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1. 发明授权

US5035709A Mechanical heart valve with compliant sewing ring 失效
标题翻译：机械式心脏瓣膜，具有柔顺缝纫环
公开(公告)号：US5035709A
公开(公告)日：1991-07-30
申请号：US502158
申请日：1990-03-29
申请人： David W. Wieting , Than Nguyen , Robert Stobie , Hung L. Lam , Ralph Kafesjian
发明人： David W. Wieting , Than Nguyen , Robert Stobie , Hung L. Lam , Ralph Kafesjian
IPC分类号： A61F2/24
CPC分类号： A61F2/2409
摘要： A mechanical heart valve having one or more leaflets pivotally fitted in a substantially cylindrical shaped valve body formed from a resiliently deformable material. A stiffening member formed from substantially nonresilient material fit about the valve body exterior wall to provide structural integrity to the valve body. Stresses which are normally applied to the heart valve body during the opening and closing of the valve are absorbed or cushioned by the incorporation of a rubber-like body between the stiffening member and the retainer member. Further cushioning is provided by incorporating another rubber-like body in the sewing ring. This second body extends out from the exterior surface of the valve body. Finally, a length of fabric is positioned about the retainer and shock absorbing bodies. This design provides a precisely calibrated rotational torque which allows for optimum orientation of the leaflets by the implanting surgeon.
摘要翻译：机械式心脏瓣膜，其具有一个或多个可旋转地装配在由可弹性变形的材料形成的大致圆柱形的阀体中的传单。由基本上非弹性材料形成的加强构件围绕阀体外壁安装，以向阀体提供结构完整性。在阀门的打开和关闭期间通常施加到心脏瓣膜体的应力通过在加强构件和保持构件之间并入橡胶状体而被吸收或缓冲。通过在缝合环中并入另一个橡胶状体来提供进一步的缓冲。该第二主体从阀体的外表面延伸出来。最后，将一定长度的织物定位在保持器和减震体周围。该设计提供精确校准的旋转扭矩，其允许植入外科医生对瓣叶的最佳取向。

2. 发明授权

US06964682B2 Heart valve holder that resist suture looping 有权
标题翻译：心脏瓣膜支架阻止缝合环
公开(公告)号：US06964682B2
公开(公告)日：2005-11-15
申请号：US09745386
申请日：2000-12-21
申请人： Diana Nguyen-Thien-Nhon , Myron Howanec, Jr. , Ralph Kafesjian , Delos M. Cosgrove , Robert Stobie , Hung Ly Lam
发明人： Diana Nguyen-Thien-Nhon , Myron Howanec, Jr. , Ralph Kafesjian , Delos M. Cosgrove , Robert Stobie , Hung Ly Lam
IPC分类号： A61F2/24 , A61F2/48
CPC分类号： A61F2/2427 , A61F2/2412
摘要： An improved holder, system and method for implanting a tissue-type prosthetic mitral heart valve that prevents suture looping and may also constrict the commissure posts of the valve. The holder may include two relatively movable plates, one of which attaches to the valve sewing on the inflow end of the valve ring and the other which attaches via sutures or similar expedient to the valve commissures on the outflow end. Separation of the plates places the sutures in tension and constricts the commissures. The sutures may be strands or filaments, or may be wider bands of flexible biocompatible material. If bands are used, they desirably cover the commissure post tips to further help prevent suture looping thereover. The flexible lengths of material extend directly between commissures of the valve, or may extending radially inward from each commissure to a central upstanding member. Desirably, a slide is created by the flexible lengths of material adjacent each commissure post, for example by crossing over suture filaments at or radially inward from the commissure posts. If an upstanding member is used, the lengths of suture extend axially beyond the commissure post tips to create a tent that wards off sutures that otherwise might loop around the tips during advancement of the valve along an array of pre-implanted sutures.
摘要翻译：改进的用于植入组织型假体二尖瓣心脏瓣膜的保持器，系统和方法，其防止缝合线环绕并且还可以约束瓣膜的连合柱。保持器可以包括两个相对可移动的板，其中一个连接到阀环的流入端上的阀缝合，另一个通过缝合线或类似的方式附接到流出端上的阀连接。板的分离使缝合线处于紧张状态并限制合缝。缝合线可以是股线或长丝，或者可以是更宽的柔性生物相容性材料带。如果使用条带，它们理想地覆盖连合后端，以进一步有助于防止缝合在其上。柔性长度的材料在阀的连合之间直接延伸，或者可以从每个连接处径向向内延伸到中心直立构件。期望地，通过邻近每个连合柱的柔性长度的材料产生滑块，例如通过在接合柱上或径向向内穿过缝合线。如果使用直立的构件，则缝合线的长度轴向延伸超过连合后端，以产生防止缝合线的帐篷，否则，可以沿着预先植入的缝合线阵列推进阀门周围的尖端。

