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1. 发明授权

US08433415B2 Apparatus and method for modulating neurochemical levels in the brain 有权
公开(公告)号：US08433415B2
公开(公告)日：2013-04-30
申请号：US13449559
申请日：2012-04-18
申请人： James C. Leiter , Mykyta M. Chemov , David W. Roberts
发明人： James C. Leiter , Mykyta M. Chemov , David W. Roberts
IPC分类号： A61N1/36
CPC分类号： A61N1/36082 , A61B5/4094 , A61N1/0534
摘要： A treatment for Parkinson's Disease uses a stimulus electrode implanted in a subthalamic nucleus with a chemosensor implanted in a globus pallidus pars interna (GPi) of the subject. A level of a neurochemical is sensed with the chemosensor, and compared to a desired level. When the level of the neurochemical is less than desired, an electrical stimulation is provided to the stimulus electrode. In alternative embodiments, the neurochemical sensed is glutamate or dopamine. An alternative system uses a chemosensor implanted in the striatum instead of the GPi. An alternative system for treating benign essential tremor uses a stimulus electrode implanted in the thalamus with feedback taken from a chemosensor in the striatum.

2. 发明申请

US20120209347A1 Apparatus And Method For Modulating Neurochemical Levels In the Brain 有权
标题翻译：在脑中调节神经化学水平的装置和方法
公开(公告)号：US20120209347A1
公开(公告)日：2012-08-16
申请号：US13449559
申请日：2012-04-18
申请人： James C. Leiter , Mykyta M. Chemov , David W. Roberts
发明人： James C. Leiter , Mykyta M. Chemov , David W. Roberts
IPC分类号： A61N1/372
CPC分类号： A61N1/36082 , A61B5/4094 , A61N1/0534
摘要： A treatment for Parkinson's Disease uses a stimulus electrode implanted in a subthalamic nucleus with a chemosensor implanted in a globus pallidus pars interna (GPi) of the subject. A level of a neurochemical is sensed with the chemosensor, and compared to a desired level. When the level of the neurochemical is less than desired, an electrical stimulation is provided to the stimulus electrode. In alternative embodiments, the neurochemical sensed is glutamate or dopamine. An alternative system uses a chemosensor implanted in the striatum instead of the GPi. An alternative system for treating benign essential tremor uses a stimulus electrode implanted in the thalamus with feedback taken from a chemosensor in the striatum.
摘要翻译：帕金森氏症的治疗使用植入在丘脑底核内的刺激电极，其中植入化学传感器，其被植入对象的苍白球（GPI）。用化学传感器检测神经化学物质的水平，并与期望的水平进行比较。当神经化学物质的水平低于期望值时，向刺激电极提供电刺激。在替代实施方案中，所感测的神经化学物质是谷氨酸盐或多巴胺。替代系统使用植入纹状体中的化学传感器代替GPi。用于治疗良性原发性震颤的替代系统使用植入在丘脑中的刺激电极，其具有来自纹状体中的化学传感器的反馈。

3. 发明申请

US20100312305A1 Apparatus And Method For Modulating Neurochemical Levels In the Brain 有权
标题翻译：在脑中调节神经化学水平的装置和方法
公开(公告)号：US20100312305A1
公开(公告)日：2010-12-09
申请号：US12649963
申请日：2009-12-30
申请人： James C. Leiter , Mykyta M. Chernov , David W. Roberts
发明人： James C. Leiter , Mykyta M. Chernov , David W. Roberts
IPC分类号： A61N1/36
CPC分类号： A61N1/36082 , A61B5/4094 , A61N1/0534
摘要： A treatment for Parkinson's Disease uses a stimulus electrode implanted in a subthalamic nucleus with a chemosensor implanted in a globus pallidus pars interna (GPi) of the subject. A level of a neurochemical is sensed with the chemosensor, and compared to a desired level. When the level of the neurochemical is less than desired, an electrical stimulation is provided to the stimulus electrode. In alternative embodiments, the neurochemical sensed is glutamate or dopamine. An alternative system uses a chemosensor implanted in the striatum instead of the GPi. An alternative system for treating benign essential tremor uses a stimulus electrode implanted in the thalamus with feedback taken from a chemosensor in the striatum.
摘要翻译：帕金森氏症的治疗使用植入在丘脑底核内的刺激电极，其中植入化学传感器，其被植入对象的苍白球（GPI）。用化学传感器检测神经化学物质的水平，并与期望的水平进行比较。当神经化学物质的水平低于期望值时，向刺激电极提供电刺激。在替代实施方案中，所感测的神经化学物质是谷氨酸盐或多巴胺。替代系统使用植入纹状体中的化学传感器代替GPi。用于治疗良性原发性震颤的替代系统使用植入在丘脑中的刺激电极，其具有来自纹状体中的化学传感器的反馈。

