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1. 发明授权

US4788316A Preparation of sulphonated aromatic esters 失效
标题翻译：磺化芳族酯的制备
公开(公告)号：US4788316A
公开(公告)日：1988-11-29
申请号：US942564
申请日：1986-12-16
申请人： David W. Thornthwaite , David W. Roberts , Stephen A. Madison
发明人： David W. Thornthwaite , David W. Roberts , Stephen A. Madison
IPC分类号： C07C309/42 , C07C309/58 , C07C143/38
CPC分类号： C07C303/42 , C07C309/00
摘要： A process for preparing sulphonated aromatic esters of the group consisting of substituted or unsubstituted sulphonato-phenyl carboxylates and sulphonato-phenyl carbonates is disclosed, comprising the steps of:(1) preparing the unsulphonated aromatic ester;(2) sulphonating said unsulphonated aromatic ester; and(3) neutralizing the acid-sulphonated aromatic ester in a non-aqueous organic solvent with an alkali metal, earth alkali metal or ammonium carboxylate in an amount in excess over the amount needed to neutralize the sulphonic acid group(s) and any free or complexed SO.sub.3 present in the product mixture from the sulphonation reaction.Preferred neutralizing agent is sodium acetate; preferred solvents are acetic acid or glyme and diglyme.
摘要翻译：公开了一种制备由取代或未取代的磺基 - 苯基羧酸酯和磺酸 - 苯基碳酸酯组成的组的磺化芳族酯的方法，包括以下步骤：（1）制备未磺化的芳族酯; （2）磺化所述未磺化芳族酯; 和（3）用碱金属，碱土金属或羧酸铵在非水有机溶剂中中和酸性磺化芳族酯的量超过中和磺酸基团所需的量和任何游离的或存在于磺化反应产物混合物中的络合的SO 3。优选的中和剂是乙酸钠; 优选的溶剂是乙酸或甘醇二甲醚和二甘醇二甲醚。

2. 发明授权

US5002687A Fabric washing compositions 失效
标题翻译：织物洗涤组合物
公开(公告)号：US5002687A
公开(公告)日：1991-03-26
申请号：US337246
申请日：1989-04-13
申请人： David W. Roberts , Peter S. Sims , David W. Thornthwaite
发明人： David W. Roberts , Peter S. Sims , David W. Thornthwaite
IPC分类号： C11D3/386 , C11D3/39
CPC分类号： C11D3/391 , C11D3/386
摘要： An improved alkaline enzymatic fabric-washing composition is disclosed comprising a surface-active material, detergency builders, an enzyme, a peroxide compound bleach and a peroxyacid bleach precursor of the formula: ##STR1## wherein R is an unsubstituted alkyl group containing 1 to 9 carbon atoms or a phenyl group; and M is hydrogen, alkali metal, alkaline earth metal, ammonium or alkyl or hydroxyalkyl substituted ammonium cation. The composition is effective for washing fabrics at the low temperature region of 40.degree. C. and below.
摘要翻译：公开了改进的碱性酶织物洗涤组合物，其包含表面活性材料，去污助剂，酶，过氧化物化合物漂白剂和下式的过氧酸漂白剂前体：其中R是含有1至9个的未取代的烷基碳原子或苯基; M是氢，碱金属，碱土金属，铵或烷基或羟烷基取代的铵阳离子。该组合物在40℃及以下的低温区域洗涤织物是有效的。

3. 发明申请

US20140056498A1 SYSTEM AND METHOD FOR REGISTERING ULTRASOUND AND MAGNETIC RESONANCE IMAGES 有权
标题翻译：用于注册超声和磁共振图像的系统和方法
公开(公告)号：US20140056498A1
公开(公告)日：2014-02-27
申请号：US13885270
申请日：2011-11-15
申请人： Songbai Ji , David W. Roberts , Alex Hartov , Keith D. Paulsen
发明人： Songbai Ji , David W. Roberts , Alex Hartov , Keith D. Paulsen
IPC分类号： G06T7/00
CPC分类号： G06T7/0024 , G06T3/0068 , G06T7/30
摘要： A system and methods are presented for emulating the appearance of prominent features captured in ultrasound through directional dilation of a magnetic resonance gradient image along a direction determined by the relative ultrasound scan-head location with respect to the magnetic resonance gradient image in order to improve the robustness and reliability of registration.
摘要翻译：提出了一种系统和方法，用于通过相对于磁共振梯度图像由相对超声扫描头位置确定的方向通过磁共振梯度图像的定向扩张来模拟在超声波中捕获的突出特征的外观，以改善注册的鲁棒性和可靠性。

