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1. 发明授权

US09098904B2 System and method for registering ultrasound and magnetic resonance images 有权
标题翻译：用于记录超声和磁共振图像的系统和方法
公开(公告)号：US09098904B2
公开(公告)日：2015-08-04
申请号：US13885270
申请日：2011-11-15
申请人： Songbai Ji , David W. Roberts , Alex Hartov , Keith D. Paulsen
发明人： Songbai Ji , David W. Roberts , Alex Hartov , Keith D. Paulsen
IPC分类号： G06K9/00 , G06T7/00 , G06T3/00 , A61B5/05
CPC分类号： G06T7/0024 , G06T3/0068 , G06T7/30
摘要： A system and methods are presented for emulating the appearance of prominent features captured in ultrasound through directional dilation of a magnetic resonance gradient image along a direction determined by the relative ultrasound scan-head location with respect to the magnetic resonance gradient image in order to improve the robustness and reliability of registration.
摘要翻译：提出了一种系统和方法，用于通过相对于磁共振梯度图像由相对超声扫描头位置确定的方向通过磁共振梯度图像的定向扩张来模拟在超声波中捕获的突出特征的外观，以改善注册的鲁棒性和可靠性。

2. 发明申请

US20120215093A1 SYSTEM AND METHOD FOR PROVIDING PATIENT REGISTRATION WITHOUT FIDUCIALS 有权
标题翻译：用于提供没有纤维的患者登记的系统和方法
公开(公告)号：US20120215093A1
公开(公告)日：2012-08-23
申请号：US13392173
申请日：2010-08-27
申请人： Songbai Ji , David W. Roberts , Alex Hartov , Keith D. Paulsen
发明人： Songbai Ji , David W. Roberts , Alex Hartov , Keith D. Paulsen
IPC分类号： A61B8/13 , A61B5/055
CPC分类号： A61B8/00 , A61B5/064 , A61B6/501 , A61B6/5247 , A61B8/0816 , A61B8/4245 , A61B8/5238 , A61B34/20 , A61B2017/00725 , A61B2034/2055 , A61B2090/364 , A61B2090/374 , A61B2090/378 , G06T7/30
摘要： A method for providing patient registration without fiducials comprises the steps of: spatially placing an ultrasound image of a patient randomly at different starting positions relative to a preoperative image; creating an independent registration corresponding to each different starting positions, by optimizing a spatial transformation between the preoperative image and the ultrasound image to provide a first batch of registrations; executing a second registration to fine-tune the alignment between the preoperative image and the ultrasound image; and concatenating the spatial transformation to obtain spatial transformation between the patient in an operating room and a corresponding preoperative image.
摘要翻译：一种用于提供无基准的患者登记的方法包括以下步骤：将患者的超声图像随机地相对于术前图像在不同的起始位置空间放置; 通过优化术前图像和超声图像之间的空间变换来提供第一批注册，从而产生对应于每个不同起始位置的独立注册; 执行第二注册以微调术前图像与超声图像之间的对准; 并且连接空间变换以获得手术室中的患者与相应的术前图像之间的空间变换。

3. 发明申请

US20110275932A1 Method And Apparatus For Depth-Resolved Fluorescence, Chromophore, and Oximetry Imaging For Lesion Identification During Surgery 有权
标题翻译：手术中病变识别的深度解析荧光，发色团和血氧饱和成像的方法和装置
公开(公告)号：US20110275932A1
公开(公告)日：2011-11-10
申请号：US13145505
申请日：2009-12-04
申请人： Frederic Leblond , David W. Roberts , Brian W. Pogue , Keith D. Paulsen , Alex Hartov , Scott C. Davis , Dax Kepshire
发明人： Frederic Leblond , David W. Roberts , Brian W. Pogue , Keith D. Paulsen , Alex Hartov , Scott C. Davis , Dax Kepshire
IPC分类号： A61B6/00
CPC分类号： A61B5/0073 , A61B5/0062 , A61B5/416 , A61B34/20 , A61B90/20 , G02B21/0064 , G02B21/16
摘要： A tomographic fluorescent imaging device for imaging fluorophores in biological tissues has a scanned laser for scanning the tissue and a camera for receiving light from the biological tissue at an angle to the beam at a second wavelength ten or more nanometers greater in wavelength than the wavelength of the laser. Use of both intrinsic and extrinsic fluorophores is described. Images are obtained at each of several positions of the beam. An image processing system receives the series of images, models a path of the beam through the tissue, and determines depth of fluorophore in tissue from intersections of the modeled path of the beam and the path of the received light. The laser is of 600 nm or longer wavelength, to provide penetration of tissue. The imaging device is used during surgery to visualize lesions of various types to ensure complete removal of malignant tumors. An alternative embodiment uses differences in intensity of fluorescent radiation from tissue as observed at different wavelengths to determine depth of fluorophore in tissue. An embodiment operates at multiple wavelengths to construct tomographic images of chromophores, such as hemoglobin, and is capable of dynamic imaging.
摘要翻译：用于在生物组织中成像荧光团的断层摄影荧光成像装置具有用于扫描组织的扫描激光器和用于以与波长成一定角度的波长的波长的第二波长以相对于波长的波长的波长激光。描述了内在和外在的荧光团的使用。在光束的几个位置的每一个处获得图像。图像处理系统接收一系列图像，模拟通过组织的光束的路径，并且确定组织中荧光团的深度，该距离来自光束的建模路径和接收光的路径的交叉点。激光器具有600nm或更长的波长，以提供组织的穿透。在手术期间使用成像装置可视化各种损伤以确保完全去除恶性肿瘤。替代实施例使用在不同波长处观察到的来自组织的荧光辐射的强度差来确定组织中荧光团的深度。一个实施例在多个波长下操作以构建诸如血红蛋白的发色团的断层图像，并且能够进行动态成像。