4. 发明授权

US08473060B2 Apparatus and method for modulating neurochemical levels in the brain 有权
标题翻译：用于调节脑中神经化学水平的装置和方法
公开(公告)号：US08473060B2
公开(公告)日：2013-06-25
申请号：US12649963
申请日：2009-12-30
申请人： James C. Leiter , Mykyta M. Chernov , David W. Roberts
发明人： James C. Leiter , Mykyta M. Chernov , David W. Roberts
IPC分类号： A61N1/18
CPC分类号： A61N1/36082 , A61B5/4094 , A61N1/0534
摘要： A treatment for Parkinson's Disease uses a stimulus electrode implanted in a subthalamic nucleus with a chemosensor implanted in a globus pallidus pars interna (GPi) of the subject. A level of a neurochemical is sensed with the chemosensor, and compared to a desired level. When the level of the neurochemical is less than desired, an electrical stimulation is provided to the stimulus electrode. In alternative embodiments, the neurochemical sensed is glutamate or dopamine. An alternative system uses a chemosensor implanted in the striatum instead of the GPi. An alternative system for treating benign essential tremor uses a stimulus electrode implanted in the thalamus with feedback taken from a chemosensor in the striatum.
摘要翻译：帕金森氏症的治疗使用植入在丘脑底核内的刺激电极，其中植入化学传感器，其被植入对象的苍白球（GPI）。用化学传感器检测神经化学物质的水平，并与期望的水平进行比较。当神经化学物质的水平低于期望值时，向刺激电极提供电刺激。在替代实施方案中，所感测的神经化学物质是谷氨酸盐或多巴胺。替代系统使用植入纹状体中的化学传感器代替GPi。用于治疗良性原发性震颤的替代系统使用植入在丘脑中的刺激电极，其具有来自纹状体中的化学传感器的反馈。

5. 发明申请

US20100098768A1 Method of neuroprotection from oxidant injury using metal oxide nanoparticles 审中-公开
标题翻译：使用金属氧化物纳米颗粒的氧化损伤的神经保护方法
公开(公告)号：US20100098768A1
公开(公告)日：2010-04-22
申请号：US12580859
申请日：2009-10-16
申请人： Emanuela Silvana Andreescu , James C. Leiter , Joseph S. Erlichman
发明人： Emanuela Silvana Andreescu , James C. Leiter , Joseph S. Erlichman
IPC分类号： A61K9/14 , A61K33/24 , A61P39/00 , A61P9/10
CPC分类号： A61K9/5094 , A61K33/24 , A61K47/6921 , A61K47/6923
摘要： A metal oxide nanoparticle composition including a cerium oxide nanoparticle and a metal adapted to enhance the neuroprotective activity of the cerium oxide nanoparticle. The metal can include noble metals such as platinum, and rare earth metals such as gadolinium, samarium, titanium, yttrium, zirconium, and a combination thereof Another metal oxide nanoparticle composition including a cerium oxide nanoparticle and a surface modifier, such as polyethylene oxide, polyethylene imine, dextran, polylactic acid, chitosan, alginate, and a combination thereof is provided. A method of using the metal oxide nanoparticle compositions as neuroprotective agents for the inactivation of reactive oxygen species in nervous tissues is also provided. More specifically, a neuroprotective method using the metal oxides such as ceria, yttria, or mixed ceria and yttria (or any of the other referenced metal oxide nanoparticle compositions) before, during, or after an ischemic event.
摘要翻译：一种金属氧化物纳米颗粒组合物，包括氧化铈纳米颗粒和适于增强氧化铈纳米颗粒的神经保护活性的金属。金属可以包括贵金属如铂，和诸如钆，钐，钛，钇，锆的稀土金属及其组合。另外，包括氧化铈纳米颗粒和表面改性剂如聚环氧乙烷的另一种金属氧化物纳米颗粒组合物，提供聚乙烯亚胺，葡聚糖，聚乳酸，壳聚糖，藻酸盐及其组合。还提供了将金属氧化物纳米颗粒组合物用作神经保护剂用于在神经组织中活化氧物质失活的方法。更具体地，在缺血事件之前，期间或之后使用氧化铈，氧化钇或混合二氧化铈和氧化钇（或任何其它所述金属氧化物纳米颗粒组合物）的金属氧化物的神经保护方法。

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