4. 发明授权

US08473060B2 Apparatus and method for modulating neurochemical levels in the brain 有权
标题翻译：用于调节脑中神经化学水平的装置和方法
公开(公告)号：US08473060B2
公开(公告)日：2013-06-25
申请号：US12649963
申请日：2009-12-30
申请人： James C. Leiter , Mykyta M. Chernov , David W. Roberts
发明人： James C. Leiter , Mykyta M. Chernov , David W. Roberts
IPC分类号： A61N1/18
CPC分类号： A61N1/36082 , A61B5/4094 , A61N1/0534
摘要： A treatment for Parkinson's Disease uses a stimulus electrode implanted in a subthalamic nucleus with a chemosensor implanted in a globus pallidus pars interna (GPi) of the subject. A level of a neurochemical is sensed with the chemosensor, and compared to a desired level. When the level of the neurochemical is less than desired, an electrical stimulation is provided to the stimulus electrode. In alternative embodiments, the neurochemical sensed is glutamate or dopamine. An alternative system uses a chemosensor implanted in the striatum instead of the GPi. An alternative system for treating benign essential tremor uses a stimulus electrode implanted in the thalamus with feedback taken from a chemosensor in the striatum.
摘要翻译：帕金森氏症的治疗使用植入在丘脑底核内的刺激电极，其中植入化学传感器，其被植入对象的苍白球（GPI）。用化学传感器检测神经化学物质的水平，并与期望的水平进行比较。当神经化学物质的水平低于期望值时，向刺激电极提供电刺激。在替代实施方案中，所感测的神经化学物质是谷氨酸盐或多巴胺。替代系统使用植入纹状体中的化学传感器代替GPi。用于治疗良性原发性震颤的替代系统使用植入在丘脑中的刺激电极，其具有来自纹状体中的化学传感器的反馈。

5. 发明申请

US20120209347A1 Apparatus And Method For Modulating Neurochemical Levels In the Brain 有权
标题翻译：在脑中调节神经化学水平的装置和方法
公开(公告)号：US20120209347A1
公开(公告)日：2012-08-16
申请号：US13449559
申请日：2012-04-18
申请人： James C. Leiter , Mykyta M. Chemov , David W. Roberts
发明人： James C. Leiter , Mykyta M. Chemov , David W. Roberts
IPC分类号： A61N1/372
CPC分类号： A61N1/36082 , A61B5/4094 , A61N1/0534
摘要： A treatment for Parkinson's Disease uses a stimulus electrode implanted in a subthalamic nucleus with a chemosensor implanted in a globus pallidus pars interna (GPi) of the subject. A level of a neurochemical is sensed with the chemosensor, and compared to a desired level. When the level of the neurochemical is less than desired, an electrical stimulation is provided to the stimulus electrode. In alternative embodiments, the neurochemical sensed is glutamate or dopamine. An alternative system uses a chemosensor implanted in the striatum instead of the GPi. An alternative system for treating benign essential tremor uses a stimulus electrode implanted in the thalamus with feedback taken from a chemosensor in the striatum.
摘要翻译：帕金森氏症的治疗使用植入在丘脑底核内的刺激电极，其中植入化学传感器，其被植入对象的苍白球（GPI）。用化学传感器检测神经化学物质的水平，并与期望的水平进行比较。当神经化学物质的水平低于期望值时，向刺激电极提供电刺激。在替代实施方案中，所感测的神经化学物质是谷氨酸盐或多巴胺。替代系统使用植入纹状体中的化学传感器代替GPi。用于治疗良性原发性震颤的替代系统使用植入在丘脑中的刺激电极，其具有来自纹状体中的化学传感器的反馈。

6. 外观设计

USD299070S Low profile lighting fixture 失效
公开(公告)号：USD299070S
公开(公告)日：1988-12-20
申请号：US834463
申请日：1986-02-19
申请人： Terry M. Tharp , David W. Roberts , John C. McCartney , John W. Harvey
设计人： Terry M. Tharp , David W. Roberts , John C. McCartney , John W. Harvey

7. 外观设计

USD298862S Low profile lighting fixture design 失效
公开(公告)号：USD298862S
公开(公告)日：1988-12-06
申请号：US834465
申请日：1986-02-19
申请人： Terry M. Tharp , David W. Roberts , John C. McCartney , John W. Harvey
设计人： Terry M. Tharp , David W. Roberts , John C. McCartney , John W. Harvey

8. 发明授权

US09098904B2 System and method for registering ultrasound and magnetic resonance images 有权
标题翻译：用于记录超声和磁共振图像的系统和方法
公开(公告)号：US09098904B2
公开(公告)日：2015-08-04
申请号：US13885270
申请日：2011-11-15
申请人： Songbai Ji , David W. Roberts , Alex Hartov , Keith D. Paulsen
发明人： Songbai Ji , David W. Roberts , Alex Hartov , Keith D. Paulsen
IPC分类号： G06K9/00 , G06T7/00 , G06T3/00 , A61B5/05
CPC分类号： G06T7/0024 , G06T3/0068 , G06T7/30
摘要： A system and methods are presented for emulating the appearance of prominent features captured in ultrasound through directional dilation of a magnetic resonance gradient image along a direction determined by the relative ultrasound scan-head location with respect to the magnetic resonance gradient image in order to improve the robustness and reliability of registration.
摘要翻译：提出了一种系统和方法，用于通过相对于磁共振梯度图像由相对超声扫描头位置确定的方向通过磁共振梯度图像的定向扩张来模拟在超声波中捕获的突出特征的外观，以改善注册的鲁棒性和可靠性。

