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1. 发明授权

US5565486A Sesquiterpenes, their preparation and their use as inhibitors acting on the gaba-benzodiazepine receptor 失效
标题翻译：倍半萜，它们的制备及其作为抑制剂作用于gaba苯并二氮杂受体的用途
公开(公告)号：US5565486A
公开(公告)日：1996-10-15
申请号：US464737
申请日：1995-08-29
申请人： Didier V. Renno , Gerard B. O'Beirne , Brent R. Copp
发明人： Didier V. Renno , Gerard B. O'Beirne , Brent R. Copp
IPC分类号： A61K31/35 , A61P21/02 , A61P25/08 , A61P25/20 , A61P43/00 , C07D493/06 , C07D493/16 , C12P17/18 , C12R1/645 , C07D311/94
CPC分类号： C07D493/06 , C12P17/181
摘要： Sesquiterpenes obtainable from the fungal strain Acremonium strictum XO6/15/458, and phannaceutically and veterinarily acceptable salts thereof, are inhibitors of the binding of benzodiazepine to the GABA-benzodiazepine-Cl ionophore receptor complex. These compounds are prepared by (i) fermenting, in a source of carbon, nitrogen and inorganic salts, fungal strain XO6/15/458 (IMI 354451) or a mutant thereof which produces the sesquiterpenes, (ii) isolating the sesquiterpenes from the fermentation medium; and (iii) if desired, converting the sesquiterpene into a pharmaceutically or veterinarily acceptable salt.
摘要翻译： PCT No.PCT / GB93 / 02632 Sec。 371日期1995年8月29日第 102（e）日期1995年8月29日PCT 1993年12月22日PCT公布。公开号WO94 / 14814 日期1994年7月7日可从真菌菌株Acremonium strictum XO6 / 15/458及其药物和兽医学上可接受的盐获得的四萜烯是苯并二氮杂与GABA-苯并二氮杂-Cl离子载体受体复合物结合的抑制剂。这些化合物通过（i）在碳源，氮源和无机盐源中发酵生产倍半萜的真菌菌株XO6 / 15/458（IMI 354451）或其突变体，（ii）从发酵中分离倍半萜中; 和（iii）如果需要，将倍半萜转化为药学上或兽医学上可接受的盐。

2. 发明授权

US09433942B2 Biological sample storage device 有权
标题翻译：生物样品储存装置
公开(公告)号：US09433942B2
公开(公告)日：2016-09-06
申请号：US13990144
申请日：2011-11-24
申请人： Michael John Smith , Stevan Paul Tortorella , Gerard B. O'Beirne
发明人： Michael John Smith , Stevan Paul Tortorella , Gerard B. O'Beirne
IPC分类号： B01L9/00 , B01L3/00 , G01N35/00 , G01N1/31
CPC分类号： B01L3/508 , B01L9/52 , B01L2200/025 , B01L2200/12 , B01L2300/02 , B01L2300/069 , B01L2300/0819 , B01L2300/0822 , G01N1/312 , G01N35/00732 , Y10T436/25
摘要： Apparatus for holding biological samples and methods of assembling the same are disclosed. In an embodiment, a pair of rigid frames is described, each frame comprising an aperture. A biological sample storage medium is placed between the two frames so that the biological sample storage medium at least partly overlaps each of the apertures in the frames. The two frames are joined to fix the biological sample storage medium in place while allowing access to the biological sample storage medium via each of the apertures. The frames can be rigid and waterproof, and provide a robust storage media for biological samples. At least one pre-defined area of weakness can be provided in the frames, to allow removal of a portion of the frames, which may correspond to indicia on the storage medium.
摘要翻译：公开了用于保持生物样品的装置及其组装方法。在一个实施例中，描述了一对刚性框架，每个框架包括孔。将生物样品存储介质放置在两个框架之间，使得生物样品存储介质至少部分地与框架中的每个孔重叠。连接两个框架以将生物样品存储介质固定就位，同时允许经由每个孔进入生物样品存储介质。框架可以是刚性和防水的，并为生物样品提供坚固的存储介质。可以在框架中提供至少一个预定义的弱点区域，以允许去除可能对应于存储介质上的标记的框架的一部分。

3. 发明申请

US20130260477A1 BIOLOGICAL SAMPLE STORAGE DEVICE 有权
标题翻译：生物样本储存装置
公开(公告)号：US20130260477A1
公开(公告)日：2013-10-03
申请号：US13990144
申请日：2011-11-24
申请人： Michael John Smith , Stevan Paul Tortorella , Gerard B. O'Beirne
发明人： Michael John Smith , Stevan Paul Tortorella , Gerard B. O'Beirne
IPC分类号： B01L3/00
CPC分类号： B01L3/508 , B01L9/52 , B01L2200/025 , B01L2200/12 , B01L2300/02 , B01L2300/069 , B01L2300/0819 , B01L2300/0822 , G01N1/312 , G01N35/00732 , Y10T436/25
摘要： Embodiments of the invention relate to methods of assembling an apparatus for holding biological samples. Conventionally, storage media are encased in a relatively thin flexible cardboard frame. Such constructions are vulnerable to damage from moisture and mechanical forces; these defects may subsequently cause problems for automated handling systems. In an embodiment, these defects are prevented by providing a pair of rigid frames, each frame comprising an aperture; placing a biological sample storage medium between the two frames so that the biological sample storage medium at least partly overlaps each of the apertures in the frames; and joining the two frames to fix the biological sample storage medium in place while allowing access to the biological sample storage medium via each of the apertures. Thus, in embodiments of the present invention, the frames can be rigid and waterproof, and provide a robust storage media for biological samples. At least one pre-defined area of weakness can be provided in the frames, to allow removal of a portion of the frames.
摘要翻译：本发明的实施例涉及组装用于保持生物样品的装置的方法。通常，存储介质被封装在相对薄的柔性纸板框架中。这种结构容易受到水分和机械力的损害; 这些缺陷可能随后引起自动化处理系统的问题。在一个实施例中，通过提供一对刚性框架来防止这些缺陷，每个框架包括孔; 将生物样品存储介质放置在两个框架之间，使得生物样品存储介质至少部分地与框架中的每个孔重叠; 并且连接两个框架以将生物样品存储介质固定到位，同时允许经由每个孔进入生物样品存储介质。因此，在本发明的实施例中，框架可以是刚性和防水的，并为生物样品提供坚固的存储介质。可以在框架中提供至少一个预定义的弱点区域，以允许移除框架的一部分。

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