3. 发明授权

US08202314B2 Holders for prosthetic aortic heart valves 有权
标题翻译：假体主动脉瓣瓣支架
公开(公告)号：US08202314B2
公开(公告)日：2012-06-19
申请号：US12856341
申请日：2010-08-13
申请人： Robert Stobie
发明人： Robert Stobie
IPC分类号： A61F2/24
CPC分类号： A61F2/2427 , A61F2/2412
摘要： A holder for a flexible leaflet prosthetic aortic heart valve that is less bulky than earlier holders and minimizes obstructions to vision and working space around the valve to facilitate implantation thereof. The holder may have a central hub and three outwardly extending legs that connect directly and exclusively to tips of the commissures of the aortic heart valve for better tactile feedback when parachuting and seating the valve in the annulus. The legs are sized so that they do not overlap the commissure tips and therefore afford a better view of the sewing ring adjacent the commissures. The legs may be narrow in the midsection or split into two rails to increase visibility of the valve leaflets. The hub may be vaulted axially upward relative to the outer ends of the legs to further increase visibility of the valve. A more secure engagement between the central hub and a delivery handle is also provided to ensure the holder/handle connection does not become loose during suture placement through the sewing ring and fewer handle revolutions are required to screw in and unscrew the handle from the holder.
摘要翻译：用于柔性小叶假体主动脉瓣心脏的保持器，其比较早的保持器较不庞大，并且最小化围绕瓣膜的视觉和工作空间的障碍物以便于植入。保持器可以具有中心毂和三个向外延伸的腿，其直接且专门地连接到主动脉心脏瓣膜的连合部的尖端，以在跳伞和将瓣膜安置在环中时获得更好的触觉反馈。腿部的尺寸使得它们不与连合尖端重叠，因此可以更好地观察与连合缝相邻的缝合环。腿可能在中部狭窄或分成两个轨道，以增加瓣膜单张的可视性。轮毂可以相对于腿部的外端轴向向上凸出，以进一步增加阀的可视性。还提供了中心毂和输送手柄之间更牢固的接合，以确保在通过缝合环的缝合线放置期间保持器/手柄连接不会松动，并且需要较少的手柄旋转以从保持器上拧下和松开手柄。

4. 发明申请

US20050251252A1 Heart valve holder and method for resisting suture looping 有权
公开(公告)号：US20050251252A1
公开(公告)日：2005-11-10
申请号：US11181491
申请日：2005-07-13
申请人： Robert Stobie
发明人： Robert Stobie
IPC分类号： A61F2/24 , A61F2/48
CPC分类号： A61F2/2427 , A61F2/2412
摘要： An improved holder and method for implanting a tissue-type prosthetic mitral heart valve that prevents suture looping and may also constrict the commissure posts of the valve. An upstanding or shaft member axially positioned on the holder causes the lengths of attachment sutures to extend axially beyond the commissure post tips to create a tent and prevent looping of any of an array of pre-implanted sutures around the tips during deployment of the valve. The shaft member may be axially movable such that it can be initially retracted and then actuated just prior to valve deployment. The shaft member may have notches on its distal tip for capturing the attachment sutures, which are crossed over along the valve axis to ensure engagement by the notches. The attachment sutures may be strands or filaments, or may be wider bands of flexible biocompatible material. If bands are used, they desirably cover the commissure post tips to further help prevent suture looping thereover. The flexible lengths of material extend directly between commissures of the valve, or may extending radially inward from each commissure to a central upstanding member.

