 , A61B2017/292 , A61B2017/2939 , A61B2017/294
摘要： The invention relates to a medical instrument with a hollow shaft, a handle, and a tool, where at least one jaw member of the tool can be rotated in relation to the at least one other jaw member of the tool for purposes of opening and closing by means of one rotatably configured gripping member of the handle, and the rotatable jaw member and the gripping member of the handle that serves to rotate are connected to one another by means of a push pin installed in the hollow shaft. To create a simple construction ensuring the best possible power transmission along with a good cutting sensation for the operator, a rigid casing can be inserted into the push pin, at least partly in form-locking connection, which casing in turn can be inserted, at least partly in form-locking connection, into the hollow shaft and the push pin is mounted in the casing so that it is at least partly rotation-resistant.
摘要翻译：本发明涉及具有中空轴，手柄和工具的医疗器械，其中工具的至少一个钳口构件相对于工具的至少一个其它钳口构件可旋转，用于打开和关闭通过一个可旋转地配置的把手的夹持构件，并且用于旋转的可旋转夹爪构件和手柄的夹持构件通过安装在空心轴中的推动销彼此连接。为了创建简单的结构，确保最佳的动力传递以及操作者的良好的切割感觉，刚性壳体可以插入到推销中，至少部分地形成锁定连接，该壳体又可以插入到至少部分地形成锁定连接的中空轴，并且推销安装在壳体中，使得其至少部分地具有旋转阻力。

3. 发明授权

US07211099B2 Medical instrument 有权
标题翻译：医疗仪器
公开(公告)号：US07211099B2
公开(公告)日：2007-05-01
申请号：US10457279
申请日：2003-06-09
申请人： Dieter Lang , Thomas Hopf
发明人： Dieter Lang , Thomas Hopf
IPC分类号： A61B17/00
CPC分类号： A61B17/1608 , A61B2017/2939 , A61B2017/294 , B25B7/00 , B25B7/12
摘要： The invention relates to a medical instrument, comprising a shaft, the proximal end of which has a handle, with at least two grip pieces and the distal end of which has a tool, with at least two jaw pieces, whereby at least one jaw piece of the tool may be adjusted relative to the at least one other jaw piece for opening and closing, by means a grip piece on the handle, embodied so as to pivot. Each adjustable jaw piece and the corresponding grip piece in the handle, for adjusting the jaw piece, are connected to each other, by means of a pull-/push-rod and each adjustable jaw piece is connected to the pull-/push-rod, by means of a compensation lever. According to the invention, the best possible force transfer with a good cutting feel for the operator may be achieved, whereby the compensation lever is pivotably fixed on one end to the pull-/push-rod and displaceably mounted at the other end in a guide groove, formed in the adjustable jaw piece.
摘要翻译：本发明涉及一种医疗器械，其包括轴，其近端具有柄部，其具有至少两个夹持件，并且其远端具有工具，所述工具具有至少两个钳口件，由此至少一个钳口件可以相对于至少一个其他钳口件来调节工具，以便打开和关闭手柄上的夹持件，从而枢转。每个可调节的颚板和手柄中的相应把手，用于调节颚板，通过拉/推杆相互连接，每个可调节的颚片连接到拉/推杆，通过补偿杆。根据本发明，可以实现对操作者具有良好切割感的最好的力传递，由此补偿杆在一端可枢转地固定到拉/推杆上，并且在另一端可移动地安装在导向件凹槽，形成在可调颚板中。

4. 发明授权

US09173680B2 Seal for a trocar sleeve and such trocar sleeve 有权
标题翻译：套管针套和这种套管针套的密封
公开(公告)号：US09173680B2
公开(公告)日：2015-11-03
申请号：US11744061
申请日：2007-05-03
申请人： Dieter Lang
发明人： Dieter Lang
IPC分类号： A61B1/00 , A61M5/178 , A61B17/34 , A61M39/06
CPC分类号： A61B17/3498 , A61B17/3423 , A61B17/3462 , A61B2017/3464 , A61M39/0613
摘要： A seal for a trocar sleeve comprises a sealing body which, in the direction of a longitudinal center axis of the sealing body, has a first axial end and a second axial end and, between said first and second ends, an elastic sealing element which, in a radially inner area relative to the longitudinal center axis, defines a passage for an instrument. Said sealing element has a substantially tubular hollow space whose radially inner wall area annularly surrounds the passage, and said hollow space contains a fluid and and has a radially inner wall area annularly surrounding the passage, and a radially outer wall area on a radially outer side of the hollow space, the radially outer wall area having a wall thickness larger than a wall thickness of the radially inner wall area.
摘要翻译：套针套管的密封件包括：密封体，其在密封体的纵向中心轴线的方向上具有第一轴向端部和第二轴向端部，并且在所述第一和第二端部之间具有弹性密封元件，在相对于纵向中心轴线的径向内部区域中限定用于仪器的通道。所述密封元件具有基本上管状的中空空间，其径向内壁区域环形地围绕通道，并且所述中空空间包含流体，并且具有环形环绕通道的径向内壁区域，径向外侧壁区域在径向外侧所述径向外壁区域的壁厚大于所述径向内壁区域的壁厚。

