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1. 发明授权

US08034104B2 Anatomically approximate prosthetic mitral valve 有权
标题翻译：解剖近似假性二尖瓣
公开(公告)号：US08034104B2
公开(公告)日：2011-10-11
申请号：US12889223
申请日：2010-09-23
申请人： Alain Carpentier , Hung L. Lam
发明人： Alain Carpentier , Hung L. Lam
IPC分类号： A61F2/24
CPC分类号： A61F2/2448 , A61F2/24 , A61F2/2403 , A61F2/2409 , A61F2/2412 , A61F2/2418 , A61F2230/0008 , A61F2230/0069 , A61F2230/0076 , A61F2230/0095
摘要： An anatomically approximate prosthetic heart valve includes dissimilar flexible leaflets, dissimilar commissures and/or a non-circular flow orifice. The heart valve may be implanted in the mitral position and have one larger leaflet oriented along the anterior aspect so as to mimic the natural anterior leaflet. Two other smaller leaflets extend around the posterior aspect of the valve. A basic structure providing peripheral support for the leaflets includes two taller commissures on both sides of the larger leaflet, with a third, smaller commissure between the other two leaflets. The larger leaflet may be thicker and/or stronger than the other two leaflets. The base structure defines a flow orifice intended to simulate the shape of the mitral annulus during the systolic phase. For example, the flow orifice may be elliptical. A relatively wide sewing ring has a contoured inflow end and is attached to the base structure in such a way that the valve can be implanted in an intra-atrial position and the taller commissures do not extend too far into the left ventricle, therefore avoiding injury to the ventricle.
摘要翻译：解剖学近似的假体心脏瓣膜包括不同的柔性小叶，不同的连合和/或非圆形流动孔。心脏瓣膜可以植入二尖瓣位置，并且具有沿着前方面定向的一个较大的小叶以模拟天然前叶。另外两个较小的小叶围绕阀的后部延伸。为传单提供外围支撑的基本结构包括较大传单两侧两个更高的连合体，其他两个传单之间的第三个较小的连接。较大的传单可以比其他两个传单更厚和/或更强。基部结构限定了用于在收缩期期间模拟二尖瓣环形状的流动孔。例如，流动孔口可以是椭圆形的。相对宽的缝合环具有轮廓流入端，并且以这样的方式附接到基部结构，使得瓣膜可以植入心房内的位置，并且更高的连合部不会延伸到太远的左心室，因此避免受伤到脑室

2. 发明授权

US07871435B2 Anatomically approximate prosthetic mitral heart valve 有权
标题翻译：解剖近似假体二尖瓣心脏瓣膜
公开(公告)号：US07871435B2
公开(公告)日：2011-01-18
申请号：US11039522
申请日：2005-01-19
申请人： Alain F. Carpentier , Hung L. Lam , Hugues La France
发明人： Alain F. Carpentier , Hung L. Lam , Hugues La France
IPC分类号： A61F2/24
CPC分类号： A61F2/2448 , A61F2/24 , A61F2/2403 , A61F2/2409 , A61F2/2412 , A61F2/2418 , A61F2230/0008 , A61F2230/0069 , A61F2230/0076 , A61F2230/0095
摘要： An anatomically approximate prosthetic heart valve includes dissimilar flexible leaflets, dissimilar commissures and/or a non-circular flow orifice. The heart valve may be implanted in the mitral position and have one larger leaflet oriented along the anterior aspect so as to mimic the natural anterior leaflet. Two other smaller leaflets extend around the posterior aspect of the valve. A basic structure providing peripheral support for the leaflets includes two taller commissures on both sides of the larger leaflet, with a third, smaller commissure between the other two leaflets. The larger leaflet may be thicker and/or stronger than the other two leaflets. The base structure defines a flow orifice intended to simulate the shape of the mitral annulus during the systolic phase. For example, the flow orifice may be elliptical. A relatively wide sewing ring has a contoured inflow end and is attached to the base structure in such a way that the valve can be implanted in an intra-atrial position and the taller commissures do not extend too far into the left ventricle, therefore avoiding injury to the ventricle.
摘要翻译：解剖学近似的假体心脏瓣膜包括不同的柔性小叶，不同的连合和/或非圆形流动孔。心脏瓣膜可以植入二尖瓣位置，并且具有沿着前方面定向的一个较大的小叶以模拟天然前叶。另外两个较小的小叶围绕阀的后部延伸。为传单提供外围支撑的基本结构包括较大传单两侧两个更高的连合体，其他两个传单之间的第三个较小的连接。较大的传单可以比其他两个传单更厚和/或更强。基部结构限定了用于在收缩期期间模拟二尖瓣环形状的流动孔。例如，流动孔口可以是椭圆形的。相对宽的缝合环具有轮廓流入端，并且以这样的方式附接到基部结构，使得瓣膜可以植入心房内的位置，并且更高的连合部不会延伸到太远的左心室，因此避免受伤到脑室