9. 发明申请

US20120215093A1 SYSTEM AND METHOD FOR PROVIDING PATIENT REGISTRATION WITHOUT FIDUCIALS 有权
标题翻译：用于提供没有纤维的患者登记的系统和方法
公开(公告)号：US20120215093A1
公开(公告)日：2012-08-23
申请号：US13392173
申请日：2010-08-27
申请人： Songbai Ji , David W. Roberts , Alex Hartov , Keith D. Paulsen
发明人： Songbai Ji , David W. Roberts , Alex Hartov , Keith D. Paulsen
IPC分类号： A61B8/13 , A61B5/055
CPC分类号： A61B8/00 , A61B5/064 , A61B6/501 , A61B6/5247 , A61B8/0816 , A61B8/4245 , A61B8/5238 , A61B34/20 , A61B2017/00725 , A61B2034/2055 , A61B2090/364 , A61B2090/374 , A61B2090/378 , G06T7/30
摘要： A method for providing patient registration without fiducials comprises the steps of: spatially placing an ultrasound image of a patient randomly at different starting positions relative to a preoperative image; creating an independent registration corresponding to each different starting positions, by optimizing a spatial transformation between the preoperative image and the ultrasound image to provide a first batch of registrations; executing a second registration to fine-tune the alignment between the preoperative image and the ultrasound image; and concatenating the spatial transformation to obtain spatial transformation between the patient in an operating room and a corresponding preoperative image.
摘要翻译：一种用于提供无基准的患者登记的方法包括以下步骤：将患者的超声图像随机地相对于术前图像在不同的起始位置空间放置; 通过优化术前图像和超声图像之间的空间变换来提供第一批注册，从而产生对应于每个不同起始位置的独立注册; 执行第二注册以微调术前图像与超声图像之间的对准; 并且连接空间变换以获得手术室中的患者与相应的术前图像之间的空间变换。

10. 发明申请

US20110275932A1 Method And Apparatus For Depth-Resolved Fluorescence, Chromophore, and Oximetry Imaging For Lesion Identification During Surgery 有权
标题翻译：手术中病变识别的深度解析荧光，发色团和血氧饱和成像的方法和装置
公开(公告)号：US20110275932A1
公开(公告)日：2011-11-10
申请号：US13145505
申请日：2009-12-04
申请人： Frederic Leblond , David W. Roberts , Brian W. Pogue , Keith D. Paulsen , Alex Hartov , Scott C. Davis , Dax Kepshire
发明人： Frederic Leblond , David W. Roberts , Brian W. Pogue , Keith D. Paulsen , Alex Hartov , Scott C. Davis , Dax Kepshire
IPC分类号： A61B6/00
CPC分类号： A61B5/0073 , A61B5/0062 , A61B5/416 , A61B34/20 , A61B90/20 , G02B21/0064 , G02B21/16
摘要： A tomographic fluorescent imaging device for imaging fluorophores in biological tissues has a scanned laser for scanning the tissue and a camera for receiving light from the biological tissue at an angle to the beam at a second wavelength ten or more nanometers greater in wavelength than the wavelength of the laser. Use of both intrinsic and extrinsic fluorophores is described. Images are obtained at each of several positions of the beam. An image processing system receives the series of images, models a path of the beam through the tissue, and determines depth of fluorophore in tissue from intersections of the modeled path of the beam and the path of the received light. The laser is of 600 nm or longer wavelength, to provide penetration of tissue. The imaging device is used during surgery to visualize lesions of various types to ensure complete removal of malignant tumors. An alternative embodiment uses differences in intensity of fluorescent radiation from tissue as observed at different wavelengths to determine depth of fluorophore in tissue. An embodiment operates at multiple wavelengths to construct tomographic images of chromophores, such as hemoglobin, and is capable of dynamic imaging.
摘要翻译：用于在生物组织中成像荧光团的断层摄影荧光成像装置具有用于扫描组织的扫描激光器和用于以与波长成一定角度的波长的波长的第二波长以相对于波长的波长的波长激光。描述了内在和外在的荧光团的使用。在光束的几个位置的每一个处获得图像。图像处理系统接收一系列图像，模拟通过组织的光束的路径，并且确定组织中荧光团的深度，该距离来自光束的建模路径和接收光的路径的交叉点。激光器具有600nm或更长的波长，以提供组织的穿透。在手术期间使用成像装置可视化各种损伤以确保完全去除恶性肿瘤。替代实施例使用在不同波长处观察到的来自组织的荧光辐射的强度差来确定组织中荧光团的深度。一个实施例在多个波长下操作以构建诸如血红蛋白的发色团的断层图像，并且能够进行动态成像。

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