5. 发明授权

US08329716B2 Hetaryloxy-substituted phenylamino pyrimidines as Rho kinase inhibitors 失效
标题翻译：甲氧基取代的苯基氨基嘧啶作为Rho激酶抑制剂
公开(公告)号：US08329716B2
公开(公告)日：2012-12-11
申请号：US11547975
申请日：2005-03-30
申请人： Hartmut Schirok , Martin Radtke , Joachim Mittendorf , Raimund Kast , Johannes-Peter Stasch , Mark Jean Gnoth , Klaus Münter , Dieter Lang , Santiago Figueroa Perez , Michael Thutewohl , Samir Bennabi , Heimo Ehmke
发明人： Hartmut Schirok , Martin Radtke , Joachim Mittendorf , Raimund Kast , Johannes-Peter Stasch , Mark Jean Gnoth , Klaus Münter , Dieter Lang , Santiago Figueroa Perez , Michael Thutewohl , Samir Bennabi , Heimo Ehmke
IPC分类号： C07D471/04 , A61K31/437
CPC分类号： C07D471/04
摘要： The invention relates to hetaryloxy-substituted phenylaminopyrimidines, to a process for their preparation and to their use for preparing medicaments for the treatment and/or prophylaxis of diseases in humans and animals, in particular cardiovascular disorders.
摘要翻译：本发明涉及苯甲酰氧基取代的苯基氨基嘧啶，其制备方法及其用于制备用于治疗和/或预防人和动物疾病，特别是心血管疾病的药物。

6. 发明授权

US08318761B2 Substituted arylsulfonamides as antiviral agents 有权
标题翻译：取代的芳基磺酰胺作为抗病毒剂
公开(公告)号：US08318761B2
公开(公告)日：2012-11-27
申请号：US12203793
申请日：2008-09-03
申请人： Niels Svenstrup , Holger Zimmermann , Dagmar Karthaus , Andreas Goeller , Dirk Heimbach , Kerstin Henninger , Dieter Lang , Daniela Paulsen , Bernd Riedl , Rudolf Schohe-Loop , Joachim Schuhmacher , Tobias Wunberg
发明人： Niels Svenstrup , Holger Zimmermann , Dagmar Karthaus , Andreas Goeller , Dirk Heimbach , Kerstin Henninger , Dieter Lang , Daniela Paulsen , Bernd Riedl , Rudolf Schohe-Loop , Joachim Schuhmacher , Tobias Wunberg
IPC分类号： A01N43/40 , A61K31/435 , A61K31/44
CPC分类号： C07D413/04 , C07D213/73
摘要： The invention relates to substituted arylsulfonamides of formula (I) and methods for their preparation as well as their use for the production of medicaments for the treatment and/or prophylaxis of diseases, especially for use as antiviral agents, particularly against cytomegaloviruses.
摘要翻译：本发明涉及式（I）的取代芳基磺酰胺及其制备方法及其用于生产用于治疗和/或预防疾病的药物的用途，特别是用作抗病毒剂，特别是用于巨细胞病毒的药物。

7. 发明授权

US08198267B2 Substituted oxazolidinones and their use 失效
标题翻译：取代恶唑烷酮及其用途
公开(公告)号：US08198267B2
公开(公告)日：2012-06-12
申请号：US12665728
申请日：2008-06-13
申请人： Swen Allerheiligen , Marcus Bauser , Hartmut Schirok , Michael Härter , Stephan Siegel , Ulrich Rester , Christoph Gerdes , Stefan Heitmeier , Georges Von Degenfeld , Anja Buchmüller , Elke Dittrich-Wengenroth , Uwe Saatman , Julia Strassburger , Mark Jean Gnoth , Dieter Lang
发明人： Swen Allerheiligen , Marcus Bauser , Hartmut Schirok , Michael Härter , Stephan Siegel , Ulrich Rester , Christoph Gerdes , Stefan Heitmeier , Georges Von Degenfeld , Anja Buchmüller , Elke Dittrich-Wengenroth , Uwe Saatman , Julia Strassburger , Mark Jean Gnoth , Dieter Lang
IPC分类号： C07D413/14 , A61K31/4439 , A61P7/02
CPC分类号： C07D413/14
摘要： The invention relates to novel substituted oxazolidinones, to processes for preparation thereof, to the use thereof for treatment and/or prophylaxis of diseases, and to the use thereof for producing medicaments for treatment and/or prophylaxis of diseases, especially of thromboembolic disorders.
摘要翻译：本发明涉及新型取代的恶唑烷酮，其制备方法，其用于治疗和/或预防疾病的用途及其用于制备用于治疗和/或预防疾病，特别是血栓栓塞性疾病的药物的用途。