5. 发明授权

US5554186A Bileaflet mechanical heart valve having cropped slot pivot configuration and method for preventing blood stagnation therein 失效
标题翻译：具有切口槽枢轴构造的双线性机械心脏瓣膜和用于防止血液滞留的方法
公开(公告)号：US5554186A
公开(公告)日：1996-09-10
申请号：US362633
申请日：1994-12-22
申请人： George X. Guo , Robert Stobie
发明人： George X. Guo , Robert Stobie
IPC分类号： A61F2/24
CPC分类号： A61F2/2403
摘要： A bileaflet mechanical cardiovascular valve comprising an annular valve body having a pair of occluder leaflets pivotally mounted therewithin. The occluder leaflets are pivotally mounted within the valve body by the snap-fitting of ear member which extend from the top and bottom ends of the occluder leaflets into corresponding cropped pivot slots formed within the annular valve body. Each cropped pivot slot comprises a spheroidal depression or recess having a first flat cropped edge and a second flat cropped edge. The ear members of the occluder leaflets are sized and configured relative to the cropped pivot slots to facilitate opening and closing of the occluder leaflets with minimal likelihood of hemolysis or thrombotic complications. Additionally disclosed is a specialized machine tool and method for machining the cropped pivot slots in the annular valve body.
摘要翻译：一种双回路机械心血管阀，包括环形阀体，该阀体具有枢转地安装在其中的一对闭塞器小叶。闭塞器小叶通过耳塞的卡扣配合枢转地安装在阀体内，耳部构件从封堵器小叶的顶端和底端延伸到形成在环形阀体内的相应的切割的枢轴槽中。每个裁剪的枢转槽包括具有第一平坦剪切边缘和第二平坦剪切边缘的球形凹陷或凹部。闭塞器小叶的耳朵的尺寸和构型相对于裁剪的枢轴槽，以便于以最小的溶血或血栓形成并发症的可能性打开和关闭闭塞器小叶。另外公开了一种用于在环形阀体中加工裁剪的枢转槽的专用机床和方法。

6. 发明授权

US06846324B2 Combination anatomical orifice sizer and heart valve 失效
标题翻译：组合式解剖口腔分流器和心脏瓣膜
公开(公告)号：US06846324B2
公开(公告)日：2005-01-25
申请号：US10054469
申请日：2002-01-22
申请人： Robert Stobie
发明人： Robert Stobie
IPC分类号： G01B5/08 , A61B19/00 , A61F2/24 , A61F2/06
CPC分类号： A61F2/2409 , A61B90/06 , A61F2/2496
摘要： Anatomical orifice sizers that are optimally proportional to an associated prosthetic device such as a heart valve, and methods of use are provided. The sizers are desirably slightly larger than the rigid mounting diameter of the corresponding heart valve. The heart valve sizer may be cylindrical and have a diameter about 0.3 mm larger than the valve mounting diameter. The sizer preferably has a length of between about 19 mm to 22 mm, and the edges are desirably rounded to a minimum 1 mm radius. The method includes providing a set of cylindrical sizers having varying diameters; sequentially inserting at least two of the sizers through the annulus; measuring the push force needed to pass each sizer through the annulus; selecting a valve corresponding to the sizer for which the measured push force is between about 150 and 300 grams.
摘要翻译：提供了与关节假体装置（例如心脏瓣膜）和使用方法成比例的最佳比例的解剖孔径筛分器。筛分器期望稍大于相应心脏瓣膜的刚性安装直径。心脏瓣膜分选机可以是圆柱形的，并且具有比阀安装直径大约0.3mm的直径。分切器优选地具有在约19mm至22mm之间的长度，并且希望将边缘倒圆至最小1mm半径。该方法包括提供一组具有不同直径的圆柱形筛分机; 顺序地插入至少两个筛分器通过环带; 测量通过每个分级器通过环空所需的推力; 选择对应于测量的推力在约150和300克之间的分级器的阀。

7. 发明授权

US06409758B1 Heart valve holder for constricting the valve commissures and methods of use 有权
公开(公告)号：US06409758B1
公开(公告)日：2002-06-25
申请号：US09746431
申请日：2000-12-21
申请人： Robert Stobie , Jerry L. Jackman , Cuong Ton-That , C. Roger Ekholm , Steve Newborg
发明人： Robert Stobie , Jerry L. Jackman , Cuong Ton-That , C. Roger Ekholm , Steve Newborg
IPC分类号： A61F206
摘要： An improved holder, system and method for implanting a tissue-type prosthetic heart mitral valve that constricts the commissure posts of the valve and allows the user to detach the handle of the holder prior to withdrawing the holder itself. The ability to remove the handle allows a surgeon greater access to suturing the prosthetic valve to the mitral annulus. The holder may include two relatively movable plates, one of which attaches to the valve sewing on the inflow end of the valve ring and the other which attaches via sutures to the valve commissures on the outflow end. Separation of the plates places the sutures in tension and constricts the commissures. An adjusting member or adapter is interposed between the handle and holder to enable separation of the two plates and removal of the handle. The adjusting member or adapter may be packaged with the valve and holder combination, or may be sold as a separate unit, possibly with the handle, so that prior art holders can be retrofit.