3. 发明授权

US5104407A Selectively flexible annuloplasty ring 失效
标题翻译：选择性灵活的瓣环成形术环
公开(公告)号：US5104407A
公开(公告)日：1992-04-14
申请号：US587486
申请日：1990-09-20
申请人： Hung L. Lam , Than Nguyen , Alain Carpentier
发明人： Hung L. Lam , Than Nguyen , Alain Carpentier
IPC分类号： A61F2/00 , A61F2/24
CPC分类号： A61F2/2448 , A61F2250/0018
摘要： An annuloplasty ring prosthesis which is formed from a selectively flexible body element having at least one defined length about its circumference which is substantially rigid. The remainder of the body element gradually increases in flexibility. The body element is a substantially annular shaped body element which is designed to be sutured to the annulus of a heart valve. The body element is formed from a non-corrosive, anti-magnetic material, and is wrapped in a material through which sutures can be drawn to suture the prosthesis to the heart valve annulus.
摘要翻译：瓣膜成形术假体由选择性柔性的身体元件形成，该身体元件具有围绕其圆周的至少一个限定长度，其基本上是刚性的。身体元素的其余部分的灵活性逐渐增加。身体元件是被设计成被缝合到心脏瓣膜的环的基本环形的身体元件。身体元件由非腐蚀性的抗磁性材料形成，并且被包裹在材料中，通过该材料可以将缝线拉出以将假体缝合到心脏瓣膜环。

4. 发明申请

US20120123530A1 PROSTHETIC HEART VALVE WITH DISSIMILAR LEAFLETS 有权
标题翻译：具有分裂叶的前置心脏瓣膜
公开(公告)号：US20120123530A1
公开(公告)日：2012-05-17
申请号：US13229346
申请日：2011-09-09
申请人： Alain F. Carpentier , Hung L. Lam , Hugues La France
发明人： Alain F. Carpentier , Hung L. Lam , Hugues La France
IPC分类号： A61F2/24
CPC分类号： A61F2/2448 , A61F2/24 , A61F2/2403 , A61F2/2409 , A61F2/2412 , A61F2/2418 , A61F2230/0008 , A61F2230/0069 , A61F2230/0076 , A61F2230/0095
摘要： An anatomically approximate prosthetic heart valve includes dissimilar flexible leaflets, dissimilar commissures and/or a non-circular flow orifice. The heart valve may be implanted in the mitral position and have one larger leaflet oriented along the anterior aspect so as to mimic the natural anterior leaflet. Two other smaller leaflets extend around the posterior aspect of the valve. A basic structure providing peripheral support for the leaflets includes two taller commissures on both sides of the larger leaflet, with a third, smaller commissure between the other two leaflets. The larger leaflet may be thicker and/or stronger than the other two leaflets. The base structure defines a flow orifice intended to simulate the shape of the mitral annulus during the systolic phase.
摘要翻译：解剖学近似的假体心脏瓣膜包括不同的柔性小叶，不同的连合和/或非圆形流动孔。心脏瓣膜可以植入二尖瓣位置，并且具有沿着前方面定向的一个较大的小叶以模拟天然前叶。另外两个较小的小叶围绕阀的后部延伸。为传单提供外围支撑的基本结构包括较大传单两侧两个更高的连合体，其他两个传单之间的第三个较小的连接。较大的传单可以比其他两个传单更厚和/或更强。基部结构限定了用于在收缩期期间模拟二尖瓣环形状的流动孔。