8. 发明授权

US08084481B2 Substituted arylimidazolone and triazolone as inhibitors of vasopressin receptors 有权
标题翻译：取代的芳基咪唑啉酮和三唑酮作为加压素受体的抑制剂
公开(公告)号：US08084481B2
公开(公告)日：2011-12-27
申请号：US12301616
申请日：2007-05-21
申请人： Heinrich Meier , Eckhard Bender , Ulf Brüggemeier , Ingo Flamme , Dagmar Karthaus , Peter Kolkhof , Daniel Meibom , Dirk Schneider , Verena Voehringer , Chantal Fürstner , Jörg Keldenich , Dieter Lang , Elisabeth Pook , Carsten Schmeck
发明人： Heinrich Meier , Eckhard Bender , Ulf Brüggemeier , Ingo Flamme , Dagmar Karthaus , Peter Kolkhof , Daniel Meibom , Dirk Schneider , Verena Voehringer , Chantal Fürstner , Jörg Keldenich , Dieter Lang , Elisabeth Pook , Carsten Schmeck
IPC分类号： A61K31/41 , A61K31/415 , C07D249/00 , C07D233/00
CPC分类号： C07D249/12 , C07D233/70 , C07D401/12 , C07D403/12 , C07D409/04 , C07D409/14
摘要： The present application relates to novel, substituted 4-arylimidazol-2-ones and 5-aryl-1,2,4-triazolones, processes for the production thereof, the use thereof alone or in combinations for the treatment and/or prevention of diseases and the use thereof for the production of medicaments for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of cardiovascular diseases.
摘要翻译：本申请涉及新的取代的4-芳基咪唑-2-酮和5-芳基-1,2,4-三唑烷酮，其制备方法，其单独使用或组合用于治疗和/或预防疾病以及其用于生产用于治疗和/或预防疾病的药物的用途，特别是用于治疗和/或预防心血管疾病。

9. 发明申请

US20110172207A1 SUBSTITUTED PYRAZOLAMIDES AND THEIR USE 有权
标题翻译：取代的吡唑并胺及其用途
公开(公告)号：US20110172207A1
公开(公告)日：2011-07-14
申请号：US12884113
申请日：2010-09-16
申请人： Rudolf SCHOHE-LOOP , Reinhold Welker , Arnold Paessens , Marcus Bauser , Friederike Stoll , Frank Dittmer , Kerstin Henninger , Daniela Paulsen , Dieter Lang
发明人： Rudolf SCHOHE-LOOP , Reinhold Welker , Arnold Paessens , Marcus Bauser , Friederike Stoll , Frank Dittmer , Kerstin Henninger , Daniela Paulsen , Dieter Lang
IPC分类号： A61K31/4155 , C07D413/06 , C07D403/06 , C07D417/06 , A61K31/5377 , A61K31/553 , A61K31/427 , A61K31/5386 , A61K31/541 , A61K31/496 , A61P31/12 , A61P31/18
CPC分类号： C07D231/14 , A61K31/4155 , C07D401/06 , C07D403/06 , C07D413/06 , C07D417/06 , C07D451/06 , C07D491/08 , C07D498/08
摘要： The present invention relates to novel substituted pyrazolamides, methods for their preparation, their use for the treatment and/or prophylaxis of diseases, as well as their use for the manufacture of medicaments for the treatment and/or prophylaxis of diseases, especially of retroviral diseases, in humans and/or animals.
摘要翻译：本发明涉及新型取代的吡唑啉酰胺，其制备方法，其用于治疗和/或预防疾病的用途，以及其用于制备用于治疗和/或预防疾病尤其是逆转录病毒疾病的药物的用途，在人类和/或动物中。

10. 发明申请

US20110130377A1 SUBSTITUTED ARYLOXAZOLES AND THEIR USE 失效
标题翻译：替代阿魏洛尔及其使用
公开(公告)号：US20110130377A1
公开(公告)日：2011-06-02
申请号：US12671019
申请日：2008-07-17
申请人： Peter Nell , Walter Hübsch , Barbara Albrecht-Küpper , Jorg Keldenich , Alexandros Vakalopoulos , Frank Süssmeier , Katja Zimmermann , Dieter Lang , Daniel Meibom
发明人： Peter Nell , Walter Hübsch , Barbara Albrecht-Küpper , Jorg Keldenich , Alexandros Vakalopoulos , Frank Süssmeier , Katja Zimmermann , Dieter Lang , Daniel Meibom
IPC分类号： A61K31/4439 , C07D413/12 , C07D413/14 , A61P9/00 , A61P9/12 , A61P9/10 , A61P3/04 , A61P3/10 , A61P3/06
CPC分类号： A61K31/4439 , A61K31/695 , A61K45/06 , C07D413/12 , C07D413/14 , C07D419/14 , C07F7/10
摘要： The present application relates to novel substituted aryloxazole derivatives, a method for the production thereof, the use thereof for the treatment and/or prophylaxis of diseases and the use thereof for the production of drugs for the treatment and/or prophylaxis of diseases, preferably for the treatment and/or prevention of cardiovascular and metabolic disorders.
摘要翻译：本申请涉及新型取代的芳基恶唑衍生物，其制备方法，其用于治疗和/或预防疾病的用途及其用于生产用于治疗和/或预防疾病的药物的用途，优选用于治疗和/或预防心血管和代谢紊乱。

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