4. 发明授权

US06591055B1 Sheath bonding arrangement for fiber optic cable splices 失效
标题翻译：光缆接头护套接合装置
公开(公告)号：US06591055B1
公开(公告)日：2003-07-08
申请号：US10002044
申请日：2001-11-02
申请人： Hossein Eslambolchi , John Sinclair Huffman , David W. Roberts
发明人： Hossein Eslambolchi , John Sinclair Huffman , David W. Roberts
IPC分类号： G02B600
CPC分类号： G02B6/2558
摘要： A bond device for fiber optic cables allows for an electrical bond to be made between the cables without the need to first strip away the outer poly covering on each cable. The bond device comprises a metallic lug element which includes a cable-receiving channel, the interior surface of the channel having at least one (and, preferably, a plurality of) outwardly extending barbed tooth. As the metallic lug is clamped around the cable, the tooth/teeth penetrate the outer poly layer and contact the underlying metallic sheath material. The lug may then be coupled to another such lug via a stranded wire bonding ribbon attached between the lugs.
摘要翻译：用于光纤电缆的接合装置允许在电缆之间形成电接合，而不需要首先剥离每个电缆上的外部聚合物覆盖物。接合装置包括金属突耳元件，其包括电缆接收通道，通道的内表面具有至少一个（并且优选地，多个）向外延伸的有齿齿。当金属凸耳被夹在电缆周围时，齿/齿穿透外部多层并接触下面的金属护套材料。然后可以通过连接在凸耳之间的绞合线粘合带将凸耳连接到另一个这种凸耳。

5. 发明授权

US4837669A Low profile industrial luminaire 失效
标题翻译：低调的工业灯具
公开(公告)号：US4837669A
公开(公告)日：1989-06-06
申请号：US7889
申请日：1987-01-28
申请人： Terry M. Tharp , David W. Roberts , John C. McCartney , John W. Harvey
发明人： Terry M. Tharp , David W. Roberts , John C. McCartney , John W. Harvey
IPC分类号： F21S8/06 , F21V23/00
CPC分类号： F21V23/00 , F21S8/06
摘要： A low profile HID light fixture comprising; a housing, means for mounting said housing, an optical assembly having a lamp contained therein, an electrical assembly having a ballast contained therein and means for mounting said optical assembly and said optical assembly and said electrical assembly in side by side relationship directly beneath said housing.
摘要翻译：一种低调HID灯具，包括：壳体，用于安装所述壳体的装置，具有容纳在其中的灯的光学组件，其中容纳有镇流器的电气组件和用于将所述光学组件和所述光学组件和所述电气组件直接并入所述壳体的下方的装置。

6. 外观设计

USD298863S Low profile lighting fixture 失效
公开(公告)号：USD298863S
公开(公告)日：1988-12-06
申请号：US834462
申请日：1986-02-19
申请人： Terry M. Tharp , David W. Roberts , John C. McCartney , John W. Harvey
设计人： Terry M. Tharp , David W. Roberts , John C. McCartney , John W. Harvey

7. 发明授权

US4788316A Preparation of sulphonated aromatic esters 失效
标题翻译：磺化芳族酯的制备
公开(公告)号：US4788316A
公开(公告)日：1988-11-29
申请号：US942564
申请日：1986-12-16
申请人： David W. Thornthwaite , David W. Roberts , Stephen A. Madison
发明人： David W. Thornthwaite , David W. Roberts , Stephen A. Madison
IPC分类号： C07C309/42 , C07C309/58 , C07C143/38
CPC分类号： C07C303/42 , C07C309/00
摘要： A process for preparing sulphonated aromatic esters of the group consisting of substituted or unsubstituted sulphonato-phenyl carboxylates and sulphonato-phenyl carbonates is disclosed, comprising the steps of:(1) preparing the unsulphonated aromatic ester;(2) sulphonating said unsulphonated aromatic ester; and(3) neutralizing the acid-sulphonated aromatic ester in a non-aqueous organic solvent with an alkali metal, earth alkali metal or ammonium carboxylate in an amount in excess over the amount needed to neutralize the sulphonic acid group(s) and any free or complexed SO.sub.3 present in the product mixture from the sulphonation reaction.Preferred neutralizing agent is sodium acetate; preferred solvents are acetic acid or glyme and diglyme.
摘要翻译：公开了一种制备由取代或未取代的磺基 - 苯基羧酸酯和磺酸 - 苯基碳酸酯组成的组的磺化芳族酯的方法，包括以下步骤：（1）制备未磺化的芳族酯; （2）磺化所述未磺化芳族酯; 和（3）用碱金属，碱土金属或羧酸铵在非水有机溶剂中中和酸性磺化芳族酯的量超过中和磺酸基团所需的量和任何游离的或存在于磺化反应产物混合物中的络合的SO 3。优选的中和剂是乙酸钠; 优选的溶剂是乙酸或甘醇二甲醚和二甘醇二甲醚。