5. 发明授权

US4725274A Prosthetic heart valve 失效
标题翻译：假心脏瓣膜
公开(公告)号：US4725274A
公开(公告)日：1988-02-16
申请号：US923083
申请日：1986-10-24
申请人： Ernest Lane , Hung L. Lam
发明人： Ernest Lane , Hung L. Lam
IPC分类号： A61F2/24
CPC分类号： A61F2/2409 , A61F2/2412
摘要： A prosthetic heart valve comprising a frame which includes outer and inner bands and a plurality of wire-like members interlocked with the bands and forming the tip portions of commissure supports. The bands are covered with outer and inner jackets, and valve leaflets are attached to the frame and extend over a distal edge of the bands. The ends of the jackets form flexible, resilient fingers which extend between the distal edge and the valve leaflets to shield the valve leaflets from the distal edge.
摘要翻译：一种假体心脏瓣膜，其包括框架，该框架包括外带和内带，以及多个线状构件，其与带互锁并形成接合支撑件的末端部分。带被外套和内套覆盖，并且瓣叶附接到框架并且在带的远侧边缘上延伸。夹套的端部形成柔性的弹性指状物，其在远端边缘和瓣膜单张之间延伸，以将瓣膜小叶与远侧边缘隔离。

6. 发明授权

US5035709A Mechanical heart valve with compliant sewing ring 失效
标题翻译：机械式心脏瓣膜，具有柔顺缝纫环
公开(公告)号：US5035709A
公开(公告)日：1991-07-30
申请号：US502158
申请日：1990-03-29
申请人： David W. Wieting , Than Nguyen , Robert Stobie , Hung L. Lam , Ralph Kafesjian
发明人： David W. Wieting , Than Nguyen , Robert Stobie , Hung L. Lam , Ralph Kafesjian
IPC分类号： A61F2/24
CPC分类号： A61F2/2409
摘要： A mechanical heart valve having one or more leaflets pivotally fitted in a substantially cylindrical shaped valve body formed from a resiliently deformable material. A stiffening member formed from substantially nonresilient material fit about the valve body exterior wall to provide structural integrity to the valve body. Stresses which are normally applied to the heart valve body during the opening and closing of the valve are absorbed or cushioned by the incorporation of a rubber-like body between the stiffening member and the retainer member. Further cushioning is provided by incorporating another rubber-like body in the sewing ring. This second body extends out from the exterior surface of the valve body. Finally, a length of fabric is positioned about the retainer and shock absorbing bodies. This design provides a precisely calibrated rotational torque which allows for optimum orientation of the leaflets by the implanting surgeon.
摘要翻译：机械式心脏瓣膜，其具有一个或多个可旋转地装配在由可弹性变形的材料形成的大致圆柱形的阀体中的传单。由基本上非弹性材料形成的加强构件围绕阀体外壁安装，以向阀体提供结构完整性。在阀门的打开和关闭期间通常施加到心脏瓣膜体的应力通过在加强构件和保持构件之间并入橡胶状体而被吸收或缓冲。通过在缝合环中并入另一个橡胶状体来提供进一步的缓冲。该第二主体从阀体的外表面延伸出来。最后，将一定长度的织物定位在保持器和减震体周围。该设计提供精确校准的旋转扭矩，其允许植入外科医生对瓣叶的最佳取向。

7. 发明授权

US08721716B2 Prosthetic heart valve with dissimilar leaflets 有权
标题翻译：假性心脏瓣膜与不同的传单
公开(公告)号：US08721716B2
公开(公告)日：2014-05-13
申请号：US13229346
申请日：2011-09-09
申请人： Alain F. Carpentier , Hung L. Lam , Hugues Lafrance
发明人： Alain F. Carpentier , Hung L. Lam , Hugues Lafrance
IPC分类号： A61F2/24
CPC分类号： A61F2/2448 , A61F2/24 , A61F2/2403 , A61F2/2409 , A61F2/2412 , A61F2/2418 , A61F2230/0008 , A61F2230/0069 , A61F2230/0076 , A61F2230/0095
摘要： An anatomically approximate prosthetic heart valve includes dissimilar flexible leaflets, dissimilar commissures and/or a non-circular flow orifice. The heart valve may be implanted in the mitral position and have one larger leaflet oriented along the anterior aspect so as to mimic the natural anterior leaflet. Two other smaller leaflets extend around the posterior aspect of the valve. A basic structure providing peripheral support for the leaflets includes two taller commissures on both sides of the larger leaflet, with a third, smaller commissure between the other two leaflets. The larger leaflet may be thicker and/or stronger than the other two leaflets. The base structure defines a flow orifice intended to simulate the shape of the mitral annulus during the systolic phase.
摘要翻译：解剖学近似的假体心脏瓣膜包括不同的柔性小叶，不同的连合和/或非圆形流动孔。心脏瓣膜可以植入二尖瓣位置，并且具有沿着前方面定向的一个较大的小叶以模拟天然前叶。另外两个较小的小叶围绕阀的后部延伸。为传单提供外围支撑的基本结构包括较大传单两侧两个更高的连合体，其他两个传单之间的第三个较小的连接。较大的传单可以比其他两个传单更厚和/或更强。基部结构限定了用于在收缩期期间模拟二尖瓣环形状的流动孔。