8. 发明授权

US6143025A Suture rings for rotatable artificial heart valves 失效
标题翻译：可旋转人造心脏瓣膜的缝合环
公开(公告)号：US6143025A
公开(公告)日：2000-11-07
申请号：US82848
申请日：1998-05-21
申请人： Robert Stobie , George Guo
发明人： Robert Stobie , George Guo
IPC分类号： A61F2/24
CPC分类号： A61F2/2409 , Y10S623/90
摘要： A suture ring for a rotatable artificial heart valve apparatus has a ring member covered by a fabric material. A portion of the fabric material covers a portion of the inner surface of the ring member. At least one protuberance is formed on the inner surface of the ring member so as to mitigate the frictional resistance to rotation which results from compression of the fabric between the suture ring and the heart valve. Thus, desirable rotation of the heart valve relative to the suture ring is assured over a range of thicknesses of the fabric material.
摘要翻译：用于可旋转人造心脏瓣膜装置的缝合环具有由织物材料覆盖的环构件。织物材料的一部分覆盖环件的内表面的一部分。在环形构件的内表面上形成至少一个突起，以便减轻由缝合环和心脏瓣膜之间的织物压缩引起的摩擦阻力。因此，在织物材料的厚度范围内确保了心脏瓣膜相对于缝线环的期望旋转。

9. 发明授权

US5755783A Suture rings for rotatable artificial heart valves 失效
公开(公告)号：US5755783A
公开(公告)日：1998-05-26
申请号：US688672
申请日：1996-07-29
申请人： Robert Stobie , George Guo
发明人： Robert Stobie , George Guo
IPC分类号： A61F2/24
CPC分类号： A61F2/2409 , Y10S623/90
摘要： A suture ring for a rotatable artificial heart valve apparatus has a ring member covered by a fabric material. A portion of the fabric material covers a portion of the inner surface of the ring member. At least one protuberance is formed on the inner surface of the ring member so as to mitigate the frictional resistance to rotation which results from compression of the fabric between the suture ring and the heart valve. Thus, desirable rotation of the heart valve relative to the suture ring is assured over a range of thicknesses of the fabric material.

10. 发明授权

US07819915B2 Heart valve holders and handling clips therefor 有权
标题翻译：心脏瓣膜支架及其处理夹
公开(公告)号：US07819915B2
公开(公告)日：2010-10-26
申请号：US10742215
申请日：2003-12-19
申请人： Robert Stobie , Jerry L. Jackman , Cuong Ton-That , C. Roger Ekholm , Steve Newborg
发明人： Robert Stobie , Jerry L. Jackman , Cuong Ton-That , C. Roger Ekholm , Steve Newborg
IPC分类号： A61F2/24
CPC分类号： A61F2/2427
摘要： An improved holder, system and method for implanting a tissue-type prosthetic heart mitral valve that constricts the commissure posts of the valve and allows the user to detach the handle of the holder prior to withdrawing the holder itself. The ability to remove the handle allows a surgeon greater access to suturing the prosthetic valve to the mitral annulus. The holder may include two relatively movable plates, one of which attaches to the valve sewing on the inflow end of the valve ring and the other which attaches via sutures to the valve commissures on the outflow end. Separation of the plates places the sutures in tension and constricts the commissures. An adjusting member or adapter is interposed between the handle and holder to enable separation of the two plates and removal of the handle. The adjusting member or adapter may be packaged with the valve and holder combination, or may be sold as a separate unit, possibly with the handle, so that prior art holders can be retrofit. Removable storage and handling clips secure the holder and heart valve assembly within a storage jar during transportation. A kit of a number of identical storage and handling clips and holders for different diameter tissue-type prosthetic heart valves may be provided.
摘要翻译：用于植入组织型假体心脏二尖瓣的改进的保持器，系统和方法，其限制阀的连合柱，并且允许使用者在取出保持器本身之前分离保持器的手柄。去除手柄的能力允许外科医生更大程度地将修复瓣膜缝合到二尖瓣环。保持器可以包括两个相对可移动的板，其中一个相对移动的板连接到阀环的流入端上的阀缝合，另一个通过缝线连接到流出端上的阀连接。板的分离使缝合线处于紧张状态并限制合缝。调节构件或适配器插入在手柄和保持器之间，以便能够分离两个板和移除手柄。调节构件或适配器可以与阀和保持器组合一起包装，或者可以作为单独的单元出售，可能与把手一起出售，使得可以改造现有技术的保持器。可移动的储存和处理夹在运输过程中将保持器和心脏瓣膜组件固定在储存罐内。可以提供用于不同直径的组织型假体心脏瓣膜的许多相同的存储和处理夹子和保持器的套件。

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