8. 发明申请

US20100312305A1 Apparatus And Method For Modulating Neurochemical Levels In the Brain 有权
标题翻译：在脑中调节神经化学水平的装置和方法
公开(公告)号：US20100312305A1
公开(公告)日：2010-12-09
申请号：US12649963
申请日：2009-12-30
申请人： James C. Leiter , Mykyta M. Chernov , David W. Roberts
发明人： James C. Leiter , Mykyta M. Chernov , David W. Roberts
IPC分类号： A61N1/36
CPC分类号： A61N1/36082 , A61B5/4094 , A61N1/0534
摘要： A treatment for Parkinson's Disease uses a stimulus electrode implanted in a subthalamic nucleus with a chemosensor implanted in a globus pallidus pars interna (GPi) of the subject. A level of a neurochemical is sensed with the chemosensor, and compared to a desired level. When the level of the neurochemical is less than desired, an electrical stimulation is provided to the stimulus electrode. In alternative embodiments, the neurochemical sensed is glutamate or dopamine. An alternative system uses a chemosensor implanted in the striatum instead of the GPi. An alternative system for treating benign essential tremor uses a stimulus electrode implanted in the thalamus with feedback taken from a chemosensor in the striatum.
摘要翻译：帕金森氏症的治疗使用植入在丘脑底核内的刺激电极，其中植入化学传感器，其被植入对象的苍白球（GPI）。用化学传感器检测神经化学物质的水平，并与期望的水平进行比较。当神经化学物质的水平低于期望值时，向刺激电极提供电刺激。在替代实施方案中，所感测的神经化学物质是谷氨酸盐或多巴胺。替代系统使用植入纹状体中的化学传感器代替GPi。用于治疗良性原发性震颤的替代系统使用植入在丘脑中的刺激电极，其具有来自纹状体中的化学传感器的反馈。

9. 发明授权

US5918970A Outdoor luminaire assembly 失效
标题翻译：户外灯具组件
公开(公告)号：US5918970A
公开(公告)日：1999-07-06
申请号：US590939
申请日：1996-01-24
申请人： Bonnie J. Brohard , David W. Roberts , John C. McCartney
发明人： Bonnie J. Brohard , David W. Roberts , John C. McCartney
IPC分类号： F21S8/08 , F21V21/108 , F21V21/116 , F21V23/02 , F21S1/10
CPC分类号： F21S8/086 , F21V21/108 , F21V21/116 , F21V23/02 , F21W2131/103
摘要： An outdoor luminaire assembly adapted to be attached to a mounting stanchion that includes an optical assembly having a lamp for generating light, an arm for supporting the optical assembly from the mounting stanchion, and a ballast which is enclosed within the arm. The optical assembly is adapted to receive and support a cover member which is selected from a group of differently shaped cover members. The cover member is made of a plastic material in order to provide design flexibility. The arm has a removable panel which allows for maintenance-ready access to the ballast and other electrical componentry which is enclosed within the arm.
摘要翻译：适于附接到安装支柱的室外照明器具组件，其包括具有用于产生光的灯的光学组件，用于从安装支柱支撑光学组件的臂以及封闭在所述臂内的镇流器。光学组件适于接收和支撑从一组不同形状的盖构件中选择的盖构件。盖构件由塑料材料制成，以提供设计灵活性。该臂具有一个可拆卸的面板，允许维护就绪地访问镇流器和封闭在臂内的其他电气组件。

10. 发明申请

US20140056498A1 SYSTEM AND METHOD FOR REGISTERING ULTRASOUND AND MAGNETIC RESONANCE IMAGES 有权
标题翻译：用于注册超声和磁共振图像的系统和方法
公开(公告)号：US20140056498A1
公开(公告)日：2014-02-27
申请号：US13885270
申请日：2011-11-15
申请人： Songbai Ji , David W. Roberts , Alex Hartov , Keith D. Paulsen
发明人： Songbai Ji , David W. Roberts , Alex Hartov , Keith D. Paulsen
IPC分类号： G06T7/00
CPC分类号： G06T7/0024 , G06T3/0068 , G06T7/30
摘要： A system and methods are presented for emulating the appearance of prominent features captured in ultrasound through directional dilation of a magnetic resonance gradient image along a direction determined by the relative ultrasound scan-head location with respect to the magnetic resonance gradient image in order to improve the robustness and reliability of registration.
摘要翻译：提出了一种系统和方法，用于通过相对于磁共振梯度图像由相对超声扫描头位置确定的方向通过磁共振梯度图像的定向扩张来模拟在超声波中捕获的突出特征的外观，以改善注册的鲁棒性和可靠性。

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