8. 发明申请

US20110015731A1 Anatomically Approximate Prosthetic Mitral Valve 有权
标题翻译：解剖近似假体二尖瓣
公开(公告)号：US20110015731A1
公开(公告)日：2011-01-20
申请号：US12889223
申请日：2010-09-23
申请人： Alain F. Carpentier , Hung L. Lam
发明人： Alain F. Carpentier , Hung L. Lam
IPC分类号： A61F2/24
CPC分类号： A61F2/2448 , A61F2/24 , A61F2/2403 , A61F2/2409 , A61F2/2412 , A61F2/2418 , A61F2230/0008 , A61F2230/0069 , A61F2230/0076 , A61F2230/0095
摘要： An anatomically approximate prosthetic heart valve includes dissimilar flexible leaflets, dissimilar commissures and/or a non-circular flow orifice. The heart valve may be implanted in the mitral position and have one larger leaflet oriented along the anterior aspect so as to mimic the natural anterior leaflet. Two other smaller leaflets extend around the posterior aspect of the valve. A basic structure providing peripheral support for the leaflets includes two taller commissures on both sides of the larger leaflet, with a third, smaller commissure between the other two leaflets. The larger leaflet may be thicker and/or stronger than the other two leaflets. The base structure defines a flow orifice intended to simulate the shape of the mitral annulus during the systolic phase. For example, the flow orifice may be elliptical. A relatively wide sewing ring has a contoured inflow end and is attached to the base structure in such a way that the valve can be implanted in an intra-atrial position and the taller commissures do not extend too far into the left ventricle, therefore avoiding injury to the ventricle.
摘要翻译：解剖学近似的假体心脏瓣膜包括不同的柔性小叶，不同的连合和/或非圆形流动孔。心脏瓣膜可以植入二尖瓣位置，并且具有沿着前方面定向的一个较大的小叶以模拟天然前叶。另外两个较小的小叶围绕阀的后部延伸。为传单提供外围支撑的基本结构包括较大传单两侧两个更高的连合体，其他两个传单之间的第三个较小的连接。较大的传单可以比其他两个传单更厚和/或更强。基部结构限定了用于在收缩期期间模拟二尖瓣环形状的流动孔。例如，流动孔口可以是椭圆形的。相对宽的缝合环具有轮廓流入端，并且以这样的方式附接到基部结构，使得瓣膜可以植入心房内的位置，并且更高的连合部不会延伸到太远的左心室，因此避免受伤到脑室

9. 发明授权

US4917698A Multi-segmented annuloplasty ring prosthesis 失效
标题翻译：多节段瓣环成形术假体
公开(公告)号：US4917698A
公开(公告)日：1990-04-17
申请号：US290001
申请日：1988-12-22
申请人： Alain Carpentier , Hung L. Lam , Than Nguyen
发明人： Alain Carpentier , Hung L. Lam , Than Nguyen
IPC分类号： A61F2/24
CPC分类号： A61F2/2448
摘要： A ring prosthesis which provides different flexibilities at various points about the circumference of an associated heart valve. Specifically, the annuloplasty ring prosthesis of the invention includes a segmented body formed by two or more segments. The individual segments form a body which is substantially circular and shaped proportional to fit about the annulus of the associated heart valve. The individual segments are held in position with respect to each by a flexible joint. This flexible joint is formed by covering the segments with a flexible material which fits snugly about the segments. The cover is tied off between the adjacent segments to further restrain movement of the segments with respect